5HT3A_HUMAN
Evidence for PS localization
Functions
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 5HT3A_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 56.5217 | 4 | yes |
| GO:0015267 | channel activity | 52.1739 | 4 | yes |
| GO:0005216 | monoatomic ion channel activity | 43.4783 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 34.7826 | 6 | yes |
| GO:0005261 | monoatomic cation channel activity | 34.7826 | 5 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 34.7826 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 34.7826 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 34.7826 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 34.7826 | 4 | yes |
| GO:0022836 | gated channel activity | 34.7826 | 5 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 34.7826 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 34.7826 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 34.7826 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 30.4348 | 7 | yes |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 30.4348 | 7 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 30.4348 | 6 | yes |
| GO:0022850 | serotonin-gated monoatomic cation channel activity | 26.0870 | 5 | yes |
| GO:0099589 | serotonin receptor activity | 26.0870 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 26.0870 | 4 | no |
| GO:0043169 | cation binding | 21.7391 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 21.7391 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 21.7391 | 5 | no |
| GO:0099507 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | 8.6957 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 5HT3A_HUMAN |
|---|---|---|---|---|
| GO:0098662 | inorganic cation transmembrane transport | 39.1304 | 4 | yes |
| GO:0010646 | regulation of cell communication | 39.1304 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 39.1304 | 4 | no |
| GO:0051049 | regulation of transport | 34.7826 | 4 | no |
| GO:0060341 | regulation of cellular localization | 30.4348 | 4 | no |
| GO:0006811 | monoatomic ion transport | 30.4348 | 4 | no |
| GO:0032880 | regulation of protein localization | 26.0870 | 5 | no |
| GO:0022607 | cellular component assembly | 26.0870 | 4 | no |
| GO:0051046 | regulation of secretion | 26.0870 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 26.0870 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 26.0870 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 26.0870 | 4 | no |
| GO:0008104 | protein localization | 21.7391 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.7391 | 4 | no |
| GO:0044057 | regulation of system process | 21.7391 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.7391 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.7391 | 4 | no |
| GO:0098657 | import into cell | 21.7391 | 4 | no |
| GO:0071702 | organic substance transport | 21.7391 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.7391 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 5HT3C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 5HT3D_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 5HT3E_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 5HT3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P_HUMAN | [view interactions] | High throughput | no | no |
| DOA_HUMAN | [view interactions] | High throughput | no | no |
| ABCA7_HUMAN | [view interactions] | High throughput | no | yes |
| UD3A2_HUMAN | [view interactions] | High throughput | no | no |
| LRC8D_HUMAN | [view interactions] | High throughput | no | no |
| S41A3_HUMAN | [view interactions] | High throughput | no | yes |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PLPR3_HUMAN | [view interactions] | High throughput | no | no |
| MARH6_HUMAN | [view interactions] | High throughput | no | yes |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| COA1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC8C_HUMAN | [view interactions] | High throughput | no | yes |
| D19L4_HUMAN | [view interactions] | High throughput | no | no |
| LRP12_HUMAN | [view interactions] | High throughput | no | yes |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| TM59L_HUMAN | [view interactions] | High throughput | no | yes |
| ALG9_HUMAN | [view interactions] | High throughput | no | yes |
| ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
| ALG8_HUMAN | [view interactions] | High throughput | no | yes |
| C1QRF_HUMAN | [view interactions] | High throughput | no | no |
| TAP2_HUMAN | [view interactions] | High throughput | no | no |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| ASTRB_HUMAN | [view interactions] | High throughput | no | yes |
| C1QL4_HUMAN | [view interactions] | High throughput | no | no |
| ASTRA_HUMAN | [view interactions] | High throughput | no | no |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| CNNM1_HUMAN | [view interactions] | High throughput | no | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| ERMP1_HUMAN | [view interactions] | High throughput | no | no |
| LRC8E_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| PIGO_HUMAN | [view interactions] | High throughput | no | no |
| CXG1_HUMAN | [view interactions] | High throughput | no | no |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| GP1BB_HUMAN | [view interactions] | High throughput | no | no |
| GRID1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WLS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHBD3_HUMAN | [view interactions] | High throughput | no | yes |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| MKS3_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCA3_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCX3_HUMAN | [view interactions] | High throughput | no | no |
| POMT1_HUMAN | [view interactions] | High throughput | no | no |
| IPRI_HUMAN | [view interactions] | High throughput | no | no |
| LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| TTC17_HUMAN | [view interactions] | High throughput | no | yes |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| TM39A_HUMAN | [view interactions] | High throughput | no | yes |
| S47A1_HUMAN | [view interactions] | High throughput | no | no |
| TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
| S29A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| POMT2_HUMAN | [view interactions] | High throughput | no | yes |
| APOL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGCB_HUMAN | [view interactions] | High throughput | no | no |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIGG_HUMAN | [view interactions] | High throughput | no | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| LMBR1_HUMAN | [view interactions] | High throughput | no | yes |
| NETO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| GL8D1_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| TM186_HUMAN | [view interactions] | High throughput | no | no |
| CF089_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| C1GLC_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| TMX4_HUMAN | [view interactions] | High throughput | no | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| F241B_HUMAN | [view interactions] | High throughput | no | yes |
| ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| GPAA1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABHD3_HUMAN | [view interactions] | High throughput | no | yes |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| DSE_HUMAN | [view interactions] | High throughput | no | yes |
| AT8B2_HUMAN | [view interactions] | High throughput | no | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| DMB_HUMAN | [view interactions] | High throughput | no | no |
| SUN1_HUMAN | [view interactions] | High throughput | no | yes |
| CERS6_HUMAN | [view interactions] | High throughput | no | yes |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
| SCAP_HUMAN | [view interactions] | High throughput | no | yes |