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GLNA_HUMAN

Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed, PubMed). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia . Essential for proliferation of fetal skin fibroblasts (PubMed). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed). Plays a role in ribosomal 40S subunit biogenesis (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GLNA_HUMAN
GO:0000166 nucleotide binding 30.4348 4 yes
GO:0005524 ATP binding 30.4348 5 yes
GO:0017076 purine nucleotide binding 30.4348 5 yes
GO:0030554 adenyl nucleotide binding 30.4348 6 yes
GO:0032555 purine ribonucleotide binding 30.4348 4 yes
GO:0032559 adenyl ribonucleotide binding 30.4348 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 30.4348 4 yes
GO:0043168 anion binding 30.4348 4 yes
GO:0043169 cation binding 26.0870 4 yes
GO:0046872 metal ion binding 23.9130 5 yes
GO:0003723 RNA binding 23.9130 4 no
GO:0004356 glutamine synthetase activity 4.3478 6 yes
GO:0016211 ammonia ligase activity 4.3478 5 yes
GO:0016409 palmitoyltransferase activity 4.3478 5 yes
GO:0016417 S-acyltransferase activity 4.3478 5 yes
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4.3478 4 yes
GO:0016880 acid-ammonia (or amide) ligase activity 4.3478 4 yes
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4.3478 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GLNA_HUMAN
GO:0048522 positive regulation of cellular process 56.5217 4 no
GO:0060255 regulation of macromolecule metabolic process 54.3478 4 no
GO:0031323 regulation of cellular metabolic process 52.1739 4 no
GO:0080090 regulation of primary metabolic process 52.1739 4 no
GO:0010646 regulation of cell communication 47.8261 4 no
GO:0022607 cellular component assembly 47.8261 4 no
GO:0051128 regulation of cellular component organization 47.8261 4 no
GO:0048523 negative regulation of cellular process 45.6522 4 no
GO:0006996 organelle organization 45.6522 4 no
GO:0009893 positive regulation of metabolic process 43.4783 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.4783 5 no
GO:0009889 regulation of biosynthetic process 41.3043 4 no
GO:0009966 regulation of signal transduction 41.3043 4 no
GO:0051246 regulation of protein metabolic process 39.1304 5 no
GO:0031326 regulation of cellular biosynthetic process 36.9565 5 no
GO:