FPPS_HUMAN
Evidence for PS localization
Functions
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FPPS_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 36.1111 | 4 | yes |
| GO:0046872 | metal ion binding | 30.5556 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 27.7778 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.2222 | 4 | no |
| GO:0004161 | dimethylallyltranstransferase activity | 5.5556 | 5 | yes |
| GO:0004337 | geranyltranstransferase activity | 5.5556 | 5 | yes |
| GO:0004659 | prenyltransferase activity | 5.5556 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FPPS_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 52.7778 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 52.7778 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.2222 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 38.8889 | 4 | yes |
| GO:0010468 | regulation of gene expression | 38.8889 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 36.1111 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 36.1111 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.5556 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.5556 | 5 | no |
| GO:0010941 | regulation of cell death | 27.7778 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 27.7778 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 27.7778 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 27.7778 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0090407 | organophosphate biosynthetic process | 22.2222 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 22.2222 | 4 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 22.2222 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 22.2222 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 22.2222 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 22.2222 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0071702 | organic substance transport | 22.2222 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0008202 | steroid metabolic process | 13.8889 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 13.8889 | 4 | yes |
| GO:0006644 | phospholipid metabolic process | 11.1111 | 4 | yes |
| GO:0006694 | steroid biosynthetic process | 11.1111 | 5 | yes |
| GO:0006695 | cholesterol biosynthetic process | 11.1111 | 6 | yes |
| GO:0008203 | cholesterol metabolic process | 11.1111 | 5 | yes |
| GO:0016125 | sterol metabolic process | 11.1111 | 4 | yes |
| GO:0016126 | sterol biosynthetic process | 11.1111 | 5 | yes |
| GO:0046165 | alcohol biosynthetic process | 11.1111 | 4 | yes |
| GO:1901617 | organic hydroxy compound biosynthetic process | 11.1111 | 4 | yes |
| GO:1902652 | secondary alcohol metabolic process | 11.1111 | 4 | yes |
| GO:1902653 | secondary alcohol biosynthetic process | 11.1111 | 5 | yes |
| GO:0008654 | phospholipid biosynthetic process | 8.3333 | 4 | yes |
| GO:0006720 | isoprenoid metabolic process | 5.5556 | 4 | yes |
| GO:0006721 | terpenoid metabolic process | 5.5556 | 5 | yes |
| GO:0008299 | isoprenoid biosynthetic process | 5.5556 | 4 | yes |
| GO:0016114 | terpenoid biosynthetic process | 5.5556 | 5 | yes |
| GO:0033383 | geranyl diphosphate metabolic process | 5.5556 | 5 | yes |
| GO:0033384 | geranyl diphosphate biosynthetic process | 5.5556 | 5 | yes |
| GO:0045337 | farnesyl diphosphate biosynthetic process | 5.5556 | 5 | yes |
| GO:0045338 | farnesyl diphosphate metabolic process | 5.5556 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LIRB3_HUMAN | [view interactions] | Low throughput | no | no |
| FGFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| EMC6_HUMAN | [view interactions] | High throughput | no | yes |
| EMC7_HUMAN | [view interactions] | High throughput | no | yes |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUS1_HUMAN | [view interactions] | High throughput | no | yes |
| MBTP2_HUMAN | [view interactions] | High throughput | no | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| MED9_HUMAN | [view interactions] | High throughput | no | no |
| NIP7_HUMAN | [view interactions] | High throughput | no | yes |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RINT1_HUMAN | [view interactions] | High throughput | no | yes |
| RIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| TAF2_HUMAN | [view interactions] | High throughput | no | no |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| TIM_HUMAN | [view interactions] | High throughput | no | yes |
| TSAP1_HUMAN | [view interactions] | High throughput | no | no |
| TRRAP_HUMAN | [view interactions] | High throughput | no | no |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MEP50_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| DHSO_HUMAN | [view interactions] | High throughput | no | no |
| STABP_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| NDKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| TALDO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| DPH2_HUMAN | [view interactions] | High throughput | no | no |
| AIFM3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CGL_HUMAN | [view interactions] | High throughput | no | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RA1L2_HUMAN | [view interactions] | High throughput | no | no |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| SPS1_HUMAN | [view interactions] | High throughput | no | yes |
| TTC38_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| SPEB_HUMAN | [view interactions] | High throughput | no | no |
| HYES_HUMAN | [view interactions] | High throughput | no | no |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| SPRC_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| AACS_HUMAN | [view interactions] | High throughput | no | yes |
| MVD1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| DLP1_HUMAN | [view interactions] | High throughput | no | no |
| PCYOX_HUMAN | [view interactions] | High throughput | no | yes |
| ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| PSME4_HUMAN | [view interactions] | High throughput | no | yes |
| CDC27_HUMAN | [view interactions] | High throughput | no | yes |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| HEM1_HUMAN | [view interactions] | High throughput | no | yes |
| FACE1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| SSMM1_HUMAN | [view interactions] | High throughput | no | no |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT2_HUMAN | [view interactions] | High throughput | no | no |
| ABHGA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| DPS1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| NUP88_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| RANG_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DFFA_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BDP1_HUMAN | [view interactions] | High throughput | no | no |
| SEC20_HUMAN | [view interactions] | High throughput | no | yes |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNK_HUMAN | [view interactions] | High throughput | no | yes |
| CDK12_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| DHCR7_HUMAN | [view interactions] | Computational | no | yes |
| NFYB_HUMAN | [view interactions] | Computational | no | yes |
| NGBR_HUMAN | [view interactions] | Computational | no | no |
| FNTB_HUMAN | [view interactions] | Computational | no | no |
| CP51A_HUMAN | [view interactions] | Computational | no | no |
| FNTA_HUMAN | [view interactions] | Computational | no | yes |
| NSDHL_HUMAN | [view interactions] | Computational | no | yes |
| HMCS2_HUMAN | [view interactions] | Computational | no | no |
| NFYA_HUMAN | [view interactions] | Computational | no | yes |
| DHDDS_HUMAN | [view interactions] | Computational | no | no |
| ERG1_HUMAN | [view interactions] | Computational | no | no |
| IDI2_HUMAN | [view interactions] | Computational | no | no |
| MSMO1_HUMAN | [view interactions] | Computational | no | yes |
| IDI1_HUMAN | [view interactions] | Computational | no | yes |
| RSAD2_HUMAN | [view interactions] | Computational | no | yes |
| GGPPS_HUMAN | [view interactions] | Computational | no | yes |
| NFYC_HUMAN | [view interactions] | Computational | no | no |
| SRBP2_HUMAN | [view interactions] | Computational | no | yes |
| HMDH_HUMAN | [view interactions] | Computational | no | yes |
| THIL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FDFT_HUMAN | [view interactions] | Computational | no | yes |
| SRBP1_HUMAN | [view interactions] | Computational | no | yes |
| LSS_HUMAN | [view interactions] | Computational | no | yes |
| KIME_HUMAN | [view interactions] | Computational | no | yes |
| THIC_HUMAN | [view interactions] | Computational | no | yes |