Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PRKN_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Substrates include SYT11 and VDAC1 (PubMed, PubMed). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Mediates monoubiquitination as well as Lys-6, Lys-11, Lys-48-linked and Lys-63-linked polyubiquitination of substrates depending on the context (PubMed, PubMed, PubMed, PubMed, PubMed). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating Lys-63-linked polyubiquitination of misfolded proteins such as PARK7: Lys-63-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed, PubMed). Mediates Lys-63-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed, PubMed, PubMed, PubMed, PubMed). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed, PubMed, PubMed, PubMed). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Preferentially assembles Lys-6-, Lys-11- and Lys-63-linked polyubiquitin chains, leading to mitophagy (PubMed, PubMed). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed). Involved in mitochondrial biogenesis via the Lys-48-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed). Limits the production of reactive oxygen species (ROS) (PubMed). Regulates cyclin-E during neuronal apoptosis (PubMed). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
15 Val Met Parkinsondisease2(PARK2) -
33 Arg Gln Parkinsondisease2(PARK2) -
37 Pro Leu Parkinsondisease2(PARK2) -
42 Arg Pro Parkinsondisease(PARK) -
42 Arg Pro Parkinsondisease2(PARK2) -
46 Ala Pro Parkinsondisease2(PARK2) -
82 Ala Glu Parkinsondisease2(PARK2) -
92 Ala Val Parkinsondisease2(PARK2) -
161 Lys Asn Parkinsondisease2(PARK2) -
211 Lys Asn Parkinsondisease2(PARK2) -
212 Cys Tyr Parkinsondisease2(PARK2) -
240 Thr Met Parkinsondisease2(PARK2) -
240 Thr Arg Parkinsondisease2(PARK2) -
253 Cys Tyr Parkinsondisease(PARK) -
256 Arg Cys Parkinsondisease(PARK) -
256 Arg Cys Parkinsondisease2(PARK2) -
275 Arg Trp Parkinsondisease(PARK) -
275 Arg Trp Parkinsondisease2(PARK2) -
280 Asp Asn Parkinsondisease(PARK) -
284 Gly Arg Parkinsondisease2(PARK2) -
289 Cys Gly Parkinsondisease2(PARK2) -
328 Gly Glu Parkinsondisease2(PARK2) -
351 Thr Pro Parkinsondisease2(PARK2) -
415 Thr Asn Parkinsondisease2(PARK2) -
430 Gly Asp Parkinsondisease2(PARK2) -
431 Cys Phe Parkinsondisease2(PARK2) -
437 Pro Leu Parkinsondisease2(PARK2) -
441 Cys Arg Parkinsondisease2(PARK2) -
56 Val Glu Parkinsondisease2(PARK2) -
402 Arg Cys Parkinsondisease2(PARK2) -
418 Cys Arg Parkinsondisease2(PARK2) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PRKN_HUMAN
GO:0003723 RNA binding 42.8571 4 no
GO:0017076 purine nucleotide binding 27.3810 4 no
GO:0032555 purine ribonucleotide binding 26.4881 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.1905 4 no
GO:0030554 adenyl nucleotide binding 21.4286 5 no
GO:0032559 adenyl ribonucleotide binding 20.5357 5 no
GO:0005524 ATP binding 20.2381 5 no
GO:0046872 metal ion binding 16.9643 4 yes
GO:0031625 ubiquitin protein ligase binding 15.4762 5 yes
GO:0044389 ubiquitin-like protein ligase binding 15.4762 4 yes
GO:0019900 kinase binding 13.0952 4 yes
GO:0019901 protein kinase binding 11.9048 5 yes
GO:0003779 actin binding 6.5476 4 yes
GO:0015631 tubulin binding 5.6548 4 yes
GO:0001664 G protein-coupled receptor binding 5.3571 4 yes
GO:0046914 transition metal ion binding 4.1667 5 yes
GO:0008270 zinc ion binding 3.2738 6 yes
GO:0042826 histone deacetylase binding 3.2738 4 yes
GO:0002020 protease binding 2.6786 4 yes
GO:0030544 Hsp70 protein binding 2.3810 4 yes
GO:0017124 SH3 domain binding 2.0833 4 yes
GO:0030165 PDZ domain binding 2.0833 4 yes
GO:0004842 ubiquitin-protein transferase activity 1.7857 4 yes
GO:0044390 ubiquitin-like protein conjugating enzyme binding 1.7857 4 yes
GO:0043130 ubiquitin binding 1.4881 4 yes
GO:1990381 ubiquitin-specific protease binding 1.4881 5 yes
GO:0031624 ubiquitin conjugating enzyme binding 1.1905 5 yes
GO:0043274 phospholipase binding 1.1905 4 yes
GO:0061630 ubiquitin protein ligase activity 0.8929 5 yes
GO:0061659 ubiquitin-like protein ligase activity 0.8929 4 yes
GO:1990444 F-box domain binding 0.5952 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PRKN_HUMAN
GO:0060255 regulation of macromolecule metabolic process 44.6429 4 yes
GO:0080090 regulation of primary metabolic process 44.3452 4 yes
GO:0048522 positive regulation of cellular process 43.7500 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 43.4524 4 yes
GO:0031323 regulation of cellular metabolic process 41.6667 4 yes
GO:0048523 negative regulation of cellular process 36.6071 4 yes
GO:0009893 positive regulation of metabolic process 35.1190 4 yes
GO:0010468 regulation of gene expression 33.6310 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 31.8452 5 yes
GO:0051246 regulation of protein metabolic process 30.0595 5 yes
GO:0009889 regulation of biosynthetic process 29.7619 4 yes
GO:0010646 regulation of cell communication 29.7619 4 yes
GO:0051128 regulation of cellular component organization 29.4643 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 29.4643 5 yes
GO:0031326 regulation of cellular biosynthetic process 29.1667 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.2738 5 yes
GO:0031325 positive regulation of cellular metabolic process 28.2738 5 yes
GO:0044271 cellular nitrogen compound biosynthetic process 28.2738 4 no
GO:0010556 regulation of macromolecule biosynthetic process 27.9762 5 yes
GO:0006996 organelle organization 26.7857 4 yes
GO:1901566 organonitrogen compound biosynthetic process 26.7857 4 no
GO:0022607 cellular component assembly 25.8929 4 yes
GO:0009966 regulation of signal transduction 25.2976 4 yes
GO:0009892 negative regulation of metabolic process 24.4048 4 yes
GO:0009059 macromolecule biosynthetic process 24.4048 4 no
GO:0043603 cellular amide metabolic process 24.1071 4 no
GO:0010941 regulation of cell death 23.8095 4 yes
GO:0051252 regulation of RNA metabolic process 22.3214 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 22.3214 5 yes
GO:0043067 regulation of programmed cell death 22.3214 5 yes
GO:0043604 amide biosynthetic process 22.3214 5 no
GO:0042981 regulation of apoptotic process 22.0238 6 yes
GO:0006518 peptide metabolic process 21.7262 4 no
GO:0034645 cellular macromolecule biosynthetic process 21.7262 4 no
GO:0043933 protein-containing complex organization 21.1310 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 20.8333 5 yes
GO:0051247 positive regulation of protein metabolic process 20.8333 6 yes
GO:0006412 translation 20.8333 4 no
GO:0043043 peptide biosynthetic process 20.8333 5 no
GO:0031324 negative regulation of cellular metabolic process 20.2381 5 yes
GO:1902531 regulation of intracellular signal transduction 19.9405 5 yes
GO:0071702 organic substance transport 19.3452 4 yes
GO:0048584 positive regulation of response to stimulus 19.0476 4 yes
GO:0006355 regulation of DNA-templated transcription 19.0476 6 yes
GO:0008104 protein localization 19.0476 4 yes
GO:1903506 regulation of nucleic acid-templated transcription 19.0476 7 yes
GO:0033043 regulation of organelle organization 19.0476 5 yes
GO:2001141 regulation of RNA biosynthetic process 19.0476 6 yes
GO:0065003 protein-containing complex assembly 18.7500 5 yes
GO:0051049 regulation of transport 18.4524 4 yes
GO:0009894 regulation of catabolic process 18.1548 4 yes
GO:0051130 positive regulation of cellular component organization 17.8571 5 yes
GO:0031399 regulation of protein modification process 17.8571 6 yes
GO:0023056 positive regulation of signaling 17.5595 4 yes
GO:0009891 positive regulation of biosynthetic process 17.2619 5 yes
GO:0071705 nitrogen compound transport 17.2619 4 yes
GO:0080134 regulation of response to stress 17.2619 4 yes
GO:0010647 positive regulation of cell communication 17.2619 5 yes
GO:0071310 cellular response to organic substance 16.9643 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 16.9643 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 16.6667 6 yes
GO:0060548 negative regulation of cell death 16.3690 5 yes
GO:0043412 macromolecule modification 16.3690 4 yes
GO:0010628 positive regulation of gene expression 16.0714 6 yes
GO:0048585 negative regulation of response to stimulus 15.7738 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 15.7738 6 yes
GO:0036211 protein modification process 15.7738 4 yes
GO:0009967 positive regulation of signal transduction 15.4762 5 yes
GO:0051174 regulation of phosphorus metabolic process 15.1786 5 yes
GO:0019220 regulation of phosphate metabolic process 15.1786 6 yes
GO:0043069 negative regulation of programmed cell death 15.1786 6 yes
GO:0010648 negative regulation of cell communication 14.8810 5 yes
GO:0023057 negative regulation of signaling 14.8810 4 yes
GO:0031329 regulation of cellular catabolic process 14.8810 5 yes
GO:0043066 negative regulation of apoptotic process 14.8810 7 yes
GO:0051338 regulation of transferase activity 14.2857 4 yes
GO:0060341 regulation of cellular localization 13.3929 4 yes
GO:0051129 negative regulation of cellular component organization 13.0952 5 yes
GO:0009968 negative regulation of signal transduction 13.0952 5 yes
GO:0010638 positive regulation of organelle organization 13.0952 6 yes
GO:0051248 negative regulation of protein metabolic process 12.7976 6 yes
GO:0042325 regulation of phosphorylation 12.7976 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 12.5000 7 yes
GO:0009057 macromolecule catabolic process 12.5000 4 yes
GO:0030162 regulation of proteolysis 12.5000 6 yes
GO:0051050 positive regulation of transport 11.9048 4 yes
GO:0080135 regulation of cellular response to stress 11.9048 4 yes
GO:0032880 regulation of protein localization 11.9048 5 yes
GO:0001932 regulation of protein phosphorylation 11.6071 7 yes
GO:0009890 negative regulation of biosynthetic process 11.6071 5 yes
GO:0031401 positive regulation of protein modification process 11.6071 7 yes
GO:0044087 regulation of cellular component biogenesis 11.6071 4 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 11.6071 6 yes
GO:0006508 proteolysis 11.3095 4 yes
GO:1902533 positive regulation of intracellular signal transduction 11.3095 6 yes
GO:0010629 negative regulation of gene expression 11.0119 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 11.0119 6 yes
GO:0051253 negative regulation of RNA metabolic process 10.7143 6 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 10.7143 6 yes
GO:2001233 regulation of apoptotic signaling pathway 10.7143 5 yes
GO:0044265 cellular macromolecule catabolic process 10.4167 4 yes
GO:0051094 positive regulation of developmental process 10.1190 4 yes
GO:0051254 positive regulation of RNA metabolic process 10.1190 6 yes
GO:0007005 mitochondrion organization 9.8214 5 yes
GO:0010243 response to organonitrogen compound 9.8214 4 yes
GO:1901565 organonitrogen compound catabolic process 9.8214 4 yes
GO:1901701 cellular response to oxygen-containing compound 9.8214 4 yes
GO:0014070 response to organic cyclic compound 9.8214 4 yes
GO:0016192 vesicle-mediated transport 9.8214 4 yes
GO:0033365 protein localization to organelle 9.8214 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 9.5238 4 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 9.5238 7 yes
GO:0051603 proteolysis involved in protein catabolic process 9.2262 5 yes
GO:0042176 regulation of protein catabolic process 9.2262 5 yes
GO:0043269 regulation of ion transport 9.2262 5 yes
GO:0043549 regulation of kinase activity 9.2262 5 yes
GO:0050821 protein stabilization 8.9286 4 yes
GO:0070201 regulation of establishment of protein localization 8.9286 6 yes
GO:0019941 modification-dependent protein catabolic process 8.9286 6 yes
GO:1902532 negative regulation of intracellular signal transduction 8.9286 6 yes
GO:0031400 negative regulation of protein modification process 8.9286 7 yes
GO:0043632 modification-dependent macromolecule catabolic process 8.9286 5 yes
GO:0009896 positive regulation of catabolic process 8.6310 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 8.6310 7 yes
GO:0031396 regulation of protein ubiquitination 8.6310 8 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 8.6310 8 yes
GO:1903829 positive regulation of protein localization 8.6310 5 yes
GO:0045893 positive regulation of DNA-templated transcription 8.6310 7 yes
GO:0050804 modulation of chemical synaptic transmission 8.3333 5 yes
GO:0006811 ion transport 8.3333 4 yes
GO:0099177 regulation of trans-synaptic signaling 8.3333 4 yes
GO:1902679 negative regulation of RNA biosynthetic process 8.3333 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 8.3333 8 yes
GO:0045892 negative regulation of DNA-templated transcription 8.3333 7 yes
GO:0097435 supramolecular fiber organization 8.0357 4 yes
GO:0010821 regulation of mitochondrion organization 8.0357 6 yes
GO:0043408 regulation of MAPK cascade 8.0357 6 yes
GO:0045862 positive regulation of proteolysis 8.0357 7 yes
GO:0006511 ubiquitin-dependent protein catabolic process 7.7381 7 yes
GO:0030163 protein catabolic process 7.4405 4 yes
GO:0043086 negative regulation of catalytic activity 7.4405 4 yes
GO:0048878 chemical homeostasis 7.1429 4 yes
GO:0060627 regulation of vesicle-mediated transport 7.1429 4 yes
GO:2001234 negative regulation of apoptotic signaling pathway 7.1429 6 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 7.1429 6 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 7.1429 8 yes
GO:1901214 regulation of neuron death 6.8452 5 yes
GO:1902903 regulation of supramolecular fiber organization 6.8452 5 yes
GO:0031331 positive regulation of cellular catabolic process 6.8452 6 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 6.5476 8 yes
GO:0071407 cellular response to organic cyclic compound 6.5476 5 yes
GO:0010639 negative regulation of organelle organization 6.5476 6 yes
GO:1901699 cellular response to nitrogen compound 6.5476 4 yes
GO:1903050 regulation of proteolysis involved in protein catabolic process 6.5476 7 yes
GO:0051051 negative regulation of transport 6.2500 4 yes
GO:0051223 regulation of protein transport 6.2500 5 yes
GO:0051493 regulation of cytoskeleton organization 6.2500 6 yes
GO:0071417 cellular response to organonitrogen compound 6.2500 4 yes
GO:0010506 regulation of autophagy 6.2500 6 yes
GO:0051046 regulation of secretion 5.9524 5 yes
GO:0070647 protein modification by small protein conjugation or removal 5.9524 5 yes
GO:0010038 response to metal ion 5.9524 4 yes
GO:0010498 proteasomal protein catabolic process 5.9524 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 5.9524 6 yes
GO:0045936 negative regulation of phosphate metabolic process 5.9524 7 yes
GO:0051348 negative regulation of transferase activity 5.6548 5 yes
GO:0001558 regulation of cell growth 5.6548 4 yes
GO:1903530 regulation of secretion by cell 5.6548 4 yes
GO:0061136 regulation of proteasomal protein catabolic process 5.3571 6 yes
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 5.3571 6 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 5.3571 6 yes
GO:0050801 ion homeostasis 5.0595 5 yes
GO:0006812 cation transport 5.0595 5 yes
GO:0006986 response to unfolded protein 5.0595 4 yes
GO:0098771 inorganic ion homeostasis 5.0595 6 yes
GO:0042326 negative regulation of phosphorylation 5.0595 8 yes
GO:0045732 positive regulation of protein catabolic process 5.0595 6 yes
GO:0050890 cognition 4.7619 4 yes
GO:0051093 negative regulation of developmental process 4.7619 4 yes
GO:0001933 negative regulation of protein phosphorylation 4.7619 8 yes
GO:0055080 cation homeostasis 4.7619 6 yes
GO:0022411 cellular component disassembly 4.7619 4 yes
GO:0032386 regulation of intracellular transport 4.7619 5 yes
GO:0032446 protein modification by small protein conjugation 4.7619 6 yes
GO:0043523 regulation of neuron apoptotic process 4.7619 6 yes
GO:0099537 trans-synaptic signaling 4.4643 4 yes
GO:0010822 positive regulation of mitochondrion organization 4.4643 7 yes
GO:1901796 regulation of signal transduction by p53 class mediator 4.4643 6 yes
GO:0016567 protein ubiquitination 4.4643 7 yes
GO:0043393 regulation of protein binding 4.4643 4 yes
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 4.4643 7 yes
GO:0007268 chemical synaptic transmission 4.1667 6 yes
GO:0098916 anterograde trans-synaptic signaling 4.1667 5 yes
GO:1901215 negative regulation of neuron death 4.1667 6 yes
GO:0022604 regulation of cell morphogenesis 4.1667 5 yes
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 4.1667 7 yes
GO:0032970 regulation of actin filament-based process 4.1667 4 yes
GO:0043409 negative regulation of MAPK cascade 4.1667 7 yes
GO:0055065 metal ion homeostasis 3.8690 7 yes
GO:0062012 regulation of small molecule metabolic process 3.8690 4 yes
GO:0071241 cellular response to inorganic substance 3.8690 4 yes
GO:0010823 negative regulation of mitochondrion organization 3.8690 7 yes
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 3.8690 8 yes
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 3.8690 8 yes
GO:0033673 negative regulation of kinase activity 3.8690 6 yes
GO:0051099 positive regulation of binding 3.5714 4 yes
GO:0006839 mitochondrial transport 3.5714 4 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 3.5714 5 yes
GO:0070585 protein localization to mitochondrion 3.5714 6 yes
GO:0072507 divalent inorganic cation homeostasis 3.5714 7 yes
GO:1901800 positive regulation of proteasomal protein catabolic process 3.5714 7 yes
GO:0030111 regulation of Wnt signaling pathway 3.5714 5 yes
GO:0032872 regulation of stress-activated MAPK cascade 3.5714 6 yes
GO:0032956 regulation of actin cytoskeleton organization 3.5714 5 yes
GO:2000377 regulation of reactive oxygen species metabolic process 3.5714 5 yes
GO:0048638 regulation of developmental growth 3.2738 4 yes
GO:0071248 cellular response to metal ion 3.2738 5 yes
GO:0110053 regulation of actin filament organization 3.2738 6 yes
GO:0031398 positive regulation of protein ubiquitination 3.2738 9 yes
GO:0032388 positive regulation of intracellular transport 3.2738 5 yes
GO:0034976 response to endoplasmic reticulum stress 3.2738 4 yes
GO:0035967 cellular response to topologically incorrect protein 3.2738 4 yes
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 3.2738 7 yes
GO:0050708 regulation of protein secretion 2.9762 5 yes
GO:0051881 regulation of mitochondrial membrane potential 2.9762 4 yes
GO:0060828 regulation of canonical Wnt signaling pathway 2.9762 6 yes
GO:0007612 learning 2.9762 4 yes
GO:1900407 regulation of cellular response to oxidative stress 2.9762 5 yes
GO:1902882 regulation of response to oxidative stress 2.9762 5 yes
GO:1902904 negative regulation of supramolecular fiber organization 2.9762 6 yes
GO:1903201 regulation of oxidative stress-induced cell death 2.9762 5 yes
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 2.9762 8 yes
GO:0033157 regulation of intracellular protein transport 2.9762 6 yes
GO:0034620 cellular response to unfolded protein 2.9762 5 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 2.9762 6 yes
GO:0045927 positive regulation of growth 2.9762 4 yes
GO:0050905 neuromuscular process 2.6786 4 yes
GO:0060249 anatomical structure homeostasis 2.6786 4 yes
GO:0007417 central nervous system development 2.6786 4 yes
GO:0090140 regulation of mitochondrial fission 2.6786 5 yes
GO:0010508 positive regulation of autophagy 2.6786 7 yes
GO:0090199 regulation of release of cytochrome c from mitochondria 2.6786 7 yes
GO:0017157 regulation of exocytosis 2.6786 5 yes
GO:1903146 regulation of autophagy of mitochondrion 2.6786 7 yes
GO:0032092 positive regulation of protein binding 2.6786 5 yes
GO:1903828 negative regulation of protein localization 2.6786 5 yes
GO:0043524 negative regulation of neuron apoptotic process 2.6786 7 yes
GO:0046928 regulation of neurotransmitter secretion 2.3810 4 yes
GO:0048285 organelle fission 2.3810 5 yes
GO:0050805 negative regulation of synaptic transmission 2.3810 5 yes
GO:0051048 negative regulation of secretion 2.3810 5 yes
GO:0051494 negative regulation of cytoskeleton organization 2.3810 7 yes
GO:0051588 regulation of neurotransmitter transport 2.3810 5 yes
GO:0006836 neurotransmitter transport 2.3810 4 yes
GO:0007034 vacuolar transport 2.3810 4 yes
GO:0007041 lysosomal transport 2.3810 5 yes
GO:0090141 positive regulation of mitochondrial fission 2.3810 5 yes
GO:0030307 positive regulation of cell growth 2.3810 5 yes
GO:0032231 regulation of actin filament bundle assembly 2.3810 5 yes
GO:1903531 negative regulation of secretion by cell 2.3810 5 yes
GO:1903599 positive regulation of autophagy of mitochondrion 2.3810 8 yes
GO:0036503 ERAD pathway 2.3810 5 yes
GO:1905475 regulation of protein localization to membrane 2.3810 6 yes
GO:1905897 regulation of response to endoplasmic reticulum stress 2.3810 5 yes
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 2.3810 7 yes
GO:0046328 regulation of JNK cascade 2.0833 7 yes
GO:0048639 positive regulation of developmental growth 2.0833 5 yes
GO:0051258 protein polymerization 2.0833 6 yes
GO:0000209 protein polyubiquitination 2.0833 8 yes
GO:0001959 regulation of cytokine-mediated signaling pathway 2.0833 5 yes
GO:0060759 regulation of response to cytokine stimulus 2.0833 4 yes
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade 2.0833 6 yes
GO:0008344 adult locomotory behavior 2.0833 4 yes
GO:0090201 negative regulation of release of cytochrome c from mitochondria 2.0833 7 yes
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2.0833 6 yes
GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 2.0833 7 yes
GO:0032873 negative regulation of stress-activated MAPK cascade 2.0833 7 yes
GO:1903573 negative regulation of response to endoplasmic reticulum stress 2.0833 5 yes
GO:1904950 negative regulation of establishment of protein localization 2.0833 6 yes
GO:1905477 positive regulation of protein localization to membrane 2.0833 6 yes
GO:1905952 regulation of lipid localization 2.0833 4 yes
GO:0051341 regulation of oxidoreductase activity 1.7857 4 yes
GO:0051851 modulation by host of symbiont process 1.7857 4 yes
GO:0006576 cellular biogenic amine metabolic process 1.7857 5 yes
GO:0006584 catecholamine metabolic process 1.7857 6 yes
GO:0070534 protein K63-linked ubiquitination 1.7857 9 yes
GO:0070646 protein modification by small protein removal 1.7857 5 yes
GO:0009308 amine metabolic process 1.7857 4 yes
GO:0009712 catechol-containing compound metabolic process 1.7857 5 yes
GO:0071867 response to monoamine 1.7857 5 yes
GO:0071868 cellular response to monoamine stimulus 1.7857 5 yes
GO:0071869 response to catecholamine 1.7857 4 yes
GO:0071870 cellular response to catecholamine stimulus 1.7857 5 yes
GO:0090087 regulation of peptide transport 1.7857 5 yes
GO:0098657 import into cell 1.7857 4 yes
GO:0015844 monoamine transport 1.7857 5 yes
GO:0015850 organic hydroxy compound transport 1.7857 5 yes
GO:0016236 macroautophagy 1.7857 4 yes
GO:0016579 protein deubiquitination 1.7857 6 yes
GO:0018958 phenol-containing compound metabolic process 1.7857 4 yes
GO:1902914 regulation of protein polyubiquitination 1.7857 9 yes
GO:1903008 organelle disassembly 1.7857 5 yes
GO:1903202 negative regulation of oxidative stress-induced cell death 1.7857 6 yes
GO:1903203 regulation of oxidative stress-induced neuron death 1.7857 6 yes
GO:0031648 protein destabilization 1.7857 4 yes
GO:0032368 regulation of lipid transport 1.7857 5 yes
GO:0033238 regulation of cellular amine metabolic process 1.7857 5 yes
GO:0042053 regulation of dopamine metabolic process 1.7857 6 yes
GO:0042069 regulation of catecholamine metabolic process 1.7857 5 yes
GO:0042417 dopamine metabolic process 1.7857 7 yes
GO:0044106 cellular amine metabolic process 1.7857 4 yes
GO:0044788 modulation by host of viral process 1.7857 5 yes
GO:0046883 regulation of hormone secretion 1.4881 4 yes
GO:0050433 regulation of catecholamine secretion 1.4881 5 yes
GO:0050796 regulation of insulin secretion 1.4881 6 yes
GO:0051101 regulation of DNA binding 1.4881 4 yes
GO:0051224 negative regulation of protein transport 1.4881 5 yes
GO:0051583 dopamine uptake involved in synaptic transmission 1.4881 6 yes
GO:0051589 negative regulation of neurotransmitter transport 1.4881 5 yes
GO:0000266 mitochondrial fission 1.4881 6 yes
GO:0051934 catecholamine uptake involved in synaptic transmission 1.4881 5 yes
GO:0000422 autophagy of mitochondrion 1.4881 4 yes
GO:0051937 catecholamine transport 1.4881 6 yes
GO:0051952 regulation of amine transport 1.4881 5 yes
GO:0001504 neurotransmitter uptake 1.4881 4 yes
GO:0001961 positive regulation of cytokine-mediated signaling pathway 1.4881 6 yes
GO:0002791 regulation of peptide secretion 1.4881 6 yes
GO:0006109 regulation of carbohydrate metabolic process 1.4881 5 yes
GO:0060760 positive regulation of response to cytokine stimulus 1.4881 5 yes
GO:0061726 mitochondrion disassembly 1.4881 6 yes
GO:0090276 regulation of peptide hormone secretion 1.4881 5 yes
GO:0090493 catecholamine uptake 1.4881 5 yes
GO:0090494 dopamine uptake 1.4881 6 yes
GO:0098810 neurotransmitter reuptake 1.4881 4 yes
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 1.4881 6 yes
GO:0014059 regulation of dopamine secretion 1.4881 6 yes
GO:0015872 dopamine transport 1.4881 6 yes
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 1.4881 7 yes
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1.4881 6 yes
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1.4881 6 yes
GO:1902916 positive regulation of protein polyubiquitination 1.4881 10 yes
GO:1903533 regulation of protein targeting 1.4881 7 yes
GO:1903747 regulation of establishment of protein localization to mitochondrion 1.4881 7 yes
GO:2000378 negative regulation of reactive oxygen species metabolic process 1.4881 6 yes
GO:0043388 positive regulation of DNA binding 1.4881 5 yes
GO:0045920 negative regulation of exocytosis 1.4881 6 yes
GO:0046329 negative regulation of JNK cascade 1.1905 8 yes
GO:0046929 negative regulation of neurotransmitter secretion 1.1905 5 yes
GO:0061912 selective autophagy 1.1905 5 yes
GO:0070841 inclusion body assembly 1.1905 5 yes
GO:0071287 cellular response to manganese ion 1.1905 6 yes
GO:0010042 response to manganese ion 1.1905 5 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 1.1905 7 yes
GO:0010635 regulation of mitochondrial fusion 1.1905 5 yes
GO:0010637 negative regulation of mitochondrial fusion 1.1905 5 yes
GO:0010675 regulation of cellular carbohydrate metabolic process 1.1905 5 yes
GO:1901797 negative regulation of signal transduction by p53 class mediator 1.1905 7 yes
GO:0030178 negative regulation of Wnt signaling pathway 1.1905 6 yes
GO:1903204 negative regulation of oxidative stress-induced neuron death 1.1905 7 yes
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 1.1905 7 yes
GO:1903350 response to dopamine 1.1905 5 yes
GO:1903351 cellular response to dopamine 1.1905 6 yes
GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 1.1905 7 yes
GO:1903649 regulation of cytoplasmic transport 1.1905 6 yes
GO:0035249 synaptic transmission, glutamatergic 1.1905 7 yes
GO:1990000 amyloid fibril formation 1.1905 4 yes
GO:0044827 modulation by host of viral genome replication 1.1905 6 yes
GO:0050709 negative regulation of protein secretion 0.8929 6 yes
GO:0051354 negative regulation of oxidoreductase activity 0.8929 5 yes
GO:0051580 regulation of neurotransmitter uptake 0.8929 4 yes
GO:0051590 positive regulation of neurotransmitter transport 0.8929 5 yes
GO:0051865 protein autoubiquitination 0.8929 8 yes
GO:0000423 mitophagy 0.8929 5 yes
GO:0055076 transition metal ion homeostasis 0.8929 8 yes
GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 0.8929 8 yes
GO:0070842 aggresome assembly 0.8929 6 yes
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization 0.8929 7 yes
GO:0098780 response to mitochondrial depolarisation 0.8929 4 yes
GO:0099074 mitochondrion to lysosome transport 0.8929 5 yes
GO:0099075 mitochondrion-derived vesicle mediated transport 0.8929 5 yes
GO:0150003 regulation of spontaneous synaptic transmission 0.8929 6 yes
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.8929 8 yes
GO:1903214 regulation of protein targeting to mitochondrion 0.8929 8 yes
GO:0032232 negative regulation of actin filament bundle assembly 0.8929 6 yes
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 0.8929 8 yes
GO:1903541 regulation of exosomal secretion 0.8929 6 yes
GO:1903542 negative regulation of exosomal secretion 0.8929 7 yes
GO:1903651 positive regulation of cytoplasmic transport 0.8929 6 yes
GO:1903859 regulation of dendrite extension 0.8929 5 yes
GO:1903861 positive regulation of dendrite extension 0.8929 6 yes
GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.8929 5 yes
GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.8929 6 yes
GO:1904978 regulation of endosome organization 0.8929 6 yes
GO:1904979 negative regulation of endosome organization 0.8929 7 yes
GO:1905365 regulation of intralumenal vesicle formation 0.8929 7 yes
GO:1905366 negative regulation of intralumenal vesicle formation 0.8929 5 yes
GO:0044793 negative regulation by host of viral process 0.8929 6 yes
GO:0046676 negative regulation of insulin secretion 0.5952 7 yes
GO:0046888 negative regulation of hormone secretion 0.5952 5 yes
GO:0051582 positive regulation of neurotransmitter uptake 0.5952 5 yes
GO:0055069 zinc ion homeostasis 0.5952 8 yes
GO:0002792 negative regulation of peptide secretion 0.5952 6 yes
GO:0006513 protein monoubiquitination 0.5952 8 yes
GO:0070936 protein K48-linked ubiquitination 0.5952 9 yes
GO:0070979 protein K11-linked ubiquitination 0.5952 9 yes
GO:0085020 protein K6-linked ubiquitination 0.5952 9 yes
GO:0090278 negative regulation of peptide hormone secretion 0.5952 6 yes
GO:0097237 cellular response to toxic substance 0.5952 4 yes
GO:0010636 positive regulation of mitochondrial fusion 0.5952 5 yes
GO:0010677 negative regulation of cellular carbohydrate metabolic process 0.5952 6 yes
GO:0010906 regulation of glucose metabolic process 0.5952 5 yes
GO:0010994 free ubiquitin chain polymerization 0.5952 7 yes
GO:1902283 negative regulation of primary amine oxidase activity 0.5952 6 yes
GO:1902528 regulation of protein linear polyubiquitination 0.5952 10 yes
GO:1902530 positive regulation of protein linear polyubiquitination 0.5952 11 yes
GO:1902803 regulation of synaptic vesicle transport 0.5952 5 yes
GO:1903299 regulation of hexokinase activity 0.5952 6 yes
GO:1903300 negative regulation of hexokinase activity 0.5952 7 yes
GO:1903381 regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway 0.5952 7 yes
GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway 0.5952 7 yes
GO:0033131 regulation of glucokinase activity 0.5952 6 yes
GO:0033132 negative regulation of glucokinase activity 0.5952 7 yes
GO:1904048 regulation of spontaneous neurotransmitter secretion 0.5952 5 yes
GO:1904049 negative regulation of spontaneous neurotransmitter secretion 0.5952 6 yes
GO:0035519 protein K29-linked ubiquitination 0.5952 9 yes
GO:1905279 regulation of retrograde transport, endosome to Golgi 0.5952 5 yes
GO:1905281 positive regulation of retrograde transport, endosome to Golgi 0.5952 6 yes
GO:0042415 norepinephrine metabolic process 0.5952 7 yes
GO:0044314 protein K27-linked ubiquitination 0.5952 9 yes
GO:0044828 negative regulation by host of viral genome replication 0.5952 7 yes
GO:0045912 negative regulation of carbohydrate metabolic process 0.5952 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in PRKN_HUMAN
DOID:331 central nervous system disease 2.6786 3 yes
DOID:1289 neurodegenerative disease 2.0833 4 yes
DOID:574 peripheral nervous system disease 2.0833 3 no
DOID:870 neuropathy 2.0833 4 no
DOID:10595 Charcot-Marie-Tooth disease 1.4881 6 no
DOID:440 neuromuscular disease 1.4881 5 no
DOID:0050890 synucleinopathy 1.1905 5 yes
DOID:14330 Parkinsons disease 1.1905 6 yes
DOID:700 mitochondrial metabolism disease 1.1905 3 no
DOID:0050155 sensory system disease 1.1905 3 no
DOID:0060038 specific developmental disorder 0.8929 3 no
DOID:1059 intellectual disability 0.8929 4 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 0.8929 7 no
DOID:0060892 late onset Parkinsons disease 0.8929 7 yes
DOID:0060894 early-onset Parkinsons disease 0.8929 7 yes
DOID:231 motor neuron disease 0.8929 5 no
DOID:0080000 muscular disease 0.8929 3 no
DOID:423 myopathy 0.8929 5 no
DOID:66 muscle tissue disease 0.8929 4 no
DOID:0050563 nonsyndromic deafness 0.8929 5 no
DOID:2742 auditory system disease 0.8929 4 no
DOID:0050700 cardiomyopathy 0.8929 4 no
DOID:0060036 intrinsic cardiomyopathy 0.8929 5 no
DOID:114 heart disease 0.8929 3 no
DOID:12930 dilated cardiomyopathy 0.8929 6 no
DOID:936 brain disease 0.5952 4 no
DOID:0060368 Parkinsons disease 2 0.5952 8 yes
DOID:332 amyotrophic lateral sclerosis 0.5952 6 no
DOID:1891 optic nerve disease 0.5952 6 no
DOID:5656 cranial nerve disease 0.5952 5 no
DOID:5723 optic atrophy 0.5952 7 no
DOID:0060286 combined oxidative phosphorylation deficiency 0.5952 4 no
DOID:0050564 autosomal dominant nonsyndromic deafness 0.5952 6 no
DOID:0050542 Charcot-Marie-Tooth disease type X 0.5952 7 no
DOID:0070329 mitochondrial DNA depletion syndrome 0.5952 4 no
DOID:2978 carbohydrate metabolic disorder 0.5952 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ATX3_HUMAN [view interactions] Low throughput no yes
PLK1_HUMAN [view interactions] Low throughput no yes
DNM1L_HUMAN [view entry] [view interactions] Low throughput yes yes
CCNB1_HUMAN [view interactions] Low throughput no no
C1QBP_HUMAN [view entry] [view interactions] Low throughput yes yes
GLCM_HUMAN [view interactions] Low throughput no yes
BAG5_HUMAN [view entry] [view interactions] Low throughput yes no
NEK2_HUMAN [view interactions] Low throughput no no
UBE2Z_HUMAN [view interactions] Low throughput no yes
PSMD4_HUMAN [view interactions] Low throughput no yes
F16P1_HUMAN [view interactions] Low throughput no no
PRS6A_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC12_HUMAN [view entry] [view interactions] Low throughput yes yes
ATX2_HUMAN [view interactions] Low throughput no yes
DYR1A_HUMAN [view interactions] Low throughput no yes
KC1D_HUMAN [view entry] [view interactions] Low throughput yes yes
ARI1_HUMAN [view interactions] Low throughput no yes
CAV1_HUMAN [view interactions] Low throughput no no
PTTG1_HUMAN [view interactions] Low throughput no no
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
APEX1_HUMAN [view interactions] Low throughput no yes
RAB7A_HUMAN [view entry] [view interactions] Low throughput yes yes
GRP75_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIB3_HUMAN [view interactions] Low throughput no yes
UBP30_HUMAN [view interactions] Low throughput no yes
PCNA_HUMAN [view interactions] Low throughput no no
AAPK2_HUMAN [view interactions] Low throughput no yes
PRPS1_HUMAN [view entry] [view interactions] Low throughput yes no
UB2J2_HUMAN [view interactions] Low throughput no no
FANCC_HUMAN [view interactions] Low throughput no yes
ACTS_HUMAN [view interactions] Low throughput no no
FANCA_HUMAN [view interactions] Low throughput no no
UBE2N_HUMAN [view entry] [view interactions] Low throughput yes yes
DDIT3_HUMAN [view interactions] Low throughput no yes
UB2V1_HUMAN [view entry] [view interactions] Low throughput yes no
MAVS_HUMAN [view interactions] Low throughput no yes
VDAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF31_HUMAN [view interactions] Low throughput no yes
VDAC2_HUMAN [view entry] [view interactions] Low throughput yes yes
NBN_HUMAN [view interactions] Low throughput no yes
VDAC3_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
HXK1_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
TOM70_HUMAN [view interactions] Low throughput no yes
SYT4_HUMAN [view entry] [view interactions] Low throughput yes yes
CISD1_HUMAN [view entry] [view interactions] Low throughput yes yes
BNIP3_HUMAN [view entry] [view interactions] Low throughput yes yes
BAX_HUMAN [view interactions] Low throughput no yes
HERC5_HUMAN [view interactions] Low throughput no yes
PHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
CCND2_HUMAN [view interactions] Low throughput no yes
NEDD8_HUMAN [view interactions] Low throughput no yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
CCND1_HUMAN [view interactions] Low throughput no yes
PDE2A_HUMAN [view entry] [view interactions] Low throughput yes yes
MIRO2_HUMAN [view entry] [view interactions] Low throughput yes yes
CCND3_HUMAN [view interactions] Low throughput no no
TFR1_HUMAN [view interactions] Low throughput no yes
TADBP_HUMAN [view interactions] Low throughput no yes
FBX4_HUMAN [view interactions] Low throughput no no
CRYAB_HUMAN [view entry] [view interactions] Low throughput yes no
FAF1_HUMAN [view interactions] Low throughput no yes
UBL4A_HUMAN [view entry] [view interactions] Low throughput yes yes
HIF1A_HUMAN [view interactions] Low throughput no no
OSGI1_HUMAN [view interactions] Low throughput no no
TOM40_HUMAN [view interactions] Low throughput no yes
ATAD1_HUMAN [view entry] [view interactions] Low throughput yes yes
TCHP_HUMAN [view interactions] Low throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
RIPK1_HUMAN [view interactions] Low throughput no yes
MICU1_HUMAN [view interactions] Low throughput no yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
TBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO6_HUMAN [view entry] [view interactions] Low throughput yes no
TRAF6_HUMAN [view interactions] Low throughput no yes
VPS35_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
NOD2_HUMAN [view interactions] Low throughput no yes
PSA1_HUMAN [view interactions] Low throughput no yes
CDN1A_HUMAN [view interactions] Low throughput no no
RIPK3_HUMAN [view interactions] Low throughput no no
FBXW8_HUMAN [view interactions] Low throughput no yes
OPTN_HUMAN [view interactions] Low throughput no yes
ATM_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
UBP33_HUMAN [view interactions] Low throughput no yes
UBP15_HUMAN [view entry] [view interactions] Low throughput yes yes
MSRB2_HUMAN [view interactions] Low throughput no no
NQO1_HUMAN [view interactions] Low throughput no no
TOLIP_HUMAN [view entry] [view interactions] Low throughput yes yes
YAP1_HUMAN [view interactions] Low throughput no yes
RD23A_HUMAN [view interactions] Low throughput no yes
RBP2_HUMAN [view interactions] Low throughput no yes
PDCD2_HUMAN [view interactions] Low throughput no yes
SEPT5_HUMAN [view interactions] Low throughput no no
PSA7_HUMAN [view interactions] Low throughput no yes
LPPRC_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
UB2L3_HUMAN [view interactions] Low throughput no yes
UB2G1_HUMAN [view interactions] Low throughput no yes
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
RS27A_HUMAN [view entry] [view interactions] Low throughput yes yes
RL40_HUMAN [view entry] [view interactions] Low throughput yes yes
SNCAP_HUMAN [view interactions] Low throughput no no
ZN746_HUMAN [view interactions] Low throughput no no
MIRO1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
UB2L6_HUMAN [view interactions] Low throughput no no
FBX7_HUMAN [view interactions] Low throughput no yes
PINK1_HUMAN [view interactions] Low throughput no yes
SH3G2_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] Low throughput yes no
MFN2_HUMAN [view entry] [view interactions] Low throughput yes yes
SERA_HUMAN [view entry] [view interactions] Low throughput yes yes
PSMD2_HUMAN [view entry] [view interactions] Low throughput yes yes
KPYM_HUMAN [view interactions] Low throughput no yes
NDKB_HUMAN [view entry] [view interactions] Low throughput yes yes
CH60_HUMAN [view entry] [view interactions] Low throughput yes yes
G3P_HUMAN [view entry] [view interactions] Low throughput yes yes
ABCE1_HUMAN [view interactions] Low throughput no yes
STML2_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC6_HUMAN [view interactions] Low throughput no yes
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
UBS3A_HUMAN [view interactions] Low throughput no no
UBS3B_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
MK14_HUMAN [view interactions] Low throughput no yes
MLP3B_HUMAN [view interactions] Low throughput no yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
SYT11_HUMAN [view entry] [view interactions] Low throughput yes yes
AIMP2_HUMAN [view interactions] Low throughput no yes
GPR37_HUMAN [view interactions] Low throughput no no
PSA4_HUMAN [view entry] [view interactions] Low throughput yes yes
CHSS2_HUMAN [view interactions] Low throughput no yes
ADRM1_HUMAN [view interactions] Low throughput no yes
FBXW7_HUMAN [view interactions] Low throughput no yes
CUL1_HUMAN [view interactions] Low throughput no yes
CCNE1_HUMAN [view interactions] Low throughput no no
CCNA1_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
HOME1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
UB2J1_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
HS71B_HUMAN [view entry] [view interactions] Low throughput yes yes
HS71A_HUMAN [view entry] [view interactions] Low throughput yes yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
BACH1_HUMAN [view interactions] Low throughput no no
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
LIMK1_HUMAN [view interactions] Low throughput no yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
