5HT3A_HUMAN
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in 5HT3A_HUMAN |
---|---|---|---|---|
GO:0008324 | cation transmembrane transporter activity | 54.5455 | 4 | yes |
GO:0015267 | channel activity | 50.0000 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 50.0000 | 4 | yes |
GO:0005216 | ion channel activity | 45.4545 | 4 | yes |
GO:0005261 | cation channel activity | 36.3636 | 5 | yes |
GO:0005230 | extracellular ligand-gated ion channel activity | 31.8182 | 6 | yes |
GO:0015276 | ligand-gated ion channel activity | 31.8182 | 5 | yes |
GO:0022824 | transmitter-gated ion channel activity | 31.8182 | 5 | yes |
GO:0022834 | ligand-gated channel activity | 31.8182 | 6 | yes |
GO:0022835 | transmitter-gated channel activity | 31.8182 | 4 | yes |
GO:0022836 | gated channel activity | 31.8182 | 5 | yes |
GO:0099094 | ligand-gated cation channel activity | 27.2727 | 6 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 22.7273 | 5 | no |
GO:0022850 | serotonin-gated cation-selective channel activity | 13.6364 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in 5HT3A_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 54.5455 | 4 | no |
GO:0006811 | ion transport | 45.4545 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | no |
GO:0051049 | regulation of transport | 40.9091 | 4 | no |
GO:0007268 | chemical synaptic transmission | 36.3636 | 6 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 36.3636 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 36.3636 | 4 | yes |
GO:0022607 | cellular component assembly | 31.8182 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 31.8182 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 31.8182 | 4 | no |
GO:0006812 | cation transport | 31.8182 | 5 | yes |
GO:0098660 | inorganic ion transmembrane transport | 31.8182 | 4 | yes |
GO:0048878 | chemical homeostasis | 27.2727 | 4 | no |
GO:0060341 | regulation of cellular localization | 27.2727 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 27.2727 | 4 | no |
GO:0051128 | regulation of cellular component organization | 27.2727 | 4 | no |
GO:0051046 | regulation of secretion | 27.2727 | 5 | no |
GO:1903530 | regulation of secretion by cell | 27.2727 | 4 | no |
GO:0098655 | cation transmembrane transport | 27.2727 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 27.2727 | 5 | yes |
GO:0071310 | cellular response to organic substance | 22.7273 | 4 | no |
GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
GO:0023056 | positive regulation of signaling | 22.7273 | 4 | no |
GO:0071702 | organic substance transport | 22.7273 | 4 | no |
GO:0071705 | nitrogen compound transport | 22.7273 | 4 | no |
GO:0009966 | regulation of signal transduction | 22.7273 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 22.7273 | 4 | no |
GO:0032880 | regulation of protein localization | 22.7273 | 5 | no |
GO:0043269 | regulation of ion transport | 22.7273 | 5 | no |
GO:0044057 | regulation of system process | 22.7273 | 4 | no |
GO:0048523 | negative regulation of cellular process | 22.7273 | 4 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
5HT3C_HUMAN | [view interactions] | Low throughput | no | no |
5HT3D_HUMAN | [view interactions] | Low throughput | no | no |
5HT3E_HUMAN | [view interactions] | Low throughput | no | no |
5HT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
5HT3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MAP1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CSCL1_HUMAN | [view interactions] | High throughput | no | no |
PIGO_HUMAN | [view interactions] | High throughput | no | no |
CXG1_HUMAN | [view interactions] | High throughput | no | no |
CREL1_HUMAN | [view interactions] | High throughput | no | yes |
GP1BB_HUMAN | [view interactions] | High throughput | no | no |
GRID1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
WLS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHBD3_HUMAN | [view interactions] | High throughput | no | yes |
EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
MKS3_HUMAN | [view interactions] | High throughput | no | no |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABCA3_HUMAN | [view interactions] | High throughput | no | yes |
AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCX3_HUMAN | [view interactions] | High throughput | no | no |
POMT1_HUMAN | [view interactions] | High throughput | no | no |
IPRI_HUMAN | [view interactions] | High throughput | no | no |
LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
H12_HUMAN | [view interactions] | High throughput | no | yes |
HLAC_HUMAN | [view interactions] | High throughput | no | no |
TTC17_HUMAN | [view interactions] | High throughput | no | yes |
SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
TM39A_HUMAN | [view interactions] | High throughput | no | yes |
S47A1_HUMAN | [view interactions] | High throughput | no | no |
TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
S29A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSN15_HUMAN | [view interactions] | High throughput | no | yes |
LMF2_HUMAN | [view interactions] | High throughput | no | yes |
POMT2_HUMAN | [view interactions] | High throughput | no | yes |
APOL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SGCB_HUMAN | [view interactions] | High throughput | no | no |
S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIGG_HUMAN | [view interactions] | High throughput | no | yes |
VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPPL3_HUMAN | [view interactions] | High throughput | no | no |
NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
LMBR1_HUMAN | [view interactions] | High throughput | no | yes |
NETO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EBP_HUMAN | [view interactions] | High throughput | no | no |
GL8D1_HUMAN | [view interactions] | High throughput | no | yes |
AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FURIN_HUMAN | [view interactions] | High throughput | no | yes |
TM186_HUMAN | [view interactions] | High throughput | no | no |
CF089_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
FITM2_HUMAN | [view interactions] | High throughput | no | no |
C1GLC_HUMAN | [view interactions] | High throughput | no | yes |
PTH2_HUMAN | [view interactions] | High throughput | no | yes |
ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
TMX4_HUMAN | [view interactions] | High throughput | no | yes |
BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
F241B_HUMAN | [view interactions] | High throughput | no | yes |
ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
GPX8_HUMAN | [view interactions] | High throughput | no | no |
GPAA1_HUMAN | [view interactions] | High throughput | no | yes |
LRC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ABHD3_HUMAN | [view interactions] | High throughput | no | yes |
FUT8_HUMAN | [view interactions] | High throughput | no | yes |
DSE_HUMAN | [view interactions] | High throughput | no | yes |
AT8B2_HUMAN | [view interactions] | High throughput | no | yes |
ST7_HUMAN | [view interactions] | High throughput | no | yes |
ACHA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CLPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GOLI_HUMAN | [view interactions] | High throughput | no | yes |
LSR_HUMAN | [view interactions] | High throughput | no | yes |
DMB_HUMAN | [view interactions] | High throughput | no | no |
SUN1_HUMAN | [view interactions] | High throughput | no | yes |
CERS6_HUMAN | [view interactions] | High throughput | no | yes |
NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
SCAP_HUMAN | [view interactions] | High throughput | no | yes |
P_HUMAN | [view interactions] | High throughput | no | no |
DOA_HUMAN | [view interactions] | High throughput | no | no |
ABCA7_HUMAN | [view interactions] | High throughput | no | yes |
UD3A2_HUMAN | [view interactions] | High throughput | no | no |
LRC8D_HUMAN | [view interactions] | High throughput | no | no |
S41A3_HUMAN | [view interactions] | High throughput | no | yes |
PANX1_HUMAN | [view interactions] | High throughput | no | no |
PLPR3_HUMAN | [view interactions] | High throughput | no | no |
MARH6_HUMAN | [view interactions] | High throughput | no | yes |
TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
COA1_HUMAN | [view interactions] | High throughput | no | yes |
LRC8C_HUMAN | [view interactions] | High throughput | no | yes |
D19L4_HUMAN | [view interactions] | High throughput | no | no |
LRP12_HUMAN | [view interactions] | High throughput | no | yes |
SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
TM59L_HUMAN | [view interactions] | High throughput | no | yes |
ALG9_HUMAN | [view interactions] | High throughput | no | yes |
ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
ALG8_HUMAN | [view interactions] | High throughput | no | yes |
C1QRF_HUMAN | [view interactions] | High throughput | no | no |
TAP2_HUMAN | [view interactions] | High throughput | no | no |
DYR2_HUMAN | [view interactions] | High throughput | no | yes |
ASTRB_HUMAN | [view interactions] | High throughput | no | yes |
C1QL4_HUMAN | [view interactions] | High throughput | no | no |
ASTRA_HUMAN | [view interactions] | High throughput | no | no |
DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
CNNM1_HUMAN | [view interactions] | High throughput | no | yes |
MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
TPST2_HUMAN | [view interactions] | High throughput | no | yes |
ERMP1_HUMAN | [view interactions] | High throughput | no | no |
LRC8E_HUMAN | [view interactions] | High throughput | no | no |
NMDE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RIC3_HUMAN | [view interactions] | Computational | no | yes |