SNX1_HUMAN
Evidence for PS localization
Functions
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed, PubMed). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed, PubMed). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNX1_HUMAN |
|---|---|---|---|---|
| GO:0045296 | cadherin binding | 22.2222 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 18.5185 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 18.5185 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 11.1111 | 4 | yes |
| GO:0070851 | growth factor receptor binding | 11.1111 | 4 | yes |
| GO:0005154 | epidermal growth factor receptor binding | 7.4074 | 5 | yes |
| GO:1990459 | transferrin receptor binding | 7.4074 | 4 | yes |
| GO:1990460 | leptin receptor binding | 7.4074 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNX1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 51.8519 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 51.8519 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 50.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 48.1481 | 4 | yes |
| GO:0010646 | regulation of cell communication | 48.1481 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.1481 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.1481 | 4 | no |
| GO:0008104 | protein localization | 46.2963 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 44.4444 | 4 | no |
| GO:0051049 | regulation of transport | 42.5926 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.7407 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 40.7407 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.8889 | 4 | yes |
| GO:0006996 | organelle organization | 38.8889 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.8889 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.0370 | 5 | yes |
| GO:0015031 | protein transport | 37.0370 | 4 | yes |
| GO:0071702 | organic substance transport | 37.0370 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.0370 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | yes |
| GO:0006886 | intracellular protein transport | 31.4815 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 31.4815 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 31.4815 | 4 | no |
| GO:0022607 | cellular component assembly | 31.4815 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.4815 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.6296 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.6296 | 4 | no |
| GO:0016197 | endosomal transport | 27.7778 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.7778 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.7778 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.7778 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.7778 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 25.9259 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.9259 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.9259 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.9259 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.9259 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.9259 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.9259 | 5 | no |
| GO:0006897 | endocytosis | 24.0741 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 24.0741 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 24.0741 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 24.0741 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.0741 | 6 | no |
| GO:0051050 | positive regulation of transport | 24.0741 | 4 | no |
| GO:0016482 | cytosolic transport | 22.2222 | 4 | yes |
| GO:0030030 | cell projection organization | 22.2222 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 22.2222 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 22.2222 | 5 | no |
| GO:0010941 | regulation of cell death | 22.2222 | 4 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0071310 | cellular response to organic substance | 22.2222 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
| GO:0080134 | regulation of response to stress | 22.2222 | 4 | no |
| GO:0042147 | retrograde transport, endosome to Golgi | 20.3704 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.3704 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 20.3704 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.3704 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.3704 | 6 | no |
| GO:0033043 | regulation of organelle organization | 20.3704 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 20.3704 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.3704 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.3704 | 5 | no |
| GO:0061024 | membrane organization | 20.3704 | 4 | no |
| GO:0042176 | regulation of protein catabolic process | 18.5185 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 12.9630 | 5 | yes |
| GO:0032990 | cell part morphogenesis | 12.9630 | 4 | yes |
| GO:0048858 | cell projection morphogenesis | 12.9630 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 12.9630 | 6 | yes |
| GO:0006898 | receptor-mediated endocytosis | 11.1111 | 6 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 11.1111 | 6 | yes |
| GO:0031623 | receptor internalization | 7.4074 | 7 | yes |
| GO:0048193 | Golgi vesicle transport | 7.4074 | 5 | yes |
| GO:0097581 | lamellipodium organization | 7.4074 | 6 | yes |
| GO:0034498 | early endosome to Golgi transport | 5.5556 | 6 | yes |
| GO:0072673 | lamellipodium morphogenesis | 5.5556 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SNX1_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 3.7037 | 4 | no |
| DOID:331 | central nervous system disease | 3.7037 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SNX6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VP26A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WASC5_HUMAN | [view interactions] | Low throughput | no | yes |
| WASH1_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DJC13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRDN_HUMAN | [view interactions] | Low throughput | no | no |
| IKKB_HUMAN | [view interactions] | High throughput | no | yes |
| AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX32_HUMAN | [view interactions] | High throughput | no | no |
| ARFP2_HUMAN | [view interactions] | High throughput | no | no |
| REEP6_HUMAN | [view interactions] | High throughput | no | no |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| POTB3_HUMAN | [view interactions] | High throughput | no | no |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN397_HUMAN | [view interactions] | High throughput | no | yes |
| GPX7_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| KLH10_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIN3_HUMAN | [view interactions] | High throughput | no | yes |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| HCLS1_HUMAN | [view interactions] | High throughput | no | no |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX8_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| FUND1_HUMAN | [view interactions] | High throughput | no | yes |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| COQ3_HUMAN | [view interactions] | High throughput | no | no |
| FM25C_HUMAN | [view interactions] | High throughput | no | no |
| LIME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHEX_HUMAN | [view interactions] | High throughput | no | no |
| RDHE2_HUMAN | [view interactions] | High throughput | no | yes |
| SFT2A_HUMAN | [view interactions] | High throughput | no | no |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP7_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| ATX7_HUMAN | [view interactions] | High throughput | no | no |
| SASH1_HUMAN | [view interactions] | High throughput | no | yes |
| SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC148_HUMAN | [view interactions] | High throughput | no | no |
| ARM12_HUMAN | [view interactions] | High throughput | no | no |
| CKLF4_HUMAN | [view interactions] | High throughput | no | yes |
| ACHG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM239_HUMAN | [view interactions] | High throughput | no | no |
| AVR2B_HUMAN | [view interactions] | High throughput | no | no |
| ACV1B_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| LEPR_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAT2_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| CA087_HUMAN | [view interactions] | High throughput | no | no |
| MLX_HUMAN | [view interactions] | High throughput | no | yes |
| S35F2_HUMAN | [view interactions] | High throughput | no | yes |
| STAM1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| ODAD1_HUMAN | [view interactions] | High throughput | no | no |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPNXB_HUMAN | [view interactions] | High throughput | no | no |
| BEND3_HUMAN | [view interactions] | High throughput | no | yes |
| DB136_HUMAN | [view interactions] | High throughput | no | no |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F200A_HUMAN | [view interactions] | High throughput | no | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| STAC2_HUMAN | [view interactions] | High throughput | no | no |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| BMP6_HUMAN | [view interactions] | High throughput | no | no |
| PRUN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IBPL1_HUMAN | [view interactions] | High throughput | no | no |
| LRC61_HUMAN | [view interactions] | High throughput | no | yes |
| KLHL1_HUMAN | [view interactions] | High throughput | no | no |
| S12A3_HUMAN | [view interactions] | High throughput | no | no |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAGE4_HUMAN | [view interactions] | High throughput | no | no |
| GAGE1_HUMAN | [view interactions] | High throughput | no | no |
| SPXN4_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| CBCO1_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| PAMR1_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERF3B_HUMAN | [view interactions] | High throughput | no | yes |
| MAT2B_HUMAN | [view interactions] | High throughput | no | yes |
| NASP_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| UGDH_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| LSM2_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| SMYD2_HUMAN | [view interactions] | High throughput | no | yes |
| WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
| VP26B_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| ANXA7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNX17_HUMAN | [view interactions] | Computational | no | yes |
| CTND1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GDN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DEN5A_HUMAN | [view interactions] | Computational | no | yes |