TBG1_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC4_HUMAN [view interactions] Low throughput no yes
SIM2_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
SC6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
NNRE_HUMAN [view interactions] Low throughput no yes
PRS8_HUMAN [view interactions] Low throughput no yes
NACC1_HUMAN [view interactions] Low throughput no yes
DDX58_HUMAN [view interactions] Low throughput no yes
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
BECN1_HUMAN [view interactions] Low throughput no yes
IFIH1_HUMAN [view interactions] Low throughput no yes
HTRA2_HUMAN [view interactions] Low throughput no yes
PK3C3_HUMAN [view interactions] Low throughput no yes
NLRP3_HUMAN [view interactions] Low throughput no yes
BCL2_HUMAN [view interactions] Low throughput no no
DDIT4_HUMAN [view interactions] Low throughput no yes
UBXN1_HUMAN [view interactions] Low throughput no no
RNF41_HUMAN [view interactions] Low throughput no yes
B2CL1_HUMAN [view interactions] Low throughput no yes
BRCA1_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
B2CL2_HUMAN [view interactions] Low throughput no yes
UB2G2_HUMAN [view interactions] Low throughput no yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
MCL1_HUMAN [view interactions] Low throughput no yes
UB2D2_HUMAN [view interactions] Low throughput no yes
AMRA1_HUMAN [view interactions] Low throughput no yes
UCHL1_HUMAN [view entry] [view interactions] Low throughput yes yes
UB2E1_HUMAN [view interactions] Low throughput no yes
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
AFAD_HUMAN [view interactions] Low throughput no yes
UB2D3_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
SUMO1_HUMAN [view interactions] Low throughput no yes
HCD2_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF2_HUMAN [view interactions] Low throughput no yes
COMD1_HUMAN [view interactions] Low throughput no yes
NRAM2_HUMAN [view interactions] Low throughput no yes
UB2D1_HUMAN [view interactions] Low throughput no yes
MFN1_HUMAN [view interactions] Low throughput no yes
ERR1_HUMAN [view interactions] Low throughput no yes
PTN5_HUMAN [view entry] [view interactions] Low throughput yes yes
ERR2_HUMAN [view interactions] Low throughput no no
FUBP1_HUMAN [view interactions] Low throughput no yes
ERR3_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] Low throughput yes no
BIRC5_HUMAN [view interactions] Low throughput no no
UB2E2_HUMAN [view interactions] Low throughput no yes
GRIK2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
RPTOR_HUMAN [view interactions] Low throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
UB2R2_HUMAN [view interactions] High throughput no no
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
UBE2S_HUMAN [view interactions] High throughput no no
AURKB_HUMAN [view interactions] High throughput no yes
UBE2T_HUMAN [view interactions] High throughput no no
CDC20_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
TNR17_HUMAN [view interactions] High throughput no no
BODG_HUMAN [view interactions] High throughput no no
GNL1_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B2_HUMAN [view interactions] High throughput no yes
RM13_HUMAN [view interactions] High throughput no yes
F120A_HUMAN [view interactions] High throughput no yes
ZN622_HUMAN [view interactions] High throughput no yes
LSG1_HUMAN [view interactions] High throughput no yes
NKRF_HUMAN [view interactions] High throughput no no
RM19_HUMAN [view interactions] High throughput no yes
SF3B3_HUMAN [view interactions] High throughput no yes
GTPB4_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
PACRG_HUMAN [view interactions] High throughput no no
DYRK2_HUMAN [view interactions] High throughput no yes
ACSL1_HUMAN [view interactions] High throughput no no
ACSL4_HUMAN [view entry] [view interactions] High throughput yes yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R3_HUMAN [view interactions] High throughput no yes
MARC1_HUMAN [view interactions] High throughput no yes
HXK2_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
MARH5_HUMAN [view interactions] High throughput no no
TBC15_HUMAN [view interactions] High throughput no yes
TOM1_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
ML12B_HUMAN [view interactions] High throughput no no
PSA2_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
PSB1_HUMAN [view interactions] High throughput no yes
PSB2_HUMAN [view interactions] High throughput no yes
PSB3_HUMAN [view interactions] High throughput no yes
PSB4_HUMAN [view interactions] High throughput no yes
PSB5_HUMAN [view interactions] High throughput no yes
PSB6_HUMAN [view entry] [view interactions] High throughput yes yes
PSB7_HUMAN [view interactions] High throughput no yes
PRS4_HUMAN [view entry] [view interactions] High throughput yes yes
PRS7_HUMAN [view interactions] High throughput no yes
PRS6B_HUMAN [view interactions] High throughput no yes
PRS10_HUMAN [view interactions] High throughput no yes
RINI_HUMAN [view interactions] High throughput no yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
RD23B_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
PAAF1_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
SYEP_HUMAN [view interactions] High throughput no yes
PSMD3_HUMAN [view interactions] High throughput no yes
IRS4_HUMAN [view interactions] High throughput no no
PSMD5_HUMAN [view interactions] High throughput no yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD6_HUMAN [view interactions] High throughput no yes
RACK1_HUMAN [view interactions] High throughput no yes
PSMD7_HUMAN [view interactions] High throughput no yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD8_HUMAN [view interactions] High throughput no yes
GUAA_HUMAN [view interactions] High throughput no no
PSMD9_HUMAN [view interactions] High throughput no yes
HORN_HUMAN [view interactions] High throughput no no
PSD10_HUMAN [view entry] [view interactions] High throughput yes yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
PSD11_HUMAN [view entry] [view interactions] High throughput yes yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
PSD12_HUMAN [view interactions] High throughput no yes
MANF_HUMAN [view interactions] High throughput no yes
PSD13_HUMAN [view interactions] High throughput no yes
RS9_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
PSME1_HUMAN [view interactions] High throughput no yes
IF4A1_HUMAN [view interactions] High throughput no no
RGS2_HUMAN [view interactions] High throughput no no
PSME2_HUMAN [view interactions] High throughput no no
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
PSME3_HUMAN [view interactions] High throughput no yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
CLPX_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
CBX1_HUMAN [view interactions] High throughput no yes
CSDE1_HUMAN [view interactions] High throughput no yes
AT2B3_HUMAN [view entry] [view interactions] High throughput yes yes
SYFA_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B1_HUMAN [view entry] [view interactions] High throughput yes yes
RL15_HUMAN [view entry] [view interactions] High throughput yes no
CASPE_HUMAN [view interactions] High throughput no no
RL13A_HUMAN [view entry] [view interactions] High throughput yes yes
H10_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
RT29_HUMAN [view interactions] High throughput no yes
PYR1_HUMAN [view entry] [view interactions] High throughput yes yes
GLU2B_HUMAN [view interactions] High throughput no yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
ALBU_HUMAN [view interactions] High throughput no no
ELOB_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
PLST_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
GSDMA_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
RBM8A_HUMAN [view interactions] High throughput no yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
CALU_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
RCN2_HUMAN [view interactions] High throughput no yes
RL30_HUMAN [view entry] [view interactions] High throughput yes yes
RT31_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
PA2G4_HUMAN [view interactions] High throughput no yes
MPCP_HUMAN [view entry] [view interactions] High throughput yes no
RL28_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
RL18_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
THIO_HUMAN [view interactions] High throughput no yes
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
TBB6_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
CMC2_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
H2A1A_HUMAN [view interactions] High throughput no yes
SYIC_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
RT07_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB2_HUMAN [view interactions] High throughput no yes
SET_HUMAN [view interactions] High throughput no yes
RL10A_HUMAN [view entry] [view interactions] High throughput yes yes
RS25_HUMAN [view entry] [view interactions] High throughput yes yes
OPA1_HUMAN [view entry] [view interactions] High throughput yes yes
RL18A_HUMAN [view entry] [view interactions] High throughput yes yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
RLA2_HUMAN [view entry] [view interactions] High throughput yes yes
CBX3_HUMAN [view interactions] High throughput no yes
DNJC7_HUMAN [view interactions] High throughput no yes
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
RS5_HUMAN [view entry] [view interactions] High throughput yes yes
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
SNUT1_HUMAN [view interactions] High throughput no yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
ATPK_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
PSA6_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
TECR_HUMAN [view interactions] High throughput no yes
PSA5_HUMAN [view interactions] High throughput no yes
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
RS15A_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
RL13_HUMAN [view entry] [view interactions] High throughput yes yes
DX39B_HUMAN [view interactions] High throughput no no
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
SDHA_HUMAN [view interactions] High throughput no yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
EMD_HUMAN [view interactions] High throughput no yes
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
FBX22_HUMAN [view interactions] High throughput no no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
GCN1_HUMAN [view interactions] High throughput no yes
PDIA6_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
SRPRB_HUMAN [view entry] [view interactions] High throughput yes no
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
CIRBP_HUMAN [view interactions] High throughput no no
YBOX1_HUMAN [view interactions] High throughput no yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX3_HUMAN [view interactions] High throughput no yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA1_HUMAN [view interactions] High throughput no yes
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view interactions] High throughput no yes
LBR_HUMAN [view interactions] High throughput no yes
NUCL_HUMAN [view interactions] High throughput no yes
RM12_HUMAN [view interactions] High throughput no yes
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
ML12A_HUMAN [view interactions] High throughput no no
PRP19_HUMAN [view interactions] High throughput no yes
RS23_HUMAN [view entry] [view interactions] High throughput yes yes
MATR3_HUMAN [view interactions] High throughput no yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
DIC_HUMAN [view interactions] High throughput no yes
METK2_HUMAN [view interactions] High throughput no no
RFC4_HUMAN [view interactions] High throughput no yes
RL34_HUMAN [view entry] [view interactions] High throughput yes yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
PCBP2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
CO3_HUMAN [view entry] [view interactions] High throughput yes no
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
KPRP_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
IF2B1_HUMAN [view interactions] High throughput no no
ENAH_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
RL26_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC6_HUMAN [view interactions] High throughput no yes
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPF_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
KCRB_HUMAN [view entry] [view interactions] High throughput yes no
ROAA_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
RL14_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
ELOC_HUMAN [view interactions] High throughput no no
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
VGF_HUMAN [view entry] [view interactions] High throughput yes yes
RL19_HUMAN [view entry] [view interactions] High throughput yes yes
GSTP1_HUMAN [view entry] [view interactions] High throughput yes no
ZC3HF_HUMAN [view interactions] High throughput no yes
FBRL_HUMAN [view interactions] High throughput no yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
HSDL2_HUMAN [view entry] [view interactions] High throughput yes yes
SYDC_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
AMY2B_HUMAN [view interactions] High throughput no no
ABCF2_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
MRP_HUMAN [view entry] [view interactions] High throughput yes no
MOT1_HUMAN [view interactions] High throughput no no
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
CMGA_HUMAN [view interactions] High throughput no yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
IF5A1_HUMAN [view interactions] High throughput no yes
NTPCR_HUMAN [view interactions] High throughput no yes
RS12_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
GNT2A_HUMAN [view interactions] High throughput no yes
PUR6_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
RL17_HUMAN [view entry] [view interactions] High throughput yes yes
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
SCG1_HUMAN [view interactions] High throughput no no
PUR2_HUMAN [view interactions] High throughput no yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
CEP55_HUMAN [view interactions] High throughput no yes
MCM3_HUMAN [view interactions] High throughput no no
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
HDGF_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
TBA3C_HUMAN [view interactions] High throughput no no
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
TBA3D_HUMAN [view interactions] High throughput no no
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
SYRC_HUMAN [view interactions] High throughput no yes
TCPD_HUMAN [view entry] [view interactions] High throughput yes yes
TGM3_HUMAN [view interactions] High throughput no no
SRRM2_HUMAN [view interactions] High throughput no yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
AGK_HUMAN [view entry] [view interactions] High throughput yes yes
SYTC_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
RT28_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
RT18B_HUMAN [view interactions] High throughput no yes
GARS_HUMAN [view interactions] High throughput no yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
RL26L_HUMAN [view interactions] High throughput no yes
CAH2_HUMAN [view entry] [view interactions] High throughput yes no
ANX11_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
H13_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
RS7_HUMAN [view entry] [view interactions] High throughput yes yes
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
VAT1_HUMAN [view entry] [view interactions] High throughput yes no
TCEA1_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
NACAM_HUMAN [view interactions] High throughput no no
FAF2_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
NUP93_HUMAN [view interactions] High throughput no yes
ACTBL_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
XRCC5_HUMAN [view interactions] High throughput no yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
ADPPT_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
AMOT_HUMAN [view interactions] High throughput no no
ERLN2_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH3_HUMAN [view interactions] High throughput no no
DPM1_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF9_HUMAN [view interactions] High throughput no yes
BCLF1_HUMAN [view interactions] High throughput no yes
C1TC_HUMAN [view entry] [view interactions] High throughput yes no
RT23_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
TBB1_HUMAN [view interactions] High throughput no yes
PPAC_HUMAN [view entry] [view interactions] High throughput yes yes
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
RS27_HUMAN [view entry] [view interactions] High throughput yes no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
PCCA_HUMAN [view entry] [view interactions] High throughput yes yes
EDF1_HUMAN [view interactions] High throughput no yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
RL36A_HUMAN [view entry] [view interactions] High throughput yes yes
PCCB_HUMAN [view interactions] High throughput no yes
YTHD2_HUMAN [view interactions] High throughput no yes
ACTA_HUMAN [view interactions] High throughput no no
RL21_HUMAN [view entry] [view interactions] High throughput yes yes
IKBE_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
HACD3_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
DDX47_HUMAN [view interactions] High throughput no yes
FILA2_HUMAN [view interactions] High throughput no no
PAP1L_HUMAN [view interactions] High throughput no no
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
PCH2_HUMAN [view interactions] High throughput no no
PRC2C_HUMAN [view interactions] High throughput no yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
HOIL1_HUMAN [view interactions] High throughput no no
MCCB_HUMAN [view entry] [view interactions] High throughput yes yes
RBM14_HUMAN [view interactions] High throughput no yes
MEOX1_HUMAN [view interactions] High throughput no no
HNRC1_HUMAN [view interactions] High throughput no no
DSG1_HUMAN [view entry] [view interactions] High throughput yes no
TET5C_HUMAN [view interactions] High throughput no yes
HNRDL_HUMAN [view interactions] High throughput no yes
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
DLX2_HUMAN [view interactions] High throughput no no
PIP_HUMAN [view interactions] High throughput no no
FETUA_HUMAN [view interactions] High throughput no no
CRX_HUMAN [view interactions] High throughput no no
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
PTBP1_HUMAN [view interactions] High throughput no no
PA1B2_HUMAN [view interactions] High throughput no yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
NUA4L_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
OLA1_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
ATD3B_HUMAN [view interactions] High throughput no yes
FKBP3_HUMAN [view interactions] High throughput no yes
RAD1_HUMAN [view interactions] High throughput no yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
MAZ_HUMAN [view interactions] High throughput no yes
HEXD_HUMAN [view interactions] High throughput no yes
PABP3_HUMAN [view interactions] High throughput no yes
RLA1_HUMAN [view entry] [view interactions] High throughput yes no
B9D1_HUMAN [view interactions] High throughput no yes
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
HLAB_HUMAN [view interactions] High throughput no yes
IMDH2_HUMAN [view interactions] High throughput no yes
RL32_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
MCM7_HUMAN [view interactions] High throughput no no
RL37A_HUMAN [view entry] [view interactions] High throughput yes yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
RL27_HUMAN [view entry] [view interactions] High throughput yes yes
TXTP_HUMAN [view entry] [view interactions] High throughput yes no
GHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
GNL3_HUMAN [view interactions] High throughput no yes
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
BI1_HUMAN [view interactions] High throughput no yes
RL8_HUMAN [view entry] [view interactions] High throughput yes yes
RSMB_HUMAN [view interactions] High throughput no yes
PGAM5_HUMAN [view entry] [view interactions] High throughput yes yes
DCD_HUMAN [view interactions] High throughput no no
SRSF1_HUMAN [view interactions] High throughput no yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
RALY_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
MEOX2_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
REL_HUMAN [view interactions] High throughput no yes
RS2_HUMAN [view entry] [view interactions] High throughput yes yes
HBA_HUMAN [view interactions] High throughput no no
ITF2_HUMAN [view interactions] High throughput no yes
H12_HUMAN [view interactions] High throughput no yes
B2L11_HUMAN [view interactions] High throughput no yes
RT15_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
PTCD3_HUMAN [view interactions] High throughput no yes
TRFL_HUMAN [view interactions] High throughput no no
HNRPR_HUMAN [view interactions] High throughput no yes
COPG1_HUMAN [view interactions] High throughput no yes
SRSF3_HUMAN [view interactions] High throughput no yes
H2B2F_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
RT27_HUMAN [view interactions] High throughput no yes
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
PAIRB_HUMAN [view interactions] High throughput no yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF2_HUMAN [view interactions] High throughput no yes
IPO5_HUMAN [view entry] [view interactions] High throughput yes yes
PRP6_HUMAN [view interactions] High throughput no yes
RL9_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
S10A8_HUMAN [view interactions] High throughput no no
HNRPC_HUMAN [view interactions] High throughput no yes
PA21B_HUMAN [view interactions] High throughput no no
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
RL29_HUMAN [view entry] [view interactions] High throughput yes yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
TRY1_HUMAN [view interactions] High throughput no no
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
VTNC_HUMAN [view interactions] High throughput no no
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
EI24_HUMAN [view interactions] High throughput no yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX17_HUMAN [view entry] [view interactions] High throughput yes yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
RL12_HUMAN [view entry] [view interactions] High throughput yes yes
H2A2C_HUMAN [view interactions] High throughput no yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC_HUMAN [view interactions] High throughput no yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
H2AV_HUMAN [view interactions] High throughput no yes
U520_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
RT22_HUMAN [view interactions] High throughput no yes
SURF4_HUMAN [view interactions] High throughput no yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
GRSF1_HUMAN [view interactions] High throughput no yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3H_HUMAN [view interactions] High throughput no yes
RL7_HUMAN [view entry] [view interactions] High throughput yes yes
MTDC_HUMAN [view interactions] High throughput no yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
LC7L2_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
VTDB_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
RL31_HUMAN [view entry] [view interactions] High throughput yes yes
SCMC1_HUMAN [view interactions] High throughput no no
PRAME_HUMAN [view interactions] High throughput no no
PASK_HUMAN [view interactions] High throughput no yes
PCY2_HUMAN [view interactions] High throughput no yes
UB2D4_HUMAN [view interactions] High throughput no yes
UB2E3_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
UBE2B_HUMAN [view interactions] High throughput no no
UBE2C_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
UBE2K_HUMAN [view interactions] High throughput no yes
UBE2O_HUMAN [view interactions] High throughput no yes
SEPT4_HUMAN [view interactions] Computational no no
TFAM_HUMAN [view entry] [view interactions] Computational yes yes
AOFA_HUMAN [view entry] [view interactions] Computational yes yes
HD_HUMAN [view entry] [view interactions] Computational yes yes
MTEF3_HUMAN [view interactions] Computational no no
AOFB_HUMAN [view entry] [view interactions] Computational yes yes
UBP8_HUMAN [view entry] [view interactions] Computational yes no
AT132_HUMAN [view interactions] Computational no yes