WLS_HUMAN
Evidence for PS localization
Functions
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 392 | Tyr | Cys | Zakisyndrome(ZKS) | - |
| 478 | Tyr | Cys | Zakisyndrome(ZKS) | - |
| 531 | Ile | Thr | Zakisyndrome(ZKS) | - |
| 536 | Arg | Cys | Zakisyndrome(ZKS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in WLS_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.6596 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.6596 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.6596 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 25.5319 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.5319 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.5319 | 6 | no |
| GO:0003924 | GTPase activity | 23.4043 | 7 | no |
| GO:0005525 | GTP binding | 23.4043 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 23.4043 | 5 | no |
| GO:0019003 | GDP binding | 23.4043 | 4 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.4043 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in WLS_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.4468 | 4 | yes |
| GO:0051049 | regulation of transport | 51.0638 | 4 | yes |
| GO:0008104 | protein localization | 44.6809 | 4 | yes |
| GO:0010646 | regulation of cell communication | 42.5532 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.4255 | 4 | yes |
| GO:0071702 | organic substance transport | 40.4255 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.4255 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.4255 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.2979 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 38.2979 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 36.1702 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 36.1702 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 36.1702 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 36.1702 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 34.0426 | 5 | yes |
| GO:0015031 | protein transport | 34.0426 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 34.0426 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.0426 | 4 | no |
| GO:0060341 | regulation of cellular localization | 31.9149 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.9149 | 4 | no |
| GO:0032880 | regulation of protein localization | 29.7872 | 5 | yes |
| GO:0051050 | positive regulation of transport | 29.7872 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 29.7872 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.6596 | 5 | yes |
| GO:0006996 | organelle organization | 27.6596 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.6596 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.6596 | 5 | no |
| GO:0010941 | regulation of cell death | 27.6596 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.6596 | 5 | no |
| GO:0051046 | regulation of secretion | 25.5319 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.5319 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 25.5319 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 25.5319 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.5319 | 5 | no |
| GO:0022607 | cellular component assembly | 25.5319 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.5319 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.5319 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.5319 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.4043 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.4043 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 23.4043 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.4043 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.4043 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.4043 | 4 | no |
| GO:0006886 | intracellular protein transport | 21.2766 | 4 | yes |
| GO:0051223 | regulation of protein transport | 21.2766 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 21.2766 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 21.2766 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 21.2766 | 4 | no |
| GO:0006811 | ion transport | 21.2766 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.2766 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 21.2766 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.2766 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.2766 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.2766 | 6 | no |
| GO:0060548 | negative regulation of cell death | 21.2766 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.2766 | 6 | no |
| GO:0016055 | Wnt signaling pathway | 19.1489 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 19.1489 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 19.1489 | 5 | yes |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 19.1489 | 4 | yes |
| GO:0046903 | secretion | 17.0213 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 17.0213 | 5 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 14.8936 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 14.8936 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 14.8936 | 6 | yes |
| GO:0030177 | positive regulation of Wnt signaling pathway | 12.7660 | 6 | yes |
| GO:0050714 | positive regulation of protein secretion | 12.7660 | 6 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 12.7660 | 6 | yes |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | 10.6383 | 7 | yes |
| GO:0009306 | protein secretion | 8.5106 | 4 | yes |
| GO:0023061 | signal release | 8.5106 | 4 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 8.5106 | 4 | yes |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 8.5106 | 6 | yes |
| GO:0048732 | gland development | 8.5106 | 4 | yes |
| GO:0061356 | regulation of Wnt protein secretion | 8.5106 | 4 | yes |
| GO:0071692 | protein localization to extracellular region | 8.5106 | 5 | yes |
| GO:0001707 | mesoderm formation | 6.3830 | 4 | yes |
| GO:0009948 | anterior/posterior axis specification | 6.3830 | 4 | yes |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 6.3830 | 7 | yes |
| GO:0061355 | Wnt protein secretion | 6.3830 | 5 | yes |
| GO:0061357 | positive regulation of Wnt protein secretion | 6.3830 | 5 | yes |
| GO:0031017 | exocrine pancreas development | 4.2553 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SGIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EBP_HUMAN | [view interactions] | Low throughput | no | no |
| F241B_HUMAN | [view interactions] | Low throughput | no | yes |
| WNT1_HUMAN | [view interactions] | Low throughput | no | no |
| WNT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WLS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNT5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNT5B_HUMAN | [view interactions] | Low throughput | no | no |
| WNT7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNT7B_HUMAN | [view interactions] | Low throughput | no | no |
| WNT8A_HUMAN | [view interactions] | Low throughput | no | no |
| WNT8B_HUMAN | [view interactions] | Low throughput | no | no |
| WNT9A_HUMAN | [view interactions] | Low throughput | no | no |
| WNT9B_HUMAN | [view interactions] | Low throughput | no | no |
| WNT3_HUMAN | [view interactions] | Low throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AA2AR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| ERLN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBXN4_HUMAN | [view interactions] | Low throughput | no | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| PX11B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIGW_HUMAN | [view interactions] | High throughput | no | no |
| AQP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFAS1_HUMAN | [view interactions] | High throughput | no | no |
| BORC7_HUMAN | [view interactions] | High throughput | no | yes |
| EMC7_HUMAN | [view interactions] | High throughput | no | yes |
| TM14A_HUMAN | [view interactions] | High throughput | no | yes |
| TM134_HUMAN | [view interactions] | High throughput | no | yes |
| TM160_HUMAN | [view interactions] | High throughput | no | no |
| TM230_HUMAN | [view interactions] | High throughput | no | yes |
| SOX9_HUMAN | [view interactions] | High throughput | no | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| CNIH4_HUMAN | [view interactions] | High throughput | no | yes |
| DPM2_HUMAN | [view interactions] | High throughput | no | yes |
| PCDBA_HUMAN | [view interactions] | High throughput | no | yes |
| TOM6_HUMAN | [view interactions] | High throughput | no | yes |
| TV23B_HUMAN | [view interactions] | High throughput | no | no |
| YIPF6_HUMAN | [view interactions] | High throughput | no | yes |
| OPRK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| CCR2_HUMAN | [view interactions] | High throughput | no | yes |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPR37_HUMAN | [view interactions] | High throughput | no | no |
| HRH1_HUMAN | [view interactions] | High throughput | no | no |
| SMO_HUMAN | [view interactions] | High throughput | no | yes |
| ALKMO_HUMAN | [view interactions] | High throughput | no | no |
| CRCM1_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| WNT4_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3C_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| ACHD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNT16_HUMAN | [view interactions] | High throughput | no | no |
| TMED6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| RN128_HUMAN | [view interactions] | High throughput | no | yes |
| RPRM_HUMAN | [view interactions] | High throughput | no | no |
| FCERA_HUMAN | [view interactions] | High throughput | no | yes |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| WNT2_HUMAN | [view interactions] | High throughput | no | no |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SNX8_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| DOXA2_HUMAN | [view interactions] | High throughput | no | no |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WNT6_HUMAN | [view interactions] | Computational | no | yes |
| SNX3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VP26A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VPS35_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WNT11_HUMAN | [view interactions] | Computational | no | no |
| WNT2B_HUMAN | [view interactions] | Computational | no | no |
| WN10A_HUMAN | [view interactions] | Computational | no | no |
| WN10B_HUMAN | [view interactions] | Computational | no | yes |