SRGN_HUMAN
Evidence for PS localization
Functions
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SRGN_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 60.0000 | 4 | no |
| GO:0005509 | calcium ion binding | 40.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SRGN_HUMAN |
|---|---|---|---|---|
| GO:0006508 | proteolysis | 60.0000 | 4 | yes |
| GO:0006915 | apoptotic process | 40.0000 | 4 | yes |
| GO:0006996 | organelle organization | 40.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 40.0000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.0000 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 40.0000 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 40.0000 | 7 | no |
| GO:0009057 | macromolecule catabolic process | 40.0000 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 40.0000 | 6 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 40.0000 | 5 | no |
| GO:0044265 | cellular macromolecule catabolic process | 40.0000 | 4 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 40.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PERF_HUMAN | [view interactions] | Low throughput | no | no |
| GRAB_HUMAN | [view interactions] | Low throughput | no | no |
| CSPG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MMP9_HUMAN | [view interactions] | Low throughput | no | no |
| FHL3_HUMAN | [view interactions] | High throughput | no | no |
| CREL2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP70_HUMAN | [view interactions] | High throughput | no | yes |
| PSRC1_HUMAN | [view interactions] | High throughput | no | no |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| MBL2_HUMAN | [view interactions] | High throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| NCALD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX12_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIP1_HUMAN | [view interactions] | High throughput | no | no |
| CD44_HUMAN | [view interactions] | Computational | no | yes |
| CCL3_HUMAN | [view interactions] | Computational | no | no |
| CMA1_HUMAN | [view interactions] | Computational | no | no |