Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AP2B1_HUMAN

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AP2B1_HUMAN
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 23.0769 5 no
GO:0005048 signal sequence binding 3.2051 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AP2B1_HUMAN
GO:0048522 positive regulation of cellular process 60.2564 4 yes
GO:0051128 regulation of cellular component organization 49.3590 4 yes
GO:0016192 vesicle-mediated transport 46.1538 4 yes
GO:0048523 negative regulation of cellular process 45.5128 4 yes
GO:0060255 regulation of macromolecule metabolic process 45.5128 4 no
GO:0010646 regulation of cell communication 44.8718 4 no
GO:0051171 regulation of nitrogen compound metabolic process 43.5897 4 no
GO:0080090 regulation of primary metabolic process 43.5897 4 no
GO:0008104 protein localization 41.0256 4 yes
GO:0031323 regulation of cellular metabolic process 41.0256 4 no
GO:0009966 regulation of signal transduction 39.7436 4 no
GO:0006996 organelle organization 38.4615 4 no
GO:0022607 cellular component assembly 35.8974 4 yes
GO:0051049 regulation of transport 35.8974 4 yes
GO:0071702 organic substance transport 34.6154 4 yes
GO:0009893 positive regulation of metabolic process 34.6154 4 no
GO:0071705 nitrogen compound transport 33.9744 4 yes
GO:0051246 regulation of protein metabolic process 32.6923 5 no
GO:0010604 positive regulation of macromolecule metabolic process 32.0513 5 no
GO:0006897 endocytosis 31.4103 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 30.7692 5 no
GO:0015031 protein transport 30.1282 4 yes
GO:0051130 positive regulation of cellular component organization 29.4872 5 yes
GO:0031325 positive regulation of cellular metabolic process 27.5641 5 no
GO:1902531 regulation of intracellular signal transduction 27.5641 5 no
GO:0048584 positive regulation of response to stimulus 26.2821 4 no
GO:0010468 regulation of gene expression 25.6410 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.3590 5 no
GO:0033043 regulation of organelle organization 24.3590 5 no
GO:0010647 positive regulation of cell communication 24.3590 5 no
GO:0023056 positive regulation of signaling 24.3590 4 no
GO:0031399 regulation of protein modification process 24.3590 6 no
GO:0051247 positive regulation of protein metabolic process 24.3590 6 no
GO:0043933 protein-containing complex organization 23.7179 4 yes
GO:0009889 regulation of biosynthetic process 23.7179 4 no
GO:0006886 intracellular protein transport 23.0769 4 yes
GO:0010941 regulation of cell death 23.0769 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 no
GO:0051050 positive regulation of transport 22.4359 4 yes
GO:0060627 regulation of vesicle-mediated transport 22.4359 4 yes
GO:0031326 regulation of cellular biosynthetic process 22.4359 5 no
GO:0010556 regulation of macromolecule biosynthetic process 21.7949 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.7949 5 no
GO:0007010 cytoskeleton organization 21.7949 5 no
GO:0030030 cell projection organization 21.1538 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.1538 5 no
GO:0006898 receptor-mediated endocytosis 20.5128 6 yes
GO:0019220 regulation of phosphate metabolic process 20.5128 6 no
GO:0051174 regulation of phosphorus metabolic process 20.5128 5 no
GO:0009967 positive regulation of signal transduction 20.5128 5 no
GO:0044087 regulation of cellular component biogenesis 20.5128 4 no
GO:0060341 regulation of cellular localization 19.2308 4 yes
GO:0065003 protein-containing complex assembly 19.2308 5 yes
GO:0032880 regulation of protein localization 18.5897 5 yes
GO:0030100 regulation of endocytosis 17.3077 5 yes
GO:0060548 negative regulation of cell death 14.7436 5 yes
GO:0072583 clathrin-dependent endocytosis 11.5385 7 yes
GO:0099003 vesicle-mediated transport in synapse 10.2564 5 yes
GO:1903829 positive regulation of protein localization 9.6154 5 yes
GO:0045807 positive regulation of endocytosis 8.9744 5 yes
GO:0048488 synaptic vesicle endocytosis 8.9744 5 yes
GO:0140238 presynaptic endocytosis 8.9744 4 yes
GO:0031623 receptor internalization 8.3333 7 yes
GO:1905475 regulation of protein localization to membrane 8.3333 6 yes
GO:0048268 clathrin coat assembly 7.6923 6 yes
GO:1901214 regulation of neuron death 7.6923 5 yes
GO:1901215 negative regulation of neuron death 4.4872 6 yes
GO:1905477 positive regulation of protein localization to membrane 4.4872 6 yes
GO:0001822 kidney development 1.9231 4 yes
GO:0098884 postsynaptic neurotransmitter receptor internalization 1.9231 4 yes
GO:0140239 postsynaptic endocytosis 1.9231 4 yes
GO:0003281 ventricular septum development 1.2821 4 yes
GO:0035904 aorta development 1.2821 5 yes
GO:0060840 artery development 1.2821 4 yes
GO:0060976 coronary vasculature development 1.2821 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in AP2B1_HUMAN
DOID:114 heart disease 3.2051 3 no
DOID:0050700 cardiomyopathy 2.5641 4 no
DOID:0060036 intrinsic cardiomyopathy 2.5641 5 no
DOID:2843 long QT syndrome 1.9231 6 no
DOID:1289 neurodegenerative disease 1.9231 4 no
DOID:331 central nervous system disease 1.9231 3 no
DOID:0050686 organ system cancer 1.9231 3 no
DOID:0060038 specific developmental disorder 1.2821 3 no
DOID:1059 intellectual disability 1.2821 4 no
DOID:0111198 autosomal dominant distal hereditary motor neuronopathy 1.2821 7 no
DOID:12377 spinal muscular atrophy 1.2821 6 no
DOID:231 motor neuron disease 1.2821 5 no
DOID:10534 stomach cancer 1.2821 5 no
DOID:120 female reproductive organ cancer 1.2821 5 no
DOID:193 reproductive organ cancer 1.2821 4 no
DOID:3119 gastrointestinal system cancer 1.2821 4 no
DOID:0050155 sensory system disease 1.2821 3 no
DOID:0050563 nonsyndromic deafness 1.2821 5 no
DOID:0050564 autosomal dominant nonsyndromic deafness 1.2821 6 no
DOID:2742 auditory system disease 1.2821 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NECP2_HUMAN [view interactions] Low throughput no yes
TGFR2_HUMAN [view interactions] Low throughput no no
BUB1B_HUMAN [view interactions] Low throughput no no
HIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] Low throughput yes yes
CD4_HUMAN [view interactions] Low throughput no no
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
RN111_HUMAN [view interactions] Low throughput no yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
ARFG1_HUMAN [view interactions] Low throughput no no
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
TFR1_HUMAN [view interactions] Low throughput no yes
AP2A_HUMAN [view interactions] Low throughput no no
ARH_HUMAN [view interactions] Low throughput no yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN4_HUMAN [view interactions] Low throughput no yes
PTEN_HUMAN [view entry] [view interactions] Low throughput yes yes
NECP1_HUMAN [view interactions] Low throughput no no
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
AP1M1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
PI51C_HUMAN [view entry] [view interactions] Low throughput yes yes
TNFL6_HUMAN [view interactions] Low throughput no yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
CLH1_HUMAN [view entry] [view interactions] Low throughput yes yes
TGFR1_HUMAN [view interactions] Low throughput no no
OCRL_HUMAN [view interactions] Low throughput no yes
GTR8_HUMAN [view interactions] Low throughput no yes
AP2S1_HUMAN [view entry] [view interactions] Low throughput yes no
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
MYO6_HUMAN [view entry] [view interactions] Low throughput yes no
TGON2_HUMAN [view interactions] Low throughput no yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
ADA10_HUMAN [view entry] [view interactions] Low throughput yes yes
S35F4_HUMAN [view interactions] High throughput no no
K0408_HUMAN [view entry] [view interactions] High throughput yes no
WDR97_HUMAN [view interactions] High throughput no no
DHX58_HUMAN [view interactions] High throughput no yes
CL071_HUMAN [view interactions] High throughput no no
MLH1_HUMAN [view interactions] High throughput no yes
SM34A_HUMAN [view interactions] High throughput no no
P121A_HUMAN [view interactions] High throughput no yes
ELAP2_HUMAN [view interactions] High throughput no no
CI107_HUMAN [view interactions] High throughput no no
VATG1_HUMAN [view entry] [view interactions] High throughput yes yes
PDZD2_HUMAN [view interactions] High throughput no yes
NUP54_HUMAN [view interactions] High throughput no yes
ETV2_HUMAN [view interactions] High throughput no no
TE2IP_HUMAN [view interactions] High throughput no yes
BMAL1_HUMAN [view interactions] High throughput no yes
TET5C_HUMAN [view interactions] High throughput no yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
RIBC2_HUMAN [view interactions] High throughput no yes
TRAD1_HUMAN [view interactions] High throughput no yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
MEIOS_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TET3_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
NMDE4_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC5_HUMAN [view interactions] High throughput no yes
SHIP2_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
IKKA_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
HTSF1_HUMAN [view interactions] High throughput no yes
CE128_HUMAN [view interactions] High throughput no yes
ZN292_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
MARH6_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view interactions] High throughput no yes
TOM1_HUMAN [view interactions] High throughput no yes
LMTK1_HUMAN [view interactions] High throughput no yes
PTCD1_HUMAN [view interactions] High throughput no yes
GCP4_HUMAN [view interactions] High throughput no yes
DEPD5_HUMAN [view interactions] High throughput no yes
PP6R2_HUMAN [view interactions] High throughput no no
TREA_HUMAN [view interactions] High throughput no yes
GTF2I_HUMAN [view interactions] High throughput no yes
CENPB_HUMAN [view interactions] High throughput no yes
RPGF3_HUMAN [view interactions] High throughput no yes
PRGR_HUMAN [view interactions] High throughput no no
ATP23_HUMAN [view interactions] High throughput no yes
NSD2_HUMAN [view interactions] High throughput no yes
NEUR4_HUMAN [view interactions] High throughput no no
PCNT_HUMAN [view interactions] High throughput no yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
RIMB1_HUMAN [view interactions] High throughput no yes
TEX12_HUMAN [view interactions] High throughput no no
AGFG2_HUMAN [view interactions] High throughput no yes
LONF1_HUMAN [view interactions] High throughput no yes
DEND_HUMAN [view entry] [view interactions] High throughput yes no
C2CD6_HUMAN [view interactions] High throughput no no
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
FMNL2_HUMAN [view entry] [view interactions] High throughput yes yes
CO3A1_HUMAN [view interactions] High throughput no no
PEX5_HUMAN [view interactions] High throughput no yes
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
DNMT1_HUMAN [view interactions] High throughput no no
GPAN1_HUMAN [view interactions] High throughput no yes
HAP40_HUMAN [view interactions] High throughput no no
PS1C2_HUMAN [view interactions] High throughput no no
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD4_HUMAN [view interactions] High throughput no yes
DU4L7_HUMAN [view interactions] High throughput no no
ACVR1_HUMAN [view interactions] High throughput no yes
DU4L6_HUMAN [view interactions] High throughput no no
SMUF1_HUMAN [view interactions] High throughput no yes
DU4L5_HUMAN [view interactions] High throughput no no
DU4L4_HUMAN [view interactions] High throughput no no
EDC4_HUMAN [view interactions] High throughput no yes
DU4L3_HUMAN [view interactions] High throughput no no
DU4L2_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
SP202_HUMAN [view interactions] High throughput no no
BNIP5_HUMAN [view interactions] High throughput no no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
AGFG1_HUMAN [view interactions] High throughput no yes
AP180_HUMAN [view entry] [view interactions] High throughput yes yes
STAT6_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
MESP2_HUMAN [view interactions] High throughput no no
K2C1_HUMAN [view interactions] High throughput no no
CGNL1_HUMAN [view interactions] High throughput no no
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
P5F1B_HUMAN [view interactions] High throughput no no
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
KMT2A_HUMAN [view interactions] High throughput no yes
ZN142_HUMAN [view interactions] High throughput no no
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
DAB2_HUMAN [view interactions] High throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
NTH_HUMAN [view interactions] High throughput no yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
FOXP3_HUMAN [view interactions] High throughput no no
M3K10_HUMAN [view interactions] High throughput no yes
SHRM2_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
KRR1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
MTMR3_HUMAN [view interactions] High throughput no no
RARA_HUMAN [view interactions] High throughput no no
NCOA4_HUMAN [view interactions] High throughput no no
MMS19_HUMAN [view interactions] High throughput no yes
PRS41_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
PTK6_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
S31E1_HUMAN [view interactions] High throughput no no
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
PPR3F_HUMAN [view interactions] High throughput no yes
RNF11_HUMAN [view interactions] High throughput no yes
FAT4_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
CP054_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
FIP1_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
AFTIN_HUMAN [view interactions] High throughput no yes
EPHA2_HUMAN [view interactions] High throughput no no
ANR11_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
DUX4C_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
GP179_HUMAN [view interactions] High throughput no no
MDEAS_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
ANR54_HUMAN [view interactions] High throughput no yes
MRNIP_HUMAN [view interactions] High throughput no yes
UTP25_HUMAN [view interactions] High throughput no yes
ANO7_HUMAN [view interactions] High throughput no no
OXDA_HUMAN [view interactions] High throughput no no
ELP2_HUMAN [view interactions] High throughput no yes
RUN3A_HUMAN [view interactions] High throughput no yes
K1614_HUMAN [view interactions] High throughput no yes
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
ATRN1_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
OBSCN_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
TSPO2_HUMAN [view interactions] High throughput no no
BMR1A_HUMAN [view interactions] High throughput no no
RBM26_HUMAN [view interactions] High throughput no yes
BRAF_HUMAN [view interactions] High throughput no yes
FRPD1_HUMAN [view interactions] High throughput no yes
CRYL1_HUMAN [view interactions] High throughput no yes
SYLC_HUMAN [view interactions] High throughput no yes
PERM1_HUMAN [view interactions] High throughput no no
PPP6_HUMAN [view interactions] High throughput no yes
EFHC2_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
ZN831_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
PP6R3_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
SP201_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
PKHG7_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
AGO2_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NDF2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
HERC1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
PDCD1_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
RTP5_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
MVP_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
RC3H1_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RC3H2_HUMAN [view interactions] High throughput no yes
VEZF1_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
RUNX2_HUMAN [view interactions] High throughput no no
HDAC2_HUMAN [view interactions] High throughput no yes
MICA2_HUMAN [view interactions] High throughput no yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
R3HCL_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
CCD91_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
MISP_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
LAX1_HUMAN [view interactions] High throughput no no
AUXI_HUMAN [view entry] [view interactions] High throughput yes yes
DZIP1_HUMAN [view interactions] High throughput no yes
MTMR4_HUMAN [view interactions] High throughput no no
CQ082_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
GPBP1_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
N4BP2_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
GTSC1_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
VP13B_HUMAN [view interactions] High throughput no no
K1107_HUMAN [view interactions] High throughput no yes
CTGE2_HUMAN [view interactions] High throughput no no
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
SPAG5_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
YI001_HUMAN [view interactions] High throughput no no
DVL2_HUMAN [view interactions] High throughput no yes
CKLF3_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
SCYL1_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
WNK4_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
S35A4_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
INKA1_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
REPS1_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SO4A1_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
PIEZ1_HUMAN [view interactions] High throughput no no
F16P1_HUMAN [view interactions] High throughput no no
RFFL_HUMAN [view interactions] High throughput no yes
S13A3_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
S22AH_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
ELP5_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
ZSC18_HUMAN [view interactions] High throughput no yes
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
TNR6A_HUMAN [view interactions] High throughput no yes
AP1G1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT44_HUMAN [view interactions] High throughput no yes
AP1G2_HUMAN [view interactions] High throughput no yes
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
TEX19_HUMAN [view interactions] High throughput no no
STON2_HUMAN [view interactions] High throughput no yes
CA127_HUMAN [view interactions] High throughput no no
AP1S3_HUMAN [view interactions] High throughput no yes
BBS5_HUMAN [view interactions] High throughput no yes
AP1S1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN786_HUMAN [view interactions] High throughput no no
FCHO2_HUMAN [view interactions] High throughput no yes
YJ004_HUMAN [view interactions] High throughput no no
RBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RTKN2_HUMAN [view interactions] High throughput no no
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
SP8_HUMAN [view interactions] High throughput no no
CACO1_HUMAN [view entry] [view interactions] High throughput yes yes
INLR1_HUMAN [view interactions] High throughput no no
SGIP1_HUMAN [view entry] [view interactions] High throughput yes yes
GPBL1_HUMAN [view interactions] High throughput no yes
RLGPB_HUMAN [view interactions] High throughput no yes
RDH14_HUMAN [view interactions] High throughput no yes
RGPA1_HUMAN [view entry] [view interactions] High throughput yes yes
VIAAT_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
CAPAM_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
KCQ1D_HUMAN [view interactions] High throughput no no
FGD5_HUMAN [view interactions] High throughput no yes
CK068_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
NOTC4_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
TX13A_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
PHF7_HUMAN [view interactions] High throughput no no
RHG18_HUMAN [view interactions] High throughput no yes
RTKN_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
MESP1_HUMAN [view interactions] High throughput no no
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
PIGQ_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
NUP88_HUMAN [view interactions] High throughput no yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
RNF26_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
TRPV2_HUMAN [view interactions] High throughput no yes
MAGD1_HUMAN [view interactions] High throughput no no
PLOD2_HUMAN [view interactions] High throughput no yes
MAST1_HUMAN [view interactions] High throughput no yes
LCAP_HUMAN [view interactions] High throughput no yes
RIMS2_HUMAN [view entry] [view interactions] High throughput yes no
NUSAP_HUMAN [view interactions] High throughput no no
PP6R1_HUMAN [view interactions] High throughput no no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
SYNRG_HUMAN [view interactions] High throughput no yes
CAB39_HUMAN [view interactions] High throughput no yes
MYO15_HUMAN [view interactions] High throughput no no
COX5B_HUMAN [view entry] [view interactions] High throughput yes yes
APC4_HUMAN [view interactions] High throughput no yes
NUP50_HUMAN [view interactions] High throughput no yes
DBNL_HUMAN [view entry] [view interactions] High throughput yes yes
TOM40_HUMAN [view interactions] High throughput no yes
MAGL2_HUMAN [view interactions] High throughput no no
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
SL9A2_HUMAN [view interactions] High throughput no no
AT8A1_HUMAN [view entry] [view interactions] High throughput yes yes
DUX4_HUMAN [view interactions] High throughput no no
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
EP15R_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
RTEL1_HUMAN [view interactions] High throughput no no
CTIF_HUMAN [view interactions] High throughput no yes
MCM9_HUMAN [view interactions] High throughput no yes
MEX3B_HUMAN [view interactions] High throughput no no
BMP2K_HUMAN [view interactions] High throughput no yes
SMAP2_HUMAN [view interactions] High throughput no yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
TNR6B_HUMAN [view interactions] High throughput no yes
CAH10_HUMAN [view interactions] High throughput no yes
TNR6C_HUMAN [view interactions] High throughput no no
ROBO2_HUMAN [view interactions] High throughput no yes
ALMS1_HUMAN [view interactions] High throughput no no
ZN532_HUMAN [view interactions] High throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
CMTA1_HUMAN [view interactions] High throughput no yes
ANS1A_HUMAN [view interactions] High throughput no yes
RHBD3_HUMAN [view interactions] High throughput no yes
AP1AR_HUMAN [view interactions] High throughput no yes
CA226_HUMAN [view interactions] High throughput no yes
CCD18_HUMAN [view interactions] High throughput no yes
MTR1B_HUMAN [view interactions] High throughput no yes
CP110_HUMAN [view interactions] High throughput no yes
CP131_HUMAN [view interactions] High throughput no no
CE152_HUMAN [view interactions] High throughput no yes
CE350_HUMAN [view interactions] High throughput no yes
OSB10_HUMAN [view interactions] High throughput no no
CBPD_HUMAN [view interactions] High throughput no yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
DEN1A_HUMAN [view interactions] High throughput no no
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
GGA2_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
GGA3_HUMAN [view entry] [view interactions] High throughput yes yes
MYO19_HUMAN [view interactions] High throughput no yes
HTR5B_HUMAN [view interactions] High throughput no yes
AP1S2_HUMAN [view interactions] High throughput no no
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MPRI_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
KI13A_HUMAN [view interactions] High throughput no yes
FLNB_HUMAN [view interactions] High throughput no no
NAV1_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
CAPON_HUMAN [view entry] [view interactions] High throughput yes yes
CALL3_HUMAN [view interactions] High throughput no yes
NSF1C_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
NUMBL_HUMAN [view entry] [view interactions] High throughput yes yes
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
P3C2A_HUMAN [view interactions] High throughput no yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
GTSE1_HUMAN [view interactions] High throughput no no
SCAM1_HUMAN [view interactions] High throughput no no
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
SCYL2_HUMAN [view interactions] High throughput no yes
SH319_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
S38A1_HUMAN [view interactions] High throughput no yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
S6A15_HUMAN [view interactions] High throughput no yes
KBP_HUMAN [view interactions] High throughput no yes
SNX29_HUMAN [view interactions] High throughput no yes
ITA5_HUMAN [view entry] [view interactions] High throughput yes no
SPY4_HUMAN [view interactions] High throughput no yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
STEA3_HUMAN [view interactions] High throughput no yes
GAK_HUMAN [view entry] [view interactions] High throughput yes yes
TBCD8_HUMAN [view interactions] High throughput no yes
TDRP_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP4_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
ANKH1_HUMAN [view interactions] High throughput no yes
LYRIC_HUMAN [view entry] [view interactions] High throughput yes yes
CK049_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
CC138_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
GRDN_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
CDC23_HUMAN [view interactions] High throughput no yes
CFA54_HUMAN [view interactions] High throughput no no
C170B_HUMAN [view interactions] High throughput no yes
KI67_HUMAN [view interactions] High throughput no no
CEP55_HUMAN [view interactions] High throughput no yes
RB3GP_HUMAN [view entry] [view interactions] High throughput yes yes
CEP97_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
F193A_HUMAN [view interactions] High throughput no yes
EPN1_HUMAN [view entry] [view interactions] High throughput yes yes
FKB15_HUMAN [view entry] [view interactions] High throughput yes yes
MEA1_HUMAN [view interactions] High throughput no no
GCC2_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
ICE2_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
K1671_HUMAN [view interactions] High throughput no yes
MEX3C_HUMAN [view interactions] High throughput no yes
KDIS_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
LIMD1_HUMAN [view interactions] High throughput no yes
EFNB2_HUMAN [view entry] [view interactions] High throughput yes yes
OFD1_HUMAN [view interactions] High throughput no yes
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD4_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
PAXI_HUMAN [view interactions] High throughput no yes
WNK3_HUMAN [view interactions] High throughput no no
RGPD1_HUMAN [view interactions] High throughput no no
ENTR1_HUMAN [view interactions] High throughput no no
RNPS1_HUMAN [view interactions] High throughput no yes
SC16A_HUMAN [view interactions] High throughput no yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L3_HUMAN [view interactions] High throughput no yes
SLAI2_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
TRIPB_HUMAN [view interactions] High throughput no yes
ANGI_HUMAN [view interactions] High throughput no no
TBAL3_HUMAN [view interactions] High throughput no no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
VCIP1_HUMAN [view entry] [view interactions] High throughput yes no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
WNK1_HUMAN [view entry] [view interactions] High throughput yes no
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX1_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
RCAS1_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
LITD1_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
FURIN_HUMAN [view interactions] High throughput no yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
U2AF1_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
IMA1_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
THIOM_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
TX13C_HUMAN [view interactions] High throughput no no
THAP1_HUMAN [view interactions] High throughput no no
PKHG3_HUMAN [view interactions] High throughput no yes
AFF4_HUMAN [view interactions] High throughput no yes
ZBT7C_HUMAN [view interactions] High throughput no no
AP1M2_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
DYN2_HUMAN [view entry] [view interactions] Computational yes yes
AP4M1_HUMAN [view interactions] Computational no yes
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
GRIA2_HUMAN [view entry] [view interactions] Computational yes yes
GRIP1_HUMAN [view entry] [view interactions] Computational yes yes
AP3S2_HUMAN [view entry] [view interactions] Computational yes no
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
UBQL2_HUMAN [view interactions] Computational no yes
AP4E1_HUMAN [view interactions] Computational no no
ARRS_HUMAN [view interactions] Computational no no
GRIA1_HUMAN [view entry] [view interactions] Computational yes yes
ROR2_HUMAN [view entry] [view interactions] Computational yes yes
GRIA3_HUMAN [view entry] [view interactions] Computational yes yes
KPCG_HUMAN [view entry] [view interactions] Computational yes yes
AP3M2_HUMAN [view entry] [view interactions] Computational yes yes
ROR1_HUMAN [view interactions] Computational no no
AP5M1_HUMAN [view interactions] Computational no no
FZD2_HUMAN [view interactions] Computational no no
CLH2_HUMAN [view interactions] Computational no no
AP5B1_HUMAN [view interactions] Computational no yes
AP5S1_HUMAN [view interactions] Computational no yes
EHD2_HUMAN [view interactions] Computational no no
FZD5_HUMAN [view interactions] Computational no yes
PICK1_HUMAN [view entry] [view interactions] Computational yes yes
NCALD_HUMAN [view entry] [view interactions] Computational yes yes
AP4B1_HUMAN [view interactions] Computational no yes
ATM_HUMAN [view interactions] Computational no yes
DNAL4_HUMAN [view interactions] Computational no yes
AP3S1_HUMAN [view entry] [view interactions] Computational yes no
KCNQ5_HUMAN [view interactions] Computational no yes