5HT3E_HUMAN
Evidence for PS localization
Functions
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 5HT3E_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 100.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 100.0000 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 100.0000 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 100.0000 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 100.0000 | 4 | yes |
| GO:0015267 | channel activity | 100.0000 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 100.0000 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 100.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 100.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 100.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 100.0000 | 5 | yes |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 100.0000 | 7 | yes |
| GO:0022850 | serotonin-gated monoatomic cation channel activity | 100.0000 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 100.0000 | 4 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 100.0000 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 100.0000 | 5 | yes |
| GO:0099589 | serotonin receptor activity | 100.0000 | 4 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 100.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 5HT3E_HUMAN |
|---|---|---|---|---|
| GO:0098662 | inorganic cation transmembrane transport | 100.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 5HT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DHRS7_HUMAN | [view interactions] | High throughput | no | yes |
| CP51A_HUMAN | [view interactions] | High throughput | no | no |
| NPW_HUMAN | [view interactions] | High throughput | no | no |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |