A16L1_HUMAN
Evidence for PS localization
Functions
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed, PubMed, PubMed, PubMed, PubMed). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed). Plays a role in regulating morphology and function of Paneth cell (PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [A16L1_HUMAN]
Isoform [C9J8C6] alignment
Isoform [C9J1B2] alignment
Isoform [E7EVC7] alignment
Isoform [F8WAF9] alignment
Isoform [C9JK97] alignment
Isoform [Q676U5-2] alignment
Isoform [Q676U5-3] alignment
Isoform [Q676U5-4] alignment
Isoform [Q676U5-5] alignment
Isoform [C9JAY7] alignment
LOADING 44%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in A16L1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 29.6512 | 4 | no |
| GO:0043168 | anion binding | 25.2907 | 4 | no |
| GO:0000166 | nucleotide binding | 23.5465 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.9651 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.2209 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.9302 | 4 | no |
| GO:0051020 | GTPase binding | 9.3023 | 4 | yes |
| GO:0016755 | aminoacyltransferase activity | 2.6163 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in A16L1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.8372 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.6395 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.6395 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.1860 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.5349 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.3372 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.3372 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.4651 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.1744 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.4302 | 4 | yes |
| GO:0010646 | regulation of cell communication | 33.4302 | 4 | no |
| GO:0006996 | organelle organization | 32.5581 | 4 | yes |
| GO:0022607 | cellular component assembly | 32.2674 | 4 | yes |
| GO:0010468 | regulation of gene expression | 32.2674 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 30.2326 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.9419 | 5 | no |
| GO:0008104 | protein localization | 29.3605 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 29.0698 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.9070 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.5814 | 4 | no |
| GO:0071702 | organic substance transport | 24.4186 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.1279 | 5 | no |
| GO:0071705 | nitrogen compound transport | 22.9651 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.9651 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.0930 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 5NTC_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| A16L2_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAGAB_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| ABHD5_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACB_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACL6A_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |