Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LEG8_HUMAN

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed, PubMed). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed, PubMed). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed, PubMed). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed). Also required to restrict infection of Picornaviridae viruses (PubMed). Has a marked preference for 3-O-sialylated and 3-O-sulfated glycans (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LEG8_HUMAN
GO:0046872 metal ion binding 31.1111 4 no
GO:0008324 cation transmembrane transporter activity 24.4444 4 no
GO:0017076 purine nucleotide binding 24.4444 4 no
GO:0022890 inorganic cation transmembrane transporter activity 24.4444 4 no
GO:0032555 purine ribonucleotide binding 24.4444 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.4444 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in LEG8_HUMAN
GO:0048522 positive regulation of cellular process 51.1111 4 no
GO:0010646 regulation of cell communication 48.8889 4 no
GO:0048523 negative regulation of cellular process 46.6667 4 no
GO:0031323 regulation of cellular metabolic process 42.2222 4 no
GO:0060255 regulation of macromolecule metabolic process 42.2222 4 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0009966 regulation of signal transduction 37.7778 4 no
GO:0051171 regulation of nitrogen compound metabolic process 37.7778 4 no
GO:0060341 regulation of cellular localization 37.7778 4 no
GO:0009893 positive regulation of metabolic process 35.5556 4 no
GO:0048878 chemical homeostasis 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0006873 cellular ion homeostasis 31.1111 4 no
GO:0030003 cellular cation homeostasis 31.1111 5 no
GO:0050801 ion homeostasis 31.1111 5 no
GO:0055080 cation homeostasis 31.1111 6 no
GO:0098771 inorganic ion homeostasis 31.1111 6 no
GO:1902531 regulation of intracellular signal transduction 31.1111 5 no
GO:0008104 protein localization 31.1111 4 no
GO:0051240 positive regulation of multicellular organismal process 31.1111 4 no
GO:0071702 organic substance transport 31.1111 4 no
GO:0071705 nitrogen compound transport 31.1111 4 no
GO:0051128 regulation of cellular component organization 31.1111 4 no
GO:0031325 positive regulation of cellular metabolic process 28.8889 5 no
GO:0010941 regulation of cell death 28.8889 4 no
GO:0031399 regulation of protein modification process 28.8889 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.8889 5 no
GO:0019220 regulation of phosphate metabolic process 28.8889 6 no
GO:0051174 regulation of phosphorus metabolic process 28.8889 5 no
GO:2000026 regulation of multicellular organismal development 28.8889 4 no
GO:0022607 cellular component assembly 28.8889 4 no
GO:0042981 regulation of apoptotic process 26.6667 6 no
GO:0043067 regulation of programmed cell death 26.6667 5 no
GO:0051050 positive regulation of transport 26.6667 4 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0080134 regulation of response to stress 26.6667 4 no
GO:0015031 protein transport 26.6667 4 no
GO:0023056 positive regulation of signaling 26.6667 4 no
GO:0006811 ion transport 24.4444 4 no
GO:0010468 regulation of gene expression 24.4444 5 no
GO:0010647 positive regulation of cell communication 24.4444 5 no
GO:0042325 regulation of phosphorylation 24.4444 7 no
GO:0045595 regulation of cell differentiation 24.4444 4 no
GO:0051094 positive regulation of developmental process 24.4444 4 no
GO:0051130 positive regulation of cellular component organization 24.4444 5 no
GO:0048584 positive regulation of response to stimulus 24.4444 4 no
GO:0006875 cellular metal ion homeostasis 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0055065 metal ion homeostasis 22.2222 7 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0016192 vesicle-mediated transport 22.2222 4 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0006996 organelle organization 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0001667 ameboidal-type cell migration 8.8889 4 yes
GO:0010631 epithelial cell migration 6.6667 5 yes
GO:0016236 macroautophagy 6.6667 4 yes
GO:0043542 endothelial cell migration 6.6667 6 yes
GO:0061912 selective autophagy 6.6667 5 yes
GO:0098586 cellular response to virus 6.6667 4 yes
GO:0098792 xenophagy 4.4444 6 yes
GO:1904977 lymphatic endothelial cell migration 4.4444 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TGIF1_HUMAN [view interactions] Low throughput no no
CACO2_HUMAN [view interactions] Low throughput no yes
ITA4_HUMAN [view interactions] Low throughput no no
LEG8_HUMAN [view entry] [view interactions] Low throughput yes yes
ITA3_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
NDP_HUMAN [view interactions] Low throughput no no
LRC8E_HUMAN [view interactions] High throughput no no
ENPP4_HUMAN [view interactions] High throughput no yes
ZNT1_HUMAN [view entry] [view interactions] High throughput yes no
S12A7_HUMAN [view interactions] High throughput no yes
VPP2_HUMAN [view interactions] High throughput no yes
HEG1_HUMAN [view interactions] High throughput no yes
MRC2_HUMAN [view interactions] High throughput no yes
FPRP_HUMAN [view interactions] High throughput no yes
LRC4B_HUMAN [view entry] [view interactions] High throughput yes no
S17A5_HUMAN [view interactions] High throughput no no
RRAGC_HUMAN [view interactions] High throughput no yes
AT133_HUMAN [view interactions] High throughput no yes
S12A9_HUMAN [view interactions] High throughput no yes
S35A5_HUMAN [view interactions] High throughput no no
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
SORL_HUMAN [view interactions] High throughput no yes
SL9A6_HUMAN [view entry] [view interactions] High throughput yes yes
LRC8C_HUMAN [view interactions] High throughput no yes
SPP2A_HUMAN [view interactions] High throughput no yes
LRC8A_HUMAN [view entry] [view interactions] High throughput yes no
OSTM1_HUMAN [view interactions] High throughput no yes
S36A1_HUMAN [view interactions] High throughput no yes
CSPG4_HUMAN [view interactions] High throughput no yes
EMB_HUMAN [view interactions] High throughput no no
CSCL2_HUMAN [view interactions] High throughput no yes
COL12_HUMAN [view interactions] High throughput no no
ANO6_HUMAN [view entry] [view interactions] High throughput yes no
NECT1_HUMAN [view interactions] High throughput no yes
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
ITA7_HUMAN [view interactions] High throughput no yes
PTPRJ_HUMAN [view interactions] High throughput no yes
ITA1_HUMAN [view interactions] High throughput no yes
MFAP3_HUMAN [view interactions] High throughput no yes
CLCN7_HUMAN [view interactions] High throughput no yes
CLCN5_HUMAN [view interactions] High throughput no yes
CLCN3_HUMAN [view entry] [view interactions] High throughput yes yes
S26A2_HUMAN [view interactions] High throughput no no
MUC18_HUMAN [view interactions] High throughput no yes
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRA_HUMAN [view interactions] High throughput no yes
ITA2_HUMAN [view interactions] High throughput no yes
PPAL_HUMAN [view interactions] High throughput no no
CO4A_HUMAN [view interactions] High throughput no no
CD63_HUMAN [view interactions] High throughput no no
ITA5_HUMAN [view entry] [view interactions] High throughput yes no
CSCL1_HUMAN [view interactions] High throughput no no
ADCY9_HUMAN [view interactions] High throughput no yes
SUSD5_HUMAN [view interactions] High throughput no no
RNF13_HUMAN [view interactions] High throughput no yes
COPT1_HUMAN [view interactions] High throughput no no
S4A7_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
ACPH_HUMAN [view interactions] High throughput no yes
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
CUL1_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
S15A4_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
BARD1_HUMAN [view interactions] High throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
WBP2_HUMAN [view interactions] High throughput no yes
NACC1_HUMAN [view interactions] High throughput no yes
NR1D2_HUMAN [view interactions] High throughput no yes
PAN2_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
PTPRK_HUMAN [view interactions] High throughput no no
SV2A_HUMAN [view entry] [view interactions] High throughput yes yes
MRP4_HUMAN [view interactions] High throughput no no
K319L_HUMAN [view interactions] High throughput no yes
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B2_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B3_HUMAN [view entry] [view interactions] High throughput yes yes
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
K1549_HUMAN [view entry] [view interactions] High throughput yes yes
CD166_HUMAN [view interactions] High throughput no no
B3A2_HUMAN [view interactions] High throughput no yes
PTPRG_HUMAN [view interactions] High throughput no no
CA159_HUMAN [view interactions] High throughput no no
NR3L1_HUMAN [view interactions] High throughput no no
PODXL_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
ITA6_HUMAN [view interactions] High throughput no yes
LFA3_HUMAN [view interactions] High throughput no no
S12A6_HUMAN [view interactions] High throughput no yes
S12A4_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
GLMP_HUMAN [view interactions] High throughput no no
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
ADCY6_HUMAN [view interactions] High throughput no yes
S22AN_HUMAN [view interactions] High throughput no yes
VGFR3_HUMAN [view interactions] High throughput no yes
LCAP_HUMAN [view interactions] High throughput no yes
TM237_HUMAN [view interactions] High throughput no no
NECT3_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
CD47_HUMAN [view interactions] High throughput no no
RRAGB_HUMAN [view interactions] High throughput no yes
S38A9_HUMAN [view interactions] High throughput no yes
SCRB2_HUMAN [view interactions] High throughput no yes
CD276_HUMAN [view interactions] High throughput no yes
LAMA4_HUMAN [view interactions] High throughput no no
ATG9A_HUMAN [view interactions] High throughput no yes
TRPM4_HUMAN [view interactions] High throughput no no
SDK1_HUMAN [view interactions] High throughput no yes
SE6L2_HUMAN [view interactions] High throughput no yes
EPCR_HUMAN [view interactions] High throughput no yes
ECE1_HUMAN [view interactions] High throughput no yes
MRP1_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
NUPR1_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
LEG9_HUMAN [view interactions] High throughput no yes
VANG1_HUMAN [view interactions] High throughput no no
LEUK_HUMAN [view interactions] High throughput no no
GT2D1_HUMAN [view interactions] High throughput no yes
TNFL8_HUMAN [view interactions] High throughput no no
PAPD1_HUMAN [view interactions] High throughput no yes
ICAM5_HUMAN [view entry] [view interactions] High throughput yes yes
DJC13_HUMAN [view entry] [view interactions] High throughput yes yes
LIGO1_HUMAN [view entry] [view interactions] High throughput yes no
SIGIR_HUMAN [view interactions] High throughput no no
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
CD44_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
LYSC_HUMAN [view interactions] High throughput no no
CATZ_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
LG3BP_HUMAN [view interactions] High throughput no no
CD68_HUMAN [view interactions] High throughput no no
PDIA1_HUMAN [view interactions] High throughput no yes
PDIA2_HUMAN [view interactions] High throughput no no
PDIA4_HUMAN [view interactions] High throughput no yes
PDIA6_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
HMGB1_HUMAN [view interactions] High throughput no yes
HMGB2_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
RHOC_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
TRIM5_HUMAN [view interactions] High throughput no yes
TRIM6_HUMAN [view interactions] High throughput no no
TRI17_HUMAN [view interactions] High throughput no yes
MEFV_HUMAN [view interactions] High throughput no no
TRI22_HUMAN [view interactions] High throughput no yes
TRI49_HUMAN [view interactions] High throughput no no
PDPN_HUMAN [view interactions] Computational no no
ITAM_HUMAN [view interactions] Computational no no