Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LRC4B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LRC4B_HUMAN
GO:0004725 protein tyrosine phosphatase activity 25.0000 4 no
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 25.0000 5 no
GO:0016791 phosphatase activity 25.0000 5 no
GO:0019198 transmembrane receptor protein phosphatase activity 25.0000 4 no
GO:0042578 phosphoric ester hydrolase activity 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in LRC4B_HUMAN
GO:0051128 regulation of cellular component organization 75.0000 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 62.5000 4 yes
GO:0099560 synaptic membrane adhesion 62.5000 5 yes
GO:0010646 regulation of cell communication 62.5000 4 no
GO:0010975 regulation of neuron projection development 62.5000 7 no
GO:0031344 regulation of cell projection organization 62.5000 5 no
GO:0050804 modulation of chemical synaptic transmission 62.5000 5 no
GO:0099177 regulation of trans-synaptic signaling 62.5000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 62.5000 6 no
GO:0044087 regulation of cellular component biogenesis 50.0000 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0050807 regulation of synapse organization 50.0000 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 no
GO:0033043 regulation of organelle organization 37.5000 5 yes
GO:0051094 positive regulation of developmental process 37.5000 4 yes
GO:0051130 positive regulation of cellular component organization 37.5000 5 yes
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 yes
GO:0051960 regulation of nervous system development 37.5000 5 yes
GO:0051962 positive regulation of nervous system development 37.5000 5 yes
GO:0051963 regulation of synapse assembly 37.5000 6 yes
GO:0099174 regulation of presynapse organization 37.5000 6 yes
GO:0099175 regulation of postsynapse organization 37.5000 6 yes
GO:1901888 regulation of cell junction assembly 37.5000 5 yes
GO:1905606 regulation of presynapse assembly 37.5000 7 yes
GO:2000026 regulation of multicellular organismal development 37.5000 4 yes
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0045595 regulation of cell differentiation 37.5000 4 no
GO:0048523 negative regulation of cellular process 37.5000 4 no
GO:0006996 organelle organization 37.5000 4 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 yes
GO:0051965 positive regulation of synapse assembly 25.0000 6 yes
GO:0099150 regulation of postsynaptic specialization assembly 25.0000 6 yes
GO:0099151 regulation of postsynaptic density assembly 25.0000 7 yes
GO:1901890 positive regulation of cell junction assembly 25.0000 6 yes
GO:1902115 regulation of organelle assembly 25.0000 5 yes
GO:1904889 regulation of excitatory synapse assembly 25.0000 7 yes
GO:1905874 regulation of postsynaptic density organization 25.0000 6 yes
GO:0006470 protein dephosphorylation 25.0000 5 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway 25.0000 5 no
GO:0010720 positive regulation of cell development 25.0000 6 no
GO:0016311 dephosphorylation 25.0000 5 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0030182 neuron differentiation 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0050767 regulation of neurogenesis 25.0000 6 no
GO:0050769 positive regulation of neurogenesis 25.0000 6 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0032990 cell part morphogenesis 25.0000 4 no
GO:0048812 neuron projection morphogenesis 25.0000 7 no
GO:0048858 cell projection morphogenesis 25.0000 5 no
GO:0070925 organelle assembly 25.0000 5 no
GO:0098698 postsynaptic specialization assembly 25.0000 6 no
GO:0099084 postsynaptic specialization organization 25.0000 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 6 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0000165 MAPK cascade 25.0000 4 no
GO:0007612 learning 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0048168 regulation of neuronal synaptic plasticity 25.0000 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 25.0000 5 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0050890 cognition 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
KLRG2_HUMAN [view interactions] High throughput no no
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
TAFA4_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
MX1_HUMAN [view interactions] High throughput no yes
RYK_HUMAN [view interactions] High throughput no no
SNTG1_HUMAN [view interactions] High throughput no no
LEG1_HUMAN [view interactions] High throughput no yes
TR10C_HUMAN [view interactions] High throughput no no
TAFA5_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
NTNG2_HUMAN [view entry] [view interactions] Computational yes no
NTNG1_HUMAN [view interactions] Computational no no