VATC1_HUMAN
Evidence for PS localization
Functions
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATC1_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 26.5306 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 26.5306 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 26.5306 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 24.4898 | 5 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 24.4898 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 22.4490 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 22.4490 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 22.4490 | 4 | no |
| GO:0043168 | anion binding | 22.4490 | 4 | no |
| GO:0045296 | cadherin binding | 20.4082 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATC1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 65.3061 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.8980 | 4 | no |
| GO:0009894 | regulation of catabolic process | 40.8163 | 4 | yes |
| GO:0008104 | protein localization | 40.8163 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 38.7755 | 5 | yes |
| GO:0022607 | cellular component assembly | 38.7755 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.7755 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.7347 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.7347 | 4 | no |
| GO:0010506 | regulation of autophagy | 34.6939 | 6 | yes |
| GO:0006996 | organelle organization | 34.6939 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.6939 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.6939 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 32.6531 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.6531 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.6531 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.6531 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.6531 | 5 | no |
| GO:0071702 | organic substance transport | 30.6122 | 4 | no |
| GO:0006811 | monoatomic ion transport | 28.5714 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 28.5714 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 26.5306 | 7 | yes |
| GO:0071705 | nitrogen compound transport | 26.5306 | 4 | no |
| GO:0097401 | synaptic vesicle lumen acidification | 24.4898 | 4 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 24.4898 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 24.4898 | 4 | yes |
| GO:1902600 | proton transmembrane transport | 24.4898 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 24.4898 | 5 | no |
| GO:0015031 | protein transport | 24.4898 | 4 | no |
| GO:0030030 | cell projection organization | 22.4490 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.4490 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.4490 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.4490 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.4490 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.4490 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.4490 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.4490 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.4490 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.4490 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.4490 | 5 | no |
| GO:0006886 | intracellular protein transport | 22.4490 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.4490 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.4490 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.4490 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.4490 | 4 | no |
| GO:0006873 | intracellular monoatomic ion homeostasis | 20.4082 | 4 | no |
| GO:0030003 | intracellular monoatomic cation homeostasis | 20.4082 | 5 | no |
| GO:0055080 | monoatomic cation homeostasis | 20.4082 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.4082 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.4082 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.4082 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.4082 | 4 | no |
| GO:0051049 | regulation of transport | 20.4082 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.4082 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.4082 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPP4_HUMAN | [view interactions] | High throughput | no | no |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1A_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXD17_HUMAN | [view interactions] | High throughput | no | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| AN32E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFP1_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| ERF3B_HUMAN | [view interactions] | High throughput | no | yes |
| TF2AA_HUMAN | [view interactions] | High throughput | no | yes |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| NASP_HUMAN | [view interactions] | High throughput | no | yes |
| PAWR_HUMAN | [view interactions] | High throughput | no | yes |
| PSMG3_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| GLYC_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSN_HUMAN | [view interactions] | High throughput | no | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2T_HUMAN | [view interactions] | High throughput | no | no |
| TNR6_HUMAN | [view interactions] | High throughput | no | no |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SPSY_HUMAN | [view interactions] | High throughput | no | no |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA3_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| TLDC2_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |