KIBRA_HUMAN
Evidence for PS localization
Functions
Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed). Modulates directional migration of podocytes (PubMed). Plays a role in cognition and memory performance (PubMed). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIBRA_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.9149 | 4 | no |
| GO:0000166 | nucleotide binding | 29.7872 | 4 | no |
| GO:0019900 | kinase binding | 27.6596 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 27.6596 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.6596 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.6596 | 4 | no |
| GO:0005524 | ATP binding | 25.5319 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.5319 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.5319 | 5 | no |
| GO:0043169 | cation binding | 21.2766 | 4 | no |
| GO:0046872 | metal ion binding | 21.2766 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIBRA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.5745 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 55.3191 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.1915 | 4 | yes |
| GO:0008104 | protein localization | 53.1915 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.0638 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 51.0638 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 51.0638 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.6809 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 44.6809 | 4 | no |
| GO:0006996 | organelle organization | 44.6809 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.2979 | 4 | yes |
| GO:0010468 | regulation of gene expression | 36.1702 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.1702 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 36.1702 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 36.1702 | 4 | yes |
| GO:0051049 | regulation of transport | 34.0426 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 31.9149 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.9149 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 31.9149 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 31.9149 | 5 | yes |
| GO:0022607 | cellular component assembly | 31.9149 | 4 | no |
| GO:0032880 | regulation of protein localization | 31.9149 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.7872 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 29.7872 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 29.7872 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 29.7872 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 29.7872 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 29.7872 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 29.7872 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 29.7872 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.6596 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 27.6596 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 27.6596 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 27.6596 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.5319 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 25.5319 | 6 | yes |
| GO:0071702 | organic substance transport | 25.5319 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.5319 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.5319 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.5319 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.5319 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.5319 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.4043 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 23.4043 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.4043 | 5 | no |
| GO:0036211 | protein modification process | 23.4043 | 4 | no |
| GO:0043412 | macromolecule modification | 23.4043 | 4 | no |
| GO:0015031 | protein transport | 21.2766 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.2766 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.2766 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.2766 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.2766 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.2766 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.2766 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.2766 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 21.2766 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 19.1489 | 5 | yes |
| GO:0043408 | regulation of MAPK cascade | 19.1489 | 6 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 19.1489 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 17.0213 | 8 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 17.0213 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 17.0213 | 6 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 17.0213 | 6 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 14.8936 | 8 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 14.8936 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 14.8936 | 4 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 14.8936 | 6 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 14.8936 | 7 | yes |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 12.7660 | 9 | yes |
| GO:0032386 | regulation of intracellular transport | 12.7660 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 12.7660 | 4 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 10.6383 | 7 | yes |
| GO:0048638 | regulation of developmental growth | 10.6383 | 4 | yes |
| GO:0035330 | regulation of hippo signaling | 6.3830 | 6 | yes |
| GO:0035331 | negative regulation of hippo signaling | 6.3830 | 7 | yes |
| GO:0046620 | regulation of organ growth | 6.3830 | 4 | yes |
| GO:0045926 | negative regulation of growth | 4.2553 | 4 | yes |
| GO:0046621 | negative regulation of organ growth | 4.2553 | 5 | yes |
| GO:0048640 | negative regulation of developmental growth | 4.2553 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FEZ1_HUMAN | [view interactions] | Low throughput | no | no |
| WWC2_HUMAN | [view interactions] | Low throughput | no | yes |
| WWC3_HUMAN | [view interactions] | Low throughput | no | yes |
| RHG07_HUMAN | [view interactions] | Low throughput | no | no |
| LATS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | Low throughput | no | yes |
| MERL_HUMAN | [view interactions] | Low throughput | no | yes |
| DAG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIBRA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATM_HUMAN | [view interactions] | Low throughput | no | yes |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| DEND_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EXOC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMOT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTN14_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| F219A_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| FEZ2_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| PAR6B_HUMAN | [view interactions] | High throughput | no | no |
| ARRD1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCP4_HUMAN | [view interactions] | High throughput | no | yes |
| RASF1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN21_HUMAN | [view interactions] | High throughput | no | yes |
| RHPN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| RPGF6_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| DLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAEA_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYD8_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MOC2B_HUMAN | [view interactions] | High throughput | no | yes |
| FEM1A_HUMAN | [view interactions] | High throughput | no | no |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| ADT4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH4_HUMAN | [view interactions] | High throughput | no | no |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| CNGA1_HUMAN | [view interactions] | High throughput | no | no |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDKN3_HUMAN | [view interactions] | High throughput | no | no |
| LONP2_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| US6NL_HUMAN | [view interactions] | High throughput | no | yes |
| MPP7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| SSX7_HUMAN | [view interactions] | High throughput | no | no |
| FARP2_HUMAN | [view interactions] | High throughput | no | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K0513_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |