Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DOCK4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Has a higher guanine nucleotide exchange factor activity compared to other isoforms. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DOCK4_HUMAN
GO:0019900 kinase binding 38.7097 4 yes
GO:0019901 protein kinase binding 35.4839 5 yes
GO:0043168 anion binding 25.8065 4 no
GO:0003723 RNA binding 25.8065 4 no
GO:0000166 nucleotide binding 22.5806 4 no
GO:0017076 purine nucleotide binding 22.5806 5 no
GO:0032555 purine ribonucleotide binding 22.5806 4 no
GO:0043169 cation binding 22.5806 4 no
GO:0046872 metal ion binding 22.5806 5 no
GO:0017124 SH3 domain binding 19.3548 4 yes
GO:0030695 GTPase regulator activity 19.3548 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 12.9032 5 yes
GO:0005096 GTPase activator activity 12.9032 4 yes
GO:0030971 receptor tyrosine kinase binding 12.9032 4 yes
GO:1990782 protein tyrosine kinase binding 12.9032 6 yes
GO:0031267 small GTPase binding 9.6774 5 yes
GO:0051020 GTPase binding 9.6774 4 yes
GO:0030165 PDZ domain binding 6.4516 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DOCK4_HUMAN
GO:0048522 positive regulation of cellular process 74.1935 4 yes
GO:0031323 regulation of cellular metabolic process 70.9677 4 no
GO:0010646 regulation of cell communication 67.7419 4 no
GO:0048523 negative regulation of cellular process 67.7419 4 no
GO:0060255 regulation of macromolecule metabolic process 67.7419 4 no
GO:0080090 regulation of primary metabolic process 64.5161 4 no
GO:0009966 regulation of signal transduction 58.0645 4 no
GO:0009889 regulation of biosynthetic process 54.8387 4 no
GO:0009893 positive regulation of metabolic process 54.8387 4 no
GO:0010468 regulation of gene expression 54.8387 6 no
GO:0010556 regulation of macromolecule biosynthetic process 54.8387 5 no
GO:0031325 positive regulation of cellular metabolic process 54.8387 5 no
GO:0031326 regulation of cellular biosynthetic process 54.8387 5 no
GO:0051128 regulation of cellular component organization 54.8387 4 no
GO:0051246 regulation of protein metabolic process 54.8387 5 no
GO:0010604 positive regulation of macromolecule metabolic process 51.6129 5 no
GO:0009892 negative regulation of metabolic process 48.3871 4 no
GO:0010605 negative regulation of macromolecule metabolic process 48.3871 5 no
GO:0006996 organelle organization 48.3871 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.9355 5 no
GO:0051252 regulation of RNA metabolic process 41.9355 5 no
GO:1902531 regulation of intracellular signal transduction 41.9355 5 no
GO:0031324 negative regulation of cellular metabolic process 41.9355 5 no
GO:0019220 regulation of phosphate metabolic process 38.7097 6 no
GO:0031399 regulation of protein modification process 38.7097 6 no
GO:0051174 regulation of phosphorus metabolic process 38.7097 5 no
GO:0051247 positive regulation of protein metabolic process 38.7097 6 no
GO:0006355 regulation of DNA-templated transcription 35.4839 7 no
GO:0009891 positive regulation of biosynthetic process 35.4839 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 35.4839 6 no
GO:0031328 positive regulation of cellular biosynthetic process 35.4839 6 no
GO:0051248 negative regulation of protein metabolic process 35.4839 6 no
GO:2001141 regulation of RNA biosynthetic process 35.4839 6 no
GO:0001932 regulation of protein phosphorylation 35.4839 7 no
GO:0008104 protein localization 35.4839 4 no
GO:0022607 cellular component assembly 35.4839 4 no
GO:0042325 regulation of phosphorylation 35.4839 7 no
GO:0048584 positive regulation of response to stimulus 32.2581 4 no
GO:0007010 cytoskeleton organization 32.2581 5 no
GO:0009890 negative regulation of biosynthetic process 32.2581 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 32.2581 6 no
GO:0031327 negative regulation of cellular biosynthetic process 32.2581 6 no
GO:0031401 positive regulation of protein modification process 29.0323 7 no
GO:0010629 negative regulation of gene expression 29.0323 7 no
GO:0031344 regulation of cell projection organization 29.0323 5 no
GO:0051241 negative regulation of multicellular organismal process 25.8065 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 25.8065 8 no
GO:0009968 negative regulation of signal transduction 25.8065 5 no
GO:0010648 negative regulation of cell communication 25.8065 5 no
GO:0023057 negative regulation of signaling 25.8065 4 no
GO:0042981 regulation of apoptotic process 25.8065 5 no
GO:0043067 regulation of programmed cell death 25.8065 4 no
GO:0045893 positive regulation of DNA-templated transcription 25.8065 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.8065 5 no
GO:0048585 negative regulation of response to stimulus 25.8065 4 no
GO:0051254 positive regulation of RNA metabolic process 25.8065 6 no
GO:1902680 positive regulation of RNA biosynthetic process 25.8065 7 no
GO:0001934 positive regulation of protein phosphorylation 25.8065 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.8065 6 no
GO:0042327 positive regulation of phosphorylation 25.8065 8 no
GO:0043085 positive regulation of catalytic activity 25.8065 4 no
GO:0043549 regulation of kinase activity 25.8065 5 no
GO:0045859 regulation of protein kinase activity 25.8065 6 no
GO:0045937 positive regulation of phosphate metabolic process 25.8065 7 no
GO:0051338 regulation of transferase activity 25.8065 4 no
GO:0051129 negative regulation of cellular component organization 25.8065 5 no
GO:0051130 positive regulation of cellular component organization 25.8065 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.8065 6 no
GO:0050804 modulation of chemical synaptic transmission 25.8065 5 no
GO:0099177 regulation of trans-synaptic signaling 25.8065 4 no
GO:0141124 intracellular signaling cassette 22.5806 4 yes
GO:0043086 negative regulation of catalytic activity 22.5806 4 no
GO:0002684 positive regulation of immune system process 22.5806 4 no
GO:0032101 regulation of response to external stimulus 22.5806 4 no
GO:0001817 regulation of cytokine production 22.5806 4 no
GO:0010647 positive regulation of cell communication 22.5806 5 no
GO:0023056 positive regulation of signaling 22.5806 4 no
GO:0043933 protein-containing complex organization 22.5806 4 no
GO:0031400 negative regulation of protein modification process 22.5806 7 no
GO:0007264 small GTPase-mediated signal transduction 19.3548 5 yes
GO:0030334 regulation of cell migration 16.1290 5 yes
GO:2000145 regulation of cell motility 16.1290 4 yes
GO:0030335 positive regulation of cell migration 12.9032 6 yes
GO:0040017 positive regulation of locomotion 12.9032 4 yes
GO:2000147 positive regulation of cell motility 12.9032 5 yes
GO:0044057 regulation of system process 9.6774 4 yes
GO:0060326 cell chemotaxis 9.6774 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RN115_HUMAN [view interactions] Low throughput no yes
ELMO1_HUMAN [view entry] [view interactions] Low throughput yes no
EGFR_HUMAN [view interactions] Low throughput no no
UBP36_HUMAN [view interactions] Low throughput no yes
TNFL6_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
RHGBB_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPL_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
GRK5_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
MGN_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
ELMO3_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ERMAP_HUMAN [view interactions] High throughput no yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
VSIG8_HUMAN [view interactions] High throughput no no
SNH28_HUMAN [view interactions] High throughput no no
SNAI1_HUMAN [view interactions] High throughput no yes
LTN1_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ARHG1_HUMAN [view interactions] High throughput no no
ABR_HUMAN [view entry] [view interactions] High throughput yes yes
RHG36_HUMAN [view interactions] High throughput no yes
ARHGH_HUMAN [view interactions] High throughput no yes
GAR1_HUMAN [view interactions] High throughput no yes
RL22L_HUMAN [view interactions] High throughput no no
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
EFNA4_HUMAN [view interactions] High throughput no no
GLPA_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK3_HUMAN [view entry] [view interactions] High throughput yes yes
MUL1_HUMAN [view interactions] High throughput no no
IDD_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ZDH15_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL1_HUMAN [view interactions] High throughput no no
KS6A1_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A2_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
GRRE1_HUMAN [view interactions] High throughput no no
K2C8_HUMAN [view interactions] High throughput no no
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI_HUMAN [view interactions] High throughput no yes
SYNE3_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
DDA1_HUMAN [view interactions] High throughput no yes