Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at Tyr-717 (PubMed). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on Tyr-153 and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
226 Tyr Cys Congenitalheartdefectsandskeletalmalformationssyndrome(CHDSKM) -
337 Ala Thr Congenitalheartdefectsandskeletalmalformationssyndrome(CHDSKM) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI002955 LIG_ANK_PxLPxL_1 LIG 15 22 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ABL1_HUMAN
GO:0017076 purine nucleotide binding 30.7692 4 yes
GO:0032555 purine ribonucleotide binding 30.7692 4 yes
GO:0019900 kinase binding 30.0699 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 29.3706 4 yes
GO:0019901 protein kinase binding 27.9720 5 yes
GO:0030554 adenyl nucleotide binding 25.1748 5 yes
GO:0032559 adenyl ribonucleotide binding 25.1748 5 yes
GO:0005524 ATP binding 23.7762 5 yes
GO:0003723 RNA binding 23.7762 4 no
GO:0046872 metal ion binding 21.6783 4 yes
GO:0045296 cadherin binding 20.9790 4 no
GO:0016301 kinase activity 19.5804 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 19.5804 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 18.8811 4 yes
GO:0003779 actin binding 16.0839 4 yes
GO:0017124 SH3 domain binding 16.0839 4 yes
GO:0004713 protein tyrosine kinase activity 13.2867 4 yes
GO:0045309 protein phosphorylated amino acid binding 9.7902 4 yes
GO:0003677 DNA binding 8.3916 4 yes
GO:0046875 ephrin receptor binding 8.3916 4 yes
GO:0001784 phosphotyrosine residue binding 7.6923 5 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 6.9930 5 yes
GO:0046914 transition metal ion binding 6.9930 5 yes
GO:0003690 double-stranded DNA binding 6.2937 5 yes
GO:0043565 sequence-specific DNA binding 5.5944 5 yes
GO:1990837 sequence-specific double-stranded DNA binding 4.8951 6 yes
GO:0000287 magnesium ion binding 4.1958 5 yes
GO:0005080 protein kinase C binding 3.4965 6 yes
GO:0042169 SH2 domain binding 3.4965 4 yes
GO:0000217 DNA secondary structure binding 2.0979 5 yes
GO:0003785 actin monomer binding 2.0979 5 yes
GO:0019905 syntaxin binding 2.0979 4 yes
GO:0030145 manganese ion binding 2.0979 6 yes
GO:0000400 four-way junction DNA binding 1.3986 6 yes
GO:0000405 bubble DNA binding 1.3986 6 yes
GO:0004515 nicotinate-nucleotide adenylyltransferase activity 1.3986 6 yes
GO:0016779 nucleotidyltransferase activity 1.3986 4 yes
GO:0038191 neuropilin binding 1.3986 4 yes
GO:0051019 mitogen-activated protein kinase binding 1.3986 6 yes
GO:0070566 adenylyltransferase activity 1.3986 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ABL1_HUMAN
GO:0048522 positive regulation of cellular process 69.9301 4 yes
GO:0048523 negative regulation of cellular process 57.3427 4 yes
GO:0010646 regulation of cell communication 56.6434 4 yes
GO:0060255 regulation of macromolecule metabolic process 55.9441 4 yes
GO:0051128 regulation of cellular component organization 54.5455 4 yes
GO:0080090 regulation of primary metabolic process 53.8462 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 53.1469 4 yes
GO:0009966 regulation of signal transduction 52.4476 4 yes
GO:0031323 regulation of cellular metabolic process 51.7483 4 yes
GO:0010468 regulation of gene expression 42.6573 5 yes
GO:0048584 positive regulation of response to stimulus 41.2587 4 yes
GO:0009893 positive regulation of metabolic process 41.2587 4 yes
GO:0051246 regulation of protein metabolic process 40.5594 5 yes
GO:0006996 organelle organization 40.5594 4 yes
GO:0022607 cellular component assembly 40.5594 4 yes
GO:0051049 regulation of transport 39.8601 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 39.1608 5 yes
GO:0071310 cellular response to organic substance 39.1608 4 yes
GO:1902531 regulation of intracellular signal transduction 37.7622 5 yes
GO:0051130 positive regulation of cellular component organization 36.3636 5 yes
GO:0031325 positive regulation of cellular metabolic process 35.6643 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 34.9650 5 yes
GO:0009892 negative regulation of metabolic process 34.9650 4 yes
GO:0010647 positive regulation of cell communication 34.9650 5 yes
GO:0023056 positive regulation of signaling 34.9650 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 33.5664 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 33.5664 4 yes
GO:0008104 protein localization 32.8671 4 yes
GO:0009967 positive regulation of signal transduction 32.8671 5 yes
GO:0030030 cell projection organization 32.8671 4 yes
GO:0010941 regulation of cell death 32.1678 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 32.1678 6 yes
GO:0031344 regulation of cell projection organization 32.1678 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 31.4685 5 yes
GO:0051174 regulation of phosphorus metabolic process 31.4685 5 yes
GO:0009889 regulation of biosynthetic process 31.4685 4 yes
GO:0019220 regulation of phosphate metabolic process 31.4685 6 yes
GO:0036211 protein modification process 30.7692 4 yes
GO:0043412 macromolecule modification 30.7692 4 yes
GO:0044087 regulation of cellular component biogenesis 30.7692 4 yes
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 yes
GO:0031399 regulation of protein modification process 30.7692 6 yes
GO:0033043 regulation of organelle organization 30.7692 5 yes
GO:0045595 regulation of cell differentiation 30.0699 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 30.0699 5 yes
GO:0031324 negative regulation of cellular metabolic process 30.0699 5 yes
GO:0042325 regulation of phosphorylation 29.3706 7 yes
GO:0042981 regulation of apoptotic process 29.3706 6 yes
GO:0043067 regulation of programmed cell death 29.3706 5 yes
GO:0043085 positive regulation of catalytic activity 28.6713 4 yes
GO:0006796 phosphate-containing compound metabolic process 28.6713 4 yes
GO:0051247 positive regulation of protein metabolic process 28.6713 6 yes
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 yes
GO:0032880 regulation of protein localization 26.5734 5 no
GO:0001932 regulation of protein phosphorylation 26.5734 7 yes
GO:0051094 positive regulation of developmental process 26.5734 4 yes
GO:0016192 vesicle-mediated transport 26.5734 4 yes
GO:0120036 plasma membrane bounded cell projection organization 26.5734 5 yes
GO:1901701 cellular response to oxygen-containing compound 26.5734 4 yes
GO:2000026 regulation of multicellular organismal development 25.1748 4 yes
GO:0051252 regulation of RNA metabolic process 25.1748 5 yes
GO:1902533 positive regulation of intracellular signal transduction 25.1748 6 yes
GO:0042127 regulation of cell population proliferation 24.4755 4 yes
GO:0042327 positive regulation of phosphorylation 24.4755 8 yes
GO:0045937 positive regulation of phosphate metabolic process 24.4755 7 yes
GO:0048585 negative regulation of response to stimulus 24.4755 4 yes
GO:0051050 positive regulation of transport 24.4755 4 yes
GO:0051240 positive regulation of multicellular organismal process 24.4755 4 yes
GO:0010243 response to organonitrogen compound 24.4755 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 24.4755 6 yes
GO:0080134 regulation of response to stress 24.4755 4 yes
GO:0051248 negative regulation of protein metabolic process 23.7762 6 yes
GO:0007010 cytoskeleton organization 23.7762 5 yes
GO:0051336 regulation of hydrolase activity 23.7762 4 yes
GO:0060548 negative regulation of cell death 23.7762 5 yes
GO:0010975 regulation of neuron projection development 23.7762 7 yes
GO:1903506 regulation of nucleic acid-templated transcription 23.0769 7 yes
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 yes
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0071702 organic substance transport 23.0769 4 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0006355 regulation of DNA-templated transcription 23.0769 6 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 23.0769 4 yes
GO:0051338 regulation of transferase activity 23.0769 4 yes
GO:0051493 regulation of cytoskeleton organization 23.0769 6 yes
GO:0031401 positive regulation of protein modification process 23.0769 7 yes
GO:0071705 nitrogen compound transport 22.3776 4 no
GO:0010648 negative regulation of cell communication 22.3776 5 yes
GO:0023057 negative regulation of signaling 22.3776 4 yes
GO:0043549 regulation of kinase activity 21.6783 5 yes
GO:0050804 modulation of chemical synaptic transmission 21.6783 5 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 21.6783 5 yes
GO:0060284 regulation of cell development 21.6783 5 yes
GO:0016310 phosphorylation 21.6783 5 yes
GO:0099177 regulation of trans-synaptic signaling 21.6783 4 yes
GO:1902903 regulation of supramolecular fiber organization 21.6783 5 yes
GO:0032970 regulation of actin filament-based process 21.6783 4 yes
GO:0044089 positive regulation of cellular component biogenesis 20.9790 5 yes
GO:0050776 regulation of immune response 20.9790 4 yes
GO:0001934 positive regulation of protein phosphorylation 20.9790 8 yes
GO:0006468 protein phosphorylation 20.9790 5 yes
GO:0031346 positive regulation of cell projection organization 20.9790 6 yes
GO:0032956 regulation of actin cytoskeleton organization 20.9790 5 yes
GO:0043066 negative regulation of apoptotic process 20.2797 7 yes
GO:2000145 regulation of cell motility 20.2797 4 yes
GO:0043069 negative regulation of programmed cell death 20.2797 6 yes
GO:0043933 protein-containing complex organization 20.2797 4 yes
GO:0045597 positive regulation of cell differentiation 20.2797 5 yes
GO:0030155 regulation of cell adhesion 20.2797 4 yes
GO:0009968 negative regulation of signal transduction 19.5804 5 yes
GO:0065003 protein-containing complex assembly 19.5804 5 yes
GO:0010638 positive regulation of organelle organization 19.5804 6 yes
GO:0043254 regulation of protein-containing complex assembly 18.8811 5 yes
GO:0002684 positive regulation of immune system process 18.8811 4 yes
GO:0051347 positive regulation of transferase activity 18.8811 5 yes
GO:0010628 positive regulation of gene expression 18.8811 6 yes
GO:0071417 cellular response to organonitrogen compound 18.8811 4 yes
GO:0022604 regulation of cell morphogenesis 18.8811 5 yes
GO:0097435 supramolecular fiber organization 18.8811 4 yes
GO:0030334 regulation of cell migration 18.8811 5 yes
GO:1901699 cellular response to nitrogen compound 18.8811 4 yes
GO:0043408 regulation of MAPK cascade 18.1818 6 yes
GO:0006897 endocytosis 18.1818 5 yes
GO:0008284 positive regulation of cell population proliferation 18.1818 5 yes
GO:0033674 positive regulation of kinase activity 17.4825 6 yes
GO:0034762 regulation of transmembrane transport 17.4825 4 yes
GO:0045859 regulation of protein kinase activity 17.4825 6 yes
GO:0009894 regulation of catabolic process 17.4825 4 yes
GO:0070848 response to growth factor 17.4825 4 yes
GO:0071363 cellular response to growth factor stimulus 17.4825 5 yes
GO:0010942 positive regulation of cell death 17.4825 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 16.7832 6 yes
GO:0050807 regulation of synapse organization 16.7832 5 yes
GO:0060627 regulation of vesicle-mediated transport 16.7832 4 yes
GO:0018193 peptidyl-amino acid modification 16.7832 5 yes
GO:0110053 regulation of actin filament organization 16.7832 6 yes
GO:0031400 negative regulation of protein modification process 16.7832 7 yes
GO:0043269 regulation of ion transport 16.0839 5 yes
GO:0045936 negative regulation of phosphate metabolic process 16.0839 7 yes
GO:0009891 positive regulation of biosynthetic process 16.0839 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 16.0839 6 yes
GO:0010720 positive regulation of cell development 16.0839 6 yes
GO:0014070 response to organic cyclic compound 16.0839 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 16.0839 6 yes
GO:0043065 positive regulation of apoptotic process 15.3846 7 yes
GO:0043068 positive regulation of programmed cell death 15.3846 6 yes
GO:0045785 positive regulation of cell adhesion 15.3846 5 yes
GO:0050865 regulation of cell activation 15.3846 4 yes
GO:0040017 positive regulation of locomotion 14.6853 4 yes
GO:2000147 positive regulation of cell motility 14.6853 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 14.6853 8 yes
GO:0007015 actin filament organization 14.6853 5 yes
GO:0051495 positive regulation of cytoskeleton organization 14.6853 7 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 14.6853 6 yes
GO:0030335 positive regulation of cell migration 14.6853 6 yes
GO:1902905 positive regulation of supramolecular fiber organization 14.6853 6 yes
GO:0034765 regulation of ion transmembrane transport 13.9860 5 yes
GO:0001558 regulation of cell growth 13.9860 4 yes
GO:0002694 regulation of leukocyte activation 13.9860 4 yes
GO:0080135 regulation of cellular response to stress 13.9860 4 yes
GO:0033993 response to lipid 13.2867 4 yes
GO:1904062 regulation of cation transmembrane transport 13.2867 6 yes
GO:0042326 negative regulation of phosphorylation 13.2867 8 yes
GO:0050778 positive regulation of immune response 13.2867 5 yes
GO:0051254 positive regulation of RNA metabolic process 13.2867 6 yes
GO:1901214 regulation of neuron death 13.2867 5 yes
GO:0043086 negative regulation of catalytic activity 12.5874 4 yes
GO:0044057 regulation of system process 12.5874 4 yes
GO:0045860 positive regulation of protein kinase activity 12.5874 7 yes
GO:0006915 apoptotic process 12.5874 4 yes
GO:0051249 regulation of lymphocyte activation 12.5874 5 yes
GO:0051726 regulation of cell cycle 12.5874 4 yes
GO:0090304 nucleic acid metabolic process 12.5874 4 yes
GO:0031329 regulation of cellular catabolic process 12.5874 5 yes
GO:0032271 regulation of protein polymerization 12.5874 6 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 11.8881 8 yes
GO:0043410 positive regulation of MAPK cascade 11.8881 7 yes
GO:0045893 positive regulation of DNA-templated transcription 11.8881 7 yes
GO:0001817 regulation of cytokine production 11.8881 4 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 11.8881 9 yes
GO:0001933 negative regulation of protein phosphorylation 11.8881 8 yes
GO:0051056 regulation of small GTPase mediated signal transduction 11.8881 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 11.8881 7 yes
GO:0071407 cellular response to organic cyclic compound 11.8881 5 yes
GO:0030031 cell projection assembly 11.8881 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 11.8881 7 yes
GO:0043523 regulation of neuron apoptotic process 11.1888 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 11.1888 7 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 11.1888 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 11.1888 7 yes
GO:0010976 positive regulation of neuron projection development 11.1888 7 yes
GO:0030100 regulation of endocytosis 11.1888 5 yes
GO:0046777 protein autophosphorylation 10.4895 6 yes
GO:0048638 regulation of developmental growth 10.4895 4 yes
GO:0050863 regulation of T cell activation 10.4895 6 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 10.4895 4 yes
GO:0010959 regulation of metal ion transport 10.4895 6 yes
GO:0022407 regulation of cell-cell adhesion 10.4895 5 yes
GO:0043393 regulation of protein binding 9.7902 4 yes
GO:0050773 regulation of dendrite development 9.7902 4 yes
GO:0050890 cognition 9.7902 4 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 9.7902 4 yes
GO:0051348 negative regulation of transferase activity 9.7902 5 yes
GO:0018108 peptidyl-tyrosine phosphorylation 9.7902 6 yes
GO:0018212 peptidyl-tyrosine modification 9.7902 6 yes
GO:1902532 negative regulation of intracellular signal transduction 9.7902 6 yes
GO:0033673 negative regulation of kinase activity 9.0909 6 yes
GO:0046578 regulation of Ras protein signal transduction 9.0909 7 yes
GO:0001819 positive regulation of cytokine production 9.0909 5 yes
GO:0010810 regulation of cell-substrate adhesion 9.0909 5 yes
GO:0071396 cellular response to lipid 9.0909 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 9.0909 7 yes
GO:0120031 plasma membrane bounded cell projection assembly 9.0909 6 yes
GO:0034764 positive regulation of transmembrane transport 8.3916 5 yes
GO:0051099 positive regulation of binding 8.3916 4 yes
GO:1901216 positive regulation of neuron death 8.3916 6 yes
GO:0032231 regulation of actin filament bundle assembly 8.3916 5 yes
GO:0043270 positive regulation of ion transport 7.6923 5 yes
GO:0006259 DNA metabolic process 7.6923 4 yes
GO:0006469 negative regulation of protein kinase activity 7.6923 7 yes
GO:0006974 cellular response to DNA damage stimulus 7.6923 4 yes
GO:0007162 negative regulation of cell adhesion 7.6923 5 yes
GO:0010506 regulation of autophagy 7.6923 6 yes
GO:0010811 positive regulation of cell-substrate adhesion 7.6923 6 yes
GO:1901888 regulation of cell junction assembly 7.6923 5 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 6.9930 7 yes
GO:0034599 cellular response to oxidative stress 6.9930 4 yes
GO:0034767 positive regulation of ion transmembrane transport 6.9930 6 yes
GO:1903706 regulation of hemopoiesis 6.9930 4 yes
GO:0038093 Fc receptor signaling pathway 6.9930 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 6.9930 8 yes
GO:0000302 response to reactive oxygen species 6.9930 4 yes
GO:0001667 ameboidal-type cell migration 6.9930 4 yes
GO:0048872 homeostasis of number of cells 6.9930 4 yes
GO:0051346 negative regulation of hydrolase activity 6.9930 5 yes
GO:0007612 learning 6.9930 4 yes
GO:0051924 regulation of calcium ion transport 6.9930 7 yes
GO:0061387 regulation of extent of cell growth 6.9930 5 yes
GO:0062197 cellular response to chemical stress 6.9930 4 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 6.9930 8 yes
GO:0090287 regulation of cellular response to growth factor stimulus 6.9930 4 yes
GO:0030111 regulation of Wnt signaling pathway 6.9930 5 yes
GO:1900024 regulation of substrate adhesion-dependent cell spreading 6.9930 6 yes
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 6.9930 7 yes
GO:1901342 regulation of vasculature development 6.9930 5 yes
GO:1902105 regulation of leukocyte differentiation 6.9930 5 yes
GO:1903169 regulation of calcium ion transmembrane transport 6.2937 7 yes
GO:1903201 regulation of oxidative stress-induced cell death 6.2937 5 yes
GO:1904064 positive regulation of cation transmembrane transport 6.2937 7 yes
GO:0038127 ERBB signaling pathway 6.2937 6 yes
GO:0042542 response to hydrogen peroxide 6.2937 4 yes
GO:2000249 regulation of actin cytoskeleton reorganization 6.2937 6 yes
GO:0045765 regulation of angiogenesis 6.2937 5 yes
GO:0000904 cell morphogenesis involved in differentiation 6.2937 4 yes
GO:0050851 antigen receptor-mediated signaling pathway 6.2937 5 yes
GO:0002521 leukocyte differentiation 6.2937 4 yes
GO:0007229 integrin-mediated signaling pathway 6.2937 4 yes
GO:0007346 regulation of mitotic cell cycle 6.2937 5 yes
GO:0008154 actin polymerization or depolymerization 6.2937 6 yes
GO:0051492 regulation of stress fiber assembly 6.2937 6 yes
GO:0010632 regulation of epithelial cell migration 6.2937 4 yes
GO:0110020 regulation of actomyosin structure organization 6.2937 6 yes
GO:0030516 regulation of axon extension 6.2937 5 yes
GO:1900407 regulation of cellular response to oxidative stress 6.2937 5 yes
GO:0031396 regulation of protein ubiquitination 6.2937 8 yes
GO:1902882 regulation of response to oxidative stress 6.2937 5 yes
GO:0035023 regulation of Rho protein signal transduction 5.5944 8 yes
GO:0038094 Fc-gamma receptor signaling pathway 5.5944 6 yes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 5.5944 4 yes
GO:0042110 T cell activation 5.5944 4 yes
GO:2000251 positive regulation of actin cytoskeleton reorganization 5.5944 7 yes
GO:2001020 regulation of response to DNA damage stimulus 5.5944 5 yes
GO:0043525 positive regulation of neuron apoptotic process 5.5944 7 yes
GO:0045787 positive regulation of cell cycle 5.5944 5 yes
GO:0050905 neuromuscular process 5.5944 4 yes
GO:0002431 Fc receptor mediated stimulatory signaling pathway 5.5944 5 yes
GO:0051258 protein polymerization 5.5944 6 yes
GO:0007173 epidermal growth factor receptor signaling pathway 5.5944 7 yes
GO:0010634 positive regulation of epithelial cell migration 5.5944 5 yes
GO:0032092 positive regulation of protein binding 5.5944 5 yes
GO:0032147 activation of protein kinase activity 5.5944 8 yes
GO:0032886 regulation of microtubule-based process 5.5944 4 yes
GO:0043409 negative regulation of MAPK cascade 4.8951 7 yes
GO:0045619 regulation of lymphocyte differentiation 4.8951 6 yes
GO:0002237 response to molecule of bacterial origin 4.8951 4 yes
GO:0050852 T cell receptor signaling pathway 4.8951 6 yes
GO:0003018 vascular process in circulatory system 4.8951 4 yes
GO:0051276 chromosome organization 4.8951 5 yes
GO:0051282 regulation of sequestering of calcium ion 4.8951 4 yes
GO:0051496 positive regulation of stress fiber assembly 4.8951 7 yes
GO:0051881 regulation of mitochondrial membrane potential 4.8951 4 yes
GO:0010001 glial cell differentiation 4.8951 4 yes
GO:0071560 cellular response to transforming growth factor beta stimulus 4.8951 4 yes
GO:0071867 response to monoamine 4.8951 5 yes
GO:0071868 cellular response to monoamine stimulus 4.8951 5 yes
GO:0071869 response to catecholamine 4.8951 4 yes
GO:0071870 cellular response to catecholamine stimulus 4.8951 5 yes
GO:0097193 intrinsic apoptotic signaling pathway 4.8951 4 yes
GO:0030855 epithelial cell differentiation 4.8951 4 yes
GO:0032233 positive regulation of actin filament bundle assembly 4.8951 6 yes
GO:0032496 response to lipopolysaccharide 4.8951 4 yes
GO:1903131 mononuclear cell differentiation 4.8951 5 yes
GO:0034446 substrate adhesion-dependent cell spreading 4.1958 4 yes
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 4.1958 8 yes
GO:0034614 cellular response to reactive oxygen species 4.1958 5 yes
GO:1904018 positive regulation of vasculature development 4.1958 5 yes
GO:1905244 regulation of modification of synaptic structure 4.1958 6 yes
GO:0042113 B cell activation 4.1958 4 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 4.1958 6 yes
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 4.1958 7 yes
GO:0045580 regulation of T cell differentiation 4.1958 7 yes
GO:0045766 positive regulation of angiogenesis 4.1958 6 yes
GO:0045786 negative regulation of cell cycle 4.1958 5 yes
GO:0048534 hematopoietic or lymphoid organ development 4.1958 4 yes
GO:0001952 regulation of cell-matrix adhesion 4.1958 6 yes
GO:0050885 neuromuscular process controlling balance 4.1958 5 yes
GO:0006281 DNA repair 4.1958 5 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 4.1958 5 yes
GO:0051341 regulation of oxidoreductase activity 4.1958 4 yes
GO:0051899 membrane depolarization 4.1958 4 yes
GO:0010631 epithelial cell migration 4.1958 5 yes
GO:0070507 regulation of microtubule cytoskeleton organization 4.1958 5 yes
GO:0022408 negative regulation of cell-cell adhesion 4.1958 6 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 4.1958 5 yes
GO:0030098 lymphocyte differentiation 4.1958 4 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 4.1958 6 yes
GO:0031113 regulation of microtubule polymerization 4.1958 6 yes
GO:1900271 regulation of long-term synaptic potentiation 4.1958 4 yes
GO:1901890 positive regulation of cell junction assembly 4.1958 6 yes
GO:1903522 regulation of blood circulation 3.4965 5 yes
GO:1904427 positive regulation of calcium ion transmembrane transport 3.4965 7 yes
GO:0042770 signal transduction in response to DNA damage 3.4965 4 yes
GO:2000027 regulation of animal organ morphogenesis 3.4965 5 yes
GO:0043542 endothelial cell migration 3.4965 6 yes
GO:0045931 positive regulation of mitotic cell cycle 3.4965 6 yes
GO:0046651 lymphocyte proliferation 3.4965 4 yes
GO:0001782 B cell homeostasis 3.4965 4 yes
GO:0001954 positive regulation of cell-matrix adhesion 3.4965 7 yes
GO:0050853 B cell receptor signaling pathway 3.4965 6 yes
GO:0051353 positive regulation of oxidoreductase activity 3.4965 5 yes
GO:0008306 associative learning 3.4965 5 yes
GO:0051893 regulation of focal adhesion assembly 3.4965 7 yes
GO:0051928 positive regulation of calcium ion transport 3.4965 6 yes
GO:0010517 regulation of phospholipase activity 3.4965 6 yes
GO:0060191 regulation of lipase activity 3.4965 5 yes
GO:0010594 regulation of endothelial cell migration 3.4965 5 yes
GO:0010595 positive regulation of endothelial cell migration 3.4965 6 yes
GO:0070301 cellular response to hydrogen peroxide 3.4965 5 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 3.4965 8 yes
GO:0071219 cellular response to molecule of bacterial origin 3.4965 4 yes
GO:0071222 cellular response to lipopolysaccharide 3.4965 5 yes
GO:0090109 regulation of cell-substrate junction assembly 3.4965 6 yes
GO:0030041 actin filament polymerization 3.4965 7 yes
GO:0030217 T cell differentiation 3.4965 5 yes
GO:0150116 regulation of cell-substrate junction organization 3.4965 5 yes
GO:1900006 positive regulation of dendrite development 3.4965 5 yes
GO:0031397 negative regulation of protein ubiquitination 3.4965 9 yes
GO:0032649 regulation of interferon-gamma production 3.4965 5 yes
GO:0032729 positive regulation of interferon-gamma production 3.4965 6 yes
GO:0032943 mononuclear cell proliferation 3.4965 4 yes
GO:1903209 positive regulation of oxidative stress-induced cell death 2.7972 6 yes
GO:1903350 response to dopamine 2.7972 5 yes
GO:1903351 cellular response to dopamine 2.7972 6 yes
GO:0034976 response to endoplasmic reticulum stress 2.7972 4 yes
GO:0035150 regulation of tube size 2.7972 4 yes
GO:0035296 regulation of tube diameter 2.7972 5 yes
GO:0038189 neuropilin signaling pathway 2.7972 4 yes
GO:0042100 B cell proliferation 2.7972 5 yes
GO:0043535 regulation of blood vessel endothelial cell migration 2.7972 6 yes
GO:0043536 positive regulation of blood vessel endothelial cell migration 2.7972 7 yes
GO:0045930 negative regulation of mitotic cell cycle 2.7972 6 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 2.7972 6 yes
GO:0048538 thymus development 2.7972 5 yes
GO:0048732 gland development 2.7972 4 yes
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 2.7972 6 yes
GO:0051438 regulation of ubiquitin-protein transferase activity 2.7972 5 yes
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 2.7972 5 yes
GO:0051894 positive regulation of focal adhesion assembly 2.7972 7 yes
GO:0060688 regulation of morphogenesis of a branching structure 2.7972 4 yes
GO:0071871 response to epinephrine 2.7972 5 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 2.7972 8 yes
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2.7972 6 yes
GO:0090175 regulation of establishment of planar polarity 2.7972 6 yes
GO:0097746 blood vessel diameter maintenance 2.7972 5 yes
GO:0150117 positive regulation of cell-substrate junction organization 2.7972 6 yes
GO:1900272 negative regulation of long-term synaptic potentiation 2.7972 4 yes
GO:1901532 regulation of hematopoietic progenitor cell differentiation 2.7972 5 yes
GO:1903205 regulation of hydrogen peroxide-induced cell death 2.0979 6 yes
GO:1904035 regulation of epithelial cell apoptotic process 2.0979 7 yes
GO:0038083 peptidyl-tyrosine autophosphorylation 2.0979 7 yes
GO:0042098 T cell proliferation 2.0979 5 yes
GO:1905330 regulation of morphogenesis of an epithelium 2.0979 5 yes
GO:1905332 positive regulation of morphogenesis of an epithelium 2.0979 5 yes
GO:2000351 regulation of endothelial cell apoptotic process 2.0979 8 yes
GO:2000736 regulation of stem cell differentiation 2.0979 5 yes
GO:0048145 regulation of fibroblast proliferation 2.0979 5 yes
GO:0048668 collateral sprouting 2.0979 4 yes
GO:0048708 astrocyte differentiation 2.0979 5 yes
GO:0050798 activated T cell proliferation 2.0979 6 yes
GO:0002065 columnar/cuboidal epithelial cell differentiation 2.0979 5 yes
GO:0002285 lymphocyte activation involved in immune response 2.0979 4 yes
GO:0002312 B cell activation involved in immune response 2.0979 5 yes
GO:0051444 negative regulation of ubiquitin-protein transferase activity 2.0979 6 yes
GO:0060020 Bergmann glial cell differentiation 2.0979 6 yes
GO:0060563 neuroepithelial cell differentiation 2.0979 6 yes
GO:0090049 regulation of cell migration involved in sprouting angiogenesis 2.0979 7 yes
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 2.0979 8 yes
GO:0090135 actin filament branching 2.0979 6 yes
GO:0090288 negative regulation of cellular response to growth factor stimulus 2.0979 5 yes
GO:0030177 positive regulation of Wnt signaling pathway 2.0979 6 yes
GO:0030183 B cell differentiation 2.0979 5 yes
GO:1900274 regulation of phospholipase C activity 2.0979 7 yes
GO:1901031 regulation of response to reactive oxygen species 2.0979 6 yes
GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death 2.0979 6 yes
GO:1902036 regulation of hematopoietic stem cell differentiation 2.0979 6 yes
GO:0032489 regulation of Cdc42 protein signal transduction 2.0979 9 yes
GO:0032663 regulation of interleukin-2 production 2.0979 5 yes
GO:0032743 positive regulation of interleukin-2 production 2.0979 6 yes
GO:0033688 regulation of osteoblast proliferation 1.3986 5 yes
GO:0033690 positive regulation of osteoblast proliferation 1.3986 6 yes
GO:1903210 podocyte apoptotic process 1.3986 6 yes
GO:1904019 epithelial cell apoptotic process 1.3986 5 yes
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 1.3986 7 yes
GO:1904036 negative regulation of epithelial cell apoptotic process 1.3986 8 yes
GO:1904526 regulation of microtubule binding 1.3986 5 yes
GO:1904528 positive regulation of microtubule binding 1.3986 6 yes
GO:1904529 regulation of actin filament binding 1.3986 6 yes
GO:1904531 positive regulation of actin filament binding 1.3986 7 yes
GO:1904616 regulation of actin binding 1.3986 5 yes
GO:1904618 positive regulation of actin binding 1.3986 6 yes
GO:1905206 positive regulation of hydrogen peroxide-induced cell death 1.3986 7 yes
GO:1905553 regulation of blood vessel branching 1.3986 5 yes
GO:1905555 positive regulation of blood vessel branching 1.3986 6 yes
GO:1990051 activation of protein kinase C activity 1.3986 9 yes
GO:2000050 regulation of non-canonical Wnt signaling pathway 1.3986 6 yes
GO:2000052 positive regulation of non-canonical Wnt signaling pathway 1.3986 7 yes
GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 1.3986 7 yes
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway 1.3986 8 yes
GO:2000352 negative regulation of endothelial cell apoptotic process 1.3986 9 yes
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 1.3986 7 yes
GO:2000772 regulation of cellular senescence 1.3986 5 yes
GO:2000773 negative regulation of cellular senescence 1.3986 6 yes
GO:0045907 positive regulation of vasoconstriction 1.3986 5 yes
GO:0046631 alpha-beta T cell activation 1.3986 5 yes
GO:0046632 alpha-beta T cell differentiation 1.3986 6 yes
GO:0048146 positive regulation of fibroblast proliferation 1.3986 6 yes
GO:0048536 spleen development 1.3986 5 yes
GO:0001843 neural tube closure 1.3986 5 yes
GO:0001922 B-1 B cell homeostasis 1.3986 5 yes
GO:0002322 B cell proliferation involved in immune response 1.3986 6 yes
GO:0002327 immature B cell differentiation 1.3986 6 yes
GO:0002332 transitional stage B cell differentiation 1.3986 7 yes
GO:0002333 transitional one stage B cell differentiation 1.3986 8 yes
GO:0006298 mismatch repair 1.3986 6 yes
GO:0006975 DNA damage induced protein phosphorylation 1.3986 5 yes
GO:0051882 mitochondrial depolarization 1.3986 5 yes
GO:0010519 negative regulation of phospholipase activity 1.3986 7 yes
GO:0060192 negative regulation of lipase activity 1.3986 6 yes
GO:0060606 tube closure 1.3986 4 yes
GO:0071103 DNA conformation change 1.3986 6 yes
GO:0072359 circulatory system development 1.3986 4 yes
GO:0019229 regulation of vasoconstriction 1.3986 6 yes
GO:0030035 microspike assembly 1.3986 7 yes
GO:0030510 regulation of BMP signaling pathway 1.3986 5 yes
GO:0030514 negative regulation of BMP signaling pathway 1.3986 6 yes
GO:1900275 negative regulation of phospholipase C activity 1.3986 8 yes
GO:1901033 positive regulation of response to reactive oxygen species 1.3986 6 yes
GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death 1.3986 7 yes
GO:1902884 positive regulation of response to oxidative stress 1.3986 5 yes
GO:1903053 regulation of extracellular matrix organization 1.3986 5 yes
GO:1903055 positive regulation of extracellular matrix organization 1.3986 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in ABL1_HUMAN
DOID:331 central nervous system disease 4.8951 3 no
DOID:936 brain disease 2.7972 4 no
DOID:1289 neurodegenerative disease 2.7972 4 no
DOID:0111962 combined immunodeficiency 2.0979 4 no
DOID:612 primary immunodeficiency disease 2.0979 3 no
DOID:0080001 bone disease 1.3986 4 no
DOID:0080006 bone development disease 1.3986 5 no
DOID:65 connective tissue disease 1.3986 3 no
DOID:0050701 electroclinical syndrome 1.3986 6 no
DOID:0112202 developmental and epileptic encephalopathy 1.3986 7 no
DOID:1826 epilepsy 1.3986 5 no
DOID:0050686 organ system cancer 1.3986 3 no
DOID:193 reproductive organ cancer 1.3986 4 no
DOID:627 severe combined immunodeficiency 1.3986 5 no
DOID:231 motor neuron disease 1.3986 5 no
DOID:332 amyotrophic lateral sclerosis 1.3986 6 no
DOID:0050890 synucleinopathy 1.3986 5 no
DOID:0060894 early-onset Parkinsons disease 1.3986 7 no
DOID:14330 Parkinsons disease 1.3986 6 no
DOID:114 heart disease 1.3986 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABI1_HUMAN [view entry] [view interactions] Low throughput yes yes
PPIP1_HUMAN [view interactions] Low throughput no no
MSH5_HUMAN [view interactions] Low throughput no no
CDON_HUMAN [view interactions] Low throughput no no
EPHA4_HUMAN [view entry] [view interactions] Low throughput yes yes
ATM_HUMAN [view interactions] Low throughput no yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
DOK1_HUMAN [view interactions] Low throughput no yes
VINEX_HUMAN [view interactions] Low throughput no no
MUC1_HUMAN [view interactions] Low throughput no no
ABI2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAVS_HUMAN [view interactions] Low throughput no yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
XRCC6_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
WASF1_HUMAN [view entry] [view interactions] Low throughput yes yes
APBB1_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
HCK_HUMAN [view entry] [view interactions] Low throughput yes no
DOK2_HUMAN [view interactions] Low throughput no no
DEN2B_HUMAN [view interactions] Low throughput no yes
P73_HUMAN [view interactions] Low throughput no no
RAD51_HUMAN [view interactions] Low throughput no yes
SHB_HUMAN [view interactions] Low throughput no yes
ADA15_HUMAN [view interactions] Low throughput no yes
ITB2_HUMAN [view interactions] Low throughput no no
TLN2_HUMAN [view entry] [view interactions] Low throughput yes yes
VAV_HUMAN [view interactions] Low throughput no no
TOP1_HUMAN [view interactions] Low throughput no yes
FINC_HUMAN [view interactions] Low throughput no yes
ERCC6_HUMAN [view interactions] Low throughput no no
EP300_HUMAN [view interactions] Low throughput no yes
3BP2_HUMAN [view interactions] Low throughput no yes
3BP1_HUMAN [view interactions] Low throughput no no
BGIN_HUMAN [view interactions] Low throughput no no
STA5B_HUMAN [view interactions] Low throughput no yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
B2CL1_HUMAN [view interactions] Low throughput no yes
RIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
CBL_HUMAN [view interactions] Low throughput no yes
CDN1B_HUMAN [view interactions] Low throughput no yes
CCNA2_HUMAN [view interactions] Low throughput no no
CDK2_HUMAN [view interactions] Low throughput no yes
STA5A_HUMAN [view interactions] Low throughput no no
ABL2_HUMAN [view entry] [view interactions] Low throughput yes yes
MED25_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
MSH4_HUMAN [view interactions] Low throughput no no
BCAR1_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
SPR2A_HUMAN [view interactions] Low throughput no no
CAV1_HUMAN [view interactions] Low throughput no no
PRDX1_HUMAN [view entry] [view interactions] Low throughput yes yes
BRCA1_HUMAN [view interactions] Low throughput no yes
PTN1_HUMAN [view interactions] Low throughput no yes
KAT5_HUMAN [view interactions] Low throughput no yes
NTRK1_HUMAN [view interactions] Low throughput no yes
NCK1_HUMAN [view interactions] Low throughput no yes
ZDH16_HUMAN [view interactions] Low throughput no no
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRBS1_HUMAN [view entry] [view interactions] Low throughput yes yes
RYBP_HUMAN [view interactions] Low throughput no no
CRKL_HUMAN [view entry] [view interactions] Low throughput yes yes
PHAG1_HUMAN [view interactions] Low throughput no yes
SRBS2_HUMAN [view entry] [view interactions] Low throughput yes no
SHD_HUMAN [view interactions] Low throughput no no
SHE_HUMAN [view interactions] Low throughput no yes
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
DDB1_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
M4K1_HUMAN [view interactions] Low throughput no no
GPX1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN6_HUMAN [view interactions] Low throughput no no
RB_HUMAN [view interactions] Low throughput no yes
BCR_HUMAN [view entry] [view interactions] Low throughput yes yes
CREB1_HUMAN [view interactions] Low throughput no yes
YTDC1_HUMAN [view interactions] Low throughput no yes
CATA_HUMAN [view entry] [view interactions] Low throughput yes no
GRAP2_HUMAN [view interactions] Low throughput no no
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHIP2_HUMAN [view interactions] Low throughput no yes
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
ZAP70_HUMAN [view interactions] Low throughput no no
RFX1_HUMAN [view interactions] Low throughput no yes
RAD9A_HUMAN [view interactions] Low throughput no yes
TERF1_HUMAN [view interactions] Low throughput no no
MDM2_HUMAN [view interactions] Low throughput no yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTA1_HUMAN [view interactions] Low throughput no no
CASL_HUMAN [view interactions] Low throughput no yes
CABL2_HUMAN [view interactions] Low throughput no no
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
RAN_HUMAN [view entry] [view interactions] Low throughput yes no
PAXI_HUMAN [view interactions] Low throughput no yes
NCOA3_HUMAN [view interactions] Low throughput no yes
TOPB1_HUMAN [view interactions] Low throughput no yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
IKBA_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
STK4_HUMAN [view interactions] Low throughput no yes
ATR_HUMAN [view interactions] Low throughput no no
BAG1_HUMAN [view interactions] Low throughput no yes
HSP7C_HUMAN [view entry] [view interactions] Low throughput yes yes
PCNA_HUMAN [view interactions] Low throughput no no
PSA7_HUMAN [view interactions] Low throughput no yes
PSA4_HUMAN [view entry] [view interactions] Low throughput yes yes
ASGL1_HUMAN [view interactions] Low throughput no yes
CEP43_HUMAN [view interactions] Low throughput no no
JUN_HUMAN [view interactions] Low throughput no yes
CISH_HUMAN [view interactions] Low throughput no yes
GAB3_HUMAN [view interactions] Low throughput no yes
SHIP1_HUMAN [view interactions] Low throughput no no
MDM4_HUMAN [view interactions] Low throughput no yes
DOK3_HUMAN [view interactions] Low throughput no no
SOCS3_HUMAN [view interactions] Low throughput no yes
SOCS1_HUMAN [view interactions] Low throughput no yes
RASA1_HUMAN [view interactions] Low throughput no yes
TEBP_HUMAN [view interactions] Low throughput no yes
CH60_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP7_HUMAN [view interactions] Low throughput no yes
LATS2_HUMAN [view interactions] Low throughput no yes
CASP9_HUMAN [view interactions] Low throughput no yes
YAP1_HUMAN [view interactions] Low throughput no yes
FOS_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
JIP4_HUMAN [view interactions] Low throughput no yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
RPGF1_HUMAN [view interactions] Low throughput no yes
PPARG_HUMAN [view interactions] Low throughput no yes
HIPK2_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
JAK1_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
SL9A2_HUMAN [view interactions] Low throughput no no
PRKDC_HUMAN [view entry] [view interactions] Low throughput yes yes
EVL_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB10_HUMAN [view entry] [view interactions] Low throughput yes yes
MICA1_HUMAN [view interactions] Low throughput no yes
EPHA3_HUMAN [view interactions] Low throughput no yes
ENAH_HUMAN [view entry] [view interactions] Low throughput yes yes
FMN1_HUMAN [view interactions] Low throughput no no
CCND2_HUMAN [view interactions] Low throughput no yes
ACTS_HUMAN [view interactions] Low throughput no no
TUB_HUMAN [view interactions] Low throughput no yes
WRIP1_HUMAN [view interactions] Low throughput no yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
HUWE1_HUMAN [view interactions] Low throughput no yes
GRAB_HUMAN [view interactions] Low throughput no no
CDK1_HUMAN [view interactions] Low throughput no no
MBP_HUMAN [view entry] [view interactions] Low throughput yes no
CDN1A_HUMAN [view interactions] Low throughput no no
EMD_HUMAN [view interactions] Low throughput no yes
LAP2A_HUMAN [view interactions] Low throughput no yes
PGFRB_HUMAN [view interactions] Low throughput no yes
RA51B_HUMAN [view interactions] Low throughput no yes
SRCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
HERC1_HUMAN [view interactions] Low throughput no no
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
T2FA_HUMAN [view interactions] Low throughput no yes
XPO1_HUMAN [view entry] [view interactions] Low throughput yes yes
PSMD4_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
TCP4_HUMAN [view interactions] High throughput no yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
DRG1_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
RS21_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
EIF2A_HUMAN [view interactions] High throughput no yes
RLA1_HUMAN [view entry] [view interactions] High throughput yes no
CH10_HUMAN [view interactions] High throughput no yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
APC5_HUMAN [view interactions] High throughput no yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
TZAP_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
CUL4B_HUMAN [view interactions] High throughput no yes
KHDR1_HUMAN [view interactions] High throughput no yes
LRRK1_HUMAN [view interactions] High throughput no yes
FNBP1_HUMAN [view interactions] High throughput no yes
CIP4_HUMAN [view interactions] High throughput no no
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
PRP4B_HUMAN [view interactions] High throughput no yes
TYRO3_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
APC15_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CE57L_HUMAN [view interactions] High throughput no yes
CEP76_HUMAN [view interactions] High throughput no yes
CTDS2_HUMAN [view interactions] High throughput no yes
NOL4_HUMAN [view interactions] High throughput no no
NOTC1_HUMAN [view interactions] High throughput no yes
TCL1A_HUMAN [view interactions] High throughput no no
TRM2_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB3_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
FLT3_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
KIT_HUMAN [view interactions] High throughput no no
SF01_HUMAN [view interactions] High throughput no yes
PACN1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
PRIC3_HUMAN [view interactions] High throughput no yes
TRI39_HUMAN [view interactions] High throughput no no
NFS1_HUMAN [view interactions] High throughput no yes
RPP38_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
CXA8_HUMAN [view interactions] High throughput no no
HNRPR_HUMAN [view interactions] High throughput no yes
PAR3_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
HCN2_HUMAN [view entry] [view interactions] High throughput yes no
CNTP1_HUMAN [view entry] [view interactions] High throughput yes yes
ASB16_HUMAN [view interactions] High throughput no no
SOS2_HUMAN [view interactions] High throughput no yes
NFASC_HUMAN [view entry] [view interactions] High throughput yes yes
SELN_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
DNSL2_HUMAN [view interactions] High throughput no no
CSMD2_HUMAN [view interactions] High throughput no no
PKD1_HUMAN [view interactions] High throughput no yes
NKX21_HUMAN [view interactions] High throughput no no
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
SREC2_HUMAN [view interactions] High throughput no yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
HXC8_HUMAN [view interactions] High throughput no no
TF3A_HUMAN [view interactions] High throughput no yes
DDX41_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
SF3B4_HUMAN [view interactions] High throughput no yes
ABR_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP6_HUMAN [view interactions] High throughput no no
GNS_HUMAN [view interactions] High throughput no yes
PAX3_HUMAN [view interactions] High throughput no no
BAZ2A_HUMAN [view interactions] High throughput no no
NOTC3_HUMAN [view interactions] High throughput no yes
ORC1_HUMAN [view interactions] High throughput no yes
HEXA_HUMAN [view interactions] High throughput no yes
CHRD_HUMAN [view interactions] High throughput no no
BRCA2_HUMAN [view interactions] High throughput no no
KMT2B_HUMAN [view interactions] High throughput no no
FOXF2_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
GABR1_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK3_HUMAN [view entry] [view interactions] High throughput yes yes
DPOD1_HUMAN [view interactions] High throughput no yes
CELR3_HUMAN [view interactions] High throughput no no
CP4F2_HUMAN [view interactions] High throughput no no
MAAI_HUMAN [view interactions] High throughput no yes
SUV92_HUMAN [view interactions] High throughput no no
KI67_HUMAN [view interactions] High throughput no no
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
P85B_HUMAN [view interactions] High throughput no yes
PDIA2_HUMAN [view interactions] High throughput no no
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP5_HUMAN [view interactions] High throughput no no
UBS3B_HUMAN [view interactions] High throughput no yes
DLGP3_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX8_HUMAN [view interactions] High throughput no yes
BMP2K_HUMAN [view interactions] High throughput no yes
EPS15_HUMAN [view entry] [view interactions] High throughput yes yes
REPS1_HUMAN [view interactions] High throughput no yes
VP13A_HUMAN [view interactions] High throughput no yes
STON2_HUMAN [view interactions] High throughput no yes
SNX12_HUMAN [view entry] [view interactions] High throughput yes yes
CBLB_HUMAN [view interactions] High throughput no yes
GRIP2_HUMAN [view entry] [view interactions] High throughput yes no
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
SNX17_HUMAN [view interactions] High throughput no yes
BMP8B_HUMAN [view interactions] High throughput no no
CDC27_HUMAN [view interactions] High throughput no yes
S22A3_HUMAN [view interactions] High throughput no yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
CNTFR_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
LRBA_HUMAN [view interactions] High throughput no yes
RGS20_HUMAN [view interactions] High throughput no no
DLX4_HUMAN [view interactions] High throughput no no
MIA2_HUMAN [view interactions] High throughput no yes
F110A_HUMAN [view interactions] High throughput no yes
ICAL_HUMAN [view interactions] High throughput no yes
DUS15_HUMAN [view interactions] High throughput no no
FETUA_HUMAN [view interactions] High throughput no no
WNK2_HUMAN [view interactions] High throughput no yes
RL37_HUMAN [view entry] [view interactions] High throughput yes no
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
CD2AP_HUMAN [view interactions] High throughput no no
CXX1_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NXPH3_HUMAN [view interactions] High throughput no no
EFS_HUMAN [view interactions] High throughput no no
BACE2_HUMAN [view interactions] High throughput no yes
ARHGB_HUMAN [view interactions] High throughput no yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
SP1_HUMAN [view interactions] High throughput no yes
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
LRP2_HUMAN [view interactions] High throughput no no
KS6B1_HUMAN [view entry] [view interactions] High throughput yes yes
NEK8_HUMAN [view interactions] High throughput no yes
OSBL5_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
MED14_HUMAN [view interactions] High throughput no no
DKKL1_HUMAN [view interactions] High throughput no no
RHG17_HUMAN [view interactions] High throughput no no
PRAX_HUMAN [view interactions] High throughput no no
AIRE_HUMAN [view interactions] High throughput no no
KIFC2_HUMAN [view interactions] High throughput no yes
NPVF_HUMAN [view interactions] High throughput no no
SYNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
GASR_HUMAN [view interactions] High throughput no no
ACAP1_HUMAN [view interactions] High throughput no yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
NELFB_HUMAN [view interactions] High throughput no no
TM74B_HUMAN [view interactions] High throughput no yes
CO6_HUMAN [view interactions] High throughput no yes
NED4L_HUMAN [view interactions] High throughput no yes
P2RX7_HUMAN [view interactions] High throughput no yes
FYB1_HUMAN [view interactions] High throughput no no
LTBP2_HUMAN [view interactions] High throughput no no
MEPE_HUMAN [view interactions] High throughput no no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
GT2D1_HUMAN [view interactions] High throughput no yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
DNLI3_HUMAN [view interactions] High throughput no yes
DLGP2_HUMAN [view entry] [view interactions] High throughput yes no
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
GSX2_HUMAN [view interactions] High throughput no no
TSKS_HUMAN [view interactions] High throughput no no
VPREB_HUMAN [view interactions] High throughput no no
BRPF3_HUMAN [view interactions] High throughput no yes
ANRA2_HUMAN [view interactions] High throughput no no
HCN4_HUMAN [view interactions] High throughput no yes
TULP4_HUMAN [view interactions] High throughput no yes
NCKX1_HUMAN [view interactions] High throughput no no
PFD4_HUMAN [view interactions] High throughput no yes
SEM7A_HUMAN [view interactions] High throughput no yes
RTF2_HUMAN [view interactions] High throughput no yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
SYLC_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
NAA25_HUMAN [view interactions] High throughput no yes
APOL5_HUMAN [view interactions] High throughput no no
SYNC_HUMAN [view interactions] High throughput no yes
UHMK1_HUMAN [view interactions] High throughput no no
PAK4_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
PPM1B_HUMAN [view interactions] High throughput no yes
PTN4_HUMAN [view interactions] High throughput no no
PCDA7_HUMAN [view interactions] High throughput no no
EFNA5_HUMAN [view interactions] High throughput no yes
MIME_HUMAN [view interactions] High throughput no no
DCE1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] Computational yes yes
WWTR1_HUMAN [view interactions] Computational no yes
EVPL_HUMAN [view interactions] Computational no yes
CTND1_HUMAN [view entry] [view interactions] Computational yes no
EPHA7_HUMAN [view entry] [view interactions] Computational yes no
TFDP1_HUMAN [view interactions] Computational no yes
ROBO1_HUMAN [view interactions] Computational no yes
IGDC3_HUMAN [view interactions] Computational no no
RAC3_HUMAN [view entry] [view interactions] Computational yes no
MK08_HUMAN [view interactions] Computational no yes
CDK5_HUMAN [view entry] [view interactions] Computational yes yes
RUNX1_HUMAN [view interactions] Computational no yes
CCNE1_HUMAN [view interactions] Computational no no
CCND1_HUMAN [view interactions] Computational no yes
NOX5_HUMAN [view interactions] Computational no no
CCND3_HUMAN [view interactions] Computational no no
EPHB4_HUMAN [view interactions] Computational no yes
SHC2_HUMAN [view interactions] Computational no yes
NTRK2_HUMAN [view entry] [view interactions] Computational yes yes
YES_HUMAN [view entry] [view interactions] Computational yes yes
LRP8_HUMAN [view entry] [view interactions] Computational yes no
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
PEBB_HUMAN [view interactions] Computational no no
RAC2_HUMAN [view entry] [view interactions] Computational yes yes
BAIP2_HUMAN [view entry] [view interactions] Computational yes yes
BLK_HUMAN [view interactions] Computational no no
MEF2A_HUMAN [view interactions] Computational no yes
HDAC1_HUMAN [view interactions] Computational no no
E2F1_HUMAN [view interactions] Computational no yes
P63_HUMAN [view interactions] Computational no no
MP2K6_HUMAN [view interactions] Computational no yes
LYN_HUMAN [view entry] [view interactions] Computational yes no
RAC1_HUMAN [view entry] [view interactions] Computational yes no
EPS8_HUMAN [view entry] [view interactions] Computational yes yes
FGR_HUMAN [view interactions] Computational no no
CDK4_HUMAN [view interactions] Computational no no
NCKPL_HUMAN [view entry] [view interactions] Computational yes yes
EPHA8_HUMAN [view interactions] Computational no no
RELN_HUMAN [view interactions] Computational no no
EPHA2_HUMAN [view interactions] Computational no no
LCK_HUMAN [view entry] [view interactions] Computational yes no
CABL1_HUMAN [view interactions] Computational no no
CDN1C_HUMAN [view interactions] Computational no yes
NRP1_HUMAN [view entry] [view interactions] Computational yes yes
SLIT1_HUMAN [view interactions] Computational no no
CDK6_HUMAN [view interactions] Computational no yes
EPHA1_HUMAN [view interactions] Computational no yes
BRK1_HUMAN [view interactions] Computational no no
EPHB1_HUMAN [view interactions] Computational no no
RUNX2_HUMAN [view interactions] Computational no no
ROBO2_HUMAN [view interactions] Computational no yes
EPHB3_HUMAN [view interactions] Computational no yes
NU214_HUMAN [view interactions] Computational no no
CDN2A_HUMAN [view interactions] Computational no yes
SHC4_HUMAN [view entry] [view interactions] Computational yes no
RAD52_HUMAN [view interactions] Computational no no
TERT_HUMAN [view interactions] Computational no no
NTRK3_HUMAN [view entry] [view interactions] Computational yes yes
WASF3_HUMAN [view entry] [view interactions] Computational yes yes
SHC3_HUMAN [view interactions] Computational no yes
CADH2_HUMAN [view entry] [view interactions] Computational yes no
CTNA1_HUMAN [view entry] [view interactions] Computational yes yes
PDGFB_HUMAN [view interactions] Computational no yes
TFE2_HUMAN [view interactions] Computational no no