AKAP1_HUMAN
Evidence for PS localization
Functions
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane . Involved in mitochondrial-mediated antiviral innate immunity (PubMed). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity . [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 64%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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AKAP1_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [AKAP1_HUMAN]
Isoform [I3NI36] alignment
Isoform [I3L3V6] alignment
Isoform [I3L3L9] alignment
Isoform [I3L3K1] alignment
Isoform [I3L2N7] alignment
Isoform [I3L364] alignment
Isoform [I3L2A2] alignment
Isoform [I3L0V5] alignment
Isoform [I3L0W0] alignment
Isoform [I3L0K6] alignment
Isoform [A0A0G2JLF7] alignment
Isoform [Q92667-2] alignment
LOADING 26%
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002437 | DOC_PP1_RVXF_1 | DOC | 151 | 158 | - |
| ELMI002437 | DOC_PP1_RVXF_1 | DOC | 151 | 158 | - |
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Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AKAP1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 43.0939 | 4 | no |
| GO:0000166 | nucleotide binding | 41.9890 | 4 | no |
| GO:0017076 | purine nucleotide binding | 39.7790 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 39.7790 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.0166 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 24.8619 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.8619 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.8619 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 23.7569 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.7569 | 5 | no |
| GO:0043169 | cation binding | 23.2044 | 4 | no |
| GO:0003723 | RNA binding | 22.6519 | 4 | yes |
| GO:0046872 | metal ion binding | 22.0994 | 5 | no |
| GO:0005524 | ATP binding | 20.9945 | 5 | no |
| GO:0034237 | protein kinase A regulatory subunit binding | 1.1050 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AKAP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 41.4365 | 4 | no |
| GO:0006996 | organelle organization | 40.3315 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 38.1215 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.4641 | 4 | no |
| GO:0008104 | protein localization | 34.8066 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.2541 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.2541 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.7017 | 4 | no |
| GO:0071702 | organic substance transport | 33.1492 | 4 | no |
| GO:0010646 | regulation of cell communication | 31.4917 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.3867 | 4 | no |
| GO:0015031 | protein transport | 27.0718 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.9669 | 4 | no |
| GO:0022607 | cellular component assembly | 25.4144 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 24.8619 | 5 | no |
| GO:0009966 | regulation of signal transduction | 24.8619 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 24.3094 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.3094 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.2044 | 5 | no |
| GO:0010468 | regulation of gene expression | 22.6519 | 6 | no |
| GO:0051049 | regulation of transport | 22.0994 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.0994 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.0994 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.0994 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.0994 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5NT3A_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAAS_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB7_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALG13_HUMAN | [view interactions] | High throughput | no | yes |
| AMRP_HUMAN | [view interactions] | High throughput | no | yes |
| AMY1A_HUMAN | [view interactions] | Low throughput | no | no |
| AMY1B_HUMAN | [view interactions] | Low throughput | no | no |
| AMY1C_HUMAN | [view interactions] | Low throughput | no | no |
| AOFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB2_HUMAN | [view interactions] | High throughput | no | yes |
| APOL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |