Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

5HT2A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in 5HT2A_HUMAN
GO:0043169 cation binding 39.1304 4 yes
GO:0000166 nucleotide binding 39.1304 4 no
GO:0017076 purine nucleotide binding 39.1304 5 no
GO:0032555 purine ribonucleotide binding 39.1304 4 no
GO:0035639 purine ribonucleoside triphosphate binding 39.1304 4 no
GO:0043168 anion binding 39.1304 4 no
GO:0005524 ATP binding 30.4348 5 no
GO:0030554 adenyl nucleotide binding 30.4348 6 no
GO:0032559 adenyl ribonucleotide binding 30.4348 5 no
GO:0016301 kinase activity 26.0870 4 no
GO:0046872 metal ion binding 26.0870 5 no
GO:0019900 kinase binding 21.7391 4 no
GO:0004930 G protein-coupled receptor activity 17.3913 4 yes
GO:0001587 Gq/11-coupled serotonin receptor activity 8.6957 7 yes
GO:0001618 virus receptor activity 8.6957 4 yes
GO:0004993 G protein-coupled serotonin receptor activity 8.6957 6 yes
GO:0008227 G protein-coupled amine receptor activity 8.6957 5 yes
GO:0019209 kinase activator activity 8.6957 4 yes
GO:0019887 protein kinase regulator activity 8.6957 4 yes
GO:0030295 protein kinase activator activity 8.6957 5 yes
GO:0030296 protein tyrosine kinase activator activity 8.6957 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in 5HT2A_HUMAN
GO:0048522 positive regulation of cellular process 60.8696 4 yes
GO:0048523 negative regulation of cellular process 60.8696 4 yes
GO:0010646 regulation of cell communication 60.8696 4 yes
GO:0009966 regulation of signal transduction 52.1739 4 yes
GO:0048584 positive regulation of response to stimulus 47.8261 4 yes
GO:0051049 regulation of transport 47.8261 4 yes
GO:0060255 regulation of macromolecule metabolic process 47.8261 4 yes
GO:0080090 regulation of primary metabolic process 47.8261 4 yes
GO:1902531 regulation of intracellular signal transduction 47.8261 5 yes
GO:0051128 regulation of cellular component organization 47.8261 4 no
GO:0051246 regulation of protein metabolic process 43.4783 5 yes
GO:0009967 positive regulation of signal transduction 43.4783 5 yes
GO:0010647 positive regulation of cell communication 43.4783 5 yes
GO:0023056 positive regulation of signaling 43.4783 4 yes
GO:0031323 regulation of cellular metabolic process 43.4783 4 yes
GO:0050804 modulation of chemical synaptic transmission 39.1304 5 yes
GO:0099177 regulation of trans-synaptic signaling 39.1304 4 yes
GO:1902533 positive regulation of intracellular signal transduction 39.1304 6 yes
GO:0006796 phosphate-containing compound metabolic process 39.1304 4 yes
GO:0008104 protein localization 39.1304 4 yes
GO:0009889 regulation of biosynthetic process 39.1304 4 yes
GO:0009893 positive regulation of metabolic process 39.1304 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 39.1304 5 yes
GO:0031325 positive regulation of cellular metabolic process 39.1304 5 yes
GO:0031326 regulation of cellular biosynthetic process 39.1304 5 yes
GO:0051094 positive regulation of developmental process 34.7826 4 yes
GO:0051174 regulation of phosphorus metabolic process 34.7826 5 yes
GO:0001932 regulation of protein phosphorylation 34.7826 7 yes
GO:0010648 negative regulation of cell communication 34.7826 5 yes
GO:0019220 regulation of phosphate metabolic process 34.7826 6 yes
GO:0023057 negative regulation of signaling 34.7826 4 yes
GO:0031399 regulation of protein modification process 34.7826 6 yes
GO:0042325 regulation of phosphorylation 34.7826 7 yes
GO:0043408 regulation of MAPK cascade 34.7826 6 yes
GO:0045595 regulation of cell differentiation 30.4348 4 yes
GO:0045597 positive regulation of cell differentiation 30.4348 5 yes
GO:0045937 positive regulation of phosphate metabolic process 30.4348 7 yes
GO:0051046 regulation of secretion 30.4348 5 yes
GO:0051247 positive regulation of protein metabolic process 30.4348 6 yes
GO:0098916 anterograde trans-synaptic signaling 30.4348 6 yes
GO:0099536 synaptic signaling 30.4348 4 yes
GO:0099537 trans-synaptic signaling 30.4348 5 yes
GO:1903530 regulation of secretion by cell 30.4348 4 yes
GO:0009892 negative regulation of metabolic process 30.4348 4 no
GO:0010468 regulation of gene expression 30.4348 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.4348 5 no
GO:0010605 negative regulation of macromolecule metabolic process 30.4348 5 no
GO:0036211 protein modification process 30.4348 4 no
GO:0043412 macromolecule modification 30.4348 4 no
GO:0010243 response to organonitrogen compound 30.4348 4 no
GO:0014070 response to organic cyclic compound 30.4348 4 no
GO:0030030 cell projection organization 30.4348 4 no
GO:0051130 positive regulation of cellular component organization 30.4348 5 no
GO:0071702 organic substance transport 30.4348 4 no
GO:0071705 nitrogen compound transport 30.4348 4 no
GO:0022607 cellular component assembly 30.4348 4 no
GO:0001934 positive regulation of protein phosphorylation 30.4348 8 yes
GO:0007268 chemical synaptic transmission 30.4348 7 yes
GO:0008284 positive regulation of cell population proliferation 30.4348 5 yes
GO:0009891 positive regulation of biosynthetic process 30.4348 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 30.4348 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.4348 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 30.4348 6 yes
GO:0031401 positive regulation of protein modification process 30.4348 7 yes
GO:0042127 regulation of cell population proliferation 30.4348 4 yes
GO:0042327 positive regulation of phosphorylation 30.4348 8 yes
GO:0043410 positive regulation of MAPK cascade 26.0870 7 yes
GO:0051240 positive regulation of multicellular organismal process 26.0870 4 yes
GO:0051336 regulation of hydrolase activity 26.0870 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 26.0870 7 yes
GO:0141124 intracellular signaling cassette 26.0870 4 yes
GO:0032101 regulation of response to external stimulus 26.0870 4 no
GO:0033993 response to lipid 26.0870 4 no
GO:0051248 negative regulation of protein metabolic process 26.0870 6 no
GO:0030334 regulation of cell migration 26.0870 5 no
GO:0060627 regulation of vesicle-mediated transport 26.0870 4 no
GO:0120036 plasma membrane bounded cell projection organization 26.0870 5 no
GO:2000145 regulation of cell motility 26.0870 4 no
GO:0032880 regulation of protein localization 26.0870 5 no
GO:0060341 regulation of cellular localization 26.0870 4 no
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 26.0870 6 no
GO:0043085 positive regulation of catalytic activity 26.0870 4 yes
GO:0044057 regulation of system process 21.7391 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.7391 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 21.7391 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 21.7391 9 yes
GO:0050805 negative regulation of synaptic transmission 21.7391 5 yes
GO:0050890 cognition 21.7391 4 yes
GO:0051051 negative regulation of transport 21.7391 4 yes
GO:0051345 positive regulation of hydrolase activity 21.7391 5 yes
GO:0006355 regulation of DNA-templated transcription 21.7391 7 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.7391 6 no
GO:0016310 phosphorylation 21.7391 5 no
GO:0031347 regulation of defense response 21.7391 5 no
GO:0050776 regulation of immune response 21.7391 4 no
GO:0051252 regulation of RNA metabolic process 21.7391 5 no
GO:0080134 regulation of response to stress 21.7391 4 no
GO:2001141 regulation of RNA biosynthetic process 21.7391 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.7391 4 no
GO:0031324 negative regulation of cellular metabolic process 21.7391 5 no
GO:0034654 nucleobase-containing compound biosynthetic process 21.7391 4 no
GO:1901362 organic cyclic compound biosynthetic process 21.7391 4 no
GO:0033043 regulation of organelle organization 21.7391 5 no
GO:0051493 regulation of cytoskeleton organization 21.7391 6 no
GO:0030100 regulation of endocytosis 21.7391 5 no
GO:0048259 regulation of receptor-mediated endocytosis 21.7391 6 no
GO:0051050 positive regulation of transport 21.7391 4 no
GO:0010959 regulation of metal ion transport 21.7391 6 yes
GO:0033365 protein localization to organelle 21.7391 5 yes
GO:0042981 regulation of apoptotic process 21.7391 5 yes
GO:0043067 regulation of programmed cell death 21.7391 4 yes
GO:0043269 regulation of monoatomic ion transport 21.7391 5 yes
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction 17.3913 5 yes
GO:0050433 regulation of catecholamine secretion 17.3913 5 yes
GO:0051282 regulation of sequestering of calcium ion 17.3913 4 yes
GO:0051952 regulation of amine transport 17.3913 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 17.3913 6 yes
GO:0055080 monoatomic cation homeostasis 17.3913 4 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 17.3913 8 yes
GO:0072521 purine-containing compound metabolic process 17.3913 4 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 17.3913 6 yes
GO:1901565 organonitrogen compound catabolic process 17.3913 4 yes
GO:1903522 regulation of blood circulation 17.3913 5 yes
GO:0006163 purine nucleotide metabolic process 17.3913 5 yes
GO:0006753 nucleoside phosphate metabolic process 17.3913 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 17.3913 4 yes
GO:0006936 muscle contraction 17.3913 4 yes
GO:0006939 smooth muscle contraction 17.3913 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 17.3913 4 yes
GO:0007613 memory 17.3913 4 yes
GO:0009117 nucleotide metabolic process 17.3913 5 yes
GO:0009141 nucleoside triphosphate metabolic process 17.3913 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 17.3913 6 yes
GO:0009150 purine ribonucleotide metabolic process 17.3913 6 yes
GO:0009199 ribonucleoside triphosphate metabolic process 17.3913 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 17.3913 7 yes
GO:0009259 ribonucleotide metabolic process 17.3913 5 yes
GO:0014059 regulation of dopamine secretion 17.3913 6 yes
GO:0019693 ribose phosphate metabolic process 17.3913 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 17.3913 5 yes
GO:0043065 positive regulation of apoptotic process 17.3913 6 yes
GO:0043068 positive regulation of programmed cell death 17.3913 5 yes
GO:0043266 regulation of potassium ion transport 17.3913 7 yes
GO:0043436 oxoacid metabolic process 13.0435 4 yes
GO:0043523 regulation of neuron apoptotic process 13.0435 6 yes
GO:0046034 ATP metabolic process 13.0435 7 yes
GO:0048148 behavioral response to cocaine 13.0435 4 yes
GO:0051209 release of sequestered calcium ion into cytosol 13.0435 6 yes
GO:0051283 negative regulation of sequestering of calcium ion 13.0435 5 yes
GO:0051967 negative regulation of synaptic transmission, glutamatergic 13.0435 6 yes
GO:0055074 calcium ion homeostasis 13.0435 4 yes
GO:0070588 calcium ion transmembrane transport 13.0435 5 yes
GO:0097553 calcium ion transmembrane import into cytosol 13.0435 6 yes
GO:0098655 monoatomic cation transmembrane transport 13.0435 4 yes
GO:0098662 inorganic cation transmembrane transport 13.0435 4 yes
GO:0006811 monoatomic ion transport 13.0435 4 yes
GO:0006812 monoatomic cation transport 13.0435 5 yes
GO:0006816 calcium ion transport 13.0435 7 yes
GO:0006874 intracellular calcium ion homeostasis 13.0435 5 yes
GO:0009894 regulation of catabolic process 13.0435 4 yes
GO:0019752 carboxylic acid metabolic process 13.0435 5 yes
GO:0030001 metal ion transport 13.0435 6 yes
GO:0043271 negative regulation of monoatomic ion transport 13.0435 5 yes
GO:0043467 regulation of generation of precursor metabolites and energy 8.6957 5 yes
GO:0043470 regulation of carbohydrate catabolic process 8.6957 5 yes
GO:0043525 positive regulation of neuron apoptotic process 8.6957 7 yes
GO:0044380 protein localization to cytoskeleton 8.6957 6 yes
GO:0045598 regulation of fat cell differentiation 8.6957 5 yes
GO:0045600 positive regulation of fat cell differentiation 8.6957 6 yes
GO:0045821 positive regulation of glycolytic process 8.6957 6 yes
GO:0045834 positive regulation of lipid metabolic process 8.6957 5 yes
GO:0045907 positive regulation of vasoconstriction 8.6957 5 yes
GO:0045913 positive regulation of carbohydrate metabolic process 8.6957 5 yes
GO:0045981 positive regulation of nucleotide metabolic process 8.6957 6 yes
GO:0046031 ADP metabolic process 8.6957 7 yes
GO:0046032 ADP catabolic process 8.6957 7 yes
GO:0046434 organophosphate catabolic process 8.6957 4 yes
GO:0046496 nicotinamide nucleotide metabolic process 8.6957 6 yes
GO:0046889 positive regulation of lipid biosynthetic process 8.6957 6 yes
GO:0046890 regulation of lipid biosynthetic process 8.6957 5 yes
GO:0050961 detection of temperature stimulus involved in sensory perception 8.6957 4 yes
GO:0050965 detection of temperature stimulus involved in sensory perception of pain 8.6957 5 yes
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain 8.6957 5 yes
GO:0050974 detection of mechanical stimulus involved in sensory perception 8.6957 4 yes
GO:0050982 detection of mechanical stimulus 8.6957 4 yes
GO:0060191 regulation of lipase activity 8.6957 5 yes
GO:0060193 positive regulation of lipase activity 8.6957 6 yes
GO:0062012 regulation of small molecule metabolic process 8.6957 4 yes
GO:0062013 positive regulation of small molecule metabolic process 8.6957 5 yes
GO:0062149 detection of stimulus involved in sensory perception of pain 8.6957 4 yes
GO:0071071 regulation of phospholipid biosynthetic process 8.6957 6 yes
GO:0071073 positive regulation of phospholipid biosynthetic process 8.6957 7 yes
GO:0072523 purine-containing compound catabolic process 8.6957 5 yes
GO:0072524 pyridine-containing compound metabolic process 8.6957 4 yes
GO:0072526 pyridine-containing compound catabolic process 8.6957 5 yes
GO:0097746 blood vessel diameter maintenance 8.6957 5 yes
GO:0098664 G protein-coupled serotonin receptor signaling pathway 8.6957 4 yes
GO:1900274 regulation of phospholipase C activity 8.6957 7 yes
GO:1900542 regulation of purine nucleotide metabolic process 8.6957 6 yes
GO:1900544 positive regulation of purine nucleotide metabolic process 8.6957 7 yes
GO:1901136 carbohydrate derivative catabolic process 8.6957 4 yes
GO:1901292 nucleoside phosphate catabolic process 8.6957 5 yes
GO:1901361 organic cyclic compound catabolic process 8.6957 4 yes
GO:1903578 regulation of ATP metabolic process 8.6957 7 yes
GO:1903580 positive regulation of ATP metabolic process 8.6957 8 yes
GO:1903725 regulation of phospholipid metabolic process 8.6957 6 yes
GO:1903727 positive regulation of phospholipid metabolic process 8.6957 6 yes
GO:0003018 vascular process in circulatory system 8.6957 4 yes
GO:0006090 pyruvate metabolic process 8.6957 7 yes
GO:0006096 glycolytic process 8.6957 4 yes
GO:0006109 regulation of carbohydrate metabolic process 8.6957 5 yes
GO:0006110 regulation of glycolytic process 8.6957 6 yes
GO:0006140 regulation of nucleotide metabolic process 8.6957 5 yes
GO:0006195 purine nucleotide catabolic process 8.6957 6 yes
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 8.6957 4 yes
GO:0007202 activation of phospholipase C activity 8.6957 9 yes
GO:0007208 phospholipase C-activating serotonin receptor signaling pathway 8.6957 5 yes
GO:0009132 nucleoside diphosphate metabolic process 8.6957 5 yes
GO:0009134 nucleoside diphosphate catabolic process 8.6957 6 yes
GO:0009135 purine nucleoside diphosphate metabolic process 8.6957 6 yes
GO:0009137 purine nucleoside diphosphate catabolic process 8.6957 7 yes
GO:0009154 purine ribonucleotide catabolic process 8.6957 6 yes
GO:0009166 nucleotide catabolic process 8.6957 6 yes
GO:0009179 purine ribonucleoside diphosphate metabolic process 8.6957 7 yes
GO:0009181 purine ribonucleoside diphosphate catabolic process 8.6957 8 yes
GO:0009185 ribonucleoside diphosphate metabolic process 8.6957 6 yes
GO:0009191 ribonucleoside diphosphate catabolic process 8.6957 7 yes
GO:0009261 ribonucleotide catabolic process 8.6957 5 yes
GO:0009896 positive regulation of catabolic process 8.6957 5 yes
GO:0010511 regulation of phosphatidylinositol biosynthetic process 8.6957 6 yes
GO:0010513 positive regulation of phosphatidylinositol biosynthetic process 8.6957 7 yes
GO:0010517 regulation of phospholipase activity 8.6957 6 yes
GO:0010518 positive regulation of phospholipase activity 8.6957 7 yes
GO:0010863 positive regulation of phospholipase C activity 8.6957 8 yes
GO:0014820 tonic smooth muscle contraction 8.6957 6 yes
GO:0014824 artery smooth muscle contraction 8.6957 7 yes
GO:0014829 vascular associated smooth muscle contraction 8.6957 6 yes
GO:0014832 urinary bladder smooth muscle contraction 8.6957 7 yes
GO:0014848 urinary tract smooth muscle contraction 8.6957 6 yes
GO:0016048 detection of temperature stimulus 8.6957 4 yes
GO:0016052 carbohydrate catabolic process 8.6957 4 yes
GO:0019216 regulation of lipid metabolic process 8.6957 5 yes
GO:0019229 regulation of vasoconstriction 8.6957 6 yes
GO:0019362 pyridine nucleotide metabolic process 8.6957 5 yes
GO:0019364 pyridine nucleotide catabolic process 8.6957 6 yes
GO:0030811 regulation of nucleotide catabolic process 8.6957 5 yes
GO:0030813 positive regulation of nucleotide catabolic process 8.6957 6 yes
GO:0031329 regulation of cellular catabolic process 8.6957 5 yes
GO:0031331 positive regulation of cellular catabolic process 8.6957 6 yes
GO:0032787 monocarboxylic acid metabolic process 8.6957 6 yes
GO:0033121 regulation of purine nucleotide catabolic process 8.6957 6 yes
GO:0033123 positive regulation of purine nucleotide catabolic process 8.6957 7 yes
GO:0034655 nucleobase-containing compound catabolic process 8.6957 4 yes
GO:0035150 regulation of tube size 8.6957 4 yes
GO:0035296 regulation of tube diameter 8.6957 5 yes
GO:0042310 vasoconstriction 8.6957 6 yes
GO:0043267 negative regulation of potassium ion transport 8.6957 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KS6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM2_HUMAN [view entry] [view interactions] Low throughput yes yes
5HT2C_HUMAN [view interactions] Low throughput no no
5HT2B_HUMAN [view interactions] Low throughput no no
5HT2A_HUMAN [view entry] [view interactions] Low throughput yes yes
OXYR_HUMAN [view interactions] Low throughput no no
MPDZ_HUMAN [view entry] [view interactions] Low throughput yes yes
5HT1A_HUMAN [view interactions] Low throughput no yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
CNR1_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GLNA_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
PON2_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3F_HUMAN [view interactions] High throughput no yes
NDK3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
RM28_HUMAN [view interactions] High throughput no yes
WRIP1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
SSR3_HUMAN [view interactions] High throughput no yes