LEG8_HUMAN
Evidence for PS localization
Functions
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed, PubMed). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed, PubMed). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed, PubMed). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed). Also required to restrict infection of Picornaviridae viruses (PubMed). Has a marked preference for 3-O-sialylated and 3-O-sulfated glycans (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LEG8_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.0000 | 4 | no |
| GO:0043169 | cation binding | 32.0000 | 4 | no |
| GO:0046872 | metal ion binding | 32.0000 | 5 | no |
| GO:0000166 | nucleotide binding | 28.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.0000 | 4 | no |
| GO:0005524 | ATP binding | 22.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.0000 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LEG8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 38.0000 | 4 | no |
| GO:0051049 | regulation of transport | 38.0000 | 4 | no |
| GO:0008104 | protein localization | 36.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 36.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 34.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 34.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 34.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.0000 | 5 | no |
| GO:0055080 | monoatomic cation homeostasis | 32.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 32.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0006873 | intracellular monoatomic ion homeostasis | 30.0000 | 4 | no |
| GO:0030003 | intracellular monoatomic cation homeostasis | 30.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 30.0000 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 30.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.0000 | 4 | no |
| GO:0080134 | regulation of response to stress | 28.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 28.0000 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 26.0000 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 26.0000 | 5 | no |
| GO:0071702 | organic substance transport | 26.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.0000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 26.0000 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 26.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.0000 | 5 | no |
| GO:0098657 | import into cell | 26.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.0000 | 7 | no |
| GO:0006996 | organelle organization | 24.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 24.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:0015031 | protein transport | 22.0000 | 4 | no |
| GO:0006811 | monoatomic ion transport | 22.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.0000 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 22.0000 | 4 | no |
| GO:2000145 | regulation of cell motility | 22.0000 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 22.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 22.0000 | 4 | no |
| GO:0001667 | ameboidal-type cell migration | 10.0000 | 4 | yes |
| GO:0010631 | epithelial cell migration | 8.0000 | 5 | yes |
| GO:0043542 | endothelial cell migration | 8.0000 | 6 | yes |
| GO:0016236 | macroautophagy | 6.0000 | 4 | yes |
| GO:0098586 | cellular response to virus | 6.0000 | 4 | yes |
| GO:0098792 | xenophagy | 4.0000 | 5 | yes |
| GO:1904977 | lymphatic endothelial cell migration | 4.0000 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDP_HUMAN | [view interactions] | Low throughput | no | no |
| TGIF1_HUMAN | [view interactions] | Low throughput | no | no |
| ITA4_HUMAN | [view interactions] | Low throughput | no | no |
| CACO2_HUMAN | [view interactions] | Low throughput | no | yes |
| LEG8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| SV2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRP4_HUMAN | [view interactions] | High throughput | no | no |
| K319L_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1549_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD166_HUMAN | [view interactions] | High throughput | no | no |
| B3A2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| CA159_HUMAN | [view interactions] | High throughput | no | no |
| NR3L1_HUMAN | [view interactions] | High throughput | no | no |
| PODXL_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ITA6_HUMAN | [view interactions] | High throughput | no | yes |
| LFA3_HUMAN | [view interactions] | High throughput | no | no |
| S12A6_HUMAN | [view interactions] | High throughput | no | yes |
| S12A4_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCY6_HUMAN | [view interactions] | High throughput | no | yes |
| S22AN_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| LCAP_HUMAN | [view interactions] | High throughput | no | yes |
| TM237_HUMAN | [view interactions] | High throughput | no | no |
| NECT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD47_HUMAN | [view interactions] | High throughput | no | no |
| RRAGB_HUMAN | [view interactions] | High throughput | no | yes |
| S38A9_HUMAN | [view interactions] | High throughput | no | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| CD276_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA4_HUMAN | [view interactions] | High throughput | no | no |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| TRPM4_HUMAN | [view interactions] | High throughput | no | no |
| SDK1_HUMAN | [view interactions] | High throughput | no | yes |
| SE6L2_HUMAN | [view interactions] | High throughput | no | yes |
| EPCR_HUMAN | [view interactions] | High throughput | no | yes |
| ECE1_HUMAN | [view interactions] | High throughput | no | yes |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| LEUK_HUMAN | [view interactions] | High throughput | no | no |
| GT2D1_HUMAN | [view interactions] | High throughput | no | yes |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| PAPD1_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIGO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIGIR_HUMAN | [view interactions] | High throughput | no | no |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| LYSC_HUMAN | [view interactions] | High throughput | no | no |
| CATZ_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| CD68_HUMAN | [view interactions] | High throughput | no | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA2_HUMAN | [view interactions] | High throughput | no | no |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM6_HUMAN | [view interactions] | High throughput | no | no |
| TRI17_HUMAN | [view interactions] | High throughput | no | yes |
| MEFV_HUMAN | [view interactions] | High throughput | no | no |
| TRI22_HUMAN | [view interactions] | High throughput | no | yes |
| TRI49_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| S4A7_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| RNF13_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD5_HUMAN | [view interactions] | High throughput | no | no |
| ADCY9_HUMAN | [view interactions] | High throughput | no | yes |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| CO4A_HUMAN | [view interactions] | High throughput | no | no |
| PPAL_HUMAN | [view interactions] | High throughput | no | no |
| ITA2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| S26A2_HUMAN | [view interactions] | High throughput | no | no |
| CLCN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCN5_HUMAN | [view interactions] | High throughput | no | yes |
| CLCN7_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP3_HUMAN | [view interactions] | High throughput | no | yes |
| ITA1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| ITA7_HUMAN | [view interactions] | High throughput | no | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NECT1_HUMAN | [view interactions] | High throughput | no | yes |
| ANO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COL12_HUMAN | [view interactions] | High throughput | no | no |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| LRC8E_HUMAN | [view interactions] | High throughput | no | no |
| EMB_HUMAN | [view interactions] | High throughput | no | no |
| CSPG4_HUMAN | [view interactions] | High throughput | no | yes |
| S36A1_HUMAN | [view interactions] | High throughput | no | yes |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPP2A_HUMAN | [view interactions] | High throughput | no | yes |
| LRC8C_HUMAN | [view interactions] | High throughput | no | yes |
| SL9A6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SORL_HUMAN | [view interactions] | High throughput | no | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S35A5_HUMAN | [view interactions] | High throughput | no | no |
| S12A9_HUMAN | [view interactions] | High throughput | no | yes |
| AT133_HUMAN | [view interactions] | High throughput | no | yes |
| RRAGC_HUMAN | [view interactions] | High throughput | no | yes |
| S17A5_HUMAN | [view interactions] | High throughput | no | no |
| LRC4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FPRP_HUMAN | [view interactions] | High throughput | no | yes |
| MRC2_HUMAN | [view interactions] | High throughput | no | yes |
| HEG1_HUMAN | [view interactions] | High throughput | no | yes |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| S12A7_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENPP4_HUMAN | [view interactions] | High throughput | no | yes |
| NF2L2_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| S15A4_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| WBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NACC1_HUMAN | [view interactions] | High throughput | no | yes |
| NR1D2_HUMAN | [view interactions] | High throughput | no | yes |