DAG1_HUMAN

G2C

SynGO

SynaptomeDB

(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed, PubMed, PubMed). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed). [View more on UniProt]

Transmembrane

Phase separation

ELM

Phosphorylation

PFAM

Coiled coil

Anchor

Disordered

Interacting regions

Sequence

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DAG1_HUMAN

SRC_HUMAN

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DAG1_HUMAN

FYN_HUMAN

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DAG1_HUMAN

GRB2_HUMAN

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DAG1_HUMAN

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DAG1_HUMAN

DMD_HUMAN

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Interacting regions

Canonical [DAG1_HUMAN]

Isoform [C9J6Z6] alignment

Isoform [C9J6Z6] sequence

Isoform [C9J196] alignment

Isoform [C9J196] sequence

Isoform [C9JY76] alignment

Isoform [C9JY76] sequence

Isoform [C9JYS1] alignment

Isoform [C9JYS1] sequence

Isoform [C9JQL4] alignment

Isoform [C9JQL4] sequence

Isoform [C9JEH2] alignment

Isoform [C9JEH2] sequence

Isoform [C9JEN1] alignment

Isoform [C9JEN1] sequence

Isoform [A0A669KB80] alignment

Isoform [A0A669KB80] sequence

Isoform [A0A1D5RMP6] alignment

Isoform [A0A1D5RMP6] sequence

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Position	Amino acid	Mutation	Disease	Overlap with binding region
192	Thr	Met	Musculardystrophy-dystroglycanopathylimb-girdleC9(MDDGC9)	-
74	Val	Ile	Musculardystrophy-dystroglycanopathylimb-girdleC9(MDDGC9)	-
111	Asp	Asn	Musculardystrophy-dystroglycanopathylimb-girdleC9(MDDGC9)	-
669	Cys	Phe	Musculardystrophy-dystroglycanopathycongenitalwithbrainandeyeanomaliesA9(MDDGA9)	-

ELM instance	Name	Type	Start	End	Partner
ELMI002167	LIG_SH2_SRC	LIG	892	895	-
ELMI002281	LIG_SH3_3	LIG	888	894	-
ELMI001104	LIG_WW_1	LIG	889	892	-
ELMI002179	TRG_NLS_MonoExtN_4	TRG	778	783	-
ELMI002167	LIG_SH2_SRC	LIG	892	895	-
ELMI002281	LIG_SH3_3	LIG	888	894	-
ELMI001104	LIG_WW_1	LIG	889	892	-
ELMI002179	TRG_NLS_MonoExtN_4	TRG	778	783	-

Molecular function

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Search:

Term	Name	%	Distance from the top of the tree	Annotated in DAG1_HUMAN
GO:0043168	anion binding	32.8571	4	no
GO:0043169	cation binding	31.4286	4	yes
GO:0046872	metal ion binding	30.0000	5	yes
GO:0000166	nucleotide binding	28.5714	4	no
GO:0017076	purine nucleotide binding	28.5714	5	no
GO:0032555	purine ribonucleotide binding	27.1429	4	no
GO:0035639	purine ribonucleoside triphosphate binding	27.1429	4	no
GO:0019900	kinase binding	21.4286	4	no
GO:0003779	actin binding	15.7143	4	yes
GO:0005509	calcium ion binding	12.8571	6	yes
GO:0001618	virus receptor activity	10.0000	4	yes
GO:0017166	vinculin binding	8.5714	4	yes
GO:0015631	tubulin binding	7.1429	4	yes
GO:0042169	SH2 domain binding	5.7143	4	yes
GO:0042805	actinin binding	2.8571	4	yes
GO:0043237	laminin-1 binding	2.8571	4	yes
GO:0051393	alpha-actinin binding	2.8571	5	yes

Showing 1 to 17 of 17 entries

Biological process

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Search:

Term	Name	%	Distance from top the of the tree	Annotated in DAG1_HUMAN
GO:0048522	positive regulation of cellular process	60.0000	4	yes
GO:0051128	regulation of cellular component organization	50.0000	4	yes
GO:0048523	negative regulation of cellular process	44.2857	4	yes
GO:0022607	cellular component assembly	41.4286	4	no
GO:0010646	regulation of cell communication	40.0000	4	yes
GO:0060255	regulation of macromolecule metabolic process	35.7143	4	no
GO:0009966	regulation of signal transduction	35.7143	4	yes
GO:0031323	regulation of cellular metabolic process	34.2857	4	no
GO:0080090	regulation of primary metabolic process	34.2857	4	no
GO:0006996	organelle organization	34.2857	4	yes
GO:0030030	cell projection organization	34.2857	4	yes
GO:0044087	regulation of cellular component biogenesis	31.4286	4	yes
GO:0048584	positive regulation of response to stimulus	30.0000	4	no
GO:0009893	positive regulation of metabolic process	30.0000	4	no
GO:0008104	protein localization	30.0000	4	yes
GO:1902531	regulation of intracellular signal transduction	28.5714	5	yes
GO:0010604	positive regulation of macromolecule metabolic process	28.5714	5	no
GO:0120036	plasma membrane bounded cell projection organization	28.5714	5	yes
GO:0042127	regulation of cell population proliferation	27.1429	4	no
GO:0023056	positive regulation of signaling	27.1429	4	no
GO:0051130	positive regulation of cellular component organization	27.1429	5	yes
GO:2000145	regulation of cell motility	25.7143	4	yes
GO:0051049	regulation of transport	25.7143	4	no
GO:0051246	regulation of protein metabolic process	25.7143	5	no
GO:0009889	regulation of biosynthetic process	25.7143	4	no

Showing 1 to 25 of 158 entries

Disease

No data found.

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Uniprot ID	Details	Highest evidence	Localizing into PSD	HPA (protein expression in neurons)
4F2_HUMAN	[view entry] [view interactions]	High throughput	yes	no
5HT3C_HUMAN	[view entry] [view interactions]	High throughput	yes	no
AATC_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AATM_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ACHB_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
ACHE_HUMAN	[view entry] [view interactions]	High throughput	yes	no
ACTN1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
AGR2_HUMAN	[view interactions]	Low throughput	no	no
AGR3_HUMAN	[view interactions]	Low throughput	no	no
AGRIN_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
AQP4_HUMAN	[view entry] [view interactions]	High throughput	yes	no
BIP_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
BRCA1_HUMAN	[view interactions]	High throughput	no	yes
BRID5_HUMAN	[view interactions]	High throughput	no	no
BTNL2_HUMAN	[view interactions]	High throughput	no	no
BTNL3_HUMAN	[view interactions]	High throughput	no	no
CA054_HUMAN	[view interactions]	High throughput	no	yes
CAD16_HUMAN	[view interactions]	High throughput	no	no
CADH1_HUMAN	[view entry] [view interactions]	High throughput	yes	no
CADH5_HUMAN	[view interactions]	High throughput	no	yes
CAH9_HUMAN	[view interactions]	High throughput	no	no
CATA_HUMAN	[view entry] [view interactions]	High throughput	yes	no
CAV1_HUMAN	[view interactions]	Low throughput	no	no
CAV3_HUMAN	[view interactions]	Low throughput	no	no
CBLN4_HUMAN	[view interactions]	High throughput	no	no

Showing 1 to 25 of 169 entries

DAG1_HUMAN

Evidence for PS localization

Functions

Protein features

Binary interactions with known binding regions

Network

Isoforms

Disease-causing germline mutations

Linear motifs

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Molecular function

Biological process

Disease

All partners