EAA4_HUMAN
Evidence for PS localization
Functions
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport . Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EAA4_HUMAN |
|---|---|---|---|---|
| GO:0005283 | amino acid:sodium symporter activity | 66.6667 | 5 | yes |
| GO:0005310 | dicarboxylic acid transmembrane transporter activity | 66.6667 | 5 | yes |
| GO:0005313 | L-glutamate transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0005314 | high-affinity L-glutamate transmembrane transporter activity | 66.6667 | 7 | yes |
| GO:0005343 | organic acid:sodium symporter activity | 66.6667 | 4 | yes |
| GO:0005416 | amino acid:cation symporter activity | 66.6667 | 6 | yes |
| GO:0008324 | cation transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0008509 | anion transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0008514 | organic anion transmembrane transporter activity | 66.6667 | 5 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0015171 | amino acid transmembrane transporter activity | 66.6667 | 5 | yes |
| GO:0015172 | acidic amino acid transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0015175 | neutral amino acid transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0015179 | L-amino acid transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0015183 | L-aspartate transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0015293 | symporter activity | 66.6667 | 5 | yes |
| GO:0015294 | solute:cation symporter activity | 66.6667 | 5 | yes |
| GO:0015370 | solute:sodium symporter activity | 66.6667 | 6 | yes |
| GO:0015501 | glutamate:sodium symporter activity | 66.6667 | 6 | yes |
| GO:0015556 | C4-dicarboxylate transmembrane transporter activity | 66.6667 | 6 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 66.6667 | 4 | yes |
| GO:0046872 | metal ion binding | 66.6667 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 66.6667 | 5 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 66.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EAA4_HUMAN |
|---|---|---|---|---|
| GO:0003333 | amino acid transmembrane transport | 66.6667 | 5 | yes |
| GO:0006811 | ion transport | 66.6667 | 4 | yes |
| GO:0006820 | anion transport | 66.6667 | 5 | yes |
| GO:0006835 | dicarboxylic acid transport | 66.6667 | 7 | yes |
| GO:0006836 | neurotransmitter transport | 66.6667 | 4 | yes |
| GO:0006865 | amino acid transport | 66.6667 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 66.6667 | 6 | yes |
| GO:0015711 | organic anion transport | 66.6667 | 5 | yes |
| GO:0015740 | C4-dicarboxylate transport | 66.6667 | 8 | yes |
| GO:0015800 | acidic amino acid transport | 66.6667 | 6 | yes |
| GO:0015807 | L-amino acid transport | 66.6667 | 5 | yes |
| GO:0015813 | L-glutamate transmembrane transport | 66.6667 | 5 | yes |
| GO:0015849 | organic acid transport | 66.6667 | 5 | yes |
| GO:0046942 | carboxylic acid transport | 66.6667 | 6 | yes |
| GO:0051938 | L-glutamate import | 66.6667 | 6 | yes |
| GO:0071702 | organic substance transport | 66.6667 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 66.6667 | 4 | yes |
| GO:0089718 | amino acid import across plasma membrane | 66.6667 | 4 | yes |
| GO:0098656 | anion transmembrane transport | 66.6667 | 4 | yes |
| GO:0098657 | import into cell | 66.6667 | 4 | yes |
| GO:0098712 | L-glutamate import across plasma membrane | 66.6667 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 66.6667 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 66.6667 | 4 | yes |
| GO:1902475 | L-alpha-amino acid transmembrane transport | 66.6667 | 6 | yes |
| GO:1905039 | carboxylic acid transmembrane transport | 66.6667 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 66.6667 | 4 | no |
| GO:0034330 | cell junction organization | 66.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 66.6667 | 4 | no |
| GO:0050808 | synapse organization | 66.6667 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| SATT_HUMAN | [view interactions] | High throughput | no | no |
| SPTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RORA_HUMAN | [view interactions] | Computational | no | yes |
| ARHGB_HUMAN | [view interactions] | Computational | no | yes |
| EAA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KAT5_HUMAN | [view interactions] | Computational | no | yes |