NU2M_HUMAN
Evidence for PS localization
Functions
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed). Essential for the catalytic activity and assembly of complex I (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NU2M_HUMAN |
|---|---|---|---|---|
| GO:0015399 | primary active transmembrane transporter activity | 80.5556 | 4 | yes |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 80.5556 | 5 | yes |
| GO:0003954 | NADH dehydrogenase activity | 63.8889 | 4 | yes |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 63.8889 | 5 | yes |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 63.8889 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 63.8889 | 4 | yes |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 63.8889 | 5 | yes |
| GO:0046872 | metal ion binding | 38.8889 | 4 | no |
| GO:0019900 | kinase binding | 11.1111 | 4 | yes |
| GO:0019901 | protein kinase binding | 8.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NU2M_HUMAN |
|---|---|---|---|---|
| GO:0022900 | electron transport chain | 83.3333 | 4 | yes |
| GO:0022904 | respiratory electron transport chain | 83.3333 | 5 | yes |
| GO:0009060 | aerobic respiration | 80.5556 | 6 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 80.5556 | 4 | yes |
| GO:0045333 | cellular respiration | 80.5556 | 5 | yes |
| GO:0019646 | aerobic electron transport chain | 77.7778 | 6 | yes |
| GO:0022607 | cellular component assembly | 61.1111 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 61.1111 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 61.1111 | 5 | yes |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 58.3333 | 7 | yes |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 52.7778 | 6 | yes |
| GO:0010257 | NADH dehydrogenase complex assembly | 50.0000 | 6 | yes |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | 50.0000 | 7 | yes |
| GO:0031323 | regulation of cellular metabolic process | 22.2222 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDUAB_HUMAN | [view interactions] | Low throughput | no | no |
| ACPM_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YMEL1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUC2_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUBB_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB5_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUC1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUA3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB2_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUS5_HUMAN | [view interactions] | Low throughput | no | yes |
| NU6M_HUMAN | [view interactions] | Low throughput | no | no |
| NDUB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU5M_HUMAN | [view interactions] | Low throughput | no | no |
| NU3M_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUA1_HUMAN | [view interactions] | Low throughput | no | yes |
| NU4LM_HUMAN | [view interactions] | Low throughput | no | no |
| NDUB8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU1M_HUMAN | [view interactions] | Low throughput | no | yes |
| NU4M_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| IPPK_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FNDC4_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | Computational | no | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| COX5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATP8_HUMAN | [view interactions] | Computational | no | no |
| QCR7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDUS4_HUMAN | [view interactions] | Computational | no | yes |
| PGH1_HUMAN | [view interactions] | Computational | no | yes |
| COX3_HUMAN | [view interactions] | Computational | no | yes |
| NDUF5_HUMAN | [view interactions] | Computational | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FXRD1_HUMAN | [view interactions] | Computational | no | no |
| ATP6_HUMAN | [view interactions] | Computational | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CIA30_HUMAN | [view interactions] | Computational | no | yes |
| RAG1_HUMAN | [view interactions] | Computational | no | no |
| NDUS8_HUMAN | [view interactions] | Computational | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| COX1_HUMAN | [view interactions] | Computational | no | yes |
| CYB_HUMAN | [view interactions] | Computational | no | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| QCR8_HUMAN | [view interactions] | Computational | no | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| QCR9_HUMAN | [view interactions] | Computational | no | no |
| QCR10_HUMAN | [view interactions] | Computational | no | no |