PROF1_HUMAN
Evidence for PS localization
Functions
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PROF1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 25.3012 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 23.4940 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.8916 | 4 | no |
| GO:0003723 | RNA binding | 22.2892 | 4 | yes |
| GO:0019900 | kinase binding | 21.6867 | 4 | no |
| GO:0003779 | actin binding | 21.0843 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 20.4819 | 5 | yes |
| GO:0045296 | cadherin binding | 18.6747 | 4 | yes |
| GO:0051020 | GTPase binding | 11.4458 | 4 | yes |
| GO:0031267 | small GTPase binding | 9.6386 | 5 | yes |
| GO:0035091 | phosphatidylinositol binding | 6.6265 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 4.2169 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 3.6145 | 6 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 3.0120 | 4 | yes |
| GO:0045309 | protein phosphorylated amino acid binding | 3.0120 | 4 | yes |
| GO:0001784 | phosphotyrosine residue binding | 2.4096 | 5 | yes |
| GO:0003785 | actin monomer binding | 1.8072 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PROF1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.0241 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.6024 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 48.1928 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.1928 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.5904 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.3855 | 4 | yes |
| GO:0006996 | organelle organization | 42.1687 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.9639 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.9639 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.1566 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.3494 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.9398 | 5 | no |
| GO:0008104 | protein localization | 34.3373 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.3373 | 5 | no |
| GO:0022607 | cellular component assembly | 33.7349 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.1325 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.3253 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.1205 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 29.5181 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 28.3133 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.3133 | 4 | no |
| GO:0033043 | regulation of organelle organization | 27.7108 | 5 | yes |
| GO:0051049 | regulation of transport | 27.7108 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.1084 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.5060 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 25.9036 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.9036 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 25.9036 | 4 | no |
| GO:0071702 | organic substance transport | 25.9036 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.9036 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.3012 | 5 | yes |
| GO:0010941 | regulation of cell death | 25.3012 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.6988 | 4 | no |
| GO:0036211 | protein modification process | 24.6988 | 4 | no |
| GO:0043412 | macromolecule modification | 24.6988 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 24.6988 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 24.6988 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.6988 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.0964 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.0964 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.0964 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.0964 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.4940 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 22.8916 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 22.8916 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.2892 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2892 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.6867 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.6867 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.6867 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.0843 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 21.0843 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.4819 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.4819 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.4819 | 6 | yes |
| GO:0015031 | protein transport | 20.4819 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.4819 | 4 | no |
| GO:0030334 | regulation of cell migration | 18.0723 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 18.0723 | 5 | yes |
| GO:2000145 | regulation of cell motility | 18.0723 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 17.4699 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 16.8675 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 16.2651 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 15.6627 | 4 | yes |
| GO:0034330 | cell junction organization | 15.6627 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 15.0602 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 15.0602 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 14.4578 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 13.8554 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 13.8554 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 12.0482 | 7 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 11.4458 | 7 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 11.4458 | 6 | yes |
| GO:0032271 | regulation of protein polymerization | 10.2410 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 10.2410 | 4 | yes |
| GO:0030335 | positive regulation of cell migration | 9.6386 | 6 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 9.6386 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 9.6386 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 9.6386 | 5 | yes |
| GO:0010639 | negative regulation of organelle organization | 9.0361 | 6 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 8.4337 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 8.4337 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 8.4337 | 7 | yes |
| GO:0050821 | protein stabilization | 8.4337 | 4 | yes |
| GO:0060491 | regulation of cell projection assembly | 8.4337 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 8.4337 | 6 | yes |
| GO:0031346 | positive regulation of cell projection organization | 7.8313 | 6 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 7.8313 | 5 | yes |
| GO:0050808 | synapse organization | 7.8313 | 5 | yes |
| GO:0051494 | negative regulation of cytoskeleton organization | 7.8313 | 7 | yes |
| GO:1902904 | negative regulation of supramolecular fiber organization | 7.8313 | 6 | yes |
| GO:0031333 | negative regulation of protein-containing complex assembly | 7.2289 | 6 | yes |
| GO:0032273 | positive regulation of protein polymerization | 6.6265 | 7 | yes |
| GO:0051492 | regulation of stress fiber assembly | 6.6265 | 6 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 6.6265 | 6 | yes |
| GO:0010632 | regulation of epithelial cell migration | 6.0241 | 4 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 6.0241 | 6 | yes |
| GO:0030837 | negative regulation of actin filament polymerization | 4.8193 | 7 | yes |
| GO:0030838 | positive regulation of actin filament polymerization | 4.8193 | 7 | yes |
| GO:0032233 | positive regulation of actin filament bundle assembly | 4.8193 | 6 | yes |
| GO:0032272 | negative regulation of protein polymerization | 4.8193 | 7 | yes |
| GO:0099563 | modification of synaptic structure | 4.2169 | 6 | yes |
| GO:1900027 | regulation of ruffle assembly | 3.6145 | 7 | yes |
| GO:0032232 | negative regulation of actin filament bundle assembly | 3.0120 | 6 | yes |
| GO:0010634 | positive regulation of epithelial cell migration | 2.4096 | 5 | yes |
| GO:0032781 | positive regulation of ATP-dependent activity | 2.4096 | 4 | yes |
| GO:0051497 | negative regulation of stress fiber assembly | 2.4096 | 7 | yes |
| GO:0098885 | modification of postsynaptic actin cytoskeleton | 2.4096 | 8 | yes |
| GO:0099010 | modification of postsynaptic structure | 2.4096 | 7 | yes |
| GO:0001843 | neural tube closure | 1.8072 | 5 | yes |
| GO:0060606 | tube closure | 1.8072 | 4 | yes |
| GO:1900029 | positive regulation of ruffle assembly | 1.8072 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PROF1_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 3.0120 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.4096 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.4096 | 5 | no |
| DOID:1289 | neurodegenerative disease | 2.4096 | 4 | no |
| DOID:331 | central nervous system disease | 2.4096 | 3 | no |
| DOID:2843 | long QT syndrome | 1.8072 | 6 | no |
| DOID:0050890 | synucleinopathy | 1.8072 | 5 | no |
| DOID:0060894 | early-onset Parkinsons disease | 1.8072 | 7 | no |
| DOID:14330 | Parkinsons disease | 1.8072 | 6 | no |
| DOID:574 | peripheral nervous system disease | 1.2048 | 3 | no |
| DOID:870 | neuropathy | 1.2048 | 4 | no |
| DOID:936 | brain disease | 1.2048 | 4 | no |
| DOID:0050686 | organ system cancer | 1.2048 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AFAD_HUMAN | [view interactions] | Low throughput | no | yes |
| XPO6_HUMAN | [view interactions] | Low throughput | no | yes |
| GLRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FMNL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYPOP_HUMAN | [view interactions] | Low throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NAA80_HUMAN | [view interactions] | Low throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | Low throughput | no | yes |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOQ_HUMAN | [view interactions] | Low throughput | no | no |
| VIPR1_HUMAN | [view interactions] | Low throughput | no | yes |
| ENAH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAD51_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| WASF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DIAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VASP_HUMAN | [view interactions] | Low throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP13C_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| WIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| DMRTB_HUMAN | [view interactions] | High throughput | no | no |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| AHNK2_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF7_HUMAN | [view interactions] | High throughput | no | yes |
| AKP13_HUMAN | [view interactions] | High throughput | no | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA13_HUMAN | [view interactions] | High throughput | no | yes |
| ANKH1_HUMAN | [view interactions] | High throughput | no | yes |
| ANR26_HUMAN | [view interactions] | High throughput | no | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG35_HUMAN | [view interactions] | High throughput | no | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG05_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| CARL1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| CDC23_HUMAN | [view interactions] | High throughput | no | yes |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CE350_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| CEP97_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| CT2NL_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| DCP1B_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| ASB1_HUMAN | [view interactions] | High throughput | no | yes |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| ASB2_HUMAN | [view interactions] | High throughput | no | no |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| ASB12_HUMAN | [view interactions] | High throughput | no | no |
| DJC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EF2K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| F135A_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| GGA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| IFT74_HUMAN | [view interactions] | High throughput | no | yes |
| SAC2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| KI13A_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| KNTC1_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| LIMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYO9A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| TISD_HUMAN | [view interactions] | High throughput | no | no |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| KPB1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| R3HCL_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| RBGP1_HUMAN | [view interactions] | High throughput | no | yes |
| EYA1_HUMAN | [view interactions] | High throughput | no | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPGF6_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASF5_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| RBM11_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
| RHGBB_HUMAN | [view interactions] | High throughput | no | no |
| SH319_HUMAN | [view interactions] | High throughput | no | no |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| SI1L2_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN3_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNRG_HUMAN | [view interactions] | High throughput | no | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYTC_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBD2B_HUMAN | [view interactions] | High throughput | no | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD3_HUMAN | [view interactions] | High throughput | no | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEX2_HUMAN | [view interactions] | High throughput | no | yes |
| ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
| THADA_HUMAN | [view interactions] | High throughput | no | yes |
| PTMS_HUMAN | [view interactions] | High throughput | no | yes |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMF1_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| TB182_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTF2_HUMAN | [view interactions] | High throughput | no | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| REN3B_HUMAN | [view interactions] | High throughput | no | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR44_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDR62_HUMAN | [view interactions] | High throughput | no | no |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP3_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHSL1_HUMAN | [view interactions] | High throughput | no | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| SWAHC_HUMAN | [view interactions] | High throughput | no | no |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| K1522_HUMAN | [view interactions] | High throughput | no | yes |
| FMN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EVL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMNL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BPIA3_HUMAN | [view interactions] | High throughput | no | no |
| MTFR1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAPH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| DIAP2_HUMAN | [view interactions] | High throughput | no | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI15_HUMAN | [view interactions] | High throughput | no | no |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RM53_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| TYB10_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALG13_HUMAN | [view interactions] | High throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFP1_HUMAN | [view interactions] | High throughput | no | no |
| RHG29_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGB_HUMAN | [view interactions] | High throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT6_HUMAN | [view interactions] | High throughput | no | yes |
| CF132_HUMAN | [view interactions] | High throughput | no | no |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF16_HUMAN | [view interactions] | High throughput | no | no |
| CP131_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| COBL1_HUMAN | [view interactions] | High throughput | no | yes |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| COG1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| CRBG3_HUMAN | [view interactions] | High throughput | no | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| DOCK4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAD52_HUMAN | [view interactions] | High throughput | no | no |
| DOP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| FHOD1_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCC2_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA3_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| JMY_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDIS_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF15_HUMAN | [view interactions] | High throughput | no | no |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| KIF7_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP9_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| MRTFA_HUMAN | [view interactions] | High throughput | no | yes |
| MON2_HUMAN | [view interactions] | High throughput | no | no |
| PHOP1_HUMAN | [view interactions] | High throughput | no | no |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRF2_HUMAN | [view interactions] | High throughput | no | yes |
| MTSS2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO9B_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| N4BP2_HUMAN | [view interactions] | High throughput | no | yes |
| CBLB_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| NBAS_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RLGPB_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| SCIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| ERG28_HUMAN | [view interactions] | High throughput | no | yes |
| SHOT1_HUMAN | [view interactions] | High throughput | no | no |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| TLE1_HUMAN | [view interactions] | High throughput | no | yes |
| SOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK068_HUMAN | [view interactions] | High throughput | no | yes |
| STX5_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AF10_HUMAN | [view interactions] | High throughput | no | no |
| SYNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | Computational | no | no |
| AB1IP_HUMAN | [view interactions] | Computational | no | no |
| DAAM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FMN1_HUMAN | [view interactions] | Computational | no | no |
| WASP_HUMAN | [view interactions] | Computational | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PROF4_HUMAN | [view interactions] | Computational | no | no |
| PROF3_HUMAN | [view interactions] | Computational | no | no |