GBRR2_HUMAN
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GBRR2_HUMAN |
---|---|---|---|---|
GO:0004890 | GABA-A receptor activity | 100.0000 | 5 | yes |
GO:0005216 | ion channel activity | 100.0000 | 4 | yes |
GO:0005230 | extracellular ligand-gated ion channel activity | 100.0000 | 6 | yes |
GO:0005253 | anion channel activity | 100.0000 | 5 | yes |
GO:0005254 | chloride channel activity | 100.0000 | 6 | yes |
GO:0008509 | anion transmembrane transporter activity | 100.0000 | 4 | yes |
GO:0015103 | inorganic anion transmembrane transporter activity | 100.0000 | 4 | yes |
GO:0015108 | chloride transmembrane transporter activity | 100.0000 | 5 | yes |
GO:0015267 | channel activity | 100.0000 | 4 | yes |
GO:0015276 | ligand-gated ion channel activity | 100.0000 | 5 | yes |
GO:0016917 | GABA receptor activity | 100.0000 | 4 | yes |
GO:0022834 | ligand-gated channel activity | 100.0000 | 6 | yes |
GO:0022836 | gated channel activity | 100.0000 | 5 | yes |
GO:0022824 | transmitter-gated ion channel activity | 66.6667 | 5 | yes |
GO:0022835 | transmitter-gated channel activity | 66.6667 | 4 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 66.6667 | 4 | yes |
GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 66.6667 | 5 | yes |
GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 66.6667 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GBRR2_HUMAN |
---|---|---|---|---|
GO:0006811 | ion transport | 100.0000 | 4 | yes |
GO:0006820 | anion transport | 100.0000 | 5 | yes |
GO:0006821 | chloride transport | 100.0000 | 7 | yes |
GO:0007268 | chemical synaptic transmission | 100.0000 | 6 | yes |
GO:0015698 | inorganic anion transport | 100.0000 | 6 | yes |
GO:0098656 | anion transmembrane transport | 100.0000 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 100.0000 | 4 | yes |
GO:0098661 | inorganic anion transmembrane transport | 100.0000 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 100.0000 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 100.0000 | 4 | yes |
GO:1902476 | chloride transmembrane transport | 100.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GBRR3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GBRR1_HUMAN | [view entry] [view interactions] | Computational | yes | no |