GBRR3_HUMAN
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GBRR3_HUMAN |
---|---|---|---|---|
GO:0008509 | anion transmembrane transporter activity | 100.0000 | 4 | yes |
GO:0015103 | inorganic anion transmembrane transporter activity | 100.0000 | 4 | yes |
GO:0015108 | chloride transmembrane transporter activity | 100.0000 | 5 | yes |
GO:0015267 | channel activity | 100.0000 | 4 | yes |
GO:0015276 | ligand-gated ion channel activity | 100.0000 | 5 | yes |
GO:0016917 | GABA receptor activity | 100.0000 | 4 | yes |
GO:0022834 | ligand-gated channel activity | 100.0000 | 6 | yes |
GO:0022836 | gated channel activity | 100.0000 | 5 | yes |
GO:0004890 | GABA-A receptor activity | 100.0000 | 5 | yes |
GO:0005216 | ion channel activity | 100.0000 | 4 | yes |
GO:0005230 | extracellular ligand-gated ion channel activity | 100.0000 | 6 | yes |
GO:0005253 | anion channel activity | 100.0000 | 5 | yes |
GO:0005254 | chloride channel activity | 100.0000 | 6 | yes |
GO:0022824 | transmitter-gated ion channel activity | 66.6667 | 5 | no |
GO:0022835 | transmitter-gated channel activity | 66.6667 | 4 | no |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 66.6667 | 4 | no |
GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 66.6667 | 5 | no |
GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 66.6667 | 6 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GBRR3_HUMAN |
---|---|---|---|---|
GO:0006811 | ion transport | 100.0000 | 4 | yes |
GO:0006820 | anion transport | 100.0000 | 5 | yes |
GO:0006821 | chloride transport | 100.0000 | 7 | yes |
GO:0007268 | chemical synaptic transmission | 100.0000 | 6 | yes |
GO:0015698 | inorganic anion transport | 100.0000 | 6 | yes |
GO:0098656 | anion transmembrane transport | 100.0000 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 100.0000 | 4 | yes |
GO:0098661 | inorganic anion transmembrane transport | 100.0000 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 100.0000 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 100.0000 | 4 | yes |
GO:1902476 | chloride transmembrane transport | 100.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
GBRR2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GBRR1_HUMAN | [view entry] [view interactions] | Computational | yes | no |