Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PAR4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002073 TRG_ER_diArg_1 TRG 182 185 -
ELMI002073 TRG_ER_diArg_1 TRG 182 185 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PAR4_HUMAN
GO:0000166 nucleotide binding 75.0000 4 no
GO:0017076 purine nucleotide binding 75.0000 5 no
GO:0032555 purine ribonucleotide binding 75.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 75.0000 4 no
GO:0043168 anion binding 75.0000 4 no
GO:0004674 protein serine/threonine kinase activity 50.0000 4 no
GO:0005524 ATP binding 50.0000 5 no
GO:0016301 kinase activity 50.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 50.0000 4 no
GO:0030554 adenyl nucleotide binding 50.0000 6 no
GO:0032559 adenyl ribonucleotide binding 50.0000 5 no
GO:0106310 protein serine kinase activity 50.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PAR4_HUMAN
GO:0009966 regulation of signal transduction 100.0000 4 yes
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0009967 positive regulation of signal transduction 75.0000 5 yes
GO:0010647 positive regulation of cell communication 75.0000 5 yes
GO:0023056 positive regulation of signaling 75.0000 4 yes
GO:0048584 positive regulation of response to stimulus 75.0000 4 yes
GO:0006915 apoptotic process 75.0000 4 no
GO:0031323 regulation of cellular metabolic process 75.0000 4 no
GO:0042981 regulation of apoptotic process 75.0000 5 no
GO:0043066 negative regulation of apoptotic process 75.0000 6 no
GO:0043067 regulation of programmed cell death 75.0000 4 no
GO:0043069 negative regulation of programmed cell death 75.0000 5 no
GO:0048523 negative regulation of cellular process 75.0000 4 no
GO:0051246 regulation of protein metabolic process 75.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 no
GO:0080090 regulation of primary metabolic process 75.0000 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 50.0000 6 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 50.0000 7 yes
GO:1902531 regulation of intracellular signal transduction 50.0000 5 yes
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 yes
GO:0006259 DNA metabolic process 50.0000 5 no
GO:0006281 DNA repair 50.0000 5 no
GO:0006302 double-strand break repair 50.0000 6 no
GO:0006468 protein phosphorylation 50.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 no
GO:0006974 DNA damage response 50.0000 4 no
GO:0008284 positive regulation of cell population proliferation 50.0000 5 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0009895 negative regulation of catabolic process 50.0000 5 no
GO:0009968 negative regulation of signal transduction 50.0000 5 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010564 regulation of cell cycle process 50.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 no
GO:0010648 negative regulation of cell communication 50.0000 5 no
GO:0016055 Wnt signaling pathway 50.0000 4 no
GO:0016310 phosphorylation 50.0000 5 no
GO:0018105 peptidyl-serine phosphorylation 50.0000 6 no
GO:0018193 peptidyl-amino acid modification 50.0000 5 no
GO:0018209 peptidyl-serine modification 50.0000 6 no
GO:0023057 negative regulation of signaling 50.0000 4 no
GO:0030162 regulation of proteolysis 50.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0036211 protein modification process 50.0000 4 no
GO:0042127 regulation of cell population proliferation 50.0000 4 no
GO:0043412 macromolecule modification 50.0000 4 no
GO:0045861 negative regulation of proteolysis 50.0000 7 no
GO:0048585 negative regulation of response to stimulus 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051248 negative regulation of protein metabolic process 50.0000 6 no
GO:0051726 regulation of cell cycle 50.0000 4 no
GO:0051983 regulation of chromosome segregation 50.0000 6 no
GO:0090304 nucleic acid metabolic process 50.0000 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 50.0000 7 no
GO:1903051 negative regulation of proteolysis involved in protein catabolic process 50.0000 8 no
GO:1905818 regulation of chromosome separation 50.0000 7 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 50.0000 5 no
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 50.0000 6 no
GO:2001233 regulation of apoptotic signaling pathway 50.0000 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 50.0000 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EGR2_HUMAN [view interactions] Low throughput no no
THRB_HUMAN [view interactions] Low throughput no no
VIR_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
CSK23_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no