LRC4B_HUMAN
Evidence for PS localization
Functions
Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LRC4B_HUMAN |
|---|---|---|---|---|
| GO:0001664 | G protein-coupled receptor binding | 25.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0043168 | anion binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LRC4B_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 75.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 75.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 66.6667 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 66.6667 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 58.3333 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 58.3333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 58.3333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 50.0000 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 50.0000 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 50.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 50.0000 | 7 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 50.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 41.6667 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 41.6667 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 41.6667 | 4 | yes |
| GO:0051962 | positive regulation of nervous system development | 41.6667 | 5 | yes |
| GO:0022607 | cellular component assembly | 41.6667 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 41.6667 | 4 | no |
| GO:0050767 | regulation of neurogenesis | 41.6667 | 6 | no |
| GO:0060284 | regulation of cell development | 41.6667 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 41.6667 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 41.6667 | 5 | no |
| GO:0023056 | positive regulation of signaling | 41.6667 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 41.6667 | 4 | no |
| GO:0050807 | regulation of synapse organization | 33.3333 | 5 | yes |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 33.3333 | 4 | yes |
| GO:0099175 | regulation of postsynapse organization | 33.3333 | 6 | yes |
| GO:0099560 | synaptic membrane adhesion | 33.3333 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 33.3333 | 4 | no |
| GO:0010720 | positive regulation of cell development | 33.3333 | 6 | no |
| GO:0022604 | regulation of cell morphogenesis | 33.3333 | 5 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 33.3333 | 5 | no |
| GO:0050769 | positive regulation of neurogenesis | 33.3333 | 6 | no |
| GO:0099536 | synaptic signaling | 33.3333 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 33.3333 | 5 | no |
| GO:0030030 | cell projection organization | 33.3333 | 4 | no |
| GO:0031175 | neuron projection development | 33.3333 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0007612 | learning | 33.3333 | 4 | no |
| GO:0050890 | cognition | 33.3333 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 33.3333 | 5 | no |
| GO:1902115 | regulation of organelle assembly | 25.0000 | 5 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.0000 | 4 | no |
| GO:0030182 | neuron differentiation | 25.0000 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 25.0000 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 25.0000 | 7 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 25.0000 | 6 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0048168 | regulation of neuronal synaptic plasticity | 25.0000 | 4 | no |
| GO:0048169 | regulation of long-term neuronal synaptic plasticity | 25.0000 | 5 | no |
| GO:0048812 | neuron projection morphogenesis | 25.0000 | 5 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 25.0000 | 4 | no |
| GO:0001558 | regulation of cell growth | 25.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0048638 | regulation of developmental growth | 25.0000 | 4 | no |
| GO:0051093 | negative regulation of developmental process | 25.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
| GO:0050770 | regulation of axonogenesis | 25.0000 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 16.6667 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 16.6667 | 6 | yes |
| GO:0051965 | positive regulation of synapse assembly | 16.6667 | 6 | yes |
| GO:0099150 | regulation of postsynaptic specialization assembly | 16.6667 | 6 | yes |
| GO:0099151 | regulation of postsynaptic density assembly | 16.6667 | 7 | yes |
| GO:1901888 | regulation of cell junction assembly | 16.6667 | 5 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 16.6667 | 6 | yes |
| GO:1904889 | regulation of excitatory synapse assembly | 16.6667 | 7 | yes |
| GO:1905874 | regulation of postsynaptic density organization | 16.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KLRG2_HUMAN | [view interactions] | High throughput | no | no |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAFA4_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MX1_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNTG1_HUMAN | [view interactions] | High throughput | no | no |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| TAFA5_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |