SYJ2B_HUMAN
Evidence for PS localization
Functions
Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYJ2B_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 33.3333 | 4 | no |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYJ2B_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.7778 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.2222 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.2222 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.2222 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.2222 | 4 | no |
| GO:0009966 | regulation of signal transduction | 41.6667 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 41.6667 | 4 | yes |
| GO:0008104 | protein localization | 38.8889 | 4 | yes |
| GO:0010468 | regulation of gene expression | 36.1111 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 36.1111 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.5556 | 4 | yes |
| GO:0051049 | regulation of transport | 30.5556 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.5556 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 30.5556 | 7 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.5556 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 27.7778 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 27.7778 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 27.7778 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 27.7778 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 27.7778 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.7778 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 27.7778 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.7778 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 27.7778 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.7778 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 27.7778 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.7778 | 4 | no |
| GO:0051050 | positive regulation of transport | 27.7778 | 4 | no |
| GO:0015031 | protein transport | 25.0000 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0051093 | negative regulation of developmental process | 22.2222 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 22.2222 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 22.2222 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 22.2222 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 22.2222 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.2222 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.2222 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 22.2222 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0006996 | organelle organization | 22.2222 | 4 | no |
| GO:0030334 | regulation of cell migration | 19.4444 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 19.4444 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 19.4444 | 4 | yes |
| GO:2000145 | regulation of cell motility | 19.4444 | 4 | yes |
| GO:0006886 | intracellular protein transport | 16.6667 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 16.6667 | 5 | yes |
| GO:0043408 | regulation of MAPK cascade | 16.6667 | 6 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 13.8889 | 5 | yes |
| GO:0072657 | protein localization to membrane | 13.8889 | 4 | yes |
| GO:0006605 | protein targeting | 11.1111 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 11.1111 | 6 | yes |
| GO:0040013 | negative regulation of locomotion | 11.1111 | 4 | yes |
| GO:2000146 | negative regulation of cell motility | 11.1111 | 5 | yes |
| GO:0007264 | small GTPase mediated signal transduction | 8.3333 | 4 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 8.3333 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 8.3333 | 5 | yes |
| GO:0045765 | regulation of angiogenesis | 8.3333 | 5 | yes |
| GO:0050678 | regulation of epithelial cell proliferation | 8.3333 | 5 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 8.3333 | 7 | yes |
| GO:1901342 | regulation of vasculature development | 8.3333 | 5 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 8.3333 | 6 | yes |
| GO:0001936 | regulation of endothelial cell proliferation | 5.5556 | 6 | yes |
| GO:0007265 | Ras protein signal transduction | 5.5556 | 5 | yes |
| GO:0007266 | Rho protein signal transduction | 5.5556 | 6 | yes |
| GO:0007268 | chemical synaptic transmission | 5.5556 | 6 | yes |
| GO:0008593 | regulation of Notch signaling pathway | 5.5556 | 5 | yes |
| GO:0016525 | negative regulation of angiogenesis | 5.5556 | 6 | yes |
| GO:0043113 | receptor clustering | 5.5556 | 5 | yes |
| GO:0043409 | negative regulation of MAPK cascade | 5.5556 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 5.5556 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 5.5556 | 4 | yes |
| GO:1901343 | negative regulation of vasculature development | 5.5556 | 5 | yes |
| GO:2000181 | negative regulation of blood vessel morphogenesis | 5.5556 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AVR2A_HUMAN | [view interactions] | Low throughput | no | yes |
| SYNJ2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AVR2B_HUMAN | [view interactions] | Low throughput | no | no |
| RBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLL1_HUMAN | [view interactions] | Low throughput | no | no |
| DLL4_HUMAN | [view interactions] | Low throughput | no | no |
| TM101_HUMAN | [view interactions] | High throughput | no | no |
| LRP8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FCERG_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| T22D3_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| VANG2_HUMAN | [view interactions] | High throughput | no | no |
| SYTC2_HUMAN | [view interactions] | High throughput | no | yes |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| SNG2_HUMAN | [view interactions] | High throughput | no | no |
| TMM72_HUMAN | [view interactions] | High throughput | no | no |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| RELL2_HUMAN | [view interactions] | High throughput | no | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T150A_HUMAN | [view interactions] | High throughput | no | yes |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| KCNK1_HUMAN | [view interactions] | High throughput | no | yes |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| GPR55_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| KPRA_HUMAN | [view interactions] | High throughput | no | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| GPBAR_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| FACE1_HUMAN | [view interactions] | High throughput | no | yes |
| MGT4B_HUMAN | [view interactions] | High throughput | no | no |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAF_HUMAN | [view interactions] | High throughput | no | no |
| 5NTD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SE1L1_HUMAN | [view interactions] | High throughput | no | yes |
| MRP2_HUMAN | [view interactions] | High throughput | no | no |
| RM44_HUMAN | [view interactions] | High throughput | no | yes |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| RHG19_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| SDF2_HUMAN | [view interactions] | High throughput | no | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IOD2_HUMAN | [view interactions] | High throughput | no | no |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| GRPL2_HUMAN | [view interactions] | High throughput | no | no |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOIP2_HUMAN | [view interactions] | High throughput | no | no |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRD_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| PROM1_HUMAN | [view interactions] | High throughput | no | no |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| STR3N_HUMAN | [view interactions] | High throughput | no | yes |
| THY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| LRP2_HUMAN | [view interactions] | High throughput | no | no |
| AKA28_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINX1_HUMAN | [view interactions] | High throughput | no | yes |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| MEDAG_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| CPLX4_HUMAN | [view interactions] | High throughput | no | no |
| THEM5_HUMAN | [view interactions] | High throughput | no | no |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| ELOV7_HUMAN | [view interactions] | High throughput | no | no |
| TLCD4_HUMAN | [view interactions] | High throughput | no | no |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| F210B_HUMAN | [view interactions] | High throughput | no | yes |
| CY561_HUMAN | [view interactions] | High throughput | no | yes |
| TM242_HUMAN | [view interactions] | High throughput | no | yes |
| LAT2_HUMAN | [view interactions] | High throughput | no | no |
| LHPL5_HUMAN | [view interactions] | High throughput | no | no |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |