Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DOCK3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DOCK3_HUMAN
GO:0019900 kinase binding 45.8333 4 no
GO:0019901 protein kinase binding 45.8333 5 no
GO:0017124 SH3 domain binding 29.1667 4 yes
GO:0043169 cation binding 29.1667 4 no
GO:0046872 metal ion binding 29.1667 5 no
GO:0000166 nucleotide binding 25.0000 4 no
GO:0017076 purine nucleotide binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0043168 anion binding 25.0000 4 no
GO:0003723 RNA binding 25.0000 4 no
GO:0005524 ATP binding 20.8333 5 no
GO:0030554 adenyl nucleotide binding 20.8333 6 no
GO:0032559 adenyl ribonucleotide binding 20.8333 5 no
GO:0046875 ephrin receptor binding 20.8333 4 no
GO:0030695 GTPase regulator activity 16.6667 4 yes
GO:0005096 GTPase activator activity 12.5000 4 yes
GO:0031267 small GTPase binding 12.5000 5 yes
GO:0051020 GTPase binding 12.5000 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 8.3333 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DOCK3_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 58.3333 4 no
GO:0080090 regulation of primary metabolic process 58.3333 4 no
GO:0031323 regulation of cellular metabolic process 54.1667 4 no
GO:0048523 negative regulation of cellular process 54.1667 4 no
GO:0009966 regulation of signal transduction 54.1667 4 yes
GO:0010646 regulation of cell communication 54.1667 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0006996 organelle organization 45.8333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 45.8333 5 no
GO:1902531 regulation of intracellular signal transduction 45.8333 5 yes
GO:0009892 negative regulation of metabolic process 41.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 41.6667 5 no
GO:0048584 positive regulation of response to stimulus 41.6667 4 no
GO:0051049 regulation of transport 41.6667 4 no
GO:0051128 regulation of cellular component organization 41.6667 4 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0141124 intracellular signaling cassette 41.6667 4 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.1667 5 no
GO:0022603 regulation of anatomical structure morphogenesis 29.1667 4 no
GO:0022607 cellular component assembly 29.1667 4 no
GO:0031344 regulation of cell projection organization 29.1667 5 no
GO:0031400 negative regulation of protein modification process 29.1667 7 no
GO:0034762 regulation of transmembrane transport 29.1667 4 no
GO:0036211 protein modification process 29.1667 4 no
GO:0042981 regulation of apoptotic process 29.1667 5 no
GO:0043067 regulation of programmed cell death 29.1667 4 no
GO:0043412 macromolecule modification 29.1667 4 no
GO:0044057 regulation of system process 29.1667 4 no
GO:0048585 negative regulation of response to stimulus 29.1667 4 no
GO:0051336 regulation of hydrolase activity 29.1667 4 no
GO:0071310 cellular response to organic substance 29.1667 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.1667 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 29.1667 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 29.1667 5 yes
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0008104 protein localization 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0034765 regulation of monoatomic ion transmembrane transport 25.0000 5 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0043269 regulation of monoatomic ion transport 25.0000 5 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0051924 regulation of calcium ion transport 25.0000 7 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:1903169 regulation of calcium ion transmembrane transport 25.0000 7 no
GO:1903522 regulation of blood circulation 25.0000 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 25.0000 6 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0002768 immune response-regulating cell surface receptor signaling pathway 20.8333 4 no
GO:0006355 regulation of DNA-templated transcription 20.8333 7 no
GO:0006357 regulation of transcription by RNA polymerase II 20.8333 8 no
GO:0006796 phosphate-containing compound metabolic process 20.8333 4 no
GO:0007015 actin filament organization 20.8333 5 no
GO:0009968 negative regulation of signal transduction 20.8333 5 no
GO:0010243 response to organonitrogen compound 20.8333 4 no
GO:0010563 negative regulation of phosphorus metabolic process 20.8333 6 no
GO:0010648 negative regulation of cell communication 20.8333 5 no
GO:0010975 regulation of neuron projection development 20.8333 7 no
GO:0023057 negative regulation of signaling 20.8333 4 no
GO:0030155 regulation of cell adhesion 20.8333 4 no
GO:0031346 positive regulation of cell projection organization 20.8333 6 no
GO:0033043 regulation of organelle organization 20.8333 5 no
GO:0033674 positive regulation of kinase activity 20.8333 6 no
GO:0034764 positive regulation of transmembrane transport 20.8333 5 no
GO:0042326 negative regulation of phosphorylation 20.8333 8 no
GO:0043065 positive regulation of apoptotic process 20.8333 6 no
GO:0043066 negative regulation of apoptotic process 20.8333 6 no
GO:0043068 positive regulation of programmed cell death 20.8333 5 no
GO:0043069 negative regulation of programmed cell death 20.8333 5 no
GO:0043254 regulation of protein-containing complex assembly 20.8333 5 no
GO:0043549 regulation of kinase activity 20.8333 5 no
GO:0044087 regulation of cellular component biogenesis 20.8333 4 no
GO:0044089 positive regulation of cellular component biogenesis 20.8333 5 no
GO:0045785 positive regulation of cell adhesion 20.8333 5 no
GO:0045859 regulation of protein kinase activity 20.8333 6 no
GO:0045860 positive regulation of protein kinase activity 20.8333 7 no
GO:0045936 negative regulation of phosphate metabolic process 20.8333 7 no
GO:0050778 positive regulation of immune response 20.8333 5 no
GO:0051240 positive regulation of multicellular organismal process 20.8333 4 no
GO:0051338 regulation of transferase activity 20.8333 4 no
GO:0051347 positive regulation of transferase activity 20.8333 5 no
GO:0065003 protein-containing complex assembly 20.8333 5 no
GO:0071363 cellular response to growth factor stimulus 20.8333 4 no
GO:0071417 cellular response to organonitrogen compound 20.8333 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 20.8333 7 no
GO:0080134 regulation of response to stress 20.8333 4 no
GO:0097435 supramolecular fiber organization 20.8333 4 no
GO:1901699 cellular response to nitrogen compound 20.8333 4 no
GO:2001141 regulation of RNA biosynthetic process 20.8333 6 no
GO:0009890 negative regulation of biosynthetic process 20.8333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0022604 regulation of cell morphogenesis 20.8333 5 no
GO:0031327 negative regulation of cellular biosynthetic process 20.8333 6 no
GO:0032880 regulation of protein localization 20.8333 5 no
GO:0060341 regulation of cellular localization 20.8333 4 no
GO:0071702 organic substance transport 20.8333 4 no
GO:0007264 small GTPase-mediated signal transduction 20.8333 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 20.8333 6 yes
GO:0001933 negative regulation of protein phosphorylation 20.8333 8 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 20.8333 4 no
GO:0038179 neurotrophin signaling pathway 8.3333 4 yes
GO:0048011 neurotrophin TRK receptor signaling pathway 8.3333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CASL_HUMAN [view interactions] Low throughput no yes
ELMO1_HUMAN [view entry] [view interactions] Low throughput yes no
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PSN2_HUMAN [view entry] [view interactions] Low throughput yes no
TOP3B_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
KHDR1_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
FYN_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
RHG05_HUMAN [view interactions] High throughput no yes
ABCD3_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ATPK_HUMAN [view interactions] High throughput no yes
CCD47_HUMAN [view interactions] High throughput no yes
DHCR7_HUMAN [view interactions] High throughput no yes
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
GCN1_HUMAN [view interactions] High throughput no yes
HLAC_HUMAN [view interactions] High throughput no no
RM47_HUMAN [view interactions] High throughput no yes
PSMD3_HUMAN [view interactions] High throughput no yes
HACD3_HUMAN [view interactions] High throughput no yes
REPI1_HUMAN [view interactions] High throughput no yes
SEC13_HUMAN [view entry] [view interactions] High throughput yes yes
SC16A_HUMAN [view interactions] High throughput no yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF4_HUMAN [view interactions] High throughput no yes
UBP2L_HUMAN [view interactions] High throughput no yes
ZN768_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
SURF4_HUMAN [view interactions] High throughput no yes
ZNF24_HUMAN [view interactions] High throughput no yes
PDIA4_HUMAN [view interactions] High throughput no yes
DDX21_HUMAN [view interactions] High throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
HXA1_HUMAN [view interactions] High throughput no no
PKHF2_HUMAN [view interactions] High throughput no yes
RSPH1_HUMAN [view interactions] High throughput no no
ELMO3_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CIRBP_HUMAN [view interactions] High throughput no no
GAR1_HUMAN [view interactions] High throughput no yes
MAGD2_HUMAN [view interactions] High throughput no yes
METK2_HUMAN [view interactions] High throughput no no
P5CR2_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
SIR5_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
YMEL1_HUMAN [view interactions] High throughput no yes
TBC24_HUMAN [view entry] [view interactions] High throughput yes yes
H6ST3_HUMAN [view interactions] High throughput no no
AIDA_HUMAN [view interactions] High throughput no yes
TREX2_HUMAN [view interactions] High throughput no no
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
HS3S4_HUMAN [view interactions] High throughput no no