RAB18_HUMAN
Evidence for PS localization
Functions
Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed). Plays a role in apical endocytosis/recycling . Plays a key role in eye and brain development and neurodegeneration (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 24 | Leu | Gln | Warburgmicrosyndrome3(WARBM3) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB18_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 35.7143 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 35.7143 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.7143 | 4 | yes |
| GO:0019001 | guanyl nucleotide binding | 25.0000 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 25.0000 | 5 | yes |
| GO:0003924 | GTPase activity | 23.2143 | 7 | yes |
| GO:0005525 | GTP binding | 23.2143 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 23.2143 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.2143 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.2143 | 6 | yes |
| GO:0019900 | kinase binding | 21.4286 | 4 | no |
| GO:0019003 | GDP binding | 10.7143 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB18_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.5714 | 4 | no |
| GO:0006996 | organelle organization | 48.2143 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | no |
| GO:0008104 | protein localization | 41.0714 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.0714 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.2857 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.7143 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.7143 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.7143 | 4 | no |
| GO:0022607 | cellular component assembly | 35.7143 | 4 | no |
| GO:0071702 | organic substance transport | 32.1429 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 32.1429 | 4 | no |
| GO:0033043 | regulation of organelle organization | 32.1429 | 5 | no |
| GO:0071705 | nitrogen compound transport | 30.3571 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 30.3571 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.3571 | 5 | no |
| GO:0015031 | protein transport | 28.5714 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.7857 | 5 | no |
| GO:0006886 | intracellular protein transport | 25.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.2143 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.2143 | 4 | no |
| GO:0051049 | regulation of transport | 23.2143 | 4 | no |
| GO:0033365 | protein localization to organelle | 21.4286 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.4286 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.4286 | 6 | no |
| GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.4286 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.4286 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.4286 | 4 | no |
| GO:0007264 | small GTPase mediated signal transduction | 16.0714 | 4 | yes |
| GO:0007420 | brain development | 5.3571 | 4 | yes |
| GO:0001654 | eye development | 3.5714 | 5 | yes |
| GO:0007029 | endoplasmic reticulum organization | 3.5714 | 5 | yes |
| GO:0007423 | sensory organ development | 3.5714 | 4 | yes |
| GO:0034389 | lipid droplet organization | 3.5714 | 5 | yes |
| GO:0071786 | endoplasmic reticulum tubular network organization | 3.5714 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CATA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ECHP_HUMAN | [view interactions] | Low throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| 2AAB_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB2B_HUMAN | [view interactions] | High throughput | no | no |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV4_HUMAN | [view interactions] | High throughput | no | no |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| PDE6D_HUMAN | [view interactions] | High throughput | no | yes |
| TM1L1_HUMAN | [view interactions] | High throughput | no | yes |
| IMA3_HUMAN | [view interactions] | High throughput | no | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB39B_HUMAN | [view interactions] | High throughput | no | no |
| RDH13_HUMAN | [view interactions] | High throughput | no | no |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| CENPJ_HUMAN | [view interactions] | High throughput | no | no |
| ERRFI_HUMAN | [view interactions] | High throughput | no | no |
| F107A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICAM2_HUMAN | [view interactions] | High throughput | no | no |
| DHI1_HUMAN | [view interactions] | High throughput | no | no |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| HECA2_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| CSTL1_HUMAN | [view interactions] | High throughput | no | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| KCNK1_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| CD244_HUMAN | [view interactions] | High throughput | no | no |
| GPR55_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
| CCG4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| ANTR1_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| BET1L_HUMAN | [view interactions] | High throughput | no | yes |
| PATZ1_HUMAN | [view interactions] | High throughput | no | yes |
| SRFB1_HUMAN | [view interactions] | High throughput | no | no |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BICD2_HUMAN | [view interactions] | Computational | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACTZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GALT2_HUMAN | [view interactions] | Computational | no | yes |
| GALT1_HUMAN | [view interactions] | Computational | no | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RINT1_HUMAN | [view interactions] | Computational | no | yes |
| DYL1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DC1I2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAZA3_HUMAN | [view interactions] | Computational | no | no |
| DCTN4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN6_HUMAN | [view interactions] | Computational | no | no |
| DCTN5_HUMAN | [view interactions] | Computational | no | yes |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |
| ARP10_HUMAN | [view interactions] | Computational | no | no |
| RB3GP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |