Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PAK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001918 CLV_C14_Caspase3-7 CLV 209 213 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PAK2_HUMAN
GO:0017076 purine nucleotide binding 33.3333 4 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0019900 kinase binding 26.6667 4 yes
GO:0019901 protein kinase binding 25.1852 5 yes
GO:0005524 ATP binding 24.4444 5 yes
GO:0030554 adenyl nucleotide binding 24.4444 5 yes
GO:0032559 adenyl ribonucleotide binding 24.4444 5 yes
GO:0003723 RNA binding 22.9630 4 no
GO:0045296 cadherin binding 20.7407 4 yes
GO:0046872 metal ion binding 20.7407 4 no
GO:0016301 kinase activity 15.5556 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 14.8148 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 14.8148 4 yes
GO:0004674 protein serine/threonine kinase activity 8.1481 4 yes
GO:0106310 protein serine kinase activity 8.1481 4 yes
GO:0019887 protein kinase regulator activity 5.9259 4 yes
GO:0031267 small GTPase binding 4.4444 5 yes
GO:0051020 GTPase binding 4.4444 4 yes
GO:0019209 kinase activator activity 2.9630 4 yes
GO:0030295 protein kinase activator activity 2.9630 5 yes
GO:0030296 protein tyrosine kinase activator activity 1.4815 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PAK2_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 yes
GO:0080090 regulation of primary metabolic process 54.8148 4 yes
GO:0031323 regulation of cellular metabolic process 54.0741 4 yes
GO:0048523 negative regulation of cellular process 54.0741 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 53.3333 4 yes
GO:0051128 regulation of cellular component organization 48.8889 4 yes
GO:0009893 positive regulation of metabolic process 46.6667 4 yes
GO:0010646 regulation of cell communication 46.6667 4 yes
GO:0051246 regulation of protein metabolic process 44.4444 5 yes
GO:0009966 regulation of signal transduction 43.7037 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.9630 5 yes
GO:0031325 positive regulation of cellular metabolic process 42.9630 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 41.4815 5 yes
GO:0010468 regulation of gene expression 38.5185 5 no
GO:0010941 regulation of cell death 34.8148 4 yes
GO:0022607 cellular component assembly 34.8148 4 yes
GO:0009889 regulation of biosynthetic process 34.0741 4 no
GO:0031326 regulation of cellular biosynthetic process 34.0741 5 no
GO:0051247 positive regulation of protein metabolic process 34.0741 6 yes
GO:0031399 regulation of protein modification process 33.3333 6 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 yes
GO:1902531 regulation of intracellular signal transduction 32.5926 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 32.5926 5 no
GO:0006996 organelle organization 32.5926 4 no
GO:0043067 regulation of programmed cell death 32.5926 5 yes
GO:0023056 positive regulation of signaling 31.8519 4 yes
GO:0042981 regulation of apoptotic process 31.8519 6 yes
GO:0051049 regulation of transport 31.1111 4 no
GO:0010647 positive regulation of cell communication 30.3704 5 yes
GO:0009967 positive regulation of signal transduction 29.6296 5 yes
GO:0019220 regulation of phosphate metabolic process 29.6296 6 yes
GO:0033043 regulation of organelle organization 29.6296 5 yes
GO:0044087 regulation of cellular component biogenesis 29.6296 4 yes
GO:0051174 regulation of phosphorus metabolic process 29.6296 5 yes
GO:0051130 positive regulation of cellular component organization 28.8889 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.1481 5 no
GO:0043412 macromolecule modification 28.1481 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 27.4074 4 yes
GO:0036211 protein modification process 27.4074 4 yes
GO:0042325 regulation of phosphorylation 27.4074 7 yes
GO:0008104 protein localization 26.6667 4 yes
GO:0009892 negative regulation of metabolic process 26.6667 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.9259 6 yes
GO:0051252 regulation of RNA metabolic process 25.9259 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.9259 5 yes
GO:0031344 regulation of cell projection organization 25.9259 5 yes
GO:0071310 cellular response to organic substance 25.1852 4 yes
GO:0080134 regulation of response to stress 25.1852 4 yes
GO:0009891 positive regulation of biosynthetic process 25.1852 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.1852 6 no
GO:0048585 negative regulation of response to stimulus 25.1852 4 no
GO:0045595 regulation of cell differentiation 25.1852 4 no
GO:0001932 regulation of protein phosphorylation 25.1852 7 yes
GO:0060341 regulation of cellular localization 24.4444 4 no
GO:0030030 cell projection organization 24.4444 4 no
GO:0009894 regulation of catabolic process 24.4444 4 no
GO:0031401 positive regulation of protein modification process 24.4444 7 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 24.4444 5 yes
GO:0060548 negative regulation of cell death 23.7037 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 23.7037 6 no
GO:0007010 cytoskeleton organization 23.7037 5 no
GO:0051493 regulation of cytoskeleton organization 22.9630 6 yes
GO:0006355 regulation of DNA-templated transcription 22.9630 6 no
GO:0042127 regulation of cell population proliferation 22.9630 4 no
GO:1903506 regulation of nucleic acid-templated transcription 22.9630 7 no
GO:2001141 regulation of RNA biosynthetic process 22.9630 6 no
GO:0006796 phosphate-containing compound metabolic process 22.9630 4 yes
GO:0031324 negative regulation of cellular metabolic process 22.9630 5 yes
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0051094 positive regulation of developmental process 21.4815 4 no
GO:0009968 negative regulation of signal transduction 21.4815 5 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4815 6 yes
GO:0042327 positive regulation of phosphorylation 21.4815 8 yes
GO:0045937 positive regulation of phosphate metabolic process 21.4815 7 yes
GO:0030155 regulation of cell adhesion 20.7407 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.7407 6 no
GO:0120036 plasma membrane bounded cell projection organization 20.7407 5 no
GO:0001934 positive regulation of protein phosphorylation 20.7407 8 yes
GO:0043066 negative regulation of apoptotic process 20.7407 7 yes
GO:0043069 negative regulation of programmed cell death 20.7407 6 yes
GO:0051338 regulation of transferase activity 20.0000 4 yes
GO:0010942 positive regulation of cell death 20.0000 5 yes
GO:0051129 negative regulation of cellular component organization 20.0000 5 yes
GO:0051248 negative regulation of protein metabolic process 20.0000 6 yes
GO:0043408 regulation of MAPK cascade 19.2593 6 yes
GO:0034330 cell junction organization 18.5185 4 yes
GO:0051336 regulation of hydrolase activity 18.5185 4 yes
GO:0014070 response to organic cyclic compound 17.7778 4 yes
GO:0030162 regulation of proteolysis 17.7778 6 yes
GO:0032970 regulation of actin filament-based process 17.7778 4 yes
GO:0043065 positive regulation of apoptotic process 17.7778 7 yes
GO:0043068 positive regulation of programmed cell death 17.7778 6 yes
GO:0006468 protein phosphorylation 17.0370 5 yes
GO:0016310 phosphorylation 17.0370 5 yes
GO:0043549 regulation of kinase activity 17.0370 5 yes
GO:0002684 positive regulation of immune system process 16.2963 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 16.2963 4 yes
GO:0032956 regulation of actin cytoskeleton organization 16.2963 5 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 15.5556 5 yes
GO:0010975 regulation of neuron projection development 15.5556 7 yes
GO:0031400 negative regulation of protein modification process 15.5556 7 yes
GO:0032101 regulation of response to external stimulus 15.5556 4 yes
GO:0045859 regulation of protein kinase activity 15.5556 6 yes
GO:1902903 regulation of supramolecular fiber organization 14.8148 5 yes
GO:2001233 regulation of apoptotic signaling pathway 14.8148 5 yes
GO:0050776 regulation of immune response 14.8148 4 yes
GO:0071407 cellular response to organic cyclic compound 13.3333 5 yes
GO:0034329 cell junction assembly 13.3333 5 yes
GO:0006915 apoptotic process 12.5926 4 yes
GO:0018193 peptidyl-amino acid modification 12.5926 5 yes
GO:0110053 regulation of actin filament organization 11.1111 6 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 11.1111 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 11.1111 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 11.1111 6 yes
GO:0031347 regulation of defense response 11.1111 5 yes
GO:0045936 negative regulation of phosphate metabolic process 11.1111 7 yes
GO:0050778 positive regulation of immune response 11.1111 5 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 9.6296 6 yes
GO:0032103 positive regulation of response to external stimulus 9.6296 5 yes
GO:0043086 negative regulation of catalytic activity 9.6296 4 yes
GO:0046777 protein autophosphorylation 9.6296 6 yes
GO:0042326 negative regulation of phosphorylation 8.8889 8 yes
GO:0045216 cell-cell junction organization 8.8889 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 8.8889 8 yes
GO:0051348 negative regulation of transferase activity 8.1481 5 yes
GO:0052547 regulation of peptidase activity 8.1481 5 yes
GO:0052548 regulation of endopeptidase activity 8.1481 6 yes
GO:0001933 negative regulation of protein phosphorylation 8.1481 8 yes
GO:0002831 regulation of response to biotic stimulus 8.1481 4 yes
GO:0050770 regulation of axonogenesis 8.1481 5 yes
GO:0070848 response to growth factor 7.4074 4 yes
GO:0031349 positive regulation of defense response 7.4074 5 yes
GO:0071363 cellular response to growth factor stimulus 6.6667 5 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 6.6667 7 yes
GO:2001235 positive regulation of apoptotic signaling pathway 6.6667 6 yes
GO:0006469 negative regulation of protein kinase activity 6.6667 7 yes
GO:0007043 cell-cell junction assembly 6.6667 6 yes
GO:0010639 negative regulation of organelle organization 6.6667 6 yes
GO:0033673 negative regulation of kinase activity 6.6667 6 yes
GO:0045088 regulation of innate immune response 6.6667 5 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 6.6667 9 yes
GO:0051346 negative regulation of hydrolase activity 5.9259 5 yes
GO:0002758 innate immune response-activating signal transduction 5.9259 4 yes
GO:0002833 positive regulation of response to biotic stimulus 5.9259 5 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 5.9259 8 yes
GO:0045089 positive regulation of innate immune response 5.9259 6 yes
GO:0051492 regulation of stress fiber assembly 5.1852 6 yes
GO:0110020 regulation of actomyosin structure organization 5.1852 6 yes
GO:1990858 cellular response to lectin 5.1852 4 yes
GO:0002220 innate immune response activating cell surface receptor signaling pathway 5.1852 5 yes
GO:0002223 stimulatory C-type lectin receptor signaling pathway 5.1852 5 yes
GO:0018105 peptidyl-serine phosphorylation 5.1852 6 yes
GO:0018209 peptidyl-serine modification 5.1852 6 yes
GO:0032231 regulation of actin filament bundle assembly 5.1852 5 yes
GO:0034332 adherens junction organization 5.1852 6 yes
GO:0045861 negative regulation of proteolysis 4.4444 7 yes
GO:0071560 cellular response to transforming growth factor beta stimulus 3.7037 4 yes
GO:2000117 negative regulation of cysteine-type endopeptidase activity 3.7037 8 yes
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 3.7037 7 yes
GO:0010466 negative regulation of peptidase activity 3.7037 6 yes
GO:0010951 negative regulation of endopeptidase activity 3.7037 7 yes
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 3.7037 8 yes
GO:0048010 vascular endothelial growth factor receptor signaling pathway 3.7037 6 yes
GO:0051494 negative regulation of cytoskeleton organization 2.9630 7 yes
GO:1902414 protein localization to cell junction 2.9630 5 yes
GO:1902904 negative regulation of supramolecular fiber organization 2.9630 6 yes
GO:0034333 adherens junction assembly 2.9630 7 yes
GO:0150105 protein localization to cell-cell junction 2.2222 6 yes
GO:0051497 negative regulation of stress fiber assembly 1.4815 7 yes
GO:0070830 bicellular tight junction assembly 1.4815 8 yes
GO:0120192 tight junction assembly 1.4815 7 yes
GO:0120193 tight junction organization 1.4815 6 yes
GO:1900117 regulation of execution phase of apoptosis 1.4815 4 yes
GO:1900118 negative regulation of execution phase of apoptosis 1.4815 5 yes
GO:2001270 regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis 1.4815 9 yes
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis 1.4815 6 yes
GO:0003300 cardiac muscle hypertrophy 1.4815 6 yes
GO:0014896 muscle hypertrophy 1.4815 4 yes
GO:0014897 striated muscle hypertrophy 1.4815 5 yes
GO:0032232 negative regulation of actin filament bundle assembly 1.4815 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in PAK2_HUMAN
DOID:612 primary immunodeficiency disease 2.9630 3 no
DOID:3635 congenital myasthenic syndrome 2.2222 7 no
DOID:439 neuromuscular junction disease 2.2222 6 no
DOID:440 neuromuscular disease 2.2222 5 no
DOID:574 peripheral nervous system disease 2.2222 3 no
DOID:870 neuropathy 2.2222 4 no
DOID:0111962 combined immunodeficiency 2.2222 4 no
DOID:0050155 sensory system disease 1.4815 3 no
DOID:0050563 nonsyndromic deafness 1.4815 5 no
DOID:0050564 autosomal dominant nonsyndromic deafness 1.4815 6 no
DOID:2742 auditory system disease 1.4815 4 no
DOID:0060038 specific developmental disorder 1.4815 3 no
DOID:1059 intellectual disability 1.4815 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
CASP7_HUMAN [view interactions] Low throughput no no
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
LIMK1_HUMAN [view interactions] Low throughput no yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
ACK1_HUMAN [view interactions] Low throughput no yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYC_HUMAN [view interactions] Low throughput no yes
BIP_HUMAN [view entry] [view interactions] Low throughput yes yes
MK14_HUMAN [view interactions] Low throughput no yes
RAC2_HUMAN [view entry] [view interactions] Low throughput yes yes
ABI3_HUMAN [view entry] [view interactions] Low throughput yes no
DOCK2_HUMAN [view entry] [view interactions] Low throughput yes no
MLRV_HUMAN [view interactions] Low throughput no no
H4_HUMAN [view interactions] Low throughput no yes
MBP_HUMAN [view entry] [view interactions] Low throughput yes no
PPM1A_HUMAN [view interactions] Low throughput no yes
PML_HUMAN [view interactions] High throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
HCK_HUMAN [view entry] [view interactions] High throughput yes no
ARHG6_HUMAN [view interactions] High throughput no no
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
VINEX_HUMAN [view interactions] High throughput no no
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
SH3R3_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
KEAP1_HUMAN [view interactions] High throughput no yes
RIOK3_HUMAN [view interactions] High throughput no yes
RGAP1_HUMAN [view interactions] High throughput no no
ML12B_HUMAN [view interactions] High throughput no no
GIT2_HUMAN [view interactions] High throughput no yes
SKP1_HUMAN [view interactions] High throughput no yes
FBX28_HUMAN [view interactions] High throughput no yes
CARF_HUMAN [view interactions] High throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
ICAM1_HUMAN [view interactions] High throughput no no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
SOX2_HUMAN [view interactions] High throughput no yes
FSD1_HUMAN [view entry] [view interactions] High throughput yes no
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
PLK2_HUMAN [view interactions] High throughput no yes
UBP47_HUMAN [view interactions] High throughput no yes
LPXN_HUMAN [view interactions] High throughput no yes
O10H3_HUMAN [view interactions] High throughput no no
PAXI_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
LRP4_HUMAN [view entry] [view interactions] High throughput yes yes
RHOU_HUMAN [view interactions] High throughput no no
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
ECM1_HUMAN [view interactions] High throughput no no
DSRAD_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA5_HUMAN [view interactions] High throughput no no
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
SPD2A_HUMAN [view entry] [view interactions] High throughput yes yes
SH3R1_HUMAN [view interactions] High throughput no yes
GSTM3_HUMAN [view entry] [view interactions] High throughput yes yes
UB2V1_HUMAN [view entry] [view interactions] High throughput yes no
SEPT2_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
SODM_HUMAN [view entry] [view interactions] High throughput yes no
PSA1_HUMAN [view interactions] High throughput no yes
CSDE1_HUMAN [view interactions] High throughput no yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view interactions] High throughput no yes
2ABB_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
PSB7_HUMAN [view interactions] High throughput no yes
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
CPSF6_HUMAN [view interactions] High throughput no yes
IF4G1_HUMAN [view entry] [view interactions] High throughput yes yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA1_HUMAN [view interactions] High throughput no yes
MCM3_HUMAN [view interactions] High throughput no no
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
ECHM_HUMAN [view interactions] High throughput no yes
