Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at Tyr-717 (PubMed). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on Tyr-153 and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity . [View more on UniProt]

Protein features

Binary interactions with known binding regions

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Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
226 Tyr Cys Congenitalheartdefectsandskeletalmalformationssyndrome(CHDSKM) -
337 Ala Thr Congenitalheartdefectsandskeletalmalformationssyndrome(CHDSKM) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI002955 LIG_ANK_PxLPxL_1 LIG 15 22 -
ELMI002955 LIG_ANK_PxLPxL_1 LIG 15 22 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ABL1_HUMAN
GO:0019900 kinase binding 27.4074 4 yes
GO:0043168 anion binding 27.4074 4 yes
GO:0000166 nucleotide binding 26.6667 4 yes
GO:0017076 purine nucleotide binding 26.6667 5 yes
GO:0043169 cation binding 26.6667 4 yes
GO:0046872 metal ion binding 26.6667 5 yes
GO:0019901 protein kinase binding 25.1852 5 yes
GO:0032555 purine ribonucleotide binding 25.1852 4 yes
GO:0003723 RNA binding 25.1852 4 no
GO:0030554 adenyl nucleotide binding 23.7037 6 yes
GO:0035639 purine ribonucleoside triphosphate binding 23.7037 4 yes
GO:0032559 adenyl ribonucleotide binding 22.2222 5 yes
GO:0045296 cadherin binding 21.4815 4 no
GO:0005524 ATP binding 20.7407 5 yes
GO:0017124 SH3 domain binding 17.0370 4 yes
GO:0016301 kinase activity 15.5556 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 15.5556 4 yes
GO:0003779 actin binding 14.0741 4 yes
GO:0045309 protein phosphorylated amino acid binding 11.1111 4 yes
GO:0046914 transition metal ion binding 10.3704 6 yes
GO:0003677 DNA binding 9.6296 4 yes
GO:0004713 protein tyrosine kinase activity 8.8889 4 yes
GO:0001784 phosphotyrosine residue binding 7.4074 5 yes
GO:0003690 double-stranded DNA binding 7.4074 5 yes
GO:0043565 sequence-specific DNA binding 6.6667 5 yes
GO:0046875 ephrin receptor binding 6.6667 4 yes
GO:1990837 sequence-specific double-stranded DNA binding 5.9259 6 yes
GO:0000287 magnesium ion binding 5.1852 6 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 5.1852 5 yes
GO:0005080 protein kinase C binding 3.7037 6 yes
GO:0042169 SH2 domain binding 2.9630 4 yes
GO:0000217 DNA secondary structure binding 2.2222 5 yes
GO:0003785 actin monomer binding 2.2222 5 yes
GO:0016779 nucleotidyltransferase activity 2.2222 4 yes
GO:0019905 syntaxin binding 2.2222 4 yes
GO:0030145 manganese ion binding 2.2222 7 yes
GO:0000400 four-way junction DNA binding 1.4815 6 yes
GO:0000405 bubble DNA binding 1.4815 6 yes
GO:0004515 nicotinate-nucleotide adenylyltransferase activity 1.4815 6 yes
GO:0038191 neuropilin binding 1.4815 4 yes
GO:0051019 mitogen-activated protein kinase binding 1.4815 6 yes
GO:0070566 adenylyltransferase activity 1.4815 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ABL1_HUMAN
GO:0048522 positive regulation of cellular process 65.1852 4 yes
GO:0048523 negative regulation of cellular process 57.7778 4 yes
GO:0060255 regulation of macromolecule metabolic process 53.3333 4 yes
GO:0031323 regulation of cellular metabolic process 52.5926 4 yes
GO:0010646 regulation of cell communication 51.1111 4 yes
GO:0080090 regulation of primary metabolic process 51.1111 4 yes
GO:0051128 regulation of cellular component organization 51.1111 4 yes
GO:0009966 regulation of signal transduction 46.6667 4 yes
GO:0009889 regulation of biosynthetic process 42.9630 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.9630 5 yes
GO:0031326 regulation of cellular biosynthetic process 42.9630 5 yes
GO:0006996 organelle organization 41.4815 4 yes
GO:0009893 positive regulation of metabolic process 40.0000 4 yes
GO:0010468 regulation of gene expression 39.2593 6 yes
GO:0048584 positive regulation of response to stimulus 39.2593 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 38.5185 5 yes
GO:0009892 negative regulation of metabolic process 37.7778 4 yes
GO:0008104 protein localization 36.2963 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 36.2963 5 yes
GO:0022607 cellular component assembly 36.2963 4 yes
GO:0031325 positive regulation of cellular metabolic process 36.2963 5 yes
GO:0051049 regulation of transport 36.2963 4 yes
GO:0051246 regulation of protein metabolic process 35.5556 5 yes
GO:1902531 regulation of intracellular signal transduction 35.5556 5 yes
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 yes
GO:0023056 positive regulation of signaling 32.5926 4 yes
GO:0010647 positive regulation of cell communication 31.8519 5 yes
GO:0051130 positive regulation of cellular component organization 31.1111 5 yes
GO:0036211 protein modification process 30.3704 4 yes
GO:0042981 regulation of apoptotic process 30.3704 5 yes
GO:0043067 regulation of programmed cell death 30.3704 4 yes
GO:0043412 macromolecule modification 30.3704 4 yes
GO:0009967 positive regulation of signal transduction 29.6296 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.8889 5 yes
GO:0060341 regulation of cellular localization 28.8889 4 no
GO:0080134 regulation of response to stress 28.1481 4 yes
GO:0032880 regulation of protein localization 28.1481 5 no
GO:0009891 positive regulation of biosynthetic process 27.4074 5 yes
GO:0071310 cellular response to organic substance 27.4074 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 27.4074 6 yes
GO:0048585 negative regulation of response to stimulus 27.4074 4 yes
GO:0030030 cell projection organization 26.6667 4 yes
GO:0006796 phosphate-containing compound metabolic process 26.6667 4 yes
GO:0051247 positive regulation of protein metabolic process 25.9259 6 yes
GO:0051252 regulation of RNA metabolic process 25.9259 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 25.9259 6 yes
GO:0010648 negative regulation of cell communication 25.9259 5 yes
GO:0023057 negative regulation of signaling 25.9259 4 yes
GO:0031399 regulation of protein modification process 25.9259 6 yes
GO:0051240 positive regulation of multicellular organismal process 25.9259 4 yes
GO:0019220 regulation of phosphate metabolic process 25.1852 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.1852 6 yes
GO:0031344 regulation of cell projection organization 25.1852 5 yes
GO:0044087 regulation of cellular component biogenesis 25.1852 4 yes
GO:0051174 regulation of phosphorus metabolic process 25.1852 5 yes
GO:0009968 negative regulation of signal transduction 24.4444 5 yes
GO:0042127 regulation of cell population proliferation 24.4444 4 yes
GO:2001141 regulation of RNA biosynthetic process 24.4444 6 yes
GO:0006355 regulation of DNA-templated transcription 24.4444 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 23.7037 4 yes
GO:1902533 positive regulation of intracellular signal transduction 23.7037 6 yes
GO:0043066 negative regulation of apoptotic process 23.7037 6 yes
GO:0043069 negative regulation of programmed cell death 23.7037 5 yes
GO:0051248 negative regulation of protein metabolic process 22.9630 6 yes
GO:0033043 regulation of organelle organization 22.9630 5 yes
GO:0042325 regulation of phosphorylation 22.9630 7 yes
GO:0009890 negative regulation of biosynthetic process 22.9630 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.9630 6 no
GO:0031327 negative regulation of cellular biosynthetic process 22.9630 6 no
GO:0007010 cytoskeleton organization 21.4815 5 yes
GO:0120036 plasma membrane bounded cell projection organization 21.4815 5 yes
GO:1901701 cellular response to oxygen-containing compound 21.4815 4 yes
GO:0051129 negative regulation of cellular component organization 21.4815 5 no
GO:0071702 organic substance transport 21.4815 4 no
GO:0001932 regulation of protein phosphorylation 21.4815 7 yes
GO:0050776 regulation of immune response 21.4815 4 yes
GO:0002684 positive regulation of immune system process 21.4815 4 yes
GO:0051094 positive regulation of developmental process 21.4815 4 yes
GO:0009894 regulation of catabolic process 20.7407 4 yes
GO:0010243 response to organonitrogen compound 20.7407 4 yes
GO:0141124 intracellular signaling cassette 20.7407 4 yes
GO:0043933 protein-containing complex organization 20.7407 4 yes
GO:0098657 import into cell 20.7407 4 no
GO:0071705 nitrogen compound transport 20.7407 4 no
GO:0051050 positive regulation of transport 20.7407 4 yes
GO:0010975 regulation of neuron projection development 20.0000 7 yes
GO:0045595 regulation of cell differentiation 20.0000 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 19.2593 4 yes
GO:0010628 positive regulation of gene expression 19.2593 7 yes
GO:0043085 positive regulation of catalytic activity 19.2593 4 yes
GO:0065003 protein-containing complex assembly 18.5185 5 yes
GO:0016310 phosphorylation 18.5185 5 yes
GO:0099177 regulation of trans-synaptic signaling 18.5185 4 yes
GO:0031401 positive regulation of protein modification process 18.5185 7 yes
GO:2000026 regulation of multicellular organismal development 18.5185 4 yes
GO:0050804 modulation of chemical synaptic transmission 18.5185 5 yes
GO:0006468 protein phosphorylation 18.5185 5 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 17.7778 5 yes
GO:0008284 positive regulation of cell population proliferation 17.7778 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 17.7778 6 yes
GO:0030334 regulation of cell migration 17.7778 5 yes
GO:0090304 nucleic acid metabolic process 17.7778 4 yes
GO:1902903 regulation of supramolecular fiber organization 17.7778 5 yes
GO:0042327 positive regulation of phosphorylation 17.7778 8 yes
GO:2000145 regulation of cell motility 17.7778 4 yes
GO:0045937 positive regulation of phosphate metabolic process 17.7778 7 yes
GO:0051336 regulation of hydrolase activity 17.0370 4 yes
GO:0043408 regulation of MAPK cascade 17.0370 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 17.0370 5 yes
GO:0051493 regulation of cytoskeleton organization 16.2963 6 yes
GO:0030155 regulation of cell adhesion 16.2963 4 yes
GO:0034762 regulation of transmembrane transport 16.2963 4 yes
GO:0044089 positive regulation of cellular component biogenesis 16.2963 5 yes
GO:0001934 positive regulation of protein phosphorylation 16.2963 8 yes
GO:0051338 regulation of transferase activity 15.5556 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 15.5556 6 yes
GO:0010638 positive regulation of organelle organization 15.5556 6 yes
GO:0071363 cellular response to growth factor stimulus 15.5556 4 yes
GO:0018193 peptidyl-amino acid modification 15.5556 5 yes
GO:0071417 cellular response to organonitrogen compound 15.5556 4 yes
GO:0031346 positive regulation of cell projection organization 15.5556 6 yes
GO:0031400 negative regulation of protein modification process 15.5556 7 yes
GO:1901699 cellular response to nitrogen compound 15.5556 4 yes
GO:0033365 protein localization to organelle 15.5556 5 yes
GO:0043254 regulation of protein-containing complex assembly 15.5556 5 yes
GO:0043549 regulation of kinase activity 15.5556 5 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 15.5556 5 yes
GO:0045936 negative regulation of phosphate metabolic process 15.5556 7 yes
GO:0050778 positive regulation of immune response 15.5556 5 yes
GO:0050865 regulation of cell activation 15.5556 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 15.5556 8 yes
GO:0006915 apoptotic process 15.5556 4 yes
GO:0097435 supramolecular fiber organization 14.8148 4 yes
GO:1902532 negative regulation of intracellular signal transduction 14.8148 6 yes
GO:0032970 regulation of actin filament-based process 14.8148 4 yes
GO:0060284 regulation of cell development 14.0741 5 yes
GO:0060627 regulation of vesicle-mediated transport 14.0741 4 yes
GO:0030335 positive regulation of cell migration 14.0741 6 yes
GO:0032956 regulation of actin cytoskeleton organization 14.0741 5 yes
GO:0040017 positive regulation of locomotion 14.0741 4 yes
GO:2000147 positive regulation of cell motility 14.0741 5 yes
GO:0045859 regulation of protein kinase activity 14.0741 6 yes
GO:0050807 regulation of synapse organization 14.0741 5 yes
GO:0002694 regulation of leukocyte activation 14.0741 4 yes
GO:0051249 regulation of lymphocyte activation 13.3333 5 yes
GO:0051254 positive regulation of RNA metabolic process 13.3333 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 13.3333 7 yes
GO:0042326 negative regulation of phosphorylation 13.3333 8 yes
GO:0043068 positive regulation of programmed cell death 13.3333 5 yes
GO:0045893 positive regulation of DNA-templated transcription 13.3333 8 yes
GO:0006974 DNA damage response 12.5926 4 yes
GO:0051726 regulation of cell cycle 12.5926 4 yes
GO:0080135 regulation of cellular response to stress 12.5926 4 yes
GO:0030100 regulation of endocytosis 12.5926 5 yes
GO:0110053 regulation of actin filament organization 12.5926 6 yes
GO:0033993 response to lipid 12.5926 4 yes
GO:0043065 positive regulation of apoptotic process 12.5926 6 yes
GO:0043269 regulation of monoatomic ion transport 12.5926 5 yes
GO:0044057 regulation of system process 12.5926 4 yes
GO:0014070 response to organic cyclic compound 11.8519 4 yes
GO:0022407 regulation of cell-cell adhesion 11.8519 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 11.8519 6 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 11.8519 5 yes
GO:0043086 negative regulation of catalytic activity 11.8519 4 yes
GO:0045785 positive regulation of cell adhesion 11.8519 5 yes
GO:0001558 regulation of cell growth 11.8519 4 yes
GO:0001933 negative regulation of protein phosphorylation 11.8519 8 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 11.8519 8 yes
GO:0051056 regulation of small GTPase mediated signal transduction 11.8519 6 yes
GO:0051347 positive regulation of transferase activity 11.1111 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 11.1111 7 yes
GO:0033674 positive regulation of kinase activity 11.1111 6 yes
GO:0043410 positive regulation of MAPK cascade 11.1111 7 yes
GO:0050863 regulation of T cell activation 11.1111 6 yes
GO:0050867 positive regulation of cell activation 11.1111 5 yes
GO:0051251 positive regulation of lymphocyte activation 10.3704 6 yes
GO:0051348 negative regulation of transferase activity 10.3704 5 yes
GO:0051495 positive regulation of cytoskeleton organization 10.3704 7 yes
GO:0062197 cellular response to chemical stress 10.3704 4 yes
GO:0010959 regulation of metal ion transport 10.3704 6 yes
GO:0031329 regulation of cellular catabolic process 10.3704 5 yes
GO:0032271 regulation of protein polymerization 10.3704 6 yes
GO:0045860 positive regulation of protein kinase activity 10.3704 7 yes
GO:0001817 regulation of cytokine production 10.3704 4 yes
GO:0001819 positive regulation of cytokine production 10.3704 5 yes
GO:0048638 regulation of developmental growth 10.3704 4 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 10.3704 4 yes
GO:0002696 positive regulation of leukocyte activation 10.3704 5 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 10.3704 4 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 9.6296 6 yes
GO:0033673 negative regulation of kinase activity 9.6296 6 yes
GO:0034599 cellular response to oxidative stress 9.6296 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 9.6296 6 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 9.6296 9 yes
GO:0007015 actin filament organization 8.8889 5 yes
GO:0007162 negative regulation of cell adhesion 8.8889 5 yes
GO:0071407 cellular response to organic cyclic compound 8.8889 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 8.8889 9 yes
GO:0050773 regulation of dendrite development 8.8889 4 yes
GO:0050890 cognition 8.8889 4 yes
GO:0006259 DNA metabolic process 8.8889 5 yes
GO:0010506 regulation of autophagy 8.1481 6 yes
GO:0010976 positive regulation of neuron projection development 8.1481 7 yes
GO:0018108 peptidyl-tyrosine phosphorylation 8.1481 6 yes
GO:0018212 peptidyl-tyrosine modification 8.1481 6 yes
GO:0022409 positive regulation of cell-cell adhesion 8.1481 6 yes
GO:0030031 cell projection assembly 8.1481 5 yes
GO:0090287 regulation of cellular response to growth factor stimulus 8.1481 4 yes
GO:0031396 regulation of protein ubiquitination 8.1481 9 yes
GO:1901873 regulation of post-translational protein modification 8.1481 7 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 8.1481 7 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 8.1481 8 yes
GO:0034764 positive regulation of transmembrane transport 8.1481 5 yes
GO:0038127 ERBB signaling pathway 8.1481 6 yes
GO:0046777 protein autophosphorylation 8.1481 6 yes
GO:0000302 response to reactive oxygen species 8.1481 4 yes
GO:0050870 positive regulation of T cell activation 8.1481 7 yes
GO:0051052 regulation of DNA metabolic process 8.1481 5 yes
GO:0006469 negative regulation of protein kinase activity 8.1481 7 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 7.4074 8 yes
GO:0071396 cellular response to lipid 7.4074 5 yes
GO:0120031 plasma membrane bounded cell projection assembly 7.4074 6 yes
GO:1902105 regulation of leukocyte differentiation 7.4074 5 yes
GO:1903706 regulation of hemopoiesis 7.4074 4 yes
GO:0042542 response to hydrogen peroxide 7.4074 4 yes
GO:0050851 antigen receptor-mediated signaling pathway 7.4074 5 yes
GO:0007173 epidermal growth factor receptor signaling pathway 6.6667 7 yes
GO:0007346 regulation of mitotic cell cycle 6.6667 5 yes
GO:0051924 regulation of calcium ion transport 6.6667 7 yes
GO:0071675 regulation of mononuclear cell migration 6.6667 5 yes
GO:0030111 regulation of Wnt signaling pathway 6.6667 5 yes
GO:1901342 regulation of vasculature development 6.6667 5 yes
GO:0032231 regulation of actin filament bundle assembly 6.6667 5 yes
GO:0032496 response to lipopolysaccharide 6.6667 4 yes
GO:0038093 Fc receptor signaling pathway 6.6667 5 yes
GO:0042110 T cell activation 6.6667 4 yes
GO:0043523 regulation of neuron apoptotic process 6.6667 6 yes
GO:0002237 response to molecule of bacterial origin 6.6667 4 yes
GO:0002685 regulation of leukocyte migration 6.6667 4 yes
GO:0051276 chromosome organization 5.9259 5 yes
GO:0007612 learning 5.9259 4 yes
GO:0051346 negative regulation of hydrolase activity 5.9259 5 yes
GO:0010632 regulation of epithelial cell migration 5.9259 4 yes
GO:0010810 regulation of cell-substrate adhesion 5.9259 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 5.9259 7 yes
GO:0030182 neuron differentiation 5.9259 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 5.9259 7 yes
GO:0034614 cellular response to reactive oxygen species 5.9259 5 yes
GO:1903522 regulation of blood circulation 5.9259 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 5.9259 6 yes
GO:0043122 regulation of canonical NF-kappaB signal transduction 5.9259 6 yes
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 5.9259 7 yes
GO:0043270 positive regulation of monoatomic ion transport 5.9259 5 yes
GO:0043393 regulation of protein binding 5.9259 4 yes
GO:0045765 regulation of angiogenesis 5.9259 5 yes
GO:0045786 negative regulation of cell cycle 5.9259 5 yes
GO:0000165 MAPK cascade 5.9259 5 yes
GO:0050852 T cell receptor signaling pathway 5.9259 6 yes
GO:0051099 positive regulation of binding 5.9259 4 yes
GO:0007229 integrin-mediated signaling pathway 5.1852 4 yes
GO:0008154 actin polymerization or depolymerization 5.1852 6 yes
GO:0010001 glial cell differentiation 5.1852 4 yes
GO:0051881 regulation of mitochondrial membrane potential 5.1852 4 yes
GO:0061387 regulation of extent of cell growth 5.1852 5 yes
GO:0070301 cellular response to hydrogen peroxide 5.1852 5 yes
GO:0022408 negative regulation of cell-cell adhesion 5.1852 6 yes
GO:0097193 intrinsic apoptotic signaling pathway 5.1852 4 yes
GO:0030516 regulation of axon extension 5.1852 5 yes
GO:0030855 epithelial cell differentiation 5.1852 4 yes
GO:1901888 regulation of cell junction assembly 5.1852 5 yes
GO:0032886 regulation of microtubule-based process 5.1852 4 yes
GO:0032943 mononuclear cell proliferation 5.1852 4 yes
GO:1903131 mononuclear cell differentiation 5.1852 5 yes
GO:0035023 regulation of Rho protein signal transduction 5.1852 7 yes
GO:0042113 B cell activation 5.1852 4 yes
GO:0042770 signal transduction in response to DNA damage 5.1852 4 yes
GO:2000401 regulation of lymphocyte migration 5.1852 6 yes
GO:2000404 regulation of T cell migration 5.1852 7 yes
GO:0043409 negative regulation of MAPK cascade 5.1852 7 yes
GO:0045787 positive regulation of cell cycle 5.1852 5 yes
GO:0046651 lymphocyte proliferation 5.1852 4 yes
GO:0001667 ameboidal-type cell migration 5.1852 4 yes
GO:0002521 leukocyte differentiation 5.1852 4 yes
GO:0050905 neuromuscular process 5.1852 4 yes
GO:0003018 vascular process in circulatory system 5.1852 4 yes
GO:0006281 DNA repair 5.1852 5 yes
GO:0051258 protein polymerization 4.4444 6 yes
GO:0051282 regulation of sequestering of calcium ion 4.4444 4 yes
GO:0051341 regulation of oxidoreductase activity 4.4444 4 yes
GO:0051402 neuron apoptotic process 4.4444 5 yes
GO:0051492 regulation of stress fiber assembly 4.4444 6 yes
GO:0051899 membrane depolarization 4.4444 4 yes
GO:0010634 positive regulation of epithelial cell migration 4.4444 5 yes
GO:0010811 positive regulation of cell-substrate adhesion 4.4444 6 yes
GO:0071219 cellular response to molecule of bacterial origin 4.4444 4 yes
GO:0071222 cellular response to lipopolysaccharide 4.4444 5 yes
GO:0071559 response to transforming growth factor beta 4.4444 4 yes
GO:0071560 cellular response to transforming growth factor beta stimulus 4.4444 5 yes
GO:0071677 positive regulation of mononuclear cell migration 4.4444 6 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 4.4444 5 yes
GO:0110020 regulation of actomyosin structure organization 4.4444 6 yes
GO:1900271 regulation of long-term synaptic potentiation 4.4444 4 yes
GO:1904064 positive regulation of cation transmembrane transport 4.4444 7 yes
GO:0038094 Fc-gamma receptor signaling pathway 4.4444 6 yes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 4.4444 4 yes
GO:2000779 regulation of double-strand break repair 4.4444 6 yes
GO:0045619 regulation of lymphocyte differentiation 4.4444 6 yes
GO:0045931 positive regulation of mitotic cell cycle 4.4444 6 yes
GO:0002431 Fc receptor mediated stimulatory signaling pathway 4.4444 5 yes
GO:0002687 positive regulation of leukocyte migration 4.4444 5 yes
GO:0006282 regulation of DNA repair 4.4444 5 yes
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway 3.7037 5 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 3.7037 5 yes
GO:0007249 canonical NF-kappaB signal transduction 3.7037 5 yes
GO:0051353 positive regulation of oxidoreductase activity 3.7037 5 yes
GO:0051928 positive regulation of calcium ion transport 3.7037 6 yes
GO:0010631 epithelial cell migration 3.7037 5 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 3.7037 8 yes
GO:0070507 regulation of microtubule cytoskeleton organization 3.7037 5 yes
GO:0030098 lymphocyte differentiation 3.7037 4 yes
GO:0090288 negative regulation of cellular response to growth factor stimulus 3.7037 5 yes
GO:0097746 blood vessel diameter maintenance 3.7037 5 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 3.7037 6 yes
GO:0031113 regulation of microtubule polymerization 3.7037 6 yes
GO:0141091 transforming growth factor beta receptor superfamily signaling pathway 3.7037 6 yes
GO:1900024 regulation of substrate adhesion-dependent cell spreading 3.7037 6 yes
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 3.7037 7 yes
GO:0032092 positive regulation of protein binding 3.7037 5 yes
GO:1901532 regulation of hematopoietic progenitor cell differentiation 3.7037 5 yes
GO:0032147 activation of protein kinase activity 3.7037 8 yes
GO:0032233 positive regulation of actin filament bundle assembly 3.7037 6 yes
GO:1901874 negative regulation of post-translational protein modification 3.7037 8 yes
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 3.7037 9 yes
GO:1904018 positive regulation of vasculature development 3.7037 5 yes
GO:0034976 response to endoplasmic reticulum stress 3.7037 4 yes
GO:0035150 regulation of tube size 3.7037 4 yes
GO:0035296 regulation of tube diameter 3.7037 5 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 3.7037 7 yes
GO:0042098 T cell proliferation 3.7037 5 yes
GO:2000403 positive regulation of lymphocyte migration 3.7037 7 yes
GO:2000406 positive regulation of T cell migration 3.7037 8 yes
GO:0045580 regulation of T cell differentiation 3.7037 7 yes
GO:0045766 positive regulation of angiogenesis 3.7037 6 yes
GO:0045930 negative regulation of mitotic cell cycle 3.7037 6 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 3.7037 6 yes
GO:0048732 gland development 3.7037 4 yes
GO:0050885 neuromuscular process controlling balance 3.7037 5 yes
GO:0051053 negative regulation of DNA metabolic process 3.7037 6 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2.9630 6 yes
GO:0008306 associative learning 2.9630 5 yes
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 2.9630 5 yes
GO:0051496 positive regulation of stress fiber assembly 2.9630 7 yes
GO:0010517 regulation of phospholipase activity 2.9630 6 yes
GO:0010569 regulation of double-strand break repair via homologous recombination 2.9630 7 yes
GO:0060191 regulation of lipase activity 2.9630 5 yes
GO:0010594 regulation of endothelial cell migration 2.9630 5 yes
GO:0060688 regulation of morphogenesis of a branching structure 2.9630 4 yes
GO:0014855 striated muscle cell proliferation 2.9630 4 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 2.9630 8 yes
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2.9630 6 yes
GO:0030183 B cell differentiation 2.9630 5 yes
GO:0030217 T cell differentiation 2.9630 5 yes
GO:0031397 negative regulation of protein ubiquitination 2.9630 10 yes
GO:1900272 negative regulation of long-term synaptic potentiation 2.9630 4 yes
GO:0032649 regulation of type II interferon production 2.9630 5 yes
GO:0032663 regulation of interleukin-2 production 2.9630 5 yes
GO:0032729 positive regulation of type II interferon production 2.9630 6 yes
GO:0032743 positive regulation of interleukin-2 production 2.9630 6 yes
GO:0033077 T cell differentiation in thymus 2.9630 6 yes
GO:0034446 substrate adhesion-dependent cell spreading 2.9630 4 yes
GO:0042100 B cell proliferation 2.9630 5 yes
GO:2000736 regulation of stem cell differentiation 2.9630 5 yes
GO:0043525 positive regulation of neuron apoptotic process 2.9630 7 yes
GO:0043535 regulation of blood vessel endothelial cell migration 2.9630 6 yes
GO:0043542 endothelial cell migration 2.9630 6 yes
GO:0000018 regulation of DNA recombination 2.9630 6 yes
GO:0048534 hematopoietic or lymphoid organ development 2.9630 4 yes
GO:0048538 thymus development 2.9630 5 yes
GO:0048708 astrocyte differentiation 2.9630 5 yes
GO:0001952 regulation of cell-matrix adhesion 2.9630 6 yes
GO:0002065 columnar/cuboidal epithelial cell differentiation 2.9630 5 yes
GO:0050853 B cell receptor signaling pathway 2.9630 6 yes
GO:0051438 regulation of ubiquitin-protein transferase activity 2.2222 5 yes
GO:0051444 negative regulation of ubiquitin-protein transferase activity 2.2222 6 yes
GO:0051893 regulation of focal adhesion assembly 2.2222 7 yes
GO:0060020 Bergmann glial cell differentiation 2.2222 6 yes
GO:0060038 cardiac muscle cell proliferation 2.2222 5 yes
GO:0010595 positive regulation of endothelial cell migration 2.2222 6 yes
GO:0060563 neuroepithelial cell differentiation 2.2222 6 yes
GO:0060606 tube closure 2.2222 4 yes
GO:0070371 ERK1 and ERK2 cascade 2.2222 6 yes
GO:0019229 regulation of vasoconstriction 2.2222 6 yes
GO:0071867 response to monoamine 2.2222 5 yes
GO:0071868 cellular response to monoamine stimulus 2.2222 5 yes
GO:0071869 response to catecholamine 2.2222 4 yes
GO:0071870 cellular response to catecholamine stimulus 2.2222 5 yes
GO:0030041 actin filament polymerization 2.2222 7 yes
GO:0090049 regulation of cell migration involved in sprouting angiogenesis 2.2222 7 yes
GO:0030177 positive regulation of Wnt signaling pathway 2.2222 6 yes
GO:0090109 regulation of cell-substrate junction assembly 2.2222 6 yes
GO:0030509 BMP signaling pathway 2.2222 7 yes
GO:0030510 regulation of BMP signaling pathway 2.2222 5 yes
GO:0030514 negative regulation of BMP signaling pathway 2.2222 6 yes
GO:0150116 regulation of cell-substrate junction organization 2.2222 5 yes
GO:1900006 positive regulation of dendrite development 2.2222 5 yes
GO:1900274 regulation of phospholipase C activity 2.2222 7 yes
GO:1901890 positive regulation of cell junction assembly 2.2222 6 yes
GO:1902036 regulation of hematopoietic stem cell differentiation 2.2222 6 yes
GO:0032878 regulation of establishment or maintenance of cell polarity 2.2222 4 yes
GO:1903053 regulation of extracellular matrix organization 2.2222 5 yes
GO:1903350 response to dopamine 2.2222 5 yes
GO:1903351 cellular response to dopamine 2.2222 6 yes
GO:1903903 regulation of establishment of T cell polarity 2.2222 6 yes
GO:1903905 positive regulation of establishment of T cell polarity 2.2222 7 yes
GO:1904035 regulation of epithelial cell apoptotic process 2.2222 6 yes
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 2.2222 7 yes
GO:1905244 regulation of modification of synaptic structure 2.2222 6 yes
GO:1905330 regulation of morphogenesis of an epithelium 2.2222 5 yes
GO:1905332 positive regulation of morphogenesis of an epithelium 2.2222 5 yes
GO:2000114 regulation of establishment of cell polarity 2.2222 5 yes
GO:2000351 regulation of endothelial cell apoptotic process 2.2222 7 yes
GO:0043536 positive regulation of blood vessel endothelial cell migration 2.2222 7 yes
GO:0046631 alpha-beta T cell activation 2.2222 5 yes
GO:0048145 regulation of fibroblast proliferation 2.2222 5 yes
GO:0001782 B cell homeostasis 2.2222 4 yes
GO:0001843 neural tube closure 2.2222 5 yes
GO:0001954 positive regulation of cell-matrix adhesion 2.2222 7 yes
GO:0002285 lymphocyte activation involved in immune response 2.2222 4 yes
GO:0002312 B cell activation involved in immune response 2.2222 5 yes
GO:0050798 activated T cell proliferation 2.2222 6 yes
GO:0002327 immature B cell differentiation 2.2222 6 yes
GO:0051882 mitochondrial depolarization 1.4815 5 yes
GO:0051894 positive regulation of focal adhesion assembly 1.4815 7 yes
GO:0010519 negative regulation of phospholipase activity 1.4815 7 yes
GO:0060192 negative regulation of lipase activity 1.4815 6 yes
GO:0071103 DNA conformation change 1.4815 6 yes
GO:0072698 protein localization to microtubule cytoskeleton 1.4815 7 yes
GO:0030035 microspike assembly 1.4815 7 yes
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 1.4815 8 yes
GO:0150117 positive regulation of cell-substrate junction organization 1.4815 6 yes
GO:1900275 negative regulation of phospholipase C activity 1.4815 8 yes
GO:0032489 regulation of Cdc42 protein signal transduction 1.4815 8 yes
GO:1903055 positive regulation of extracellular matrix organization 1.4815 6 yes
GO:0033688 regulation of osteoblast proliferation 1.4815 5 yes
GO:1903210 podocyte apoptotic process 1.4815 6 yes
GO:0033690 positive regulation of osteoblast proliferation 1.4815 6 yes
GO:1904019 epithelial cell apoptotic process 1.4815 5 yes
GO:1904036 negative regulation of epithelial cell apoptotic process 1.4815 7 yes
GO:0035372 protein localization to microtubule 1.4815 8 yes
GO:1904157 DN4 thymocyte differentiation 1.4815 7 yes
GO:0038083 peptidyl-tyrosine autophosphorylation 1.4815 7 yes
GO:1904518 protein localization to cytoplasmic microtubule plus-end 1.4815 10 yes
GO:1904526 regulation of microtubule binding 1.4815 5 yes
GO:1904528 positive regulation of microtubule binding 1.4815 6 yes
GO:1904529 regulation of actin filament binding 1.4815 6 yes
GO:1904531 positive regulation of actin filament binding 1.4815 7 yes
GO:0038189 neuropilin signaling pathway 1.4815 4 yes
GO:1904616 regulation of actin binding 1.4815 5 yes
GO:1904618 positive regulation of actin binding 1.4815 6 yes
GO:1904825 protein localization to microtubule plus-end 1.4815 10 yes
GO:1905553 regulation of blood vessel branching 1.4815 5 yes
GO:1905555 positive regulation of blood vessel branching 1.4815 6 yes
GO:1905725 protein localization to microtubule end 1.4815 9 yes
GO:1905755 protein localization to cytoplasmic microtubule 1.4815 9 yes
GO:1990051 activation of protein kinase C activity 1.4815 9 yes
GO:2000042 negative regulation of double-strand break repair via homologous recombination 1.4815 7 yes
GO:2000050 regulation of non-canonical Wnt signaling pathway 1.4815 6 yes
GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1.4815 7 yes
GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 1.4815 7 yes
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway 1.4815 8 yes
GO:2000352 negative regulation of endothelial cell apoptotic process 1.4815 8 yes
GO:0043124 negative regulation of canonical NF-kappaB signal transduction 1.4815 7 yes
GO:2000772 regulation of cellular senescence 1.4815 5 yes
GO:2000773 negative regulation of cellular senescence 1.4815 6 yes
GO:2000780 negative regulation of double-strand break repair 1.4815 6 yes
GO:0044380 protein localization to cytoskeleton 1.4815 6 yes
GO:0045738 negative regulation of DNA repair 1.4815 5 yes
GO:0045907 positive regulation of vasoconstriction 1.4815 5 yes
GO:0045910 negative regulation of DNA recombination 1.4815 7 yes
GO:0046632 alpha-beta T cell differentiation 1.4815 6 yes
GO:0048146 positive regulation of fibroblast proliferation 1.4815 6 yes
GO:0048536 spleen development 1.4815 5 yes
GO:0001922 B-1 B cell homeostasis 1.4815 5 yes
GO:0002322 B cell proliferation involved in immune response 1.4815 6 yes
GO:0002332 transitional stage B cell differentiation 1.4815 7 yes
GO:0002333 transitional one stage B cell differentiation 1.4815 8 yes
GO:0006298 mismatch repair 1.4815 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
XRCC6_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
WASF1_HUMAN [view entry] [view interactions] Low throughput yes yes
APBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
HCK_HUMAN [view entry] [view interactions] Low throughput yes no
DOK2_HUMAN [view interactions] Low throughput no no
DEN2B_HUMAN [view interactions] Low throughput no yes
P73_HUMAN [view interactions] Low throughput no no
RAD51_HUMAN [view interactions] Low throughput no yes
SHB_HUMAN [view interactions] Low throughput no yes
ADA15_HUMAN [view interactions] Low throughput no yes
ITB2_HUMAN [view interactions] Low throughput no no
TLN2_HUMAN [view entry] [view interactions] Low throughput yes yes
VAV_HUMAN [view interactions] Low throughput no no
TOP1_HUMAN [view interactions] Low throughput no yes
ERCC6_HUMAN [view interactions] Low throughput no no
EP300_HUMAN [view interactions] Low throughput no yes
MUC1_HUMAN [view interactions] Low throughput no no
3BP2_HUMAN [view interactions] Low throughput no yes
3BP1_HUMAN [view interactions] Low throughput no no
BGIN_HUMAN [view interactions] Low throughput no no
STA5B_HUMAN [view interactions] Low throughput no yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
B2CL1_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
PAXI_HUMAN [view interactions] Low throughput no yes
CBL_HUMAN [view interactions] Low throughput no yes
CDN1B_HUMAN [view interactions] Low throughput no yes
CCNA2_HUMAN [view interactions] Low throughput no no
CDK2_HUMAN [view interactions] Low throughput no yes
STA5A_HUMAN [view interactions] Low throughput no no
ABL2_HUMAN [view entry] [view interactions] Low throughput yes yes
MED25_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
MSH4_HUMAN [view interactions] Low throughput no no
BCAR1_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
SPR2A_HUMAN [view interactions] Low throughput no no
CAV1_HUMAN [view interactions] Low throughput no no
PRDX1_HUMAN [view entry] [view interactions] Low throughput yes yes
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
BRCA1_HUMAN [view interactions] Low throughput no yes
NCK1_HUMAN [view interactions] Low throughput no yes
PTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRBS1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] Low throughput yes no
KAT5_HUMAN [view interactions] Low throughput no yes
CRKL_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK1_HUMAN [view interactions] Low throughput no yes
ZDH16_HUMAN [view interactions] Low throughput no no
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
RIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
RYBP_HUMAN [view interactions] Low throughput no no
PHAG1_HUMAN [view interactions] Low throughput no yes
SHD_HUMAN [view interactions] Low throughput no no
SHE_HUMAN [view interactions] Low throughput no yes
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
DDB1_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
M4K1_HUMAN [view interactions] Low throughput no no
GPX1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN6_HUMAN [view interactions] Low throughput no no
RB_HUMAN [view interactions] Low throughput no yes
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
CREB1_HUMAN [view interactions] Low throughput no yes
YTDC1_HUMAN [view interactions] Low throughput no yes
CATA_HUMAN [view entry] [view interactions] Low throughput yes no
GRAP2_HUMAN [view interactions] Low throughput no no
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHIP2_HUMAN [view interactions] Low throughput no yes
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
ZAP70_HUMAN [view interactions] Low throughput no no
RFX1_HUMAN [view interactions] Low throughput no yes
RAD9A_HUMAN [view interactions] Low throughput no yes
TERF1_HUMAN [view interactions] Low throughput no no
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTA1_HUMAN [view interactions] Low throughput no no
CASL_HUMAN [view interactions] Low throughput no yes
CABL2_HUMAN [view interactions] Low throughput no no
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
RAN_HUMAN [view entry] [view interactions] Low throughput yes no
NCOA3_HUMAN [view interactions] Low throughput no yes
TOPB1_HUMAN [view interactions] Low throughput no yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
IKBA_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
STK4_HUMAN [view interactions] Low throughput no yes
ATR_HUMAN [view entry] [view interactions] Low throughput yes no
BAG1_HUMAN [view interactions] Low throughput no yes
HSP7C_HUMAN [view entry] [view interactions] Low throughput yes yes
PCNA_HUMAN [view interactions] Low throughput no no
PSA7_HUMAN [view interactions] Low throughput no yes
PSA4_HUMAN [view entry] [view interactions] Low throughput yes yes
ASGL1_HUMAN [view interactions] Low throughput no yes
CEP43_HUMAN [view interactions] Low throughput no no
JUN_HUMAN [view interactions] Low throughput no yes
CISH_HUMAN [view interactions] Low throughput no yes
GAB3_HUMAN [view interactions] Low throughput no yes
SHIP1_HUMAN [view interactions] Low throughput no no
MDM4_HUMAN [view interactions] Low throughput no yes
DOK3_HUMAN [view interactions] Low throughput no no
SOCS3_HUMAN [view interactions] Low throughput no yes
SOCS1_HUMAN [view interactions] Low throughput no yes
RASA1_HUMAN [view interactions] Low throughput no yes
TEBP_HUMAN [view interactions] Low throughput no yes
CH60_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP7_HUMAN [view interactions] Low throughput no yes
LATS2_HUMAN [view interactions] Low throughput no yes
CASP9_HUMAN [view interactions] Low throughput no yes
YAP1_HUMAN [view interactions] Low throughput no yes
FOS_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP4_HUMAN [view interactions] Low throughput no yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
PPARG_HUMAN [view interactions] Low throughput no yes
RPGF1_HUMAN [view interactions] Low throughput no yes
HIPK2_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
ERRFI_HUMAN [view interactions] Low throughput no no
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
TMPS2_HUMAN [view interactions] Low throughput no no
JAK1_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
SL9A2_HUMAN [view interactions] Low throughput no no
PRKDC_HUMAN [view entry] [view interactions] Low throughput yes yes
EVL_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB10_HUMAN [view entry] [view interactions] Low throughput yes yes
MICA1_HUMAN [view interactions] Low throughput no yes
EPHA3_HUMAN [view interactions] Low throughput no yes
ENAH_HUMAN [view entry] [view interactions] Low throughput yes yes
FMN1_HUMAN [view interactions] Low throughput no no
CCND2_HUMAN [view interactions] Low throughput no yes
ACTS_HUMAN [view interactions] Low throughput no no
TUB_HUMAN [view interactions] Low throughput no yes
WRIP1_HUMAN [view interactions] Low throughput no yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
HUWE1_HUMAN [view interactions] Low throughput no yes
GRAB_HUMAN [view interactions] Low throughput no no
CDK1_HUMAN [view interactions] Low throughput no no
MBP_HUMAN [view entry] [view interactions] Low throughput yes no
CDN1A_HUMAN [view interactions] Low throughput no no
EMD_HUMAN [view interactions] Low throughput no yes
LAP2A_HUMAN [view interactions] Low throughput no yes
PGFRB_HUMAN [view interactions] Low throughput no yes
RA51B_HUMAN [view interactions] Low throughput no yes
SRCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
HERC1_HUMAN [view interactions] Low throughput no no
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
T2FA_HUMAN [view interactions] Low throughput no yes
XPO1_HUMAN [view entry] [view interactions] Low throughput yes yes
PSMD4_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
FINC_HUMAN [view interactions] Low throughput no yes
ABI1_HUMAN [view entry] [view interactions] Low throughput yes yes
PPIP1_HUMAN [view interactions] Low throughput no no
MSH5_HUMAN [view interactions] Low throughput no no
CDON_HUMAN [view interactions] Low throughput no no
EPHA4_HUMAN [view entry] [view interactions] Low throughput yes yes
ATM_HUMAN [view interactions] Low throughput no yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
DOK1_HUMAN [view interactions] Low throughput no yes
VINEX_HUMAN [view interactions] Low throughput no no
ABI2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAVS_HUMAN [view interactions] Low throughput no yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
TCP4_HUMAN [view interactions] High throughput no yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
APC5_HUMAN [view interactions] High throughput no yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
TZAP_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
CUL4B_HUMAN [view interactions] High throughput no yes
KHDR1_HUMAN [view interactions] High throughput no yes
LRRK1_HUMAN [view interactions] High throughput no yes
FNBP1_HUMAN [view interactions] High throughput no yes
CIP4_HUMAN [view interactions] High throughput no no
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
PRP4B_HUMAN [view interactions] High throughput no yes
TYRO3_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
APC15_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CE57L_HUMAN [view interactions] High throughput no yes
CEP76_HUMAN [view interactions] High throughput no yes
CTDS2_HUMAN [view interactions] High throughput no yes
NOL4_HUMAN [view interactions] High throughput no no
NOTC1_HUMAN [view entry] [view interactions] High throughput yes yes
TCL1A_HUMAN [view interactions] High throughput no no
TRM2B_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB3_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
FLT3_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
KIT_HUMAN [view interactions] High throughput no no
SF01_HUMAN [view interactions] High throughput no yes
PACN1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
FOSL1_HUMAN [view interactions] High throughput no yes
HNRL1_HUMAN [view interactions] High throughput no yes
EP15R_HUMAN [view entry] [view interactions] High throughput yes yes
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
PRIC3_HUMAN [view interactions] High throughput no yes
TRI39_HUMAN [view interactions] High throughput no no
NFS1_HUMAN [view interactions] High throughput no yes
RPP38_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
CXA8_HUMAN [view interactions] High throughput no no
HNRPR_HUMAN [view interactions] High throughput no yes
PAR3_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
HCN2_HUMAN [view entry] [view interactions] High throughput yes no
CNTP1_HUMAN [view entry] [view interactions] High throughput yes yes
ASB16_HUMAN [view interactions] High throughput no no
SOS2_HUMAN [view interactions] High throughput no yes
NFASC_HUMAN [view entry] [view interactions] High throughput yes yes
SELN_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
DNSL2_HUMAN [view interactions] High throughput no no
PKD1_HUMAN [view interactions] High throughput no yes
CSMD2_HUMAN [view entry] [view interactions] High throughput yes no
NKX21_HUMAN [view interactions] High throughput no no
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
SREC2_HUMAN [view interactions] High throughput no yes
TF3A_HUMAN [view interactions] High throughput no yes
HXC8_HUMAN [view interactions] High throughput no no
DDX41_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B4_HUMAN [view interactions] High throughput no yes
ABR_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP6_HUMAN [view interactions] High throughput no no
GNS_HUMAN [view interactions] High throughput no yes
BAZ2A_HUMAN [view interactions] High throughput no no
PAX3_HUMAN [view interactions] High throughput no no
NOTC3_HUMAN [view interactions] High throughput no yes
ORC1_HUMAN [view interactions] High throughput no yes
HEXA_HUMAN [view interactions] High throughput no yes
CHRD_HUMAN [view interactions] High throughput no no
KMT2B_HUMAN [view interactions] High throughput no no
BRCA2_HUMAN [view interactions] High throughput no no
FOXF2_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
GABR1_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK3_HUMAN [view entry] [view interactions] High throughput yes yes
DPOD1_HUMAN [view interactions] High throughput no yes
CELR3_HUMAN [view entry] [view interactions] High throughput yes no
MAAI_HUMAN [view interactions] High throughput no yes
CP4F2_HUMAN [view interactions] High throughput no no
SUV92_HUMAN [view interactions] High throughput no no
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
P85B_HUMAN [view interactions] High throughput no yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP5_HUMAN [view interactions] High throughput no no
UBS3B_HUMAN [view interactions] High throughput no yes
PDIA2_HUMAN [view interactions] High throughput no no
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP3_HUMAN [view entry] [view interactions] High throughput yes yes
BMP2K_HUMAN [view interactions] High throughput no yes
SNX8_HUMAN [view interactions] High throughput no yes
REPS1_HUMAN [view interactions] High throughput no yes
EPS15_HUMAN [view entry] [view interactions] High throughput yes yes
STON2_HUMAN [view interactions] High throughput no yes
VP13A_HUMAN [view interactions] High throughput no yes
CBLB_HUMAN [view entry] [view interactions] High throughput yes yes
SNX12_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX17_HUMAN [view interactions] High throughput no yes
GRIP2_HUMAN [view entry] [view interactions] High throughput yes no
CDC27_HUMAN [view interactions] High throughput no yes
BMP8B_HUMAN [view interactions] High throughput no no
S22A3_HUMAN [view interactions] High throughput no yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
CNTFR_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
LRBA_HUMAN [view interactions] High throughput no yes
RGS20_HUMAN [view interactions] High throughput no no
DLX4_HUMAN [view interactions] High throughput no no
MIA2_HUMAN [view interactions] High throughput no yes
ICAL_HUMAN [view interactions] High throughput no yes
DUS15_HUMAN [view interactions] High throughput no no
F110A_HUMAN [view interactions] High throughput no yes
WNK2_HUMAN [view interactions] High throughput no yes
RL37_HUMAN [view entry] [view interactions] High throughput yes no
FETUA_HUMAN [view interactions] High throughput no no
CD2AP_HUMAN [view interactions] High throughput no no
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
CXX1_HUMAN [view interactions] High throughput no no
EFS_HUMAN [view interactions] High throughput no no
BACE2_HUMAN [view interactions] High throughput no yes
NXPH3_HUMAN [view interactions] High throughput no no
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARHGB_HUMAN [view interactions] High throughput no yes
LRP2_HUMAN [view interactions] High throughput no no
SP1_HUMAN [view interactions] High throughput no yes
TF3C4_HUMAN [view interactions] High throughput no no
OSBL5_HUMAN [view interactions] High throughput no yes
BST2_HUMAN [view interactions] High throughput no yes
NEK8_HUMAN [view interactions] High throughput no yes
SCAI_HUMAN [view entry] [view interactions] High throughput yes yes
MED14_HUMAN [view interactions] High throughput no no
BCAR3_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SPRE_HUMAN [view interactions] High throughput no yes
PRAX_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
DKKL1_HUMAN [view interactions] High throughput no no
KIFC2_HUMAN [view interactions] High throughput no yes
KS6B1_HUMAN [view entry] [view interactions] High throughput yes yes
AIRE_HUMAN [view interactions] High throughput no no
SYNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
NPVF_HUMAN [view interactions] High throughput no no
GASR_HUMAN [view interactions] High throughput no no
ACAP1_HUMAN [view interactions] High throughput no yes
RHG17_HUMAN [view interactions] High throughput no no
NELFB_HUMAN [view interactions] High throughput no yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
TM74B_HUMAN [view interactions] High throughput no yes
CO6_HUMAN [view interactions] High throughput no yes
FYB1_HUMAN [view interactions] High throughput no no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
P2RX7_HUMAN [view interactions] High throughput no yes
MEPE_HUMAN [view interactions] High throughput no no
LTBP2_HUMAN [view interactions] High throughput no no
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
GT2D1_HUMAN [view interactions] High throughput no yes
NED4L_HUMAN [view entry] [view interactions] High throughput yes yes
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
DNLI3_HUMAN [view interactions] High throughput no yes
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP2_HUMAN [view entry] [view interactions] High throughput yes no
TSKS_HUMAN [view interactions] High throughput no no
GSX2_HUMAN [view interactions] High throughput no no
BRPF3_HUMAN [view interactions] High throughput no yes
VPREB_HUMAN [view interactions] High throughput no no
FBX7_HUMAN [view interactions] High throughput no yes
TULP4_HUMAN [view interactions] High throughput no yes
HCN4_HUMAN [view interactions] High throughput no yes
NCKX1_HUMAN [view interactions] High throughput no no
SEM7A_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
UHMK1_HUMAN [view interactions] High throughput no no
ANRA2_HUMAN [view interactions] High throughput no no
APOL5_HUMAN [view interactions] High throughput no no
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
PHAR4_HUMAN [view interactions] High throughput no yes
PTN4_HUMAN [view interactions] High throughput no no
EFNA5_HUMAN [view interactions] High throughput no yes
PFD4_HUMAN [view interactions] High throughput no yes
PCDA7_HUMAN [view interactions] High throughput no no
RTF2_HUMAN [view interactions] High throughput no yes
DCE1_HUMAN [view entry] [view interactions] High throughput yes yes
SYLC_HUMAN [view interactions] High throughput no yes
MIME_HUMAN [view interactions] High throughput no no
NAA25_HUMAN [view interactions] High throughput no yes
SYNC_HUMAN [view interactions] High throughput no yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
PAK4_HUMAN [view interactions] High throughput no yes
PPM1B_HUMAN [view interactions] High throughput no yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
CH10_HUMAN [view interactions] High throughput no yes
RLA1_HUMAN [view entry] [view interactions] High throughput yes no
EIF2A_HUMAN [view interactions] High throughput no yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
RS21_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
DRG1_HUMAN [view interactions] High throughput no yes