Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AGRL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AGRL1_HUMAN
GO:0019900 kinase binding 35.4839 4 no
GO:0019901 protein kinase binding 35.4839 5 no
GO:0017076 purine nucleotide binding 29.0323 4 no
GO:0032555 purine ribonucleotide binding 29.0323 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.0323 4 no
GO:0003924 GTPase activity 25.8065 7 no
GO:0005525 GTP binding 25.8065 5 no
GO:0016462 pyrophosphatase activity 25.8065 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.8065 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.8065 6 no
GO:0019001 guanyl nucleotide binding 25.8065 5 no
GO:0032561 guanyl ribonucleotide binding 25.8065 5 no
GO:0004930 G protein-coupled receptor activity 9.6774 4 yes
GO:0016524 latrotoxin receptor activity 6.4516 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AGRL1_HUMAN
GO:0048522 positive regulation of cellular process 77.4194 4 yes
GO:0051128 regulation of cellular component organization 64.5161 4 yes
GO:0022607 cellular component assembly 61.2903 4 no
GO:0030030 cell projection organization 48.3871 4 no
GO:0031323 regulation of cellular metabolic process 48.3871 4 no
GO:0048523 negative regulation of cellular process 48.3871 4 no
GO:0051094 positive regulation of developmental process 41.9355 4 yes
GO:0051130 positive regulation of cellular component organization 41.9355 5 yes
GO:0010646 regulation of cell communication 41.9355 4 no
GO:0051171 regulation of nitrogen compound metabolic process 41.9355 4 no
GO:0060255 regulation of macromolecule metabolic process 41.9355 4 no
GO:0080090 regulation of primary metabolic process 41.9355 4 no
GO:0120036 plasma membrane bounded cell projection organization 41.9355 5 no
GO:0009893 positive regulation of metabolic process 38.7097 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.7097 5 no
GO:0031344 regulation of cell projection organization 38.7097 5 no
GO:0042127 regulation of cell population proliferation 38.7097 4 no
GO:0044087 regulation of cellular component biogenesis 38.7097 4 no
GO:0051049 regulation of transport 38.7097 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.7097 6 no
GO:0006996 organelle organization 35.4839 4 no
GO:0009966 regulation of signal transduction 35.4839 4 no
GO:0022603 regulation of anatomical structure morphogenesis 35.4839 4 no
GO:0045595 regulation of cell differentiation 35.4839 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.4839 5 no
GO:0050807 regulation of synapse organization 32.2581 5 yes
GO:0010647 positive regulation of cell communication 32.2581 5 no
GO:0023056 positive regulation of signaling 32.2581 4 no
GO:0031325 positive regulation of cellular metabolic process 32.2581 5 no
GO:0032970 regulation of actin filament-based process 32.2581 4 no
GO:0033043 regulation of organelle organization 32.2581 5 no
GO:0034330 cell junction organization 32.2581 4 no
GO:0048584 positive regulation of response to stimulus 32.2581 4 no
GO:0051493 regulation of cytoskeleton organization 32.2581 6 no
GO:0031175 neuron projection development 32.2581 6 no
GO:0007010 cytoskeleton organization 29.0323 5 no
GO:0009967 positive regulation of signal transduction 29.0323 5 no
GO:0010468 regulation of gene expression 29.0323 5 no
GO:0030334 regulation of cell migration 29.0323 5 no
GO:0032956 regulation of actin cytoskeleton organization 29.0323 5 no
GO:0034329 cell junction assembly 29.0323 5 no
GO:0051246 regulation of protein metabolic process 29.0323 5 no
GO:0051247 positive regulation of protein metabolic process 29.0323 6 no
GO:2000145 regulation of cell motility 29.0323 4 no
GO:0008284 positive regulation of cell population proliferation 29.0323 5 no
GO:0007264 small GTPase mediated signal transduction 25.8065 4 no
GO:0009892 negative regulation of metabolic process 25.8065 4 no
GO:0019220 regulation of phosphate metabolic process 25.8065 6 no
GO:0030155 regulation of cell adhesion 25.8065 4 no
GO:0042325 regulation of phosphorylation 25.8065 7 no
GO:0044089 positive regulation of cellular component biogenesis 25.8065 5 no
GO:0045597 positive regulation of cell differentiation 25.8065 5 no
GO:0051174 regulation of phosphorus metabolic process 25.8065 5 no
GO:0051240 positive regulation of multicellular organismal process 25.8065 4 no
GO:0030031 cell projection assembly 25.8065 5 no
GO:0008104 protein localization 25.8065 4 no
GO:0050808 synapse organization 25.8065 5 no
GO:0001932 regulation of protein phosphorylation 22.5806 7 no
GO:0007015 actin filament organization 22.5806 5 no
GO:0007265 Ras protein signal transduction 22.5806 5 no
GO:0010562 positive regulation of phosphorus metabolic process 22.5806 6 no
GO:0010941 regulation of cell death 22.5806 4 no
GO:0022604 regulation of cell morphogenesis 22.5806 5 no
GO:0031324 negative regulation of cellular metabolic process 22.5806 5 no
GO:0031399 regulation of protein modification process 22.5806 6 no
GO:0042327 positive regulation of phosphorylation 22.5806 8 no
GO:0042981 regulation of apoptotic process 22.5806 6 no
GO:0043067 regulation of programmed cell death 22.5806 5 no
GO:0043269 regulation of ion transport 22.5806 5 no
GO:0045785 positive regulation of cell adhesion 22.5806 5 no
GO:0045937 positive regulation of phosphate metabolic process 22.5806 7 no
GO:0097435 supramolecular fiber organization 22.5806 4 no
GO:1902531 regulation of intracellular signal transduction 22.5806 5 no
GO:2000026 regulation of multicellular organismal development 22.5806 4 no
GO:0050804 modulation of chemical synaptic transmission 22.5806 5 no
GO:0050890 cognition 22.5806 4 no
GO:0099177 regulation of trans-synaptic signaling 22.5806 4 no
GO:0031346 positive regulation of cell projection organization 22.5806 6 no
GO:0010605 negative regulation of macromolecule metabolic process 22.5806 5 no
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 19.3548 4 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 9.6774 5 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 9.6774 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 9.6774 5 yes
GO:0019722 calcium-mediated signaling 9.6774 5 yes
GO:0019932 second-messenger-mediated signaling 9.6774 4 yes
GO:0035584 calcium-mediated signaling using intracellular calcium source 9.6774 6 yes
GO:0090128 regulation of synapse maturation 9.6774 4 yes
GO:0090129 positive regulation of synapse maturation 6.4516 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FLRT3_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRL1_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
F189B_HUMAN [view interactions] High throughput no no
PCDGD_HUMAN [view interactions] High throughput no no
CC50B_HUMAN [view interactions] High throughput no yes
CLC2D_HUMAN [view interactions] High throughput no yes
ZNRF4_HUMAN [view interactions] High throughput no no
B4GA1_HUMAN [view interactions] High throughput no yes
UPK1A_HUMAN [view interactions] High throughput no no
GPR21_HUMAN [view interactions] High throughput no no
PCDAC_HUMAN [view interactions] High throughput no yes
VNN2_HUMAN [view interactions] High throughput no no
NRN1_HUMAN [view entry] [view interactions] High throughput yes no
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
TM11B_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
LRAD1_HUMAN [view interactions] High throughput no no
ACHB2_HUMAN [view entry] [view interactions] High throughput yes no
UPK2_HUMAN [view interactions] High throughput no no
TMM59_HUMAN [view interactions] High throughput no yes
TMED7_HUMAN [view interactions] High throughput no yes
CLN5_HUMAN [view interactions] High throughput no yes
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
IL2RA_HUMAN [view interactions] High throughput no no
PCAT2_HUMAN [view interactions] High throughput no yes
SCN4A_HUMAN [view interactions] High throughput no no
NKAI1_HUMAN [view interactions] High throughput no no
TM130_HUMAN [view interactions] High throughput no no
ZDH12_HUMAN [view interactions] High throughput no yes
LSME2_HUMAN [view interactions] High throughput no no
ARMC6_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
HLAC_HUMAN [view interactions] High throughput no no
KLRB1_HUMAN [view interactions] High throughput no yes
RAMP3_HUMAN [view interactions] High throughput no no
EDNRA_HUMAN [view interactions] High throughput no yes
GPIX_HUMAN [view interactions] High throughput no no
EVA1C_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
AGRL3_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
CAC1A_HUMAN [view interactions] High throughput no no
TSN15_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
PSA3_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CD1B_HUMAN [view interactions] High throughput no yes
NRG1_HUMAN [view entry] [view interactions] High throughput yes no
CC50A_HUMAN [view interactions] High throughput no yes
VSIG4_HUMAN [view interactions] High throughput no no
F1892_HUMAN [view interactions] High throughput no yes
EDIL3_HUMAN [view interactions] High throughput no yes
FLRT1_HUMAN [view interactions] High throughput no no
TEN1_HUMAN [view interactions] Computational no no
S35A1_HUMAN [view interactions] Computational no no
TEN2_HUMAN [view entry] [view interactions] Computational yes no
NRX2A_HUMAN [view entry] [view interactions] Computational yes no
TEN4_HUMAN [view interactions] Computational no no