Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBRT_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBRT_HUMAN
GO:0005216 ion channel activity 100.0000 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 100.0000 6 yes
GO:0005253 anion channel activity 100.0000 5 yes
GO:0005254 chloride channel activity 100.0000 6 yes
GO:0008509 anion transmembrane transporter activity 100.0000 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 100.0000 4 yes
GO:0015108 chloride transmembrane transporter activity 100.0000 5 yes
GO:0015267 channel activity 100.0000 4 yes
GO:0015276 ligand-gated ion channel activity 100.0000 5 yes
GO:0016917 GABA receptor activity 100.0000 4 yes
GO:0022834 ligand-gated channel activity 100.0000 6 yes
GO:0022836 gated channel activity 100.0000 5 yes
GO:0004890 GABA-A receptor activity 100.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GBRT_HUMAN
GO:0006811 ion transport 100.0000 4 yes
GO:0006820 anion transport 100.0000 5 yes
GO:0006821 chloride transport 100.0000 7 yes
GO:0007268 chemical synaptic transmission 100.0000 6 yes
GO:0015698 inorganic anion transport 100.0000 6 yes
GO:0098656 anion transmembrane transport 100.0000 4 yes
GO:0098660 inorganic ion transmembrane transport 100.0000 4 yes
GO:0098661 inorganic anion transmembrane transport 100.0000 5 yes
GO:0098916 anterograde trans-synaptic signaling 100.0000 5 yes
GO:0099537 trans-synaptic signaling 100.0000 4 yes
GO:1902476 chloride transmembrane transport 100.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TXD12_HUMAN [view interactions] High throughput no no
GNMT_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
HLAG_HUMAN [view interactions] High throughput no no
CLC2B_HUMAN [view interactions] High throughput no yes
GBRA1_HUMAN [view entry] [view interactions] Computational yes yes