PX11B_HUMAN
Evidence for PS localization
Functions
Involved in peroxisomal proliferation (PubMed). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PX11B_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 47.0588 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 47.0588 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 41.1765 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 41.1765 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 41.1765 | 6 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 41.1765 | 4 | no |
| GO:0042803 | protein homodimerization activity | 35.2941 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.5294 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.5294 | 5 | no |
| GO:0003924 | GTPase activity | 23.5294 | 7 | no |
| GO:0005525 | GTP binding | 23.5294 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 23.5294 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.5294 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PX11B_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 52.9412 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 41.1765 | 4 | no |
| GO:0051049 | regulation of transport | 41.1765 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.1765 | 4 | no |
| GO:0008104 | protein localization | 35.2941 | 4 | no |
| GO:0071702 | organic substance transport | 35.2941 | 4 | no |
| GO:0048285 | organelle fission | 29.4118 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 29.4118 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 29.4118 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 29.4118 | 4 | no |
| GO:0010646 | regulation of cell communication | 29.4118 | 4 | no |
| GO:0033043 | regulation of organelle organization | 29.4118 | 5 | no |
| GO:0051050 | positive regulation of transport | 29.4118 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 23.5294 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.5294 | 5 | no |
| GO:0006886 | intracellular protein transport | 23.5294 | 4 | no |
| GO:0007005 | mitochondrion organization | 23.5294 | 5 | no |
| GO:0015031 | protein transport | 23.5294 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.5294 | 4 | no |
| GO:0007031 | peroxisome organization | 23.5294 | 5 | yes |
| GO:0016559 | peroxisome fission | 23.5294 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 23.5294 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.5294 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.5294 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.5294 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.5294 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0010821 | regulation of mitochondrion organization | 23.5294 | 6 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.5294 | 5 | no |
| GO:0032535 | regulation of cellular component size | 11.7647 | 4 | yes |
| GO:0044375 | regulation of peroxisome size | 11.7647 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PX11B_HUMAN |
|---|---|---|---|---|
| DOID:574 | peripheral nervous system disease | 11.7647 | 3 | no |
| DOID:870 | neuropathy | 11.7647 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PEX19_HUMAN | [view interactions] | Low throughput | no | yes |
| PX11C_HUMAN | [view interactions] | Low throughput | no | yes |
| PX11B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FIS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WLS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYPD3_HUMAN | [view interactions] | High throughput | no | no |
| F234B_HUMAN | [view interactions] | High throughput | no | yes |
| SYCE3_HUMAN | [view interactions] | High throughput | no | no |
| BIN3_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| CARL3_HUMAN | [view interactions] | High throughput | no | no |
| CHM1B_HUMAN | [view interactions] | High throughput | no | yes |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PXMP4_HUMAN | [view interactions] | Computational | no | yes |
| PM34_HUMAN | [view interactions] | Computational | no | yes |
| PEX7_HUMAN | [view interactions] | Computational | no | yes |
| PEX13_HUMAN | [view interactions] | Computational | no | yes |
| PX11A_HUMAN | [view interactions] | Computational | no | no |
| GDAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ABCD1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ATAD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PEX16_HUMAN | [view interactions] | Computational | no | yes |
| PEX14_HUMAN | [view interactions] | Computational | no | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PEX2_HUMAN | [view interactions] | Computational | no | yes |
| ABCD2_HUMAN | [view interactions] | Computational | no | no |
| PEX10_HUMAN | [view interactions] | Computational | no | yes |
| PEX26_HUMAN | [view interactions] | Computational | no | yes |