KAD2_HUMAN [view interactions] High throughput no no
NUDC_HUMAN [view interactions] High throughput no yes
PPAC_HUMAN [view entry] [view interactions] High throughput yes yes
GANAB_HUMAN [view interactions] High throughput no yes
PSD13_HUMAN [view interactions] High throughput no yes
EIF3I_HUMAN [view interactions] High throughput no yes
PSA2_HUMAN [view interactions] High throughput no yes
RL32_HUMAN [view entry] [view interactions] High throughput yes yes
AATM_HUMAN [view entry] [view interactions] High throughput yes yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view interactions] High throughput no yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
EP300_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
MKNK1_HUMAN [view interactions] High throughput no yes
CASP3_HUMAN [view interactions] High throughput no yes
SCLT1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TFE2_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
OCRL_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
TLR9_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
RGS4_HUMAN [view interactions] High throughput no no
TX1B3_HUMAN [view interactions] High throughput no no
SERF2_HUMAN [view interactions] High throughput no no
NHRF2_HUMAN [view entry] [view interactions] High throughput yes no
FA24B_HUMAN [view interactions] High throughput no no
PDK1_HUMAN [view interactions] High throughput no yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
SPXN4_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO1_HUMAN [view interactions] High throughput no yes
SETX_HUMAN [view interactions] High throughput no yes
BUD13_HUMAN [view interactions] High throughput no yes
MK04_HUMAN [view interactions] High throughput no no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX32_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
CSK_HUMAN [view interactions] High throughput no yes
SPRNG_HUMAN [view interactions] High throughput no yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
PSA_HUMAN [view entry] [view interactions] High throughput yes yes
CPNS1_HUMAN [view interactions] High throughput no yes
KCRB_HUMAN [view entry] [view interactions] High throughput yes no
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
ERP44_HUMAN [view interactions] High throughput no yes
ISOC1_HUMAN [view interactions] High throughput no no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
SCLY_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PUR4_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
TGM2_HUMAN [view interactions] High throughput no no
UB2R2_HUMAN [view interactions] High throughput no no
UBFD1_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ANCHR_HUMAN [view interactions] High throughput no yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
ILKAP_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
PLAP_HUMAN [view interactions] High throughput no yes
PSME1_HUMAN [view interactions] High throughput no yes
THOC3_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
OPTN_HUMAN [view interactions] High throughput no yes
MK11_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
LAMC2_HUMAN [view interactions] Computational no no
PSB1_HUMAN [view interactions] Computational no yes
MK13_HUMAN [view interactions] Computational no yes
PRS7_HUMAN [view interactions] Computational no yes
PSME3_HUMAN [view interactions] Computational no yes
LAMB2_HUMAN [view interactions] Computational no yes
KPCE_HUMAN [view entry] [view interactions] Computational yes yes
PSA6_HUMAN [view interactions] Computational no yes
MP2K1_HUMAN [view entry] [view interactions] Computational yes yes
PSB3_HUMAN [view interactions] Computational no yes
PAK5_HUMAN [view interactions] Computational no yes
ITA1_HUMAN [view interactions] Computational no yes
PSMD4_HUMAN [view interactions] Computational no yes
ML12A_HUMAN [view interactions] Computational no no
PAK3_HUMAN [view entry] [view interactions] Computational yes no
PSA4_HUMAN [view entry] [view interactions] Computational yes yes
MYLK_HUMAN [view interactions] Computational no no
ITB1_HUMAN [view entry] [view interactions] Computational yes no
PAR3_HUMAN [view interactions] Computational no no
PLAK_HUMAN [view entry] [view interactions] Computational yes yes
MYH9_HUMAN [view entry] [view interactions] Computational yes no
LAMB1_HUMAN [view interactions] Computational no yes
PSMD1_HUMAN [view entry] [view interactions] Computational yes yes
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
PSB8_HUMAN [view interactions] Computational no yes
MK12_HUMAN [view interactions] Computational no no
LAMB3_HUMAN [view interactions] Computational no yes
M3K1_HUMAN [view interactions] Computational no yes
PSB5_HUMAN [view interactions] Computational no yes
ROBO2_HUMAN [view interactions] Computational no yes
LAMA3_HUMAN [view interactions] Computational no no
PSMF1_HUMAN [view interactions] Computational no yes
PSA3_HUMAN [view interactions] Computational no no
PAR6A_HUMAN [view interactions] Computational no yes
CADH5_HUMAN [view interactions] Computational no yes
LAMC1_HUMAN [view interactions] Computational no yes
PSMD6_HUMAN [view interactions] Computational no yes
ACHA_HUMAN [view entry] [view interactions] Computational yes no
M3K4_HUMAN [view interactions] Computational no yes
PSD12_HUMAN [view interactions] Computational no yes
MUSK_HUMAN [view entry] [view interactions] Computational yes no
LAMA1_HUMAN [view interactions] Computational no no
UBB_HUMAN [view entry] [view interactions] Computational yes yes
RS27A_HUMAN [view entry] [view interactions] Computational yes yes
RL40_HUMAN [view entry] [view interactions] Computational yes yes
PSB10_HUMAN [view interactions] Computational no no
PRS6A_HUMAN [view entry] [view interactions] Computational yes yes
PSB6_HUMAN [view entry] [view interactions] Computational yes yes
LAMA2_HUMAN [view interactions] Computational no no
PSMD2_HUMAN [view entry] [view interactions] Computational yes yes
MYH11_HUMAN [view entry] [view interactions] Computational yes no
PAK4_HUMAN [view interactions] Computational no yes
STAT4_HUMAN [view interactions] Computational no yes
CTND1_HUMAN [view entry] [view interactions] Computational yes no
M3K2_HUMAN [view interactions] Computational no yes
PSB4_HUMAN [view interactions] Computational no yes
PRS10_HUMAN [view interactions] Computational no yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
PSD10_HUMAN [view entry] [view interactions] Computational yes yes
MYL6_HUMAN [view entry] [view interactions] Computational yes no
PSMA8_HUMAN [view interactions] Computational no no
CTNA1_HUMAN [view entry] [view interactions] Computational yes yes
MYL9_HUMAN [view interactions] Computational no no
GBG12_HUMAN [view entry] [view interactions] Computational yes yes
ACTS_HUMAN [view interactions] Computational no no
DVL1_HUMAN [view entry] [view interactions] Computational yes yes
LAMA5_HUMAN [view entry] [view interactions] Computational yes no
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
PSD11_HUMAN [view entry] [view interactions] Computational yes yes
PSB2_HUMAN [view interactions] Computational no yes
DAG1_HUMAN [view entry] [view interactions] Computational yes no
UTRN_HUMAN [view entry] [view interactions] Computational yes yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
ROBO1_HUMAN [view interactions] Computational no yes
MAX_HUMAN [view interactions] Computational no yes
PSMD8_HUMAN [view interactions] Computational no yes
PSMD5_HUMAN [view interactions] Computational no yes
PSME4_HUMAN [view interactions] Computational no yes
PRS4_HUMAN [view entry] [view interactions] Computational yes yes
PSMD7_HUMAN [view interactions] Computational no yes
VGFR2_HUMAN [view interactions] Computational no no
PSA7_HUMAN [view interactions] Computational no yes
RAPSN_HUMAN [view entry] [view interactions] Computational yes no
PRS8_HUMAN [view interactions] Computational no yes
MK06_HUMAN [view interactions] Computational no yes
M3K12_HUMAN [view entry] [view interactions] Computational yes yes
PSDE_HUMAN [view entry] [view interactions] Computational yes yes
LAMC3_HUMAN [view interactions] Computational no no
PSB11_HUMAN [view interactions] Computational no no
M3K3_HUMAN [view interactions] Computational no no
PSB9_HUMAN [view interactions] Computational no no
PRS6B_HUMAN [view interactions] Computational no yes
PSA5_HUMAN [view interactions] Computational no yes
PSMD3_HUMAN [view interactions] Computational no yes
PSME2_HUMAN [view interactions] Computational no no
RASN_HUMAN [view entry] [view interactions] Computational yes no
RHG10_HUMAN [view interactions] Computational no no
PSMD9_HUMAN [view interactions] Computational no yes