VATC1_HUMAN
Evidence for PS localization
Functions
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATC1_HUMAN |
|---|---|---|---|---|
| GO:0015399 | primary active transmembrane transporter activity | 28.8889 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 26.6667 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 26.6667 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 24.4444 | 5 | yes |
| GO:0009678 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity | 22.2222 | 5 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 22.2222 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 22.2222 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 22.2222 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATC1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 57.7778 | 4 | yes |
| GO:0008104 | protein localization | 46.6667 | 4 | no |
| GO:0009894 | regulation of catabolic process | 44.4444 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 40.0000 | 5 | yes |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0010506 | regulation of autophagy | 37.7778 | 6 | yes |
| GO:0048522 | positive regulation of cellular process | 37.7778 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.7778 | 4 | no |
| GO:0071702 | organic substance transport | 35.5556 | 4 | no |
| GO:0006996 | organelle organization | 35.5556 | 4 | no |
| GO:0022607 | cellular component assembly | 35.5556 | 4 | no |
| GO:0016241 | regulation of macroautophagy | 31.1111 | 7 | yes |
| GO:0015031 | protein transport | 31.1111 | 4 | no |
| GO:0071705 | nitrogen compound transport | 31.1111 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.1111 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.1111 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.1111 | 4 | no |
| GO:0006886 | intracellular protein transport | 28.8889 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 28.8889 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 26.6667 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | no |
| GO:0006811 | ion transport | 24.4444 | 4 | yes |
| GO:0010468 | regulation of gene expression | 24.4444 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 24.4444 | 4 | no |
| GO:0006812 | cation transport | 22.2222 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 22.2222 | 5 | no |
| GO:0010941 | regulation of cell death | 22.2222 | 4 | no |
| GO:0098655 | cation transmembrane transport | 17.7778 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 17.7778 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 17.7778 | 5 | yes |
| GO:1902600 | proton transmembrane transport | 17.7778 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in VATC1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.4444 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPSY_HUMAN | [view interactions] | High throughput | no | no |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA3_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLDC2_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| VATO_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPP4_HUMAN | [view interactions] | High throughput | no | no |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXD17_HUMAN | [view interactions] | High throughput | no | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| AN32E_HUMAN | [view interactions] | High throughput | no | yes |
| ARFP1_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| ERF3B_HUMAN | [view interactions] | High throughput | no | yes |
| TF2AA_HUMAN | [view interactions] | High throughput | no | yes |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| NASP_HUMAN | [view interactions] | High throughput | no | yes |
| PAWR_HUMAN | [view interactions] | High throughput | no | yes |
| PSMG3_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| GLYC_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSN_HUMAN | [view interactions] | High throughput | no | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| VATL_HUMAN | [view interactions] | Computational | no | no |
| SAMTR_HUMAN | [view interactions] | Computational | no | yes |
| NPRL2_HUMAN | [view interactions] | Computational | no | yes |
| AT5G3_HUMAN | [view interactions] | Computational | no | no |
| VATG3_HUMAN | [view interactions] | Computational | no | no |
| ITFG2_HUMAN | [view interactions] | Computational | no | yes |
| TM199_HUMAN | [view interactions] | Computational | no | yes |
| SH3B4_HUMAN | [view interactions] | Computational | no | yes |
| CAST2_HUMAN | [view interactions] | Computational | no | no |
| VA0E2_HUMAN | [view interactions] | Computational | no | no |
| CAST1_HUMAN | [view interactions] | Computational | no | yes |
| VA0D2_HUMAN | [view interactions] | Computational | no | no |
| SESN2_HUMAN | [view interactions] | Computational | no | no |
| FLCN_HUMAN | [view interactions] | Computational | no | yes |
| MIO_HUMAN | [view interactions] | Computational | no | yes |
| SESN1_HUMAN | [view interactions] | Computational | no | no |
| SZT2_HUMAN | [view interactions] | Computational | no | yes |
| FNIP2_HUMAN | [view interactions] | Computational | no | yes |
| SEH1_HUMAN | [view interactions] | Computational | no | no |
| AT5G2_HUMAN | [view interactions] | Computational | no | yes |
| ATPG_HUMAN | [view interactions] | Computational | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WDR24_HUMAN | [view interactions] | Computational | no | yes |
| VATE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VA0E1_HUMAN | [view interactions] | Computational | no | no |
| WDR59_HUMAN | [view interactions] | Computational | no | yes |
| FNIP1_HUMAN | [view interactions] | Computational | no | yes |
| AT5G1_HUMAN | [view interactions] | Computational | no | no |
| KPTN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |