Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DOCK3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DOCK3_HUMAN
GO:0019900 kinase binding 54.5455 4 no
GO:0019901 protein kinase binding 54.5455 5 no
GO:0046872 metal ion binding 31.8182 4 no
GO:0017076 purine nucleotide binding 31.8182 4 no
GO:0032555 purine ribonucleotide binding 31.8182 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.8182 4 no
GO:0017124 SH3 domain binding 27.2727 4 yes
GO:0003723 RNA binding 27.2727 4 no
GO:0005524 ATP binding 22.7273 5 no
GO:0030554 adenyl nucleotide binding 22.7273 5 no
GO:0032559 adenyl ribonucleotide binding 22.7273 5 no
GO:0046875 ephrin receptor binding 22.7273 4 no
GO:0030695 GTPase regulator activity 13.6364 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 9.0909 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DOCK3_HUMAN
GO:0048522 positive regulation of cellular process 72.7273 4 yes
GO:0031323 regulation of cellular metabolic process 68.1818 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 63.6364 4 yes
GO:0060255 regulation of macromolecule metabolic process 63.6364 4 yes
GO:0080090 regulation of primary metabolic process 63.6364 4 yes
GO:0009893 positive regulation of metabolic process 59.0909 4 yes
GO:1902531 regulation of intracellular signal transduction 54.5455 5 yes
GO:0009966 regulation of signal transduction 54.5455 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 54.5455 5 yes
GO:0010646 regulation of cell communication 54.5455 4 yes
GO:0031325 positive regulation of cellular metabolic process 54.5455 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 yes
GO:0006996 organelle organization 50.0000 4 no
GO:0051128 regulation of cellular component organization 45.4545 4 no
GO:0048523 negative regulation of cellular process 45.4545 4 no
GO:0051174 regulation of phosphorus metabolic process 40.9091 5 yes
GO:0051246 regulation of protein metabolic process 40.9091 5 yes
GO:0051049 regulation of transport 40.9091 4 no
GO:0010562 positive regulation of phosphorus metabolic process 40.9091 6 yes
GO:0019220 regulation of phosphate metabolic process 40.9091 6 yes
GO:0042325 regulation of phosphorylation 40.9091 7 yes
GO:0042327 positive regulation of phosphorylation 40.9091 8 yes
GO:0043085 positive regulation of catalytic activity 40.9091 4 yes
GO:0045937 positive regulation of phosphate metabolic process 40.9091 7 yes
GO:0051247 positive regulation of protein metabolic process 36.3636 6 yes
GO:0010468 regulation of gene expression 36.3636 5 no
GO:0036211 protein modification process 36.3636 4 no
GO:0043412 macromolecule modification 36.3636 4 no
GO:0009892 negative regulation of metabolic process 36.3636 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.3636 5 no
GO:0051726 regulation of cell cycle 36.3636 4 no
GO:0001932 regulation of protein phosphorylation 36.3636 7 yes
GO:0001934 positive regulation of protein phosphorylation 36.3636 8 yes
GO:0031399 regulation of protein modification process 36.3636 6 yes
GO:0031401 positive regulation of protein modification process 36.3636 7 yes
GO:0051338 regulation of transferase activity 31.8182 4 yes
GO:0051347 positive regulation of transferase activity 31.8182 5 yes
GO:0009889 regulation of biosynthetic process 31.8182 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.8182 5 no
GO:0031326 regulation of cellular biosynthetic process 31.8182 5 no
GO:0051130 positive regulation of cellular component organization 31.8182 5 no
GO:0031324 negative regulation of cellular metabolic process 31.8182 5 no
GO:0051050 positive regulation of transport 31.8182 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 31.8182 5 no
GO:0051336 regulation of hydrolase activity 31.8182 4 no
GO:0006796 phosphate-containing compound metabolic process 31.8182 4 no
GO:0033674 positive regulation of kinase activity 31.8182 6 yes
GO:0043549 regulation of kinase activity 31.8182 5 yes
GO:0022607 cellular component assembly 27.2727 4 no
GO:0043254 regulation of protein-containing complex assembly 27.2727 5 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0044089 positive regulation of cellular component biogenesis 27.2727 5 no
GO:0051252 regulation of RNA metabolic process 27.2727 5 no
GO:0044057 regulation of system process 27.2727 4 no
GO:0051248 negative regulation of protein metabolic process 27.2727 6 no
GO:0006468 protein phosphorylation 27.2727 5 no
GO:0007010 cytoskeleton organization 27.2727 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 27.2727 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 27.2727 5 no
GO:0008104 protein localization 27.2727 4 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0010941 regulation of cell death 27.2727 4 no
GO:0010942 positive regulation of cell death 27.2727 5 no
GO:0016310 phosphorylation 27.2727 5 no
GO:0022603 regulation of anatomical structure morphogenesis 27.2727 4 no
GO:0022604 regulation of cell morphogenesis 27.2727 5 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0030030 cell projection organization 27.2727 4 no
GO:0030155 regulation of cell adhesion 27.2727 4 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0045785 positive regulation of cell adhesion 27.2727 5 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0071310 cellular response to organic substance 27.2727 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 no
GO:0120036 plasma membrane bounded cell projection organization 27.2727 5 no
GO:1902533 positive regulation of intracellular signal transduction 27.2727 6 no
GO:0045859 regulation of protein kinase activity 27.2727 6 yes
GO:0045860 positive regulation of protein kinase activity 27.2727 7 yes
GO:0051056 regulation of small GTPase mediated signal transduction 22.7273 6 yes
GO:0006355 regulation of DNA-templated transcription 22.7273 6 no
GO:0010556 regulation of macromolecule biosynthetic process 22.7273 5 no
GO:0043933 protein-containing complex organization 22.7273 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.7273 6 no
GO:0065003 protein-containing complex assembly 22.7273 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.7273 7 no
GO:2001141 regulation of RNA biosynthetic process 22.7273 6 no
GO:0010564 regulation of cell cycle process 22.7273 5 no
GO:0010959 regulation of metal ion transport 22.7273 6 no
GO:0031400 negative regulation of protein modification process 22.7273 7 no
GO:0034762 regulation of transmembrane transport 22.7273 4 no
GO:0034765 regulation of ion transmembrane transport 22.7273 5 no
GO:0043269 regulation of ion transport 22.7273 5 no
GO:0051345 positive regulation of hydrolase activity 22.7273 5 no
GO:0051924 regulation of calcium ion transport 22.7273 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 22.7273 7 no
GO:1903169 regulation of calcium ion transmembrane transport 22.7273 7 no
GO:1903522 regulation of blood circulation 22.7273 5 no
GO:1904062 regulation of cation transmembrane transport 22.7273 6 no
GO:0007015 actin filament organization 22.7273 5 no
GO:0010243 response to organonitrogen compound 22.7273 4 no
GO:0010638 positive regulation of organelle organization 22.7273 6 no
GO:0010810 regulation of cell-substrate adhesion 22.7273 5 no
GO:0014070 response to organic cyclic compound 22.7273 4 no
GO:0016192 vesicle-mediated transport 22.7273 4 no
GO:0030100 regulation of endocytosis 22.7273 5 no
GO:0030334 regulation of cell migration 22.7273 5 no
GO:0030335 positive regulation of cell migration 22.7273 6 no
GO:0031346 positive regulation of cell projection organization 22.7273 6 no
GO:0032956 regulation of actin cytoskeleton organization 22.7273 5 no
GO:0032970 regulation of actin filament-based process 22.7273 4 no
GO:0040017 positive regulation of locomotion 22.7273 4 no
GO:0042981 regulation of apoptotic process 22.7273 6 no
GO:0043065 positive regulation of apoptotic process 22.7273 7 no
GO:0043067 regulation of programmed cell death 22.7273 5 no
GO:0043068 positive regulation of programmed cell death 22.7273 6 no
GO:0051094 positive regulation of developmental process 22.7273 4 no
GO:0051493 regulation of cytoskeleton organization 22.7273 6 no
GO:0060627 regulation of vesicle-mediated transport 22.7273 4 no
GO:0070848 response to growth factor 22.7273 4 no
GO:0071363 cellular response to growth factor stimulus 22.7273 5 no
GO:0080134 regulation of response to stress 22.7273 4 no
GO:0097435 supramolecular fiber organization 22.7273 4 no
GO:1901701 cellular response to oxygen-containing compound 22.7273 4 no
GO:2000145 regulation of cell motility 22.7273 4 no
GO:2000147 positive regulation of cell motility 22.7273 5 no
GO:0031175 neuron projection development 22.7273 6 no
GO:0061024 membrane organization 22.7273 4 no
GO:0007264 small GTPase mediated signal transduction 22.7273 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 18.1818 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 18.1818 9 yes
GO:0061097 regulation of protein tyrosine kinase activity 9.0909 7 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 9.0909 8 yes
GO:1903995 regulation of non-membrane spanning protein tyrosine kinase activity 9.0909 8 yes
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity 9.0909 9 yes

Disease

Term Name % Distance from top the of the tree Annotated in DOCK3_HUMAN
DOID:0050700 cardiomyopathy 9.0909 4 no
DOID:0060036 intrinsic cardiomyopathy 9.0909 5 no
DOID:114 heart disease 9.0909 3 no
DOID:2843 long QT syndrome 9.0909 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CASL_HUMAN [view interactions] Low throughput no yes
ELMO1_HUMAN [view interactions] Low throughput no no
GAR1_HUMAN [view interactions] High throughput no yes
MAGD2_HUMAN [view interactions] High throughput no yes
METK2_HUMAN [view interactions] High throughput no no
P5CR2_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
SIR5_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
YMEL1_HUMAN [view interactions] High throughput no yes
TBC24_HUMAN [view entry] [view interactions] High throughput yes yes
H6ST3_HUMAN [view interactions] High throughput no no
AIDA_HUMAN [view interactions] High throughput no yes
TREX2_HUMAN [view interactions] High throughput no no
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
HS3S4_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
KHDR1_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
UBP7_HUMAN [view interactions] High throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
RHG05_HUMAN [view interactions] High throughput no yes
TRAF4_HUMAN [view interactions] High throughput no yes
ZNF24_HUMAN [view interactions] High throughput no yes
SURF4_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
ZN768_HUMAN [view interactions] High throughput no yes
UBP2L_HUMAN [view interactions] High throughput no yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
SC16A_HUMAN [view interactions] High throughput no yes
SEC13_HUMAN [view entry] [view interactions] High throughput yes yes
REPI1_HUMAN [view interactions] High throughput no yes
HACD3_HUMAN [view interactions] High throughput no yes
PSMD3_HUMAN [view interactions] High throughput no yes
RM47_HUMAN [view interactions] High throughput no yes
HLAC_HUMAN [view interactions] High throughput no no
GCN1_HUMAN [view interactions] High throughput no yes
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
DHCR7_HUMAN [view interactions] High throughput no yes
CCD47_HUMAN [view interactions] High throughput no yes
ATPK_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ABCD3_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
DDX21_HUMAN [view interactions] High throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
HXA1_HUMAN [view interactions] High throughput no no
PKHF2_HUMAN [view interactions] High throughput no yes
ELMO3_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CIRBP_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
SL9A9_HUMAN [view interactions] Computational no yes