WLS_HUMAN
Evidence for PS localization
Functions
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 392 | Tyr | Cys | Zakisyndrome(ZKS) | - |
| 478 | Tyr | Cys | Zakisyndrome(ZKS) | - |
| 531 | Ile | Thr | Zakisyndrome(ZKS) | - |
| 536 | Arg | Cys | Zakisyndrome(ZKS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in WLS_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 29.4118 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.4118 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 27.4510 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 27.4510 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 27.4510 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 27.4510 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.4510 | 4 | no |
| GO:0043168 | anion binding | 27.4510 | 4 | no |
| GO:0003924 | GTPase activity | 23.5294 | 7 | no |
| GO:0005525 | GTP binding | 23.5294 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 23.5294 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.5294 | 5 | no |
| GO:0043169 | cation binding | 21.5686 | 4 | no |
| GO:0019003 | GDP binding | 21.5686 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in WLS_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | yes |
| GO:0008104 | protein localization | 43.1373 | 4 | yes |
| GO:0051049 | regulation of transport | 41.1765 | 4 | yes |
| GO:0010646 | regulation of cell communication | 39.2157 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.2549 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 37.2549 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 37.2549 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 35.2941 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 35.2941 | 4 | yes |
| GO:0071702 | organic substance transport | 35.2941 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 35.2941 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 35.2941 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 31.3725 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.3725 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.3725 | 4 | no |
| GO:0015031 | protein transport | 31.3725 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 31.3725 | 4 | yes |
| GO:0032880 | regulation of protein localization | 29.4118 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 29.4118 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.4118 | 5 | no |
| GO:0051050 | positive regulation of transport | 27.4510 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 27.4510 | 5 | yes |
| GO:0010468 | regulation of gene expression | 27.4510 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.4510 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.4510 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.4902 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.4902 | 4 | no |
| GO:0006996 | organelle organization | 25.4902 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.4902 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.4902 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.4902 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 25.4902 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.5294 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.5294 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 23.5294 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 23.5294 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.5686 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 21.5686 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.5686 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 21.5686 | 4 | no |
| GO:0006915 | apoptotic process | 21.5686 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.5686 | 4 | no |
| GO:0006886 | intracellular protein transport | 21.5686 | 4 | yes |
| GO:0051046 | regulation of secretion | 21.5686 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 21.5686 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 21.5686 | 7 | no |
| GO:0022607 | cellular component assembly | 21.5686 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.5686 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 17.6471 | 6 | yes |
| GO:0016055 | Wnt signaling pathway | 15.6863 | 4 | yes |
| GO:0046903 | secretion | 15.6863 | 4 | yes |
| GO:0051047 | positive regulation of secretion | 15.6863 | 5 | yes |
| GO:0051223 | regulation of protein transport | 15.6863 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 15.6863 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 13.7255 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 13.7255 | 6 | yes |
| GO:0051222 | positive regulation of protein transport | 11.7647 | 5 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 9.8039 | 5 | yes |
| GO:0030177 | positive regulation of Wnt signaling pathway | 9.8039 | 6 | yes |
| GO:0043122 | regulation of canonical NF-kappaB signal transduction | 9.8039 | 6 | yes |
| GO:0050714 | positive regulation of protein secretion | 9.8039 | 6 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 9.8039 | 6 | yes |
| GO:0009306 | protein secretion | 7.8431 | 4 | yes |
| GO:0023061 | signal release | 7.8431 | 4 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 7.8431 | 4 | yes |
| GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 7.8431 | 7 | yes |
| GO:0048732 | gland development | 7.8431 | 4 | yes |
| GO:0071692 | protein localization to extracellular region | 7.8431 | 5 | yes |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | 7.8431 | 7 | yes |
| GO:0001707 | mesoderm formation | 5.8824 | 4 | yes |
| GO:0009948 | anterior/posterior axis specification | 5.8824 | 4 | yes |
| GO:0061355 | Wnt protein secretion | 5.8824 | 5 | yes |
| GO:0061356 | regulation of Wnt protein secretion | 5.8824 | 4 | yes |
| GO:0031017 | exocrine pancreas development | 3.9216 | 5 | yes |
| GO:0031214 | biomineral tissue development | 3.9216 | 4 | yes |
| GO:0034505 | tooth mineralization | 3.9216 | 5 | yes |
| GO:0061357 | positive regulation of Wnt protein secretion | 3.9216 | 5 | yes |
| GO:0071529 | cementum mineralization | 3.9216 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| ERLN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBXN4_HUMAN | [view interactions] | Low throughput | no | yes |
| CALR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RECK_HUMAN | [view interactions] | Low throughput | no | yes |
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SGIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EBP_HUMAN | [view interactions] | Low throughput | no | no |
| F241B_HUMAN | [view interactions] | Low throughput | no | yes |
| WNT1_HUMAN | [view interactions] | Low throughput | no | no |
| WNT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WLS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNT5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNT5B_HUMAN | [view interactions] | Low throughput | no | no |
| WNT7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNT7B_HUMAN | [view interactions] | Low throughput | no | no |
| WNT8A_HUMAN | [view interactions] | Low throughput | no | no |
| WNT8B_HUMAN | [view interactions] | Low throughput | no | no |
| WNT9A_HUMAN | [view interactions] | Low throughput | no | no |
| WNT9B_HUMAN | [view interactions] | Low throughput | no | no |
| WNT3_HUMAN | [view interactions] | Low throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AA2AR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TMED6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| RN128_HUMAN | [view interactions] | High throughput | no | yes |
| RPRM_HUMAN | [view interactions] | High throughput | no | no |
| FCERA_HUMAN | [view interactions] | High throughput | no | yes |
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| WNT2_HUMAN | [view interactions] | High throughput | no | no |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SNX8_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| DOXA2_HUMAN | [view interactions] | High throughput | no | no |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| TMUB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| PX11B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIGW_HUMAN | [view interactions] | High throughput | no | no |
| AQP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFAS1_HUMAN | [view interactions] | High throughput | no | no |
| BORC7_HUMAN | [view interactions] | High throughput | no | yes |
| EMC7_HUMAN | [view interactions] | High throughput | no | yes |
| TM14A_HUMAN | [view interactions] | High throughput | no | yes |
| TM134_HUMAN | [view interactions] | High throughput | no | yes |
| TM160_HUMAN | [view interactions] | High throughput | no | no |
| TM230_HUMAN | [view interactions] | High throughput | no | yes |
| SOX9_HUMAN | [view interactions] | High throughput | no | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| CNIH4_HUMAN | [view interactions] | High throughput | no | yes |
| DPM2_HUMAN | [view interactions] | High throughput | no | yes |
| PCDBA_HUMAN | [view interactions] | High throughput | no | yes |
| TOM6_HUMAN | [view interactions] | High throughput | no | yes |
| TV23B_HUMAN | [view interactions] | High throughput | no | no |
| YIPF6_HUMAN | [view interactions] | High throughput | no | yes |
| OPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OPRK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| CCR2_HUMAN | [view interactions] | High throughput | no | yes |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPR37_HUMAN | [view interactions] | High throughput | no | no |
| HRH1_HUMAN | [view interactions] | High throughput | no | no |
| SMO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALKMO_HUMAN | [view interactions] | High throughput | no | no |
| CRCM1_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| WNT4_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| ACHD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNT16_HUMAN | [view interactions] | High throughput | no | no |