PAK2_HUMAN
Evidence for PS localization
Functions
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 435 | Glu | Lys | Knoblochsyndrome2(KNO2) | - |
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001918 | CLV_C14_Caspase3-7 | CLV | 209 | 213 | - |
| ELMI001918 | CLV_C14_Caspase3-7 | CLV | 209 | 213 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PAK2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 38.7097 | 4 | yes |
| GO:0000166 | nucleotide binding | 37.0968 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 37.0968 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 34.6774 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.8710 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 29.0323 | 6 | yes |
| GO:0003723 | RNA binding | 29.0323 | 4 | no |
| GO:0019900 | kinase binding | 26.6129 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 26.6129 | 5 | yes |
| GO:0005524 | ATP binding | 25.8065 | 5 | yes |
| GO:0019901 | protein kinase binding | 24.1935 | 5 | yes |
| GO:0016301 | kinase activity | 16.9355 | 4 | yes |
| GO:0045296 | cadherin binding | 16.9355 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 16.1290 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 9.6774 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 9.6774 | 4 | yes |
| GO:0019887 | protein kinase regulator activity | 6.4516 | 4 | yes |
| GO:0031267 | small GTPase binding | 4.8387 | 5 | yes |
| GO:0051020 | GTPase binding | 4.8387 | 4 | yes |
| GO:0019209 | kinase activator activity | 1.6129 | 4 | yes |
| GO:0030295 | protein kinase activator activity | 1.6129 | 5 | yes |
| GO:0030296 | protein tyrosine kinase activator activity | 1.6129 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PAK2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 72.5806 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.4839 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 60.4839 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 58.8710 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 56.4516 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 54.0323 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.7742 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 46.7742 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 46.7742 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 45.1613 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 45.1613 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 45.1613 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.5484 | 5 | yes |
| GO:0010468 | regulation of gene expression | 43.5484 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.9355 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 41.9355 | 4 | yes |
| GO:0006996 | organelle organization | 37.9032 | 4 | no |
| GO:0022607 | cellular component assembly | 35.4839 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 35.4839 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 35.4839 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.8710 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 33.8710 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 33.8710 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 33.8710 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 33.0645 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 33.0645 | 4 | yes |
| GO:0051049 | regulation of transport | 33.0645 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 32.2581 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 32.2581 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 32.2581 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 31.4516 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.6452 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 30.6452 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 29.8387 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 29.8387 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.8387 | 6 | no |
| GO:0043412 | macromolecule modification | 29.0323 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 29.0323 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.0323 | 5 | no |
| GO:0071310 | cellular response to organic substance | 28.2258 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.2258 | 6 | no |
| GO:0008104 | protein localization | 28.2258 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 27.4194 | 6 | yes |
| GO:0036211 | protein modification process | 27.4194 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 27.4194 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 27.4194 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 26.6129 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.8065 | 5 | no |
| GO:0009894 | regulation of catabolic process | 25.8065 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.8065 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.1935 | 6 | yes |
| GO:0080134 | regulation of response to stress | 24.1935 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 24.1935 | 5 | no |
| GO:0032880 | regulation of protein localization | 24.1935 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.3871 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 23.3871 | 7 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 23.3871 | 6 | yes |
| GO:0141124 | intracellular signaling cassette | 23.3871 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.3871 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.3871 | 7 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 22.5806 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 22.5806 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.5806 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.5806 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 21.7742 | 4 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.7742 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.7742 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.9677 | 7 | yes |
| GO:0043066 | negative regulation of apoptotic process | 20.9677 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 20.9677 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 20.9677 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 20.9677 | 4 | no |
| GO:0030030 | cell projection organization | 20.9677 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 20.9677 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.1613 | 6 | no |
| GO:2000145 | regulation of cell motility | 20.1613 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 20.1613 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 20.1613 | 4 | yes |
| GO:0016310 | phosphorylation | 19.3548 | 5 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 19.3548 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 18.5484 | 5 | yes |
| GO:0042327 | positive regulation of phosphorylation | 17.7419 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 17.7419 | 7 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 17.7419 | 8 | yes |
| GO:0006915 | apoptotic process | 17.7419 | 4 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 17.7419 | 6 | yes |
| GO:0031400 | negative regulation of protein modification process | 16.9355 | 7 | yes |
| GO:0043408 | regulation of MAPK cascade | 16.9355 | 6 | yes |
| GO:0051336 | regulation of hydrolase activity | 16.9355 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 16.1290 | 7 | yes |
| GO:0014070 | response to organic cyclic compound | 16.1290 | 4 | yes |
| GO:0031347 | regulation of defense response | 16.1290 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 16.1290 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 16.1290 | 4 | yes |
| GO:0050776 | regulation of immune response | 16.1290 | 4 | yes |
| GO:0006468 | protein phosphorylation | 16.1290 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 15.3226 | 6 | yes |
| GO:0051338 | regulation of transferase activity | 15.3226 | 4 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 15.3226 | 5 | yes |
| GO:0034330 | cell junction organization | 14.5161 | 4 | yes |
| GO:0018193 | peptidyl-amino acid modification | 13.7097 | 5 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 13.7097 | 5 | yes |
| GO:0043065 | positive regulation of apoptotic process | 13.7097 | 6 | yes |
| GO:0043068 | positive regulation of programmed cell death | 13.7097 | 5 | yes |
| GO:0050778 | positive regulation of immune response | 13.7097 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 13.7097 | 6 | yes |
| GO:0043549 | regulation of kinase activity | 12.9032 | 5 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 12.9032 | 7 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 12.9032 | 6 | yes |
| GO:0043086 | negative regulation of catalytic activity | 12.0968 | 4 | yes |
| GO:0045859 | regulation of protein kinase activity | 12.0968 | 6 | yes |
| GO:0034329 | cell junction assembly | 11.2903 | 5 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 11.2903 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 11.2903 | 4 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 11.2903 | 4 | yes |
| GO:0051348 | negative regulation of transferase activity | 10.4839 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 10.4839 | 5 | yes |
| GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 10.4839 | 6 | yes |
| GO:0031349 | positive regulation of defense response | 9.6774 | 5 | yes |
| GO:0042326 | negative regulation of phosphorylation | 9.6774 | 8 | yes |
| GO:0045088 | regulation of innate immune response | 9.6774 | 5 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 9.6774 | 8 | yes |
| GO:0046777 | protein autophosphorylation | 8.8710 | 6 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 8.8710 | 8 | yes |
| GO:0050770 | regulation of axonogenesis | 8.8710 | 5 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 8.0645 | 5 | yes |
| GO:0033673 | negative regulation of kinase activity | 8.0645 | 6 | yes |
| GO:0045089 | positive regulation of innate immune response | 8.0645 | 6 | yes |
| GO:0052547 | regulation of peptidase activity | 8.0645 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 8.0645 | 6 | yes |
| GO:0002833 | positive regulation of response to biotic stimulus | 8.0645 | 5 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 7.2581 | 9 | yes |
| GO:0051492 | regulation of stress fiber assembly | 7.2581 | 6 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 7.2581 | 6 | yes |
| GO:0006469 | negative regulation of protein kinase activity | 7.2581 | 7 | yes |
| GO:0010639 | negative regulation of organelle organization | 6.4516 | 6 | yes |
| GO:0045216 | cell-cell junction organization | 6.4516 | 5 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 6.4516 | 5 | yes |
| GO:0002758 | innate immune response-activating signaling pathway | 6.4516 | 4 | yes |
| GO:0045861 | negative regulation of proteolysis | 5.6452 | 7 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 5.6452 | 4 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 5.6452 | 7 | yes |
| GO:2001235 | positive regulation of apoptotic signaling pathway | 5.6452 | 6 | yes |
| GO:0010951 | negative regulation of endopeptidase activity | 4.8387 | 7 | yes |
| GO:0034332 | adherens junction organization | 4.8387 | 6 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 4.8387 | 8 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 4.8387 | 6 | yes |
| GO:1990858 | cellular response to lectin | 4.8387 | 4 | yes |
| GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 4.8387 | 5 | yes |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | 4.8387 | 5 | yes |
| GO:0007043 | cell-cell junction assembly | 4.8387 | 6 | yes |
| GO:0010466 | negative regulation of peptidase activity | 4.8387 | 6 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 4.0323 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 4.0323 | 6 | yes |
| GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 4.0323 | 7 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 4.0323 | 7 | yes |
| GO:0071559 | response to transforming growth factor beta | 4.0323 | 4 | yes |
| GO:0071560 | cellular response to transforming growth factor beta stimulus | 4.0323 | 5 | yes |
| GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 4.0323 | 8 | yes |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 3.2258 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 3.2258 | 5 | yes |
| GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 3.2258 | 7 | yes |
| GO:0032232 | negative regulation of actin filament bundle assembly | 2.4194 | 6 | yes |
| GO:0034333 | adherens junction assembly | 2.4194 | 7 | yes |
| GO:0150105 | protein localization to cell-cell junction | 2.4194 | 6 | yes |
| GO:0014896 | muscle hypertrophy | 1.6129 | 4 | yes |
| GO:0014897 | striated muscle hypertrophy | 1.6129 | 5 | yes |
| GO:0051497 | negative regulation of stress fiber assembly | 1.6129 | 7 | yes |
| GO:0070830 | bicellular tight junction assembly | 1.6129 | 8 | yes |
| GO:0120192 | tight junction assembly | 1.6129 | 7 | yes |
| GO:0120193 | tight junction organization | 1.6129 | 6 | yes |
| GO:1900117 | regulation of execution phase of apoptosis | 1.6129 | 4 | yes |
| GO:1900118 | negative regulation of execution phase of apoptosis | 1.6129 | 5 | yes |
| GO:2001270 | regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis | 1.6129 | 9 | yes |
| GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis | 1.6129 | 6 | yes |
| GO:0003300 | cardiac muscle hypertrophy | 1.6129 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARHG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CASP7_HUMAN | [view interactions] | Low throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIMK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DOCK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MLRV_HUMAN | [view interactions] | Low throughput | no | no |
| H4_HUMAN | [view interactions] | Low throughput | no | yes |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PPM1A_HUMAN | [view interactions] | Low throughput | no | yes |
| GUAA_HUMAN | [view interactions] | High throughput | no | no |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GT251_HUMAN | [view interactions] | High throughput | no | no |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| NIBA2_HUMAN | [view interactions] | High throughput | no | no |
| DHX36_HUMAN | [view interactions] | High throughput | no | yes |
| NUP50_HUMAN | [view interactions] | High throughput | no | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| SRBS2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIOK3_HUMAN | [view interactions] | High throughput | no | yes |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| ML12B_HUMAN | [view interactions] | High throughput | no | no |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| CARF_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| LPXN_HUMAN | [view interactions] | High throughput | no | yes |
| O10H3_HUMAN | [view interactions] | High throughput | no | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| DSRAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM1_HUMAN | [view interactions] | High throughput | no | no |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
| GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEPT2_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF4E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| PPAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| RL32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| BRAF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| MKNK1_HUMAN | [view interactions] | High throughput | no | yes |
| CASP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLR9_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RGS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TX1B3_HUMAN | [view interactions] | High throughput | no | no |
| SERF2_HUMAN | [view interactions] | High throughput | no | no |
| NHRF2_HUMAN | [view interactions] | High throughput | no | no |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPXN4_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SETX_HUMAN | [view interactions] | High throughput | no | yes |
| BUD13_HUMAN | [view interactions] | High throughput | no | yes |
| MK04_HUMAN | [view interactions] | High throughput | no | no |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| ISOC1_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCLY_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| UB2R2_HUMAN | [view interactions] | High throughput | no | no |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ILKAP_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| THOC3_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEPD_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| BGAL_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| AMRP_HUMAN | [view interactions] | High throughput | no | yes |
| AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |