NHRF2_HUMAN
Evidence for PS localization
Functions
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed). May also act as scaffold protein in the nucleus. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NHRF2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 32.0755 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.0755 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.0755 | 4 | no |
| GO:0046872 | metal ion binding | 26.4151 | 4 | no |
| GO:0045296 | cadherin binding | 24.5283 | 4 | yes |
| GO:0003723 | RNA binding | 20.7547 | 4 | no |
| GO:0005524 | ATP binding | 20.7547 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.7547 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.7547 | 5 | no |
| GO:0019902 | phosphatase binding | 11.3208 | 4 | yes |
| GO:0001664 | G protein-coupled receptor binding | 7.5472 | 4 | yes |
| GO:0035254 | glutamate receptor binding | 5.6604 | 4 | yes |
| GO:0031799 | type 2 metabotropic glutamate receptor binding | 3.7736 | 6 | yes |
| GO:0031800 | type 3 metabotropic glutamate receptor binding | 3.7736 | 6 | yes |
| GO:0035256 | G protein-coupled glutamate receptor binding | 3.7736 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NHRF2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.3774 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.8302 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.9434 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.2830 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.3962 | 4 | no |
| GO:0008104 | protein localization | 41.5094 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.5094 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.5094 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.5094 | 4 | no |
| GO:0022607 | cellular component assembly | 39.6226 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 39.6226 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.7358 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 37.7358 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.8491 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.8491 | 5 | no |
| GO:0010941 | regulation of cell death | 35.8491 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 35.8491 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 35.8491 | 5 | no |
| GO:0051049 | regulation of transport | 35.8491 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.9623 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.0755 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.0755 | 4 | no |
| GO:0006996 | organelle organization | 32.0755 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.0755 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.1887 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 30.1887 | 5 | no |
| GO:0033043 | regulation of organelle organization | 30.1887 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.1887 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.1887 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.3019 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.3019 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 28.3019 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 26.4151 | 4 | no |
| GO:0036211 | protein modification process | 26.4151 | 4 | no |
| GO:0043412 | macromolecule modification | 26.4151 | 4 | no |
| GO:0030030 | cell projection organization | 26.4151 | 4 | no |
| GO:2000145 | regulation of cell motility | 26.4151 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.5283 | 6 | no |
| GO:0031399 | regulation of protein modification process | 24.5283 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 24.5283 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 24.5283 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.5283 | 5 | no |
| GO:0034330 | cell junction organization | 24.5283 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 24.5283 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 24.5283 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 24.5283 | 5 | no |
| GO:0060548 | negative regulation of cell death | 24.5283 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 24.5283 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 24.5283 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.5283 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 24.5283 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.5283 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.5283 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.5283 | 6 | no |
| GO:0030334 | regulation of cell migration | 24.5283 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 24.5283 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 24.5283 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.6415 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 22.6415 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 22.6415 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.6415 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.6415 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.6415 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.6415 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.6415 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.7547 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.7547 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.7547 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.7547 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.7547 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.7547 | 4 | no |
| GO:0060341 | regulation of cellular localization | 20.7547 | 4 | no |
| GO:0007010 | cytoskeleton organization | 20.7547 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 20.7547 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.7547 | 6 | no |
| GO:0030335 | positive regulation of cell migration | 20.7547 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 20.7547 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 20.7547 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 20.7547 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.7547 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.7547 | 5 | no |
| GO:0072657 | protein localization to membrane | 18.8679 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 16.9811 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 15.0943 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 13.2075 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 13.2075 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SIAH1_HUMAN | [view interactions] | Low throughput | no | yes |
| SRY_HUMAN | [view interactions] | Low throughput | no | no |
| NPT2A_HUMAN | [view interactions] | Low throughput | no | no |
| ASIC3_HUMAN | [view interactions] | Low throughput | no | no |
| AT2B2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTEN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NHRF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WWTR1_HUMAN | [view interactions] | Low throughput | no | yes |
| CFTR_HUMAN | [view interactions] | Low throughput | no | no |
| TRPV5_HUMAN | [view interactions] | Low throughput | no | no |
| S26A3_HUMAN | [view interactions] | Low throughput | no | no |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| LPAR2_HUMAN | [view interactions] | Low throughput | no | yes |
| TB10A_HUMAN | [view interactions] | Low throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCNJ1_HUMAN | [view interactions] | Low throughput | no | no |
| PDPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PODXL_HUMAN | [view interactions] | Low throughput | no | no |
| AA2BR_HUMAN | [view interactions] | Low throughput | no | no |
| PTH1R_HUMAN | [view interactions] | Low throughput | no | no |
| PLCB2_HUMAN | [view interactions] | Low throughput | no | no |
| SGK1_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIP6_HUMAN | [view interactions] | Low throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MRP4_HUMAN | [view interactions] | Low throughput | no | no |
| SL9A3_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| OTU7B_HUMAN | [view interactions] | High throughput | no | yes |
| PHLP2_HUMAN | [view interactions] | High throughput | no | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHGBA_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN8_HUMAN | [view interactions] | High throughput | no | yes |
| RHG44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDT5_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| RS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF3B_HUMAN | [view interactions] | High throughput | no | no |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| USH1C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAD23_HUMAN | [view interactions] | High throughput | no | yes |
| AHI1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRQ_HUMAN | [view interactions] | High throughput | no | no |
| NHRF3_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| WASF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMA16_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG4_HUMAN | [view interactions] | High throughput | no | no |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| DTL_HUMAN | [view interactions] | High throughput | no | no |
| RIPR3_HUMAN | [view interactions] | High throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PC3_HUMAN | [view interactions] | High throughput | no | no |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| KLH24_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| BTBD1_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| CSN4_HUMAN | [view interactions] | High throughput | no | yes |
| TCHL1_HUMAN | [view interactions] | High throughput | no | no |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| O52B2_HUMAN | [view interactions] | High throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTGR3_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| PDXL2_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STEA2_HUMAN | [view interactions] | High throughput | no | yes |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| FRYL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN3_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIR2B_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| MK12_HUMAN | [view interactions] | High throughput | no | no |
| P2R3A_HUMAN | [view interactions] | High throughput | no | yes |
| ZBED1_HUMAN | [view interactions] | High throughput | no | yes |
| S4A7_HUMAN | [view interactions] | High throughput | no | no |
| COL12_HUMAN | [view interactions] | High throughput | no | no |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| PSF1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN2_HUMAN | [view interactions] | High throughput | no | yes |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD2_HUMAN | [view interactions] | High throughput | no | no |
| SMAL1_HUMAN | [view interactions] | High throughput | no | no |
| DPH2_HUMAN | [view interactions] | High throughput | no | no |
| DPH1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMF1_HUMAN | [view interactions] | High throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXC1_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| ATP7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F133A_HUMAN | [view interactions] | High throughput | no | no |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| PDZ1I_HUMAN | [view interactions] | High throughput | no | no |
| S13A1_HUMAN | [view interactions] | High throughput | no | no |
| SIN3A_HUMAN | [view interactions] | High throughput | no | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| NUSAP_HUMAN | [view interactions] | High throughput | no | no |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPC2_HUMAN | [view interactions] | High throughput | no | yes |
| SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| LSM12_HUMAN | [view interactions] | High throughput | no | yes |
| SYMM_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDGFB_HUMAN | [view interactions] | Computational | no | yes |
| KGP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |