MPDZ_HUMAN
Evidence for PS localization
Functions
Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed, PubMed). Promotes clustering of HT2RC at the cell surface . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MPDZ_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 57.5758 | 4 | yes |
| GO:0010646 | regulation of cell communication | 57.5758 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 57.5758 | 4 | no |
| GO:0009966 | regulation of signal transduction | 48.4848 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.4848 | 4 | no |
| GO:0008104 | protein localization | 48.4848 | 4 | no |
| GO:0022607 | cellular component assembly | 45.4545 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.4545 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.4242 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 36.3636 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 36.3636 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.3030 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 30.3030 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.3030 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.3030 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.3030 | 5 | no |
| GO:0051049 | regulation of transport | 30.3030 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.3030 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.3030 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.2727 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.2727 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.2727 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.2727 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.2727 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 27.2727 | 4 | no |
| GO:0034330 | cell junction organization | 24.2424 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 24.2424 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.2424 | 5 | no |
| GO:0043269 | regulation of ion transport | 24.2424 | 5 | no |
| GO:0043933 | protein-containing complex organization | 24.2424 | 4 | no |
| GO:0050890 | cognition | 24.2424 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 24.2424 | 5 | no |
| GO:0010941 | regulation of cell death | 24.2424 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 24.2424 | 4 | no |
| GO:0071702 | organic substance transport | 24.2424 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 24.2424 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.2424 | 4 | no |
| GO:0030030 | cell projection organization | 24.2424 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 24.2424 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.2424 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.2121 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 21.2121 | 6 | no |
| GO:0044057 | regulation of system process | 21.2121 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.2121 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.2121 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.2121 | 6 | no |
| GO:0007010 | cytoskeleton organization | 21.2121 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.2121 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.2121 | 5 | no |
| GO:0036211 | protein modification process | 21.2121 | 4 | no |
| GO:0043412 | macromolecule modification | 21.2121 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.2121 | 6 | no |
| GO:0071705 | nitrogen compound transport | 21.2121 | 4 | no |
| GO:0060284 | regulation of cell development | 21.2121 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.2121 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.2121 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.2121 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.2121 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.2121 | 4 | no |
| GO:0007043 | cell-cell junction assembly | 18.1818 | 6 | yes |
| GO:0034329 | cell junction assembly | 18.1818 | 5 | yes |
| GO:0045216 | cell-cell junction organization | 18.1818 | 5 | yes |
| GO:0032886 | regulation of microtubule-based process | 9.0909 | 4 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 9.0909 | 5 | yes |
| GO:0120192 | tight junction assembly | 6.0606 | 7 | yes |
| GO:0120193 | tight junction organization | 6.0606 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MPDZ_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 9.0909 | 3 | yes |
| DOID:936 | brain disease | 9.0909 | 4 | yes |
| DOID:10908 | hydrocephalus | 6.0606 | 6 | yes |
| DOID:1443 | cerebral degeneration | 6.0606 | 5 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| O2AG1_HUMAN | [view interactions] | Low throughput | no | no |
| OR1D2_HUMAN | [view interactions] | Low throughput | no | no |
| OR3A1_HUMAN | [view interactions] | Low throughput | no | no |
| 5HT2C_HUMAN | [view interactions] | Low throughput | no | no |
| SSR3_HUMAN | [view interactions] | Low throughput | no | yes |
| KIT_HUMAN | [view interactions] | Low throughput | no | no |
| DLL1_HUMAN | [view interactions] | Low throughput | no | no |
| DLL4_HUMAN | [view interactions] | Low throughput | no | no |
| PALS1_HUMAN | [view interactions] | Low throughput | no | no |
| PKHG5_HUMAN | [view interactions] | Low throughput | no | yes |
| PKHA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKHA2_HUMAN | [view interactions] | Low throughput | no | no |
| 5HT2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 5HT2B_HUMAN | [view interactions] | Low throughput | no | no |
| CLD1_HUMAN | [view interactions] | Low throughput | no | no |
| JAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CLD4_HUMAN | [view interactions] | Low throughput | no | yes |
| ADCY3_HUMAN | [view interactions] | Low throughput | no | yes |
| DRD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSPG4_HUMAN | [view interactions] | Low throughput | no | yes |
| TEAD2_HUMAN | [view interactions] | Low throughput | no | no |
| GPR37_HUMAN | [view interactions] | Low throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DAPLE_HUMAN | [view interactions] | Low throughput | no | yes |
| CRFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| RN146_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSMD2_HUMAN | [view interactions] | Low throughput | no | no |
| MPDZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| LRFN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| CHMP6_HUMAN | [view interactions] | High throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF22_HUMAN | [view interactions] | High throughput | no | no |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN166_HUMAN | [view interactions] | High throughput | no | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| T22D2_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| KIBRA_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| TNKS2_HUMAN | [view interactions] | High throughput | no | no |
| ZN664_HUMAN | [view interactions] | High throughput | no | no |
| TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAPC2_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| MK09_HUMAN | [view interactions] | High throughput | no | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSCP1_HUMAN | [view interactions] | High throughput | no | yes |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF15_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR54_HUMAN | [view interactions] | High throughput | no | no |
| F124A_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| C2C4B_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TEAD1_HUMAN | [view interactions] | High throughput | no | no |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN138_HUMAN | [view interactions] | High throughput | no | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS1_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| CRUM1_HUMAN | [view interactions] | Computational | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |