2AAA_HUMAN
Evidence for PS localization
Functions
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [2AAA_HUMAN]
Isoform [C9J9C1] alignment
Isoform [M0R0K6] alignment
Isoform [M0QXG4] alignment
Isoform [E9PH38] alignment
Isoform [B3KQV6] alignment
Isoform [A0A994J6A3] alignment
Isoform [A0A994J3N8] alignment
Isoform [A0A994J3H1] alignment
LOADING 64%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 2AAA_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.8408 | 4 | no |
| GO:0000166 | nucleotide binding | 30.3483 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.3532 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.8607 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.8657 | 4 | no |
| GO:0003723 | RNA binding | 25.8706 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 24.3781 | 6 | no |
| GO:0043169 | cation binding | 23.8806 | 4 | no |
| GO:0046872 | metal ion binding | 23.3831 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.8856 | 5 | no |
| GO:0019900 | kinase binding | 21.8905 | 4 | no |
| GO:0005524 | ATP binding | 21.8905 | 5 | no |
| GO:0046982 | protein heterodimerization activity | 5.9701 | 4 | yes |
| GO:0016791 | phosphatase activity | 5.4726 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 5.4726 | 4 | yes |
| GO:0004722 | protein serine/threonine phosphatase activity | 3.4826 | 4 | yes |
| GO:0019888 | protein phosphatase regulator activity | 1.9900 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 2AAA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.7313 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7562 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.2587 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.7662 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 46.7662 | 4 | yes |
| GO:0010646 | regulation of cell communication | 41.7910 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 39.8010 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 39.3035 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.3085 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 37.3134 | 4 | yes |
| GO:0006996 | organelle organization | 36.8159 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.3184 | 5 | no |
| GO:0009966 | regulation of signal transduction | 35.8209 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 35.8209 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.3234 | 5 | yes |
| GO:0022607 | cellular component assembly | 34.8259 | 4 | yes |
| GO:0008104 | protein localization | 33.8308 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 32.8358 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.8458 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 30.3483 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.8607 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 27.8607 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 26.8657 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 26.3682 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5A_HUMAN | [view interactions] | Low throughput | no | yes |
| 2A5B_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5G_HUMAN | [view interactions] | Low throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 2AAB_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | Low throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | Low throughput | no | yes |
| 2ABD_HUMAN | [view interactions] | Low throughput | no | yes |
| 2ABG_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCY8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |