SKIV2_HUMAN
Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SKIV2_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 54.1667 | 4 | yes |
GO:0017076 | purine nucleotide binding | 29.1667 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 29.1667 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 29.1667 | 4 | yes |
GO:0005524 | ATP binding | 20.8333 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 20.8333 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 20.8333 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SKIV2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 54.1667 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | yes |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | yes |
GO:0090304 | nucleic acid metabolic process | 33.3333 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
GO:0008104 | protein localization | 29.1667 | 4 | no |
GO:0016070 | RNA metabolic process | 25.0000 | 5 | yes |
GO:0071702 | organic substance transport | 25.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
GO:0009057 | macromolecule catabolic process | 20.8333 | 4 | yes |
GO:0010629 | negative regulation of gene expression | 20.8333 | 6 | yes |
GO:0015031 | protein transport | 20.8333 | 4 | no |
GO:0051049 | regulation of transport | 20.8333 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 20.8333 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 20.8333 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 20.8333 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 20.8333 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 20.8333 | 5 | no |
GO:0006996 | organelle organization | 20.8333 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 20.8333 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.8333 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 20.8333 | 5 | no |
GO:0022607 | cellular component assembly | 20.8333 | 4 | no |
GO:0000956 | nuclear-transcribed mRNA catabolic process | 16.6667 | 7 | yes |
GO:0006401 | RNA catabolic process | 16.6667 | 5 | yes |
GO:0006402 | mRNA catabolic process | 16.6667 | 6 | yes |
GO:0016071 | mRNA metabolic process | 16.6667 | 6 | yes |
GO:0019439 | aromatic compound catabolic process | 16.6667 | 4 | yes |
GO:0034655 | nucleobase-containing compound catabolic process | 16.6667 | 4 | yes |
GO:0044265 | cellular macromolecule catabolic process | 16.6667 | 4 | yes |
GO:0044270 | cellular nitrogen compound catabolic process | 16.6667 | 4 | yes |
GO:0046700 | heterocycle catabolic process | 16.6667 | 4 | yes |
GO:1901361 | organic cyclic compound catabolic process | 16.6667 | 4 | yes |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 12.5000 | 8 | yes |
GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic | 12.5000 | 8 | yes |
GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5 | 12.5000 | 9 | yes |
GO:0070478 | nuclear-transcribed mRNA catabolic process, 3-5 exonucleolytic nonsense-mediated decay | 8.3333 | 9 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
WDR61_HUMAN | [view interactions] | Low throughput | no | yes |
TTC37_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CDK9_HUMAN | [view interactions] | Low throughput | no | yes |
CCNK_HUMAN | [view interactions] | High throughput | no | yes |
TASOR_HUMAN | [view interactions] | High throughput | no | yes |
LEO1_HUMAN | [view interactions] | High throughput | no | yes |
PELO_HUMAN | [view interactions] | High throughput | no | yes |
SKIV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNPC1_HUMAN | [view interactions] | High throughput | no | no |
SAE2_HUMAN | [view interactions] | High throughput | no | yes |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
NDOR1_HUMAN | [view interactions] | High throughput | no | yes |
ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THOC4_HUMAN | [view interactions] | High throughput | no | no |
CBS_HUMAN | [view interactions] | High throughput | no | yes |
RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FERM1_HUMAN | [view interactions] | High throughput | no | yes |
PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
F120C_HUMAN | [view interactions] | High throughput | no | yes |
EXOS4_HUMAN | [view interactions] | High throughput | no | yes |
EXOSX_HUMAN | [view interactions] | High throughput | no | yes |
RSMB_HUMAN | [view interactions] | High throughput | no | yes |
WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD11A_HUMAN | [view interactions] | High throughput | no | yes |
RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IRF2_HUMAN | [view interactions] | High throughput | no | yes |
M3K14_HUMAN | [view interactions] | High throughput | no | yes |
OASL_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSSK2_HUMAN | [view interactions] | High throughput | no | no |
AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
CACB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
XRN1_HUMAN | [view interactions] | High throughput | no | yes |
MPPA_HUMAN | [view interactions] | High throughput | no | yes |
GLT13_HUMAN | [view interactions] | High throughput | no | no |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
FBXW4_HUMAN | [view interactions] | High throughput | no | no |
LGR4_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
ZN746_HUMAN | [view interactions] | High throughput | no | no |
TES_HUMAN | [view interactions] | High throughput | no | yes |
HBP1_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
CGAS_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUS7_HUMAN | [view interactions] | High throughput | no | yes |
PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
WWP2_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
BRD1_HUMAN | [view interactions] | High throughput | no | yes |
TRI33_HUMAN | [view interactions] | High throughput | no | yes |
TRI66_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
PFD4_HUMAN | [view interactions] | High throughput | no | yes |
PFD3_HUMAN | [view interactions] | High throughput | no | yes |
PFD2_HUMAN | [view interactions] | High throughput | no | yes |
PFD5_HUMAN | [view interactions] | High throughput | no | yes |
PFD6_HUMAN | [view interactions] | High throughput | no | yes |
CDC73_HUMAN | [view interactions] | High throughput | no | yes |
TTC33_HUMAN | [view interactions] | High throughput | no | yes |
PHF5A_HUMAN | [view interactions] | High throughput | no | yes |
PFD1_HUMAN | [view interactions] | High throughput | no | yes |
PAF1_HUMAN | [view interactions] | High throughput | no | yes |
TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H12_HUMAN | [view interactions] | High throughput | no | yes |
H14_HUMAN | [view interactions] | High throughput | no | yes |
LN28A_HUMAN | [view interactions] | High throughput | no | no |
SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
F174A_HUMAN | [view interactions] | High throughput | no | yes |
HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPR45_HUMAN | [view interactions] | High throughput | no | no |
MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GP182_HUMAN | [view interactions] | High throughput | no | no |
DHB13_HUMAN | [view interactions] | High throughput | no | yes |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
SLN11_HUMAN | [view interactions] | High throughput | no | yes |
FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF2G_HUMAN | [view interactions] | High throughput | no | yes |
FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRP72_HUMAN | [view interactions] | High throughput | no | yes |
SRP09_HUMAN | [view interactions] | High throughput | no | no |
EXOS2_HUMAN | [view interactions] | Computational | no | yes |
XRN2_HUMAN | [view interactions] | Computational | no | yes |
EXOS3_HUMAN | [view interactions] | Computational | no | yes |
EXOS9_HUMAN | [view interactions] | Computational | no | yes |
EXOS5_HUMAN | [view interactions] | Computational | no | yes |
RENT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ZCHC7_HUMAN | [view interactions] | Computational | no | yes |
EXOS7_HUMAN | [view interactions] | Computational | no | yes |
EXOS8_HUMAN | [view interactions] | Computational | no | yes |
NELFE_HUMAN | [view interactions] | Computational | no | yes |
HBS1L_HUMAN | [view interactions] | Computational | no | yes |
DI3L1_HUMAN | [view interactions] | Computational | no | yes |
EXOS6_HUMAN | [view interactions] | Computational | no | no |
EXOS1_HUMAN | [view interactions] | Computational | no | yes |
SUV3_HUMAN | [view interactions] | Computational | no | yes |
DXO_HUMAN | [view interactions] | Computational | no | yes |
RRP44_HUMAN | [view interactions] | Computational | no | yes |