LEG8_HUMAN
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed, PubMed). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed, PubMed). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed, PubMed). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed). Also required to restrict infection of Picornaviridae viruses (PubMed). Has a marked preference for 3-O-sialylated and 3-O-sulfated glycans (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in LEG8_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 31.1111 | 4 | no |
GO:0008324 | cation transmembrane transporter activity | 24.4444 | 4 | no |
GO:0017076 | purine nucleotide binding | 24.4444 | 4 | no |
GO:0022890 | inorganic cation transmembrane transporter activity | 24.4444 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 24.4444 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 24.4444 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in LEG8_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 51.1111 | 4 | no |
GO:0010646 | regulation of cell communication | 48.8889 | 4 | no |
GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 42.2222 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 42.2222 | 4 | no |
GO:0051049 | regulation of transport | 40.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 37.7778 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 37.7778 | 4 | no |
GO:0060341 | regulation of cellular localization | 37.7778 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 35.5556 | 4 | no |
GO:0048878 | chemical homeostasis | 33.3333 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
GO:0006873 | cellular ion homeostasis | 31.1111 | 4 | no |
GO:0030003 | cellular cation homeostasis | 31.1111 | 5 | no |
GO:0050801 | ion homeostasis | 31.1111 | 5 | no |
GO:0055080 | cation homeostasis | 31.1111 | 6 | no |
GO:0098771 | inorganic ion homeostasis | 31.1111 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 31.1111 | 5 | no |
GO:0008104 | protein localization | 31.1111 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 31.1111 | 4 | no |
GO:0071702 | organic substance transport | 31.1111 | 4 | no |
GO:0071705 | nitrogen compound transport | 31.1111 | 4 | no |
GO:0051128 | regulation of cellular component organization | 31.1111 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.8889 | 5 | no |
GO:0010941 | regulation of cell death | 28.8889 | 4 | no |
GO:0031399 | regulation of protein modification process | 28.8889 | 6 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.8889 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 28.8889 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 28.8889 | 5 | no |
GO:2000026 | regulation of multicellular organismal development | 28.8889 | 4 | no |
GO:0022607 | cellular component assembly | 28.8889 | 4 | no |
GO:0042981 | regulation of apoptotic process | 26.6667 | 6 | no |
GO:0043067 | regulation of programmed cell death | 26.6667 | 5 | no |
GO:0051050 | positive regulation of transport | 26.6667 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
GO:0080134 | regulation of response to stress | 26.6667 | 4 | no |
GO:0015031 | protein transport | 26.6667 | 4 | no |
GO:0023056 | positive regulation of signaling | 26.6667 | 4 | no |
GO:0006811 | ion transport | 24.4444 | 4 | no |
GO:0010468 | regulation of gene expression | 24.4444 | 5 | no |
GO:0010647 | positive regulation of cell communication | 24.4444 | 5 | no |
GO:0042325 | regulation of phosphorylation | 24.4444 | 7 | no |
GO:0045595 | regulation of cell differentiation | 24.4444 | 4 | no |
GO:0051094 | positive regulation of developmental process | 24.4444 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 24.4444 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 24.4444 | 4 | no |
GO:0006875 | cellular metal ion homeostasis | 22.2222 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 22.2222 | 7 | no |
GO:0055065 | metal ion homeostasis | 22.2222 | 7 | no |
GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 22.2222 | 6 | no |
GO:0016192 | vesicle-mediated transport | 22.2222 | 4 | no |
GO:0042327 | positive regulation of phosphorylation | 22.2222 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 22.2222 | 7 | no |
GO:0006996 | organelle organization | 22.2222 | 4 | no |
GO:0030030 | cell projection organization | 22.2222 | 4 | no |
GO:0001667 | ameboidal-type cell migration | 8.8889 | 4 | yes |
GO:0010631 | epithelial cell migration | 6.6667 | 5 | yes |
GO:0016236 | macroautophagy | 6.6667 | 4 | yes |
GO:0043542 | endothelial cell migration | 6.6667 | 6 | yes |
GO:0061912 | selective autophagy | 6.6667 | 5 | yes |
GO:0098586 | cellular response to virus | 6.6667 | 4 | yes |
GO:0098792 | xenophagy | 4.4444 | 6 | yes |
GO:1904977 | lymphatic endothelial cell migration | 4.4444 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TGIF1_HUMAN | [view interactions] | Low throughput | no | no |
CACO2_HUMAN | [view interactions] | Low throughput | no | yes |
ITA4_HUMAN | [view interactions] | Low throughput | no | no |
LEG8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NDP_HUMAN | [view interactions] | Low throughput | no | no |
LRC8E_HUMAN | [view interactions] | High throughput | no | no |
ENPP4_HUMAN | [view interactions] | High throughput | no | yes |
ZNT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S12A7_HUMAN | [view interactions] | High throughput | no | yes |
VPP2_HUMAN | [view interactions] | High throughput | no | yes |
HEG1_HUMAN | [view interactions] | High throughput | no | yes |
MRC2_HUMAN | [view interactions] | High throughput | no | yes |
FPRP_HUMAN | [view interactions] | High throughput | no | yes |
LRC4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S17A5_HUMAN | [view interactions] | High throughput | no | no |
RRAGC_HUMAN | [view interactions] | High throughput | no | yes |
AT133_HUMAN | [view interactions] | High throughput | no | yes |
S12A9_HUMAN | [view interactions] | High throughput | no | yes |
S35A5_HUMAN | [view interactions] | High throughput | no | no |
VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SORL_HUMAN | [view interactions] | High throughput | no | yes |
SL9A6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRC8C_HUMAN | [view interactions] | High throughput | no | yes |
SPP2A_HUMAN | [view interactions] | High throughput | no | yes |
LRC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
S36A1_HUMAN | [view interactions] | High throughput | no | yes |
CSPG4_HUMAN | [view interactions] | High throughput | no | yes |
EMB_HUMAN | [view interactions] | High throughput | no | no |
CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
COL12_HUMAN | [view interactions] | High throughput | no | no |
ANO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NECT1_HUMAN | [view interactions] | High throughput | no | yes |
DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITA7_HUMAN | [view interactions] | High throughput | no | yes |
PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
ITA1_HUMAN | [view interactions] | High throughput | no | yes |
MFAP3_HUMAN | [view interactions] | High throughput | no | yes |
CLCN7_HUMAN | [view interactions] | High throughput | no | yes |
CLCN5_HUMAN | [view interactions] | High throughput | no | yes |
CLCN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S26A2_HUMAN | [view interactions] | High throughput | no | no |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
ITA2_HUMAN | [view interactions] | High throughput | no | yes |
PPAL_HUMAN | [view interactions] | High throughput | no | no |
CO4A_HUMAN | [view interactions] | High throughput | no | no |
CD63_HUMAN | [view interactions] | High throughput | no | no |
ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSCL1_HUMAN | [view interactions] | High throughput | no | no |
ADCY9_HUMAN | [view interactions] | High throughput | no | yes |
SUSD5_HUMAN | [view interactions] | High throughput | no | no |
RNF13_HUMAN | [view interactions] | High throughput | no | yes |
COPT1_HUMAN | [view interactions] | High throughput | no | no |
S4A7_HUMAN | [view interactions] | High throughput | no | no |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
TRI23_HUMAN | [view interactions] | High throughput | no | yes |
ACPH_HUMAN | [view interactions] | High throughput | no | yes |
WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CUL1_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
S15A4_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
BARD1_HUMAN | [view interactions] | High throughput | no | yes |
TRIM1_HUMAN | [view interactions] | High throughput | no | no |
WBP2_HUMAN | [view interactions] | High throughput | no | yes |
NACC1_HUMAN | [view interactions] | High throughput | no | yes |
NR1D2_HUMAN | [view interactions] | High throughput | no | yes |
PAN2_HUMAN | [view interactions] | High throughput | no | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
PTPRK_HUMAN | [view interactions] | High throughput | no | no |
SV2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MRP4_HUMAN | [view interactions] | High throughput | no | no |
K319L_HUMAN | [view interactions] | High throughput | no | yes |
AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2B3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
K1549_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD166_HUMAN | [view interactions] | High throughput | no | no |
B3A2_HUMAN | [view interactions] | High throughput | no | yes |
PTPRG_HUMAN | [view interactions] | High throughput | no | no |
CA159_HUMAN | [view interactions] | High throughput | no | no |
NR3L1_HUMAN | [view interactions] | High throughput | no | no |
PODXL_HUMAN | [view interactions] | High throughput | no | no |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
ITA6_HUMAN | [view interactions] | High throughput | no | yes |
LFA3_HUMAN | [view interactions] | High throughput | no | no |
S12A6_HUMAN | [view interactions] | High throughput | no | yes |
S12A4_HUMAN | [view interactions] | High throughput | no | yes |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
GLMP_HUMAN | [view interactions] | High throughput | no | no |
SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADCY6_HUMAN | [view interactions] | High throughput | no | yes |
S22AN_HUMAN | [view interactions] | High throughput | no | yes |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
LCAP_HUMAN | [view interactions] | High throughput | no | yes |
TM237_HUMAN | [view interactions] | High throughput | no | no |
NECT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
CD47_HUMAN | [view interactions] | High throughput | no | no |
RRAGB_HUMAN | [view interactions] | High throughput | no | yes |
S38A9_HUMAN | [view interactions] | High throughput | no | yes |
SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
CD276_HUMAN | [view interactions] | High throughput | no | yes |
LAMA4_HUMAN | [view interactions] | High throughput | no | no |
ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
TRPM4_HUMAN | [view interactions] | High throughput | no | no |
SDK1_HUMAN | [view interactions] | High throughput | no | yes |
SE6L2_HUMAN | [view interactions] | High throughput | no | yes |
EPCR_HUMAN | [view interactions] | High throughput | no | yes |
ECE1_HUMAN | [view interactions] | High throughput | no | yes |
MRP1_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
VANG1_HUMAN | [view interactions] | High throughput | no | no |
LEUK_HUMAN | [view interactions] | High throughput | no | no |
GT2D1_HUMAN | [view interactions] | High throughput | no | yes |
TNFL8_HUMAN | [view interactions] | High throughput | no | no |
PAPD1_HUMAN | [view interactions] | High throughput | no | yes |
ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DJC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LIGO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SIGIR_HUMAN | [view interactions] | High throughput | no | no |
TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD44_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
LYSC_HUMAN | [view interactions] | High throughput | no | no |
CATZ_HUMAN | [view interactions] | High throughput | no | yes |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LG3BP_HUMAN | [view interactions] | High throughput | no | no |
CD68_HUMAN | [view interactions] | High throughput | no | no |
PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
PDIA2_HUMAN | [view interactions] | High throughput | no | no |
PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
THIO_HUMAN | [view interactions] | High throughput | no | yes |
ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
TRIM6_HUMAN | [view interactions] | High throughput | no | no |
TRI17_HUMAN | [view interactions] | High throughput | no | yes |
MEFV_HUMAN | [view interactions] | High throughput | no | no |
TRI22_HUMAN | [view interactions] | High throughput | no | yes |
TRI49_HUMAN | [view interactions] | High throughput | no | no |
PDPN_HUMAN | [view interactions] | Computational | no | no |
ITAM_HUMAN | [view interactions] | Computational | no | no |