STXB4_HUMAN
Evidence for PS localization
Functions
Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in STXB4_HUMAN |
|---|---|---|---|---|
| GO:0019905 | syntaxin binding | 20.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in STXB4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 66.6667 | 4 | yes |
| GO:0008104 | protein localization | 60.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 53.3333 | 4 | yes |
| GO:0022607 | cellular component assembly | 53.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 53.3333 | 4 | no |
| GO:0006996 | organelle organization | 53.3333 | 4 | no |
| GO:0071310 | cellular response to organic substance | 46.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 46.6667 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 46.6667 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 46.6667 | 5 | no |
| GO:0023056 | positive regulation of signaling | 46.6667 | 4 | no |
| GO:0015031 | protein transport | 40.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 40.0000 | 4 | no |
| GO:0006886 | intracellular protein transport | 33.3333 | 4 | yes |
| GO:0010564 | regulation of cell cycle process | 33.3333 | 5 | yes |
| GO:0032880 | regulation of protein localization | 33.3333 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | yes |
| GO:0050821 | protein stabilization | 33.3333 | 4 | yes |
| GO:0051223 | regulation of protein transport | 33.3333 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 33.3333 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 33.3333 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 33.3333 | 5 | no |
| GO:0051050 | positive regulation of transport | 33.3333 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 33.3333 | 4 | no |
| GO:0043933 | protein-containing complex organization | 33.3333 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 26.6667 | 4 | yes |
| GO:0051046 | regulation of secretion | 26.6667 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 26.6667 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
| GO:0010468 | regulation of gene expression | 26.6667 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 26.6667 | 6 | no |
| GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.6667 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 26.6667 | 5 | no |
| GO:0050776 | regulation of immune response | 26.6667 | 4 | no |
| GO:0050806 | positive regulation of synaptic transmission | 26.6667 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 26.6667 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 26.6667 | 4 | no |
| GO:0061024 | membrane organization | 26.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.6667 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 26.6667 | 5 | no |
| GO:0033043 | regulation of organelle organization | 26.6667 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.6667 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 26.6667 | 5 | no |
| GO:0002791 | regulation of peptide secretion | 20.0000 | 6 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 20.0000 | 5 | yes |
| GO:0034097 | response to cytokine | 20.0000 | 4 | yes |
| GO:0034341 | response to interferon-gamma | 20.0000 | 5 | yes |
| GO:0045787 | positive regulation of cell cycle | 20.0000 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 20.0000 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 20.0000 | 5 | yes |
| GO:0050796 | regulation of insulin secretion | 20.0000 | 6 | yes |
| GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus | 20.0000 | 7 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 20.0000 | 5 | yes |
| GO:0071346 | cellular response to interferon-gamma | 20.0000 | 6 | yes |
| GO:0090068 | positive regulation of cell cycle process | 20.0000 | 6 | yes |
| GO:0090087 | regulation of peptide transport | 20.0000 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 20.0000 | 5 | yes |
| GO:0006605 | protein targeting | 13.3333 | 5 | yes |
| GO:0006974 | cellular response to DNA damage stimulus | 13.3333 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 13.3333 | 4 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 13.3333 | 5 | yes |
| GO:0008286 | insulin receptor signaling pathway | 13.3333 | 6 | yes |
| GO:0010827 | regulation of glucose transmembrane transport | 13.3333 | 5 | yes |
| GO:0010837 | regulation of keratinocyte proliferation | 13.3333 | 6 | yes |
| GO:0010838 | positive regulation of keratinocyte proliferation | 13.3333 | 7 | yes |
| GO:0050678 | regulation of epithelial cell proliferation | 13.3333 | 5 | yes |
| GO:0050679 | positive regulation of epithelial cell proliferation | 13.3333 | 6 | yes |
| GO:1901987 | regulation of cell cycle phase transition | 13.3333 | 6 | yes |
| GO:1901989 | positive regulation of cell cycle phase transition | 13.3333 | 7 | yes |
| GO:1902806 | regulation of cell cycle G1/S phase transition | 13.3333 | 7 | yes |
| GO:1902808 | positive regulation of cell cycle G1/S phase transition | 13.3333 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P63_HUMAN | [view interactions] | Low throughput | no | no |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| F1892_HUMAN | [view interactions] | High throughput | no | yes |
| ARRD3_HUMAN | [view interactions] | High throughput | no | no |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| TM171_HUMAN | [view interactions] | High throughput | no | yes |
| CDR2_HUMAN | [view interactions] | High throughput | no | yes |
| FND11_HUMAN | [view interactions] | High throughput | no | no |
| TMG4_HUMAN | [view interactions] | High throughput | no | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD6_HUMAN | [view interactions] | High throughput | no | yes |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH42_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| PTN21_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| RGS2_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| LAPM5_HUMAN | [view interactions] | High throughput | no | yes |
| LATS1_HUMAN | [view interactions] | High throughput | no | yes |
| TMG1_HUMAN | [view interactions] | High throughput | no | no |
| EFMT2_HUMAN | [view interactions] | High throughput | no | yes |
| SPAT2_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TULP4_HUMAN | [view interactions] | High throughput | no | yes |
| LGI1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RUBIC_HUMAN | [view interactions] | High throughput | no | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| PMEPA_HUMAN | [view interactions] | High throughput | no | no |
| CUED1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG16_HUMAN | [view interactions] | High throughput | no | yes |
| TM252_HUMAN | [view interactions] | High throughput | no | no |
| RFXK_HUMAN | [view interactions] | High throughput | no | yes |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| PPARD_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| DPOD3_HUMAN | [view interactions] | High throughput | no | yes |
| STXB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| F184A_HUMAN | [view interactions] | High throughput | no | no |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX11_HUMAN | [view interactions] | Computational | no | yes |
| GLUT4_HUMAN | [view interactions] | Computational | no | no |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| YKT6_HUMAN | [view interactions] | Computational | no | yes |
| LCAP_HUMAN | [view interactions] | Computational | no | yes |