Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

5HT2A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in 5HT2A_HUMAN
GO:0017076 purine nucleotide binding 44.0000 4 no
GO:0032555 purine ribonucleotide binding 44.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 44.0000 4 no
GO:0046872 metal ion binding 36.0000 4 no
GO:0005524 ATP binding 28.0000 5 no
GO:0030554 adenyl nucleotide binding 28.0000 5 no
GO:0032559 adenyl ribonucleotide binding 28.0000 5 no
GO:0016301 kinase activity 24.0000 4 no
GO:0004930 G protein-coupled receptor activity 20.0000 4 yes
GO:0001587 Gq/11-coupled serotonin receptor activity 8.0000 6 yes
GO:0004993 G protein-coupled serotonin receptor activity 8.0000 5 yes
GO:0008227 G protein-coupled amine receptor activity 8.0000 5 yes
GO:0099589 serotonin receptor activity 8.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in 5HT2A_HUMAN
GO:0010646 regulation of cell communication 72.0000 4 yes
GO:0048522 positive regulation of cellular process 60.0000 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 yes
GO:0051049 regulation of transport 52.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.0000 4 yes
GO:0009966 regulation of signal transduction 52.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 48.0000 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 48.0000 4 yes
GO:0051246 regulation of protein metabolic process 48.0000 5 yes
GO:0080090 regulation of primary metabolic process 48.0000 4 yes
GO:0099177 regulation of trans-synaptic signaling 48.0000 4 yes
GO:0031323 regulation of cellular metabolic process 48.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 44.0000 5 yes
GO:0051128 regulation of cellular component organization 44.0000 4 no
GO:0009893 positive regulation of metabolic process 44.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.0000 5 yes
GO:0031399 regulation of protein modification process 40.0000 6 yes
GO:0042325 regulation of phosphorylation 40.0000 7 yes
GO:0045595 regulation of cell differentiation 40.0000 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 40.0000 5 yes
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 yes
GO:0001932 regulation of protein phosphorylation 40.0000 7 yes
GO:0010647 positive regulation of cell communication 40.0000 5 yes
GO:0019220 regulation of phosphate metabolic process 40.0000 6 yes
GO:0023056 positive regulation of signaling 40.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 yes
GO:0031401 positive regulation of protein modification process 36.0000 7 yes
GO:0042127 regulation of cell population proliferation 36.0000 4 yes
GO:0042327 positive regulation of phosphorylation 36.0000 8 yes
GO:0043085 positive regulation of catalytic activity 36.0000 4 yes
GO:0043269 regulation of ion transport 36.0000 5 yes
GO:0043549 regulation of kinase activity 36.0000 5 yes
GO:0045859 regulation of protein kinase activity 36.0000 6 yes
GO:0045937 positive regulation of phosphate metabolic process 36.0000 7 yes
GO:0048584 positive regulation of response to stimulus 36.0000 4 yes
GO:0051046 regulation of secretion 36.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 36.0000 6 yes
GO:0051336 regulation of hydrolase activity 36.0000 4 yes
GO:0051338 regulation of transferase activity 36.0000 4 yes
GO:1903530 regulation of secretion by cell 36.0000 4 yes
GO:0001934 positive regulation of protein phosphorylation 36.0000 8 yes
GO:0008104 protein localization 36.0000 4 yes
GO:0009967 positive regulation of signal transduction 36.0000 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 36.0000 6 yes
GO:0033674 positive regulation of kinase activity 32.0000 6 yes
GO:0043408 regulation of MAPK cascade 32.0000 6 yes
GO:0051094 positive regulation of developmental process 32.0000 4 yes
GO:0051347 positive regulation of transferase activity 32.0000 5 yes
GO:0060627 regulation of vesicle-mediated transport 32.0000 4 yes
GO:0098916 anterograde trans-synaptic signaling 32.0000 5 yes
GO:0099537 trans-synaptic signaling 32.0000 4 yes
GO:1902533 positive regulation of intracellular signal transduction 32.0000 6 yes
GO:0009892 negative regulation of metabolic process 32.0000 4 no
GO:0010468 regulation of gene expression 32.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 32.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 32.0000 5 no
GO:0071702 organic substance transport 32.0000 4 no
GO:0007268 chemical synaptic transmission 32.0000 6 yes
GO:0008284 positive regulation of cell population proliferation 32.0000 5 yes
GO:0010648 negative regulation of cell communication 32.0000 5 yes
GO:0023057 negative regulation of signaling 32.0000 4 yes
GO:0045597 positive regulation of cell differentiation 28.0000 5 yes
GO:0045860 positive regulation of protein kinase activity 28.0000 7 yes
GO:0036211 protein modification process 28.0000 4 no
GO:0043412 macromolecule modification 28.0000 4 no
GO:0043086 negative regulation of catalytic activity 28.0000 4 no
GO:0014070 response to organic cyclic compound 28.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 28.0000 5 no
GO:0033043 regulation of organelle organization 28.0000 5 no
GO:0051130 positive regulation of cellular component organization 28.0000 5 no
GO:0051248 negative regulation of protein metabolic process 28.0000 6 no
GO:0030030 cell projection organization 28.0000 4 no
GO:0071705 nitrogen compound transport 28.0000 4 no
GO:0022607 cellular component assembly 28.0000 4 no
GO:0032880 regulation of protein localization 28.0000 5 no
GO:0051050 positive regulation of transport 28.0000 4 no
GO:0060341 regulation of cellular localization 28.0000 4 no
GO:0009889 regulation of biosynthetic process 28.0000 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 28.0000 5 yes
GO:0043410 positive regulation of MAPK cascade 24.0000 7 yes
GO:0044057 regulation of system process 24.0000 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 24.0000 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 24.0000 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 24.0000 9 yes
GO:0050890 cognition 24.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 24.0000 4 yes
GO:0051345 positive regulation of hydrolase activity 24.0000 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 24.0000 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 24.0000 7 yes
GO:0010941 regulation of cell death 24.0000 4 no
GO:0030334 regulation of cell migration 24.0000 5 no
GO:0033993 response to lipid 24.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 24.0000 4 no
GO:0051493 regulation of cytoskeleton organization 24.0000 6 no
GO:2000145 regulation of cell motility 24.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 24.0000 5 no
GO:0010243 response to organonitrogen compound 24.0000 4 no
GO:1903829 positive regulation of protein localization 24.0000 5 no
GO:0006811 ion transport 24.0000 4 yes
GO:0009891 positive regulation of biosynthetic process 24.0000 5 yes
GO:0010959 regulation of metal ion transport 24.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 24.0000 6 yes
GO:0033365 protein localization to organelle 20.0000 5 yes
GO:0048878 chemical homeostasis 20.0000 4 yes
GO:0050801 ion homeostasis 20.0000 5 yes
GO:0050805 negative regulation of synaptic transmission 20.0000 5 yes
GO:0051051 negative regulation of transport 20.0000 4 yes
GO:1903522 regulation of blood circulation 20.0000 5 yes
GO:0006812 cation transport 20.0000 5 yes
GO:0007613 memory 20.0000 4 yes
GO:0043266 regulation of potassium ion transport 16.0000 7 yes
GO:0043405 regulation of MAP kinase activity 16.0000 8 yes
GO:0050433 regulation of catecholamine secretion 16.0000 5 yes
GO:0051282 regulation of sequestering of calcium ion 16.0000 4 yes
GO:0051952 regulation of amine transport 16.0000 5 yes
GO:0055065 metal ion homeostasis 16.0000 7 yes
GO:0055080 cation homeostasis 16.0000 6 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 16.0000 8 yes
GO:0071900 regulation of protein serine/threonine kinase activity 16.0000 7 yes
GO:0098655 cation transmembrane transport 16.0000 4 yes
GO:0098660 inorganic ion transmembrane transport 16.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 16.0000 5 yes
GO:0098771 inorganic ion homeostasis 16.0000 6 yes
GO:1903305 regulation of regulated secretory pathway 16.0000 6 yes
GO:0006873 cellular ion homeostasis 16.0000 4 yes
GO:0006875 cellular metal ion homeostasis 16.0000 6 yes
GO:0006936 muscle contraction 16.0000 4 yes
GO:0006939 smooth muscle contraction 16.0000 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 16.0000 4 yes
GO:0014059 regulation of dopamine secretion 16.0000 6 yes
GO:0017157 regulation of exocytosis 16.0000 5 yes
GO:0030001 metal ion transport 16.0000 6 yes
GO:0030003 cellular cation homeostasis 16.0000 5 yes
GO:0035150 regulation of tube size 12.0000 4 yes
GO:0035296 regulation of tube diameter 12.0000 5 yes
GO:0042310 vasoconstriction 12.0000 6 yes
GO:0043271 negative regulation of ion transport 12.0000 5 yes
GO:0043406 positive regulation of MAP kinase activity 12.0000 8 yes
GO:0045834 positive regulation of lipid metabolic process 12.0000 5 yes
GO:0046928 regulation of neurotransmitter secretion 12.0000 4 yes
GO:0048148 behavioral response to cocaine 12.0000 4 yes
GO:0050961 detection of temperature stimulus involved in sensory perception 12.0000 4 yes
GO:0050965 detection of temperature stimulus involved in sensory perception of pain 12.0000 5 yes
GO:0051209 release of sequestered calcium ion into cytosol 12.0000 6 yes
GO:0051283 negative regulation of sequestering of calcium ion 12.0000 5 yes
GO:0051588 regulation of neurotransmitter transport 12.0000 5 yes
GO:0051967 negative regulation of synaptic transmission, glutamatergic 12.0000 6 yes
GO:0055074 calcium ion homeostasis 12.0000 8 yes
GO:0060191 regulation of lipase activity 12.0000 5 yes
GO:0060193 positive regulation of lipase activity 12.0000 6 yes
GO:0062149 detection of stimulus involved in sensory perception of pain 12.0000 4 yes
GO:0070588 calcium ion transmembrane transport 12.0000 6 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 12.0000 8 yes
GO:0072503 cellular divalent inorganic cation homeostasis 12.0000 6 yes
GO:0072507 divalent inorganic cation homeostasis 12.0000 7 yes
GO:0097553 calcium ion transmembrane import into cytosol 12.0000 7 yes
GO:0097746 blood vessel diameter maintenance 12.0000 5 yes
GO:1900274 regulation of phospholipase C activity 12.0000 7 yes
GO:2000300 regulation of synaptic vesicle exocytosis 12.0000 5 yes
GO:0003018 vascular process in circulatory system 12.0000 4 yes
GO:0006816 calcium ion transport 12.0000 7 yes
GO:0006874 cellular calcium ion homeostasis 12.0000 7 yes
GO:0007202 activation of phospholipase C activity 12.0000 9 yes
GO:0009894 regulation of catabolic process 12.0000 4 yes
GO:0010517 regulation of phospholipase activity 12.0000 6 yes
GO:0010518 positive regulation of phospholipase activity 12.0000 7 yes
GO:0010863 positive regulation of phospholipase C activity 12.0000 8 yes
GO:0016048 detection of temperature stimulus 12.0000 4 yes
GO:0019216 regulation of lipid metabolic process 12.0000 5 yes
GO:0031329 regulation of cellular catabolic process 12.0000 5 yes
GO:0043267 negative regulation of potassium ion transport 8.0000 6 yes
GO:0043467 regulation of generation of precursor metabolites and energy 8.0000 5 yes
GO:0043470 regulation of carbohydrate catabolic process 8.0000 5 yes
GO:0044380 protein localization to cytoskeleton 8.0000 6 yes
GO:0045598 regulation of fat cell differentiation 8.0000 5 yes
GO:0045600 positive regulation of fat cell differentiation 8.0000 6 yes
GO:0045821 positive regulation of glycolytic process 8.0000 6 yes
GO:0045907 positive regulation of vasoconstriction 8.0000 5 yes
GO:0045913 positive regulation of carbohydrate metabolic process 8.0000 5 yes
GO:0045981 positive regulation of nucleotide metabolic process 8.0000 6 yes
GO:0046889 positive regulation of lipid biosynthetic process 8.0000 6 yes
GO:0046890 regulation of lipid biosynthetic process 8.0000 5 yes
GO:0048015 phosphatidylinositol-mediated signaling 8.0000 5 yes
GO:0048017 inositol lipid-mediated signaling 8.0000 4 yes
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain 8.0000 5 yes
GO:0050974 detection of mechanical stimulus involved in sensory perception 8.0000 4 yes
GO:0050982 detection of mechanical stimulus 8.0000 4 yes
GO:0062012 regulation of small molecule metabolic process 8.0000 4 yes
GO:0062013 positive regulation of small molecule metabolic process 8.0000 5 yes
GO:0071071 regulation of phospholipid biosynthetic process 8.0000 6 yes
GO:0071073 positive regulation of phospholipid biosynthetic process 8.0000 7 yes
GO:0098664 G protein-coupled serotonin receptor signaling pathway 8.0000 4 yes
GO:1900542 regulation of purine nucleotide metabolic process 8.0000 6 yes
GO:1900544 positive regulation of purine nucleotide metabolic process 8.0000 7 yes
GO:1903578 regulation of ATP metabolic process 8.0000 7 yes
GO:1903580 positive regulation of ATP metabolic process 8.0000 8 yes
GO:1903725 regulation of phospholipid metabolic process 8.0000 6 yes
GO:1903727 positive regulation of phospholipid metabolic process 8.0000 6 yes
GO:0006109 regulation of carbohydrate metabolic process 8.0000 5 yes
GO:0006110 regulation of glycolytic process 8.0000 6 yes
GO:0006140 regulation of nucleotide metabolic process 8.0000 5 yes
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 8.0000 4 yes
GO:0007208 phospholipase C-activating serotonin receptor signaling pathway 8.0000 5 yes
GO:0009896 positive regulation of catabolic process 8.0000 5 yes
GO:0010511 regulation of phosphatidylinositol biosynthetic process 8.0000 7 yes
GO:0010513 positive regulation of phosphatidylinositol biosynthetic process 8.0000 8 yes
GO:0014065 phosphatidylinositol 3-kinase signaling 8.0000 6 yes
GO:0014820 tonic smooth muscle contraction 8.0000 6 yes
GO:0014824 artery smooth muscle contraction 8.0000 7 yes
GO:0014829 vascular associated smooth muscle contraction 8.0000 6 yes
GO:0014832 urinary bladder smooth muscle contraction 8.0000 7 yes
GO:0014848 urinary tract smooth muscle contraction 8.0000 6 yes
GO:0019229 regulation of vasoconstriction 8.0000 6 yes
GO:0031331 positive regulation of cellular catabolic process 8.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KS6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM2_HUMAN [view entry] [view interactions] Low throughput yes yes
5HT2C_HUMAN [view interactions] Low throughput no no
5HT2B_HUMAN [view interactions] Low throughput no no
5HT2A_HUMAN [view entry] [view interactions] Low throughput yes yes
OXYR_HUMAN [view interactions] Low throughput no no
MPDZ_HUMAN [view entry] [view interactions] Low throughput yes yes
5HT1A_HUMAN [view interactions] Low throughput no yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
CNR1_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
PON2_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
GLNA_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3F_HUMAN [view interactions] High throughput no yes
NDK3_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
RM28_HUMAN [view interactions] High throughput no yes
WRIP1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
TPH1_HUMAN [view interactions] Computational no yes
SC6A4_HUMAN [view entry] [view interactions] Computational yes no
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
GRM3_HUMAN [view entry] [view interactions] Computational yes no
GNA11_HUMAN [view entry] [view interactions] Computational yes yes