AOFA_HUMAN
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in AOFA_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 35.2941 | 4 | no |
GO:0008131 | primary amine oxidase activity | 17.6471 | 5 | yes |
GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | 17.6471 | 4 | yes |
GO:0050660 | flavin adenine dinucleotide binding | 17.6471 | 4 | yes |
GO:0097621 | monoamine oxidase activity | 17.6471 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in AOFA_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | yes |
GO:0006576 | cellular biogenic amine metabolic process | 41.1765 | 5 | yes |
GO:0006584 | catecholamine metabolic process | 41.1765 | 6 | yes |
GO:0009308 | amine metabolic process | 41.1765 | 4 | yes |
GO:0009712 | catechol-containing compound metabolic process | 41.1765 | 5 | yes |
GO:0010646 | regulation of cell communication | 41.1765 | 4 | yes |
GO:0018958 | phenol-containing compound metabolic process | 41.1765 | 4 | yes |
GO:0042417 | dopamine metabolic process | 41.1765 | 7 | yes |
GO:0044106 | cellular amine metabolic process | 41.1765 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 35.2941 | 5 | yes |
GO:0023056 | positive regulation of signaling | 35.2941 | 4 | yes |
GO:1901565 | organonitrogen compound catabolic process | 35.2941 | 4 | yes |
GO:1901616 | organic hydroxy compound catabolic process | 35.2941 | 4 | yes |
GO:0043269 | regulation of ion transport | 35.2941 | 5 | no |
GO:0048523 | negative regulation of cellular process | 35.2941 | 4 | no |
GO:0051049 | regulation of transport | 35.2941 | 4 | no |
GO:0071702 | organic substance transport | 35.2941 | 4 | no |
GO:0009310 | amine catabolic process | 29.4118 | 5 | yes |
GO:0009966 | regulation of signal transduction | 29.4118 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 29.4118 | 5 | yes |
GO:0019336 | phenol-containing compound catabolic process | 29.4118 | 5 | yes |
GO:0019439 | aromatic compound catabolic process | 29.4118 | 4 | yes |
GO:0019614 | catechol-containing compound catabolic process | 29.4118 | 6 | yes |
GO:0042402 | cellular biogenic amine catabolic process | 29.4118 | 6 | yes |
GO:0042420 | dopamine catabolic process | 29.4118 | 8 | yes |
GO:0042424 | catecholamine catabolic process | 29.4118 | 7 | yes |
GO:0048584 | positive regulation of response to stimulus | 29.4118 | 4 | yes |
GO:1901361 | organic cyclic compound catabolic process | 29.4118 | 4 | yes |
GO:0014070 | response to organic cyclic compound | 29.4118 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 29.4118 | 4 | no |
GO:0033238 | regulation of cellular amine metabolic process | 29.4118 | 5 | no |
GO:0042053 | regulation of dopamine metabolic process | 29.4118 | 6 | no |
GO:0042069 | regulation of catecholamine metabolic process | 29.4118 | 5 | no |
GO:0051046 | regulation of secretion | 29.4118 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 29.4118 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 29.4118 | 4 | no |
GO:1903530 | regulation of secretion by cell | 29.4118 | 4 | no |
GO:0008104 | protein localization | 29.4118 | 4 | no |
GO:0071705 | nitrogen compound transport | 29.4118 | 4 | no |
GO:0010243 | response to organonitrogen compound | 29.4118 | 4 | no |
GO:0051050 | positive regulation of transport | 29.4118 | 4 | no |
GO:0042135 | neurotransmitter catabolic process | 23.5294 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 23.5294 | 4 | no |
GO:0010038 | response to metal ion | 23.5294 | 4 | no |
GO:0006811 | ion transport | 23.5294 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 23.5294 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 23.5294 | 4 | no |
GO:0051094 | positive regulation of developmental process | 23.5294 | 4 | no |
GO:0051128 | regulation of cellular component organization | 23.5294 | 4 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RN180_HUMAN | [view interactions] | Low throughput | no | yes |
AOFA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MID51_HUMAN | [view interactions] | High throughput | no | no |
AOFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
APBB1_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
A2MG_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
INS_HUMAN | [view interactions] | High throughput | no | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
ANDR_HUMAN | [view interactions] | High throughput | no | no |
VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBC17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADH6_HUMAN | [view interactions] | Computational | no | no |
ALDH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
AOC2_HUMAN | [view interactions] | Computational | no | no |
CP2CJ_HUMAN | [view interactions] | Computational | no | no |
DRD4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
IL13_HUMAN | [view interactions] | Computational | no | no |
DOPO_HUMAN | [view interactions] | Computational | no | no |
SC6A3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AOC1_HUMAN | [view interactions] | Computational | no | no |
SC6A4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
I23O2_HUMAN | [view interactions] | Computational | no | no |
AOC3_HUMAN | [view interactions] | Computational | no | no |
PNMT_HUMAN | [view interactions] | Computational | no | no |
SAT1_HUMAN | [view interactions] | Computational | no | yes |
LGUL_HUMAN | [view interactions] | Computational | no | yes |
SAT2_HUMAN | [view interactions] | Computational | no | yes |
HNMT_HUMAN | [view interactions] | Computational | no | yes |
INMT_HUMAN | [view interactions] | Computational | no | no |
AOXA_HUMAN | [view interactions] | Computational | no | no |
COMT_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
OXLA_HUMAN | [view interactions] | Computational | no | no |
ADH4_HUMAN | [view interactions] | Computational | no | no |
AL1B1_HUMAN | [view interactions] | Computational | no | yes |
TPH1_HUMAN | [view interactions] | Computational | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AL3B1_HUMAN | [view interactions] | Computational | no | yes |
GRHPR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
AL3B2_HUMAN | [view interactions] | Computational | no | yes |
AL3A1_HUMAN | [view interactions] | Computational | no | no |
ADH1B_HUMAN | [view interactions] | Computational | no | no |
SNAT_HUMAN | [view interactions] | Computational | no | no |
AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL4_HUMAN | [view interactions] | Computational | no | no |
DDC_HUMAN | [view interactions] | Computational | no | no |
I23O1_HUMAN | [view interactions] | Computational | no | no |