UBC_HUMAN

NEMO_HUMAN

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)
GO
G2C
SynGO
SynaptomeDB

HPA (protein expression in neurons)

Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: two hybrid
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 18212736
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 21113135
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 21803029
Interaction type: physical association
Evidence: LT
Inferred: from orthologous proteins
Original protein 1: O88522
Taxonomy: mouse
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 22819327
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19033441
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19285159
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 21811235
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 23807287
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 28939760
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 27669734
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 29125880
Interaction type: physical association
Evidence: HT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: affinity chromatography technology
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 31502302
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 21113135
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 22099304
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 21622647
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 21153314
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 21212807
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19285159
Interaction type: direct interaction
Evidence: HT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19422324
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19303852
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 17702576
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 17702576
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 23746843
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 25296760
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 25409927
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 21862579
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19373254
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 22605335
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 16603398
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 16603398
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19185524
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19763089
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19763089
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 23986494
Interaction type: direct interaction
Evidence: HT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 25736758
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 25736757
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 26740240
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 28190767
Interaction type: direct interaction
Evidence: HT
Inferred: from orthologous proteins
Original protein 1: O88522
Taxonomy: mouse
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG50
Taxonomy: mouse
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 28190767
Interaction type: direct interaction
Evidence: HT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 28319114
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 29111346
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 32019898
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 32410369
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: pull down
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 32726587
Interaction type: direct interaction
Evidence: LT
Inferred: from orthologous proteins
Original protein 1: O88522
Taxonomy: mouse
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: x-ray crystallography
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19766637
Interaction type: association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: x-ray crystallography
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19185524
Interaction type: association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: x-ray crystallography
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19033441
Interaction type: association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: x-ray crystallography
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19303852
Interaction type: association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: unspecified method
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19763089
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: unspecified method
Source: Biogrid
Original protein 2: P0CG48
Taxonomy: human
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: 19033441
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: bait
Biological role participant: unspecified role
Participant detection method: nucleotide sequence identification
Host: human-293
Interaction detection method: anti tag coimmunoprecipitation
Source: Intact
Original protein 2: P0CG48
Taxonomy: human
Experimental role: prey
Biological role participant: unspecified role
Participant detection method: nucleotide sequence identification
PMID: 16874300
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: bait
Biological role participant: unspecified role
Participant detection method: anti tag western blot
Host: human-jpm50.6wt
Interaction detection method: anti tag coimmunoprecipitation
Source: Intact
Original protein 2: P0CG48
Taxonomy: human
Experimental role: prey
Biological role participant: unspecified role
Participant detection method: anti tag western blot
PMID: 17363905
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: bait
Biological role participant: enzyme
Participant detection method: predetermined participant
Host: -
Interaction detection method: pull down
Source: Intact
Original protein 2: P0CG48
Taxonomy: human
Experimental role: prey
Biological role participant: unspecified role
Participant detection method: western blot
PMID: 19373254
Interaction type: direct interaction
Evidence: LT
Inferred: from orthologous proteins
Original protein 1: O88522
Taxonomy: mouse
Experimental role: prey
Biological role participant: unspecified role
Participant detection method: anti tag western blot
Host: -
Interaction detection method: pull down
Source: Intact
Original protein 2: P0CG48
Taxonomy: human
Experimental role: bait
Biological role participant: unspecified role
Participant detection method: confirmation by molecular weight
PMID: 19763089
Interaction type: physical association
Evidence: LT
Inferred: from orthologous proteins
Original protein 1: O88522
Taxonomy: mouse
Experimental role: bait
Biological role participant: unspecified role
Participant detection method: anti tag western blot
Host: -
Interaction detection method: pull down
Source: Intact
Original protein 2: P0CG48
Taxonomy: human
Experimental role: prey
Biological role participant: unspecified role
Participant detection method: western blot
PMID: 19763089
Interaction type: physical association
Evidence: LT
Inferred: from orthologous proteins
Original protein 1: O88522
Taxonomy: mouse
Experimental role: prey
Biological role participant: unspecified role
Participant detection method: anti tag western blot
Host: -
Interaction detection method: pull down
Source: Intact
Original protein 2: P0CG48
Taxonomy: human
Experimental role: bait
Biological role participant: unspecified role
Participant detection method: confirmation by molecular weight
PMID: 19763089
Interaction type: physical association
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: human
Experimental role: bait
Biological role participant: unspecified role
Participant detection method: western blot
Host: human-jpm50.6wt
Interaction detection method: anti bait coimmunoprecipitation
Source: Intact
Original protein 2: P0CG48
Taxonomy: human
Experimental role: prey
Biological role participant: unspecified role
Participant detection method: western blot
PMID: 17363905
Interaction type: physical association
Evidence: LT
Inferred: from orthologous proteins
Original protein 1: O88522
Taxonomy: mouse
Experimental role: neutral component
Biological role participant: unspecified role
Participant detection method: -
Host: -
Interaction detection method: x-ray crystallography
Source: PDB
Original protein 2: P0CG48
Taxonomy: human
Experimental role: neutral component
Biological role participant: unspecified role
Participant detection method: -
PMID: 19303852
Interaction type: direct interaction
Evidence: LT
Inferred: from orthologous proteins
Original protein 1: O88522
Taxonomy: mouse
Experimental role: neutral component
Biological role participant: unspecified role
Participant detection method: -
Host: -
Interaction detection method: x-ray crystallography
Source: PDB
Original protein 2: P0CG48
Taxonomy: human
Experimental role: neutral component
Biological role participant: unspecified role
Participant detection method: -
PMID: 19303852
Interaction type: direct interaction
Evidence: LT
Inferred: from orthologous proteins
Original protein 1: O88522
Taxonomy: mouse
Experimental role: neutral component
Biological role participant: unspecified role
Participant detection method: -
Host: -
Interaction detection method: x-ray crystallography
Source: PDB
Original protein 2: P0CG48
Taxonomy: human
Experimental role: neutral component
Biological role participant: unspecified role
Participant detection method: -
PMID: 19766637
Interaction type: direct interaction
Evidence: LT
Inferred: -
Original protein 1: Q9Y6K9
Taxonomy: -
Experimental role: -
Biological role participant: -
Participant detection method: -
Host: -
Interaction detection method: -
Source: STRING [UBC_HUMAN] [NEMO_HUMAN]
Original protein 2: P0CG48
Taxonomy: -
Experimental role: -
Biological role participant: -
Participant detection method: -
PMID: -
Interaction type: -
Evidence: Computational