Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADCY1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels . May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADCY1_HUMAN
GO:0017076 purine nucleotide binding 90.0000 4 yes
GO:0032555 purine ribonucleotide binding 90.0000 4 yes
GO:0046872 metal ion binding 70.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 65.0000 4 yes
GO:0030554 adenyl nucleotide binding 55.0000 5 yes
GO:0032559 adenyl ribonucleotide binding 55.0000 5 yes
GO:0003924 GTPase activity 40.0000 7 no
GO:0016462 pyrophosphatase activity 40.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 40.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 40.0000 6 no
GO:0001664 G protein-coupled receptor binding 35.0000 4 no
GO:0005525 GTP binding 35.0000 5 no
GO:0019001 guanyl nucleotide binding 35.0000 5 no
GO:0032561 guanyl ribonucleotide binding 35.0000 5 no
GO:0005524 ATP binding 30.0000 5 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0030551 cyclic nucleotide binding 25.0000 4 no
GO:0030552 cAMP binding 25.0000 4 no
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity 10.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADCY1_HUMAN
GO:0010646 regulation of cell communication 70.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.0000 4 yes
GO:0031323 regulation of cellular metabolic process 60.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 60.0000 4 yes
GO:0080090 regulation of primary metabolic process 60.0000 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 55.0000 4 yes
GO:0051246 regulation of protein metabolic process 55.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010468 regulation of gene expression 45.0000 5 yes
GO:0014070 response to organic cyclic compound 45.0000 4 yes
GO:0048522 positive regulation of cellular process 45.0000 4 yes
GO:0071310 cellular response to organic substance 45.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 45.0000 4 yes
GO:0009893 positive regulation of metabolic process 45.0000 4 no
GO:0010243 response to organonitrogen compound 45.0000 4 no
GO:0019220 regulation of phosphate metabolic process 45.0000 6 no
GO:0031399 regulation of protein modification process 45.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 45.0000 5 no
GO:0050804 modulation of chemical synaptic transmission 40.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 40.0000 4 yes
GO:0001932 regulation of protein phosphorylation 40.0000 7 no
GO:0009892 negative regulation of metabolic process 40.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 no
GO:0042325 regulation of phosphorylation 40.0000 7 no
GO:0071407 cellular response to organic cyclic compound 35.0000 5 yes
GO:0009968 negative regulation of signal transduction 35.0000 5 no
GO:0010648 negative regulation of cell communication 35.0000 5 no
GO:0023057 negative regulation of signaling 35.0000 4 no
GO:0048585 negative regulation of response to stimulus 35.0000 4 no
GO:0043086 negative regulation of catalytic activity 35.0000 4 no
GO:0031400 negative regulation of protein modification process 35.0000 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.0000 5 no
GO:0051248 negative regulation of protein metabolic process 35.0000 6 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 30.0000 5 yes
GO:0010647 positive regulation of cell communication 30.0000 5 yes
GO:0023056 positive regulation of signaling 30.0000 4 yes
GO:0033993 response to lipid 30.0000 4 yes
GO:0071396 cellular response to lipid 30.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 30.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 30.0000 5 no
GO:0043085 positive regulation of catalytic activity 30.0000 4 no
GO:0032880 regulation of protein localization 30.0000 5 no
GO:0051050 positive regulation of transport 30.0000 4 no
GO:0060341 regulation of cellular localization 30.0000 4 no
GO:0071417 cellular response to organonitrogen compound 30.0000 4 no
GO:1901699 cellular response to nitrogen compound 30.0000 4 no
GO:1903829 positive regulation of protein localization 30.0000 5 no
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0010563 negative regulation of phosphorus metabolic process 30.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 30.0000 5 no
GO:0043549 regulation of kinase activity 30.0000 5 no
GO:0045859 regulation of protein kinase activity 30.0000 6 no
GO:0045936 negative regulation of phosphate metabolic process 30.0000 7 no
GO:0051338 regulation of transferase activity 30.0000 4 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:0006163 purine nucleotide metabolic process 25.0000 5 yes
GO:0006753 nucleoside phosphate metabolic process 25.0000 4 yes
GO:0009117 nucleotide metabolic process 25.0000 5 yes
GO:0009150 purine ribonucleotide metabolic process 25.0000 6 yes
GO:0009259 ribonucleotide metabolic process 25.0000 5 yes
GO:0009889 regulation of biosynthetic process 25.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 yes
GO:0019693 ribose phosphate metabolic process 25.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 yes
GO:0051252 regulation of RNA metabolic process 25.0000 5 yes
GO:0072521 purine-containing compound metabolic process 25.0000 4 yes
GO:0097305 response to alcohol 25.0000 4 yes
GO:0097306 cellular response to alcohol 25.0000 5 yes
GO:1901654 response to ketone 25.0000 4 yes
GO:1901655 cellular response to ketone 25.0000 5 yes
GO:0006468 protein phosphorylation 25.0000 5 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0032870 cellular response to hormone stimulus 25.0000 4 no
GO:0043269 regulation of ion transport 25.0000 5 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:0051222 positive regulation of protein transport 25.0000 5 no
GO:0051223 regulation of protein transport 25.0000 5 no
GO:0051924 regulation of calcium ion transport 25.0000 7 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:1904951 positive regulation of establishment of protein localization 25.0000 6 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 25.0000 4 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0002768 immune response-regulating cell surface receptor signaling pathway 25.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050778 positive regulation of immune response 25.0000 5 no
GO:0001933 negative regulation of protein phosphorylation 25.0000 8 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0071900 regulation of protein serine/threonine kinase activity 25.0000 7 no
GO:0006355 regulation of DNA-templated transcription 20.0000 6 yes
GO:0009187 cyclic nucleotide metabolic process 20.0000 6 yes
GO:0019932 second-messenger-mediated signaling 20.0000 4 yes
GO:0046058 cAMP metabolic process 20.0000 7 yes
GO:0050890 cognition 20.0000 4 yes
GO:0051046 regulation of secretion 20.0000 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 20.0000 7 yes
GO:1903530 regulation of secretion by cell 20.0000 4 yes
GO:2001141 regulation of RNA biosynthetic process 20.0000 6 yes
GO:0019933 cAMP-mediated signaling 15.0000 6 yes
GO:0019935 cyclic-nucleotide-mediated signaling 15.0000 5 yes
GO:0050806 positive regulation of synaptic transmission 15.0000 5 yes
GO:0060627 regulation of vesicle-mediated transport 15.0000 4 yes
GO:1904321 response to forskolin 15.0000 5 yes
GO:1904322 cellular response to forskolin 15.0000 6 yes
GO:0006164 purine nucleotide biosynthetic process 10.0000 6 yes
GO:0006171 cAMP biosynthetic process 10.0000 8 yes
GO:0006954 inflammatory response 10.0000 4 yes
GO:0007420 brain development 10.0000 4 yes
GO:0007613 memory 10.0000 4 yes
GO:0007616 long-term memory 10.0000 5 yes
GO:0009152 purine ribonucleotide biosynthetic process 10.0000 7 yes
GO:0009165 nucleotide biosynthetic process 10.0000 6 yes
GO:0009190 cyclic nucleotide biosynthetic process 10.0000 7 yes
GO:0009260 ribonucleotide biosynthetic process 10.0000 6 yes
GO:0010038 response to metal ion 10.0000 4 yes
GO:0017157 regulation of exocytosis 10.0000 5 yes
GO:0018130 heterocycle biosynthetic process 10.0000 4 yes
GO:0019438 aromatic compound biosynthetic process 10.0000 4 yes
GO:0032793 positive regulation of CREB transcription factor activity 10.0000 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 10.0000 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 10.0000 4 yes
GO:0046390 ribose phosphate biosynthetic process 10.0000 5 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 10.0000 4 yes
GO:0051592 response to calcium ion 10.0000 5 yes
GO:0052652 cyclic purine nucleotide metabolic process 10.0000 7 yes
GO:0071241 cellular response to inorganic substance 10.0000 4 yes
GO:0071248 cellular response to metal ion 10.0000 5 yes
GO:0071277 cellular response to calcium ion 10.0000 6 yes
GO:0072522 purine-containing compound biosynthetic process 10.0000 5 yes
GO:0090407 organophosphate biosynthetic process 10.0000 4 yes
GO:0150076 neuroinflammatory response 10.0000 5 yes
GO:1900271 regulation of long-term synaptic potentiation 10.0000 4 yes
GO:1900273 positive regulation of long-term synaptic potentiation 10.0000 5 yes
GO:1901137 carbohydrate derivative biosynthetic process 10.0000 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 10.0000 5 yes
GO:1901362 organic cyclic compound biosynthetic process 10.0000 4 yes
GO:1901566 organonitrogen compound biosynthetic process 10.0000 4 yes
GO:1903305 regulation of regulated secretory pathway 10.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SRTD1_HUMAN [view interactions] Low throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
FZD7_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
IL1A_HUMAN [view interactions] Computational no no
ADCY5_HUMAN [view interactions] Computational no no
KPCE_HUMAN [view entry] [view interactions] Computational yes yes
KAPCG_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
ADCY9_HUMAN [view interactions] Computational no yes
EDN1_HUMAN [view interactions] Computational no no
KAP3_HUMAN [view entry] [view interactions] Computational yes yes
KAP0_HUMAN [view entry] [view interactions] Computational yes yes
ADCY8_HUMAN [view entry] [view interactions] Computational yes yes
EDNRA_HUMAN [view interactions] Computational no yes
ADCY6_HUMAN [view interactions] Computational no yes
ADCY7_HUMAN [view interactions] Computational no yes
GNAL_HUMAN [view interactions] Computational no yes
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
GNAZ_HUMAN [view entry] [view interactions] Computational yes yes
KAP1_HUMAN [view entry] [view interactions] Computational yes yes
PDE4D_HUMAN [view entry] [view interactions] Computational yes yes
PDE4A_HUMAN [view interactions] Computational no no
GBG1_HUMAN [view interactions] Computational no no
RPGF3_HUMAN [view interactions] Computational no yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
ADCY3_HUMAN [view interactions] Computational no yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
GNAO_HUMAN [view entry] [view interactions] Computational yes yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
S1PR1_HUMAN [view interactions] Computational no no
ADCY2_HUMAN [view interactions] Computational no yes
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
CAP1_HUMAN [view entry] [view interactions] Computational yes yes
PDE4B_HUMAN [view entry] [view interactions] Computational yes yes
KPCD_HUMAN [view entry] [view interactions] Computational yes yes
ADCY4_HUMAN [view interactions] Computational no yes