Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PAR4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002073 TRG_ER_diArg_1 TRG 182 185 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PAR4_HUMAN
GO:0003924 GTPase activity 61.5385 7 no
GO:0016462 pyrophosphatase activity 61.5385 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 61.5385 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 61.5385 6 no
GO:0005525 GTP binding 53.8462 5 no
GO:0017076 purine nucleotide binding 53.8462 4 no
GO:0019001 guanyl nucleotide binding 53.8462 5 no
GO:0032555 purine ribonucleotide binding 53.8462 4 no
GO:0032561 guanyl ribonucleotide binding 53.8462 5 no
GO:0035639 purine ribonucleoside triphosphate binding 53.8462 4 no
GO:0046872 metal ion binding 46.1538 4 no
GO:0001664 G protein-coupled receptor binding 38.4615 4 no
GO:0019003 GDP binding 23.0769 4 no
GO:0030695 GTPase regulator activity 23.0769 4 no
GO:0001648 proteinase-activated receptor activity 15.3846 5 yes
GO:0004930 G protein-coupled receptor activity 15.3846 4 yes
GO:0008528 G protein-coupled peptide receptor activity 15.3846 4 yes
GO:0015057 thrombin-activated receptor activity 15.3846 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PAR4_HUMAN
GO:0009966 regulation of signal transduction 61.5385 4 yes
GO:0010646 regulation of cell communication 61.5385 4 yes
GO:1902531 regulation of intracellular signal transduction 53.8462 5 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 53.8462 4 no
GO:0048522 positive regulation of cellular process 46.1538 4 yes
GO:0048523 negative regulation of cellular process 46.1538 4 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 38.4615 4 yes
GO:0009967 positive regulation of signal transduction 38.4615 5 yes
GO:0010647 positive regulation of cell communication 38.4615 5 yes
GO:0023056 positive regulation of signaling 38.4615 4 yes
GO:0048584 positive regulation of response to stimulus 38.4615 4 yes
GO:1902533 positive regulation of intracellular signal transduction 38.4615 6 yes
GO:0033993 response to lipid 38.4615 4 no
GO:0031323 regulation of cellular metabolic process 38.4615 4 no
GO:0051171 regulation of nitrogen compound metabolic process 38.4615 4 no
GO:0051246 regulation of protein metabolic process 38.4615 5 no
GO:0060255 regulation of macromolecule metabolic process 38.4615 4 no
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 30.7692 6 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 30.7692 5 no
GO:0010243 response to organonitrogen compound 30.7692 4 no
GO:0014070 response to organic cyclic compound 30.7692 4 no
GO:0071310 cellular response to organic substance 30.7692 4 no
GO:0071396 cellular response to lipid 30.7692 5 no
GO:0071407 cellular response to organic cyclic compound 30.7692 5 no
GO:1901701 cellular response to oxygen-containing compound 30.7692 4 no
GO:0007264 small GTPase mediated signal transduction 30.7692 4 no
GO:0007265 Ras protein signal transduction 30.7692 5 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0010468 regulation of gene expression 30.7692 5 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0010628 positive regulation of gene expression 30.7692 6 no
GO:0030334 regulation of cell migration 30.7692 5 no
GO:0031325 positive regulation of cellular metabolic process 30.7692 5 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:0043085 positive regulation of catalytic activity 30.7692 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0051336 regulation of hydrolase activity 30.7692 4 no
GO:0051345 positive regulation of hydrolase activity 30.7692 5 no
GO:2000145 regulation of cell motility 30.7692 4 no
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 30.7692 4 no
GO:0095500 acetylcholine receptor signaling pathway 30.7692 4 no
GO:0009416 response to light stimulus 23.0769 4 no
GO:0045595 regulation of cell differentiation 23.0769 4 no
GO:0006996 organelle organization 23.0769 4 yes
GO:0046578 regulation of Ras protein signal transduction 23.0769 7 yes
GO:0046579 positive regulation of Ras protein signal transduction 23.0769 8 yes
GO:0051049 regulation of transport 23.0769 4 yes
GO:0051050 positive regulation of transport 23.0769 4 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 23.0769 7 yes
GO:0032870 cellular response to hormone stimulus 23.0769 4 no
GO:0071417 cellular response to organonitrogen compound 23.0769 4 no
GO:0097305 response to alcohol 23.0769 4 no
GO:0097306 cellular response to alcohol 23.0769 5 no
GO:1901654 response to ketone 23.0769 4 no
GO:1901655 cellular response to ketone 23.0769 5 no
GO:1901699 cellular response to nitrogen compound 23.0769 4 no
GO:0001508 action potential 23.0769 4 no
GO:0001817 regulation of cytokine production 23.0769 4 no
GO:0001819 positive regulation of cytokine production 23.0769 5 no
GO:0001932 regulation of protein phosphorylation 23.0769 7 no
GO:0006355 regulation of DNA-templated transcription 23.0769 6 no
GO:0008284 positive regulation of cell population proliferation 23.0769 5 no
GO:0008285 negative regulation of cell population proliferation 23.0769 5 no
GO:0009889 regulation of biosynthetic process 23.0769 4 no
GO:0009891 positive regulation of biosynthetic process 23.0769 5 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0010517 regulation of phospholipase activity 23.0769 6 no
GO:0010518 positive regulation of phospholipase activity 23.0769 7 no
GO:0010556 regulation of macromolecule biosynthetic process 23.0769 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0010941 regulation of cell death 23.0769 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0031326 regulation of cellular biosynthetic process 23.0769 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.0769 6 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0032880 regulation of protein localization 23.0769 5 no
GO:0033043 regulation of organelle organization 23.0769 5 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:0042981 regulation of apoptotic process 23.0769 6 no
GO:0043066 negative regulation of apoptotic process 23.0769 7 no
GO:0043067 regulation of programmed cell death 23.0769 5 no
GO:0043069 negative regulation of programmed cell death 23.0769 6 no
GO:0043408 regulation of MAPK cascade 23.0769 6 no
GO:0043410 positive regulation of MAPK cascade 23.0769 7 no
GO:0043523 regulation of neuron apoptotic process 23.0769 6 no
GO:0043524 negative regulation of neuron apoptotic process 23.0769 7 no
GO:0045893 positive regulation of DNA-templated transcription 23.0769 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 6 no
GO:0050804 modulation of chemical synaptic transmission 23.0769 5 no
GO:0051128 regulation of cellular component organization 23.0769 4 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0051254 positive regulation of RNA metabolic process 23.0769 6 no
GO:0051726 regulation of cell cycle 23.0769 4 no
GO:0060191 regulation of lipase activity 23.0769 5 no
GO:0060193 positive regulation of lipase activity 23.0769 6 no
GO:0060341 regulation of cellular localization 23.0769 4 no
GO:0060548 negative regulation of cell death 23.0769 5 no
GO:0080134 regulation of response to stress 23.0769 4 no
GO:0099177 regulation of trans-synaptic signaling 23.0769 4 no
GO:1901214 regulation of neuron death 23.0769 5 no
GO:1901215 negative regulation of neuron death 23.0769 6 no
GO:1902680 positive regulation of RNA biosynthetic process 23.0769 7 no
GO:1903506 regulation of nucleic acid-templated transcription 23.0769 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 23.0769 8 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0007599 hemostasis 15.3846 4 yes
GO:0010959 regulation of metal ion transport 15.3846 6 yes
GO:0016050 vesicle organization 15.3846 5 yes
GO:0033363 secretory granule organization 15.3846 6 yes
GO:0034762 regulation of transmembrane transport 15.3846 4 yes
GO:0034764 positive regulation of transmembrane transport 15.3846 5 yes
GO:0034765 regulation of ion transmembrane transport 15.3846 5 yes
GO:0034767 positive regulation of ion transmembrane transport 15.3846 6 yes
GO:0035023 regulation of Rho protein signal transduction 15.3846 8 yes
GO:0035025 positive regulation of Rho protein signal transduction 15.3846 9 yes
GO:0043269 regulation of ion transport 15.3846 5 yes
GO:0043270 positive regulation of ion transport 15.3846 5 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 15.3846 5 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 15.3846 6 yes
GO:0051282 regulation of sequestering of calcium ion 15.3846 4 yes
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 15.3846 4 yes
GO:0051924 regulation of calcium ion transport 15.3846 7 yes
GO:0051928 positive regulation of calcium ion transport 15.3846 6 yes
GO:0060155 platelet dense granule organization 15.3846 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 15.3846 7 yes
GO:1904062 regulation of cation transmembrane transport 15.3846 6 yes
GO:1904064 positive regulation of cation transmembrane transport 15.3846 7 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 15.3846 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EGR2_HUMAN [view interactions] Low throughput no no
THRB_HUMAN [view interactions] Low throughput no no
FZR1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
VIR_HUMAN [view interactions] High throughput no yes
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
GNA14_HUMAN [view entry] [view interactions] Computational yes yes
PAR3_HUMAN [view interactions] Computational no no
GBG2_HUMAN [view entry] [view interactions] Computational yes yes
GNA15_HUMAN [view interactions] Computational no yes
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
GNA12_HUMAN [view interactions] Computational no no
GNA13_HUMAN [view entry] [view interactions] Computational yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
GBG1_HUMAN [view interactions] Computational no no
ANGT_HUMAN [view interactions] Computational no no
GBG12_HUMAN [view entry] [view interactions] Computational yes yes
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes