MPDZ_HUMAN
Evidence for PS localization
Functions
Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed, PubMed). Promotes clustering of HT2RC at the cell surface . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MPDZ_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 28.5714 | 4 | no |
| GO:0043168 | anion binding | 23.8095 | 4 | no |
| GO:0019901 | protein kinase binding | 21.4286 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MPDZ_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.5238 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.7619 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.7619 | 4 | no |
| GO:0008104 | protein localization | 47.6190 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.6190 | 4 | no |
| GO:0009966 | regulation of signal transduction | 47.6190 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.2381 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.2381 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.8571 | 4 | no |
| GO:0022607 | cellular component assembly | 40.4762 | 4 | yes |
| GO:0006996 | organelle organization | 35.7143 | 4 | no |
| GO:0033043 | regulation of organelle organization | 33.3333 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.9524 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.9524 | 5 | no |
| GO:0051049 | regulation of transport | 30.9524 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | no |
| GO:0010468 | regulation of gene expression | 28.5714 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 28.5714 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 28.5714 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.1905 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 26.1905 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.1905 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.1905 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.1905 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.1905 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.1905 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 26.1905 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.1905 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.1905 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.1905 | 4 | no |
| GO:0030030 | cell projection organization | 23.8095 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.8095 | 6 | no |
| GO:0036211 | protein modification process | 23.8095 | 4 | no |
| GO:0043412 | macromolecule modification | 23.8095 | 4 | no |
| GO:0071702 | organic substance transport | 23.8095 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 23.8095 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.8095 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.8095 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.8095 | 4 | no |
| GO:0034330 | cell junction organization | 21.4286 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 21.4286 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.4286 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.4286 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 21.4286 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.4286 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.4286 | 6 | no |
| GO:0071705 | nitrogen compound transport | 21.4286 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.4286 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 21.4286 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.4286 | 4 | no |
| GO:0051093 | negative regulation of developmental process | 21.4286 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.4286 | 5 | no |
| GO:0060284 | regulation of cell development | 21.4286 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.4286 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
| GO:1902532 | negative regulation of intracellular signal transduction | 21.4286 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.4286 | 4 | no |
| GO:0007043 | cell-cell junction assembly | 16.6667 | 6 | yes |
| GO:0034329 | cell junction assembly | 16.6667 | 5 | yes |
| GO:0045216 | cell-cell junction organization | 16.6667 | 5 | yes |
| GO:0032886 | regulation of microtubule-based process | 9.5238 | 4 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 9.5238 | 5 | yes |
| GO:0120192 | tight junction assembly | 4.7619 | 7 | yes |
| GO:0120193 | tight junction organization | 4.7619 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| O2AG1_HUMAN | [view interactions] | Low throughput | no | no |
| OR5DI_HUMAN | [view interactions] | Low throughput | no | no |
| OR1D2_HUMAN | [view interactions] | Low throughput | no | no |
| OR3A1_HUMAN | [view interactions] | Low throughput | no | no |
| 5HT2C_HUMAN | [view interactions] | Low throughput | no | no |
| SSR3_HUMAN | [view interactions] | Low throughput | no | yes |
| KIT_HUMAN | [view interactions] | Low throughput | no | no |
| DLL1_HUMAN | [view interactions] | Low throughput | no | no |
| DLL4_HUMAN | [view interactions] | Low throughput | no | no |
| PALS1_HUMAN | [view interactions] | Low throughput | no | no |
| PKHG5_HUMAN | [view interactions] | Low throughput | no | yes |
| PKHA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKHA2_HUMAN | [view interactions] | Low throughput | no | no |
| 5HT2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 5HT2B_HUMAN | [view interactions] | Low throughput | no | no |
| CLD1_HUMAN | [view interactions] | Low throughput | no | no |
| JAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CLD4_HUMAN | [view interactions] | Low throughput | no | yes |
| ADCY3_HUMAN | [view interactions] | Low throughput | no | yes |
| DRD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSPG4_HUMAN | [view interactions] | Low throughput | no | yes |
| TEAD2_HUMAN | [view interactions] | Low throughput | no | no |
| GPR37_HUMAN | [view interactions] | Low throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DAPLE_HUMAN | [view interactions] | Low throughput | no | yes |
| CRFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RN146_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSMD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MPDZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRFN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| CHMP6_HUMAN | [view interactions] | High throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF22_HUMAN | [view interactions] | High throughput | no | no |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN166_HUMAN | [view interactions] | High throughput | no | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| T22D2_HUMAN | [view interactions] | High throughput | no | yes |
| PELI2_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| KIBRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DUS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| TNKS2_HUMAN | [view interactions] | High throughput | no | no |
| ZN664_HUMAN | [view interactions] | High throughput | no | no |
| TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAPC2_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| MK09_HUMAN | [view interactions] | High throughput | no | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSCP1_HUMAN | [view interactions] | High throughput | no | yes |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF15_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR54_HUMAN | [view interactions] | High throughput | no | no |
| F124A_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| C2C4B_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TEAD1_HUMAN | [view interactions] | High throughput | no | no |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN138_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCYB1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KTI12_HUMAN | [view interactions] | High throughput | no | yes |