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GLNA_HUMAN

Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed, PubMed). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia . Essential for proliferation of fetal skin fibroblasts (PubMed). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed). Plays a role in ribosomal 40S subunit biogenesis (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GLNA_HUMAN
GO:0005524 ATP binding 25.0000 5 yes
GO:0017076 purine nucleotide binding 25.0000 4 yes
GO:0030554 adenyl nucleotide binding 25.0000 5 yes
GO:0032555 purine ribonucleotide binding 25.0000 4 yes
GO:0032559 adenyl ribonucleotide binding 25.0000 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 yes
GO:0046872 metal ion binding 22.7273 4 yes
GO:0003723 RNA binding 20.4545 4 no
GO:0016597 amino acid binding 11.3636 4 yes
GO:0046914 transition metal ion binding 11.3636 5 yes
GO:0031406 carboxylic acid binding 9.0909 4 yes
GO:0000287 magnesium ion binding 6.8182 5 yes
GO:0016595 glutamate binding 6.8182 5 yes
GO:0004356 glutamate-ammonia ligase activity 4.5455 6 yes
GO:0016211 ammonia ligase activity 4.5455 5 yes
GO:0016409 palmitoyltransferase activity 4.5455 5 yes
GO:0016417 S-acyltransferase activity 4.5455 5 yes
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4.5455 4 yes
GO:0016880 acid-ammonia (or amide) ligase activity 4.5455 4 yes
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4.5455 4 yes
GO:0030145 manganese ion binding 4.5455 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GLNA_HUMAN
GO:0048522 positive regulation of cellular process 47.7273 4 yes
GO:0010646 regulation of cell communication 45.4545 4 yes
GO:0022607 cellular component assembly 40.9091 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.9091 4 no
GO:0080090 regulation of primary metabolic process 40.9091 4 no
GO:0031323 regulation of cellular metabolic process 38.6364 4 no
GO:0060255 regulation of macromolecule metabolic process 38.6364 4 no
GO:0006996 organelle organization 36.3636 4 no
GO:0009966 regulation of signal transduction 36.3636 4 no
GO:0051128 regulation of cellular component organization 31.8182 4 no
GO:0009893 positive regulation of metabolic process 29.5455 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.5455 5 no
GO:0048523 negative regulation of cellular process 29.5455 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.5455 5 no
GO:0051246 regulation of protein metabolic process 29.5455 5 no
GO:0010647 positive regulation of cell communication 29.5455 5 yes
GO:0019752 carboxylic acid metabolic process 29.5455 5 yes
GO:0023056 positive regulation of signaling 29.5455 4 yes
GO:0043436 oxoacid metabolic process 29.5455 4 yes
GO:0050804 modulation of chemical synaptic transmission 29.5455 5 yes
GO:0099177 regulation of trans-synaptic signaling 29.5455 4 yes
GO:0043933 protein-containing complex organization 27.2727 4 no
GO:0008104 protein localization 27.2727 4 no
GO:0043412 macromolecule modification 27.2727 4 yes
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0036211 protein modification process 25.0000 4 yes
GO:1901565 organonitrogen compound catabolic process 25.0000 4 yes
GO:1901566 organonitrogen compound biosynthetic process 25.0000 4 yes
GO:0065003 protein-containing complex assembly 22.7273 5 no
GO:0019220 regulation of phosphate metabolic process 22.7273 6 no
GO:0030030 cell projection organization 22.7273 4 no
GO:0051174 regulation of phosphorus metabolic process 22.7273 5 no
GO:0120036 plasma membrane bounded cell projection organization 22.7273 5 no
GO:0048584 positive regulation of response to stimulus 22.7273 4 no
GO:0051049 regulation of transport 22.7273 4 yes
GO:0007268 chemical synaptic transmission 20.4545 6 no
GO:0098916 anterograde trans-synaptic signaling 20.4545 5 no
GO:0099537 trans-synaptic signaling 20.4545 4 no
GO:0031399 regulation of protein modification process 20.4545 6 no
GO:0042325 regulation of phosphorylation 20.4545 7 no
GO:0051130 positive regulation of cellular component organization 20.4545 5 no
GO:0009063 cellular amino acid catabolic process 20.4545 4 yes
GO:0016054 organic acid catabolic process 20.4545 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 20.4545 4 yes
GO:0032880 regulation of protein localization 20.4545 5 yes
GO:0046395 carboxylic acid catabolic process 20.4545 5 yes
GO:0060341 regulation of cellular localization 20.4545 4 yes
GO:1901605 alpha-amino acid metabolic process 20.4545 4 yes
GO:0009064 glutamine family amino acid metabolic process 18.1818 5 yes
GO:0016053 organic acid biosynthetic process 18.1818 4 yes
GO:0046394 carboxylic acid biosynthetic process 18.1818 5 yes
GO:1901606 alpha-amino acid catabolic process 18.1818 5 yes
GO:1903829 positive regulation of protein localization 18.1818 5 yes
GO:0006536 glutamate metabolic process 15.9091 6 yes
GO:0008652 cellular amino acid biosynthetic process 15.9091 4 yes
GO:0009065 glutamine family amino acid catabolic process 15.9091 6 yes
GO:0043648 dicarboxylic acid metabolic process 15.9091 6 yes
GO:2000026 regulation of multicellular organismal development 15.9091 4 yes
GO:0006541 glutamine metabolic process 13.6364 6 yes
GO:0050806 positive regulation of synaptic transmission 13.6364 5 yes
GO:0051050 positive regulation of transport 13.6364 4 yes
GO:0070201 regulation of establishment of protein localization 13.6364 6 yes
GO:1901607 alpha-amino acid biosynthetic process 13.6364 5 yes
GO:0009084 glutamine family amino acid biosynthetic process 11.3636 6 yes
GO:0042127 regulation of cell population proliferation 11.3636 4 yes
GO:0051046 regulation of secretion 11.3636 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 11.3636 6 yes
GO:1903530 regulation of secretion by cell 11.3636 4 yes
GO:1904951 positive regulation of establishment of protein localization 11.3636 6 yes
GO:0006538 glutamate catabolic process 9.0909 5 yes
GO:0008284 positive regulation of cell population proliferation 9.0909 5 yes
GO:0043543 protein acylation 9.0909 5 yes
GO:0043649 dicarboxylic acid catabolic process 9.0909 6 yes
GO:0051047 positive regulation of secretion 9.0909 5 yes
GO:1900180 regulation of protein localization to nucleus 9.0909 6 yes
GO:1903532 positive regulation of secretion by cell 9.0909 5 yes
GO:0002791 regulation of peptide secretion 6.8182 6 yes
GO:0002793 positive regulation of peptide secretion 6.8182 6 yes
GO:0032024 positive regulation of insulin secretion 6.8182 7 yes
GO:0046883 regulation of hormone secretion 6.8182 4 yes
GO:0046887 positive regulation of hormone secretion 6.8182 5 yes
GO:0050708 regulation of protein secretion 6.8182 5 yes
GO:0050714 positive regulation of protein secretion 6.8182 6 yes
GO:0050796 regulation of insulin secretion 6.8182 6 yes
GO:0051222 positive regulation of protein transport 6.8182 5 yes
GO:0051223 regulation of protein transport 6.8182 5 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 6.8182 6 yes
GO:0090087 regulation of peptide transport 6.8182 5 yes
GO:0090276 regulation of peptide hormone secretion 6.8182 5 yes
GO:0090277 positive regulation of peptide hormone secretion 6.8182 6 yes
GO:2000145 regulation of cell motility 4.5455 4 yes
GO:0006497 protein lipidation 4.5455 5 yes
GO:0006542 glutamine biosynthetic process 4.5455 7 yes
GO:0009267 cellular response to starvation 4.5455 4 yes
GO:0009743 response to carbohydrate 4.5455 4 yes
GO:0009746 response to hexose 4.5455 6 yes
GO:0009749 response to glucose 4.5455 7 yes
GO:0010594 regulation of endothelial cell migration 4.5455 5 yes
GO:0010632 regulation of epithelial cell migration 4.5455 4 yes
GO:0018345 protein palmitoylation 4.5455 6 yes
GO:0019676 ammonia assimilation cycle 4.5455 6 yes
GO:0019740 nitrogen utilization 4.5455 5 yes
GO:0022613 ribonucleoprotein complex biogenesis 4.5455 4 yes
GO:0030334 regulation of cell migration 4.5455 5 yes
GO:0031667 response to nutrient levels 4.5455 4 yes
GO:0031669 cellular response to nutrient levels 4.5455 4 yes
GO:0034284 response to monosaccharide 4.5455 5 yes
GO:0042254 ribosome biogenesis 4.5455 5 yes
GO:0045765 regulation of angiogenesis 4.5455 5 yes
GO:0050678 regulation of epithelial cell proliferation 4.5455 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 4.5455 6 yes
GO:1901342 regulation of vasculature development 4.5455 5 yes
GO:1903670 regulation of sprouting angiogenesis 4.5455 6 yes
GO:1904749 regulation of protein localization to nucleolus 4.5455 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GLNA_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOJ_HUMAN [view interactions] Low throughput no yes
ZNRF1_HUMAN [view interactions] Low throughput no yes
CRBN_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
NPL4_HUMAN [view interactions] Low throughput no yes
UFD1_HUMAN [view interactions] Low throughput no no
UBP15_HUMAN [view entry] [view interactions] Low throughput yes yes
PHF11_HUMAN [view interactions] High throughput no no
WDR59_HUMAN [view interactions] High throughput no yes
ERCC3_HUMAN [view interactions] High throughput no yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
MMTA2_HUMAN [view interactions] High throughput no yes
CR021_HUMAN [view interactions] High throughput no no
SSBP2_HUMAN [view interactions] High throughput no yes
RNH2C_HUMAN [view interactions] High throughput no yes
RN115_HUMAN [view interactions] High throughput no yes
TRIM7_HUMAN [view interactions] High throughput no yes
CREB3_HUMAN [view interactions] High throughput no no
BPHL_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
HXB6_HUMAN [view interactions] High throughput no no
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
AMPH_HUMAN [view entry] [view interactions] High throughput yes yes
NUDT3_HUMAN [view interactions] High throughput no yes
FUND2_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
PIGT_HUMAN [view interactions] High throughput no no
CCNC_HUMAN [view interactions] High throughput no yes
POGZ_HUMAN [view interactions] High throughput no yes
POTEF_HUMAN [view interactions] High throughput no no
ZN550_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
UBAC2_HUMAN [view interactions] High throughput no yes
PNMA2_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
SIK1_HUMAN [view interactions] High throughput no yes
MBNL1_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
PYRG1_HUMAN [view interactions] High throughput no no
UBP34_HUMAN [view interactions] High throughput no yes
F135A_HUMAN [view interactions] High throughput no yes
ARGL1_HUMAN [view interactions] High throughput no yes
SP16H_HUMAN [view interactions] High throughput no yes
RSRC1_HUMAN [view interactions] High throughput no yes
YTHD1_HUMAN [view interactions] High throughput no no
RBP56_HUMAN [view interactions] High throughput no yes
SRSF6_HUMAN [view interactions] High throughput no yes
TCP4_HUMAN [view interactions] High throughput no yes
STK26_HUMAN [view interactions] High throughput no no
SRBP2_HUMAN [view interactions] High throughput no yes
SPRNG_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
NIBA2_HUMAN [view interactions] High throughput no no
NUCB2_HUMAN [view interactions] High throughput no yes
SKIL_HUMAN [view interactions] High throughput no yes
BTK_HUMAN [view interactions] High throughput no no
RBBP6_HUMAN [view interactions] High throughput no yes
AP2A_HUMAN [view interactions] High throughput no no
5HT2A_HUMAN [view entry] [view interactions] High throughput yes yes
NAL12_HUMAN [view interactions] High throughput no yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
TB22B_HUMAN [view interactions] High throughput no no
CA094_HUMAN [view interactions] High throughput no no
TCHP_HUMAN [view interactions] High throughput no yes
DMXL2_HUMAN [view entry] [view interactions] High throughput yes yes
ANR16_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
HLAB_HUMAN [view interactions] High throughput no yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
RD3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
RABEK_HUMAN [view interactions] High throughput no yes
CP39A_HUMAN [view interactions] High throughput no no
ATTY_HUMAN [view interactions] High throughput no no
NUD18_HUMAN [view interactions] High throughput no no
PKHF2_HUMAN [view interactions] High throughput no yes
C8AP2_HUMAN [view interactions] High throughput no no
HIPK1_HUMAN [view interactions] High throughput no no
HIPK3_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view interactions] High throughput no yes
PIAS3_HUMAN [view interactions] High throughput no yes
PIAS2_HUMAN [view interactions] High throughput no yes
PIAS1_HUMAN [view interactions] High throughput no yes
NU5M_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CHP3_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
PPARD_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ZFN2B_HUMAN [view interactions] High throughput no yes
NDK7_HUMAN [view interactions] High throughput no yes
UBAP2_HUMAN [view interactions] High throughput no yes
ASPC1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
SOCS2_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
EYA4_HUMAN [view interactions] High throughput no yes
TNS2_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
ARI2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RIN3_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
LNP1_HUMAN [view interactions] High throughput no no
RBMS2_HUMAN [view interactions] High throughput no yes
OR2A4_HUMAN [view interactions] High throughput no no
DHE3_HUMAN [view entry] [view interactions] Computational yes yes
DHE4_HUMAN [view interactions] Computational no yes
LGSN_HUMAN [view interactions] Computational no no
SYEM_HUMAN [view interactions] Computational no yes
GABT_HUMAN [view interactions] Computational no yes
CH60_HUMAN [view entry] [view interactions] Computational yes yes
ACY2_HUMAN [view interactions] Computational no no
GLSK_HUMAN [view entry] [view interactions] Computational yes yes
GCSP_HUMAN [view interactions] Computational no yes
CRNS1_HUMAN [view interactions] Computational no no
AL4A1_HUMAN [view entry] [view interactions] Computational yes yes
DCE2_HUMAN [view interactions] Computational no yes
PYR1_HUMAN [view entry] [view interactions] Computational yes yes
PUR1_HUMAN [view interactions] Computational no yes
GFPT2_HUMAN [view interactions] Computational no yes
ASNS_HUMAN [view interactions] Computational no yes
DCE1_HUMAN [view entry] [view interactions] Computational yes yes
ALDH2_HUMAN [view entry] [view interactions] Computational yes no
AL7A1_HUMAN [view entry] [view interactions] Computational yes no
P5CS_HUMAN [view interactions] Computational no yes
GGT5_HUMAN [view interactions] Computational no yes
EAA2_HUMAN [view entry] [view interactions] Computational yes no
AL3A2_HUMAN [view entry] [view interactions] Computational yes yes
SYEP_HUMAN [view interactions] Computational no yes
FTCD_HUMAN [view interactions] Computational no no
GCSH_HUMAN [view interactions] Computational no yes
CPSM_HUMAN [view interactions] Computational no no
OPLA_HUMAN [view interactions] Computational no no
GSH0_HUMAN [view interactions] Computational no yes
EAA1_HUMAN [view entry] [view interactions] Computational yes no
AL1B1_HUMAN [view interactions] Computational no yes
CNDP1_HUMAN [view interactions] Computational no yes
GFPT1_HUMAN [view interactions] Computational no no
CNDP2_HUMAN [view entry] [view interactions] Computational yes yes
DLDH_HUMAN [view entry] [view interactions] Computational yes yes
GATM_HUMAN [view interactions] Computational no no
GGT1_HUMAN [view interactions] Computational no no
GCST_HUMAN [view interactions] Computational no yes
RIPK3_HUMAN [view interactions] Computational no no
L2HDH_HUMAN [view interactions] Computational no yes
GLSL_HUMAN [view entry] [view interactions] Computational yes yes
GGT7_HUMAN [view interactions] Computational no yes
AL9A1_HUMAN [view interactions] Computational no yes