DOCK4_HUMAN
Evidence for PS localization
Functions
Has a higher guanine nucleotide exchange factor activity compared to other isoforms. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DOCK4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 73.2673 | 4 | no |
| GO:0019900 | kinase binding | 16.8317 | 4 | yes |
| GO:0019901 | protein kinase binding | 16.8317 | 5 | yes |
| GO:0017124 | SH3 domain binding | 6.9307 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 5.9406 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 4.9505 | 5 | yes |
| GO:0030971 | receptor tyrosine kinase binding | 2.9703 | 4 | yes |
| GO:0031267 | small GTPase binding | 2.9703 | 5 | yes |
| GO:0051020 | GTPase binding | 2.9703 | 4 | yes |
| GO:1990782 | protein tyrosine kinase binding | 2.9703 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DOCK4_HUMAN |
|---|---|---|---|---|
| GO:0009059 | macromolecule biosynthetic process | 68.3168 | 4 | no |
| GO:0034645 | cellular macromolecule biosynthetic process | 68.3168 | 4 | no |
| GO:0006518 | peptide metabolic process | 67.3267 | 4 | no |
| GO:0043603 | cellular amide metabolic process | 67.3267 | 4 | no |
| GO:0006412 | translation | 66.3366 | 4 | no |
| GO:0043043 | peptide biosynthetic process | 66.3366 | 5 | no |
| GO:0043604 | amide biosynthetic process | 66.3366 | 5 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 66.3366 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 66.3366 | 4 | no |
| GO:0002181 | cytoplasmic translation | 64.3564 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.5941 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.6040 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.6040 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.6139 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 37.6238 | 4 | yes |
| GO:0010468 | regulation of gene expression | 32.6733 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 32.6733 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.6931 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 28.7129 | 4 | no |
| GO:0010646 | regulation of cell communication | 28.7129 | 4 | no |
| GO:0022607 | cellular component assembly | 28.7129 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.7228 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.7327 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.7327 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.7327 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.7426 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.7525 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7723 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.7723 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 21.7822 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.7822 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.7822 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.7921 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.7921 | 6 | no |
| GO:0007264 | small GTPase mediated signal transduction | 7.9208 | 4 | yes |
| GO:0030334 | regulation of cell migration | 5.9406 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 5.9406 | 4 | yes |
| GO:2000145 | regulation of cell motility | 5.9406 | 4 | yes |
| GO:0030335 | positive regulation of cell migration | 4.9505 | 6 | yes |
| GO:0040017 | positive regulation of locomotion | 4.9505 | 4 | yes |
| GO:0060326 | cell chemotaxis | 4.9505 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 4.9505 | 5 | yes |
| GO:0044057 | regulation of system process | 2.9703 | 4 | yes |
| GO:0003018 | vascular process in circulatory system | 1.9802 | 4 | yes |
| GO:0006937 | regulation of muscle contraction | 1.9802 | 6 | yes |
| GO:0006940 | regulation of smooth muscle contraction | 1.9802 | 7 | yes |
| GO:0014910 | regulation of smooth muscle cell migration | 1.9802 | 6 | yes |
| GO:0014911 | positive regulation of smooth muscle cell migration | 1.9802 | 7 | yes |
| GO:0090257 | regulation of muscle system process | 1.9802 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RN115_HUMAN | [view interactions] | Low throughput | no | yes |
| ELMO1_HUMAN | [view interactions] | Low throughput | no | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| UBP36_HUMAN | [view interactions] | Low throughput | no | yes |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHGBB_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ELMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGN_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ELMO3_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERMAP_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| ABR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG36_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGH_HUMAN | [view interactions] | High throughput | no | yes |
| GAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RL22L_HUMAN | [view interactions] | High throughput | no | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOCK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUL1_HUMAN | [view interactions] | High throughput | no | no |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLHL1_HUMAN | [view interactions] | High throughput | no | no |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS30_HUMAN | [view interactions] | Computational | no | yes |
| RACK1_HUMAN | [view interactions] | Computational | no | yes |
| RLA0_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL29_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL26_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RLA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL35_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL26L_HUMAN | [view interactions] | Computational | no | yes |
| RL11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL31_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| USH1C_HUMAN | [view interactions] | Computational | no | yes |
| RSSA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL3L_HUMAN | [view interactions] | Computational | no | no |
| RS15A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS21_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS23_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL18A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL10L_HUMAN | [view interactions] | Computational | no | no |
| RS29_HUMAN | [view interactions] | Computational | no | yes |
| RS20_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL37_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RS13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL38_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL21_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS28_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL28_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL36_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL15_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RL27_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PDGFB_HUMAN | [view interactions] | Computational | no | yes |
| DHX37_HUMAN | [view interactions] | Computational | no | yes |
| RS27L_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RL13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL30_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL32_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL24_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL37A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WDR31_HUMAN | [view interactions] | Computational | no | yes |
| RL3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL39_HUMAN | [view interactions] | Computational | no | no |
| RLA1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RL19_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PGFRB_HUMAN | [view interactions] | Computational | no | yes |
| RT07_HUMAN | [view interactions] | Computational | no | yes |
| RS9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL39L_HUMAN | [view interactions] | Computational | no | no |
| EF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RS15_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| EF1G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RSRC1_HUMAN | [view interactions] | Computational | no | yes |
| RL5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL23_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL10A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL34_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS24_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS16_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS26_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS19_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLEC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RL13A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RLP24_HUMAN | [view interactions] | Computational | no | yes |
| SRC8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL22_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RL36L_HUMAN | [view interactions] | Computational | no | no |
| RL4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |