Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AOFA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AOFA_HUMAN
GO:0000166 nucleotide binding 27.2727 4 yes
GO:0008131 primary amine oxidase activity 27.2727 5 yes
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 27.2727 4 yes
GO:0043168 anion binding 27.2727 4 yes
GO:0050660 flavin adenine dinucleotide binding 27.2727 5 yes
GO:0052595 aliphatic amine oxidase activity 27.2727 5 yes
GO:0097621 monoamine oxidase activity 27.2727 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AOFA_HUMAN
GO:0048522 positive regulation of cellular process 63.6364 4 yes
GO:0010646 regulation of cell communication 45.4545 4 yes
GO:0010647 positive regulation of cell communication 45.4545 5 yes
GO:0023056 positive regulation of signaling 45.4545 4 yes
GO:0008104 protein localization 45.4545 4 no
GO:0051049 regulation of transport 45.4545 4 no
GO:0048523 negative regulation of cellular process 45.4545 4 no
GO:0006576 biogenic amine metabolic process 36.3636 5 yes
GO:0006584 catecholamine metabolic process 36.3636 6 yes
GO:0009308 amine metabolic process 36.3636 4 yes
GO:0009712 catechol-containing compound metabolic process 36.3636 5 yes
GO:0009966 regulation of signal transduction 36.3636 4 yes
GO:0009967 positive regulation of signal transduction 36.3636 5 yes
GO:0018958 phenol-containing compound metabolic process 36.3636 4 yes
GO:0042417 dopamine metabolic process 36.3636 7 yes
GO:0048584 positive regulation of response to stimulus 36.3636 4 yes
GO:1901565 organonitrogen compound catabolic process 36.3636 4 yes
GO:0006996 organelle organization 36.3636 4 no
GO:0051046 regulation of secretion 36.3636 5 no
GO:0051050 positive regulation of transport 36.3636 4 no
GO:0071702 organic substance transport 36.3636 4 no
GO:0071705 nitrogen compound transport 36.3636 4 no
GO:1903530 regulation of secretion by cell 36.3636 4 no
GO:0051128 regulation of cellular component organization 36.3636 4 no
GO:0080090 regulation of primary metabolic process 27.2727 4 no
GO:0009310 amine catabolic process 27.2727 5 yes
GO:0019336 phenol-containing compound catabolic process 27.2727 5 yes
GO:0019614 catechol-containing compound catabolic process 27.2727 6 yes
GO:0042402 cellular biogenic amine catabolic process 27.2727 6 yes
GO:0042420 dopamine catabolic process 27.2727 8 yes
GO:0042424 catecholamine catabolic process 27.2727 7 yes
GO:1901361 organic cyclic compound catabolic process 27.2727 4 yes
GO:1901616 organic hydroxy compound catabolic process 27.2727 4 yes
GO:0015031 protein transport 27.2727 4 no
GO:0022607 cellular component assembly 27.2727 4 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0043269 regulation of monoatomic ion transport 27.2727 5 no
GO:0043933 protein-containing complex organization 27.2727 4 no
GO:0050804 modulation of chemical synaptic transmission 27.2727 5 no
GO:0051223 regulation of protein transport 27.2727 5 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0061024 membrane organization 27.2727 4 no
GO:0070201 regulation of establishment of protein localization 27.2727 6 no
GO:0072657 protein localization to membrane 27.2727 4 no
GO:0099177 regulation of trans-synaptic signaling 27.2727 4 no
GO:1903829 positive regulation of protein localization 27.2727 5 no
GO:0009893 positive regulation of metabolic process 27.2727 4 no
GO:0010038 response to metal ion 27.2727 4 no
GO:0022603 regulation of anatomical structure morphogenesis 27.2727 4 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0042981 regulation of apoptotic process 27.2727 5 no
GO:0043067 regulation of programmed cell death 27.2727 4 no
GO:0051094 positive regulation of developmental process 27.2727 4 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RN180_HUMAN [view interactions] Low throughput no yes
AOFA_HUMAN [view entry] [view interactions] Low throughput yes yes
AOFB_HUMAN [view entry] [view interactions] High throughput yes yes
MID51_HUMAN [view interactions] High throughput no no
COQ9_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
A2MG_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
TBC17_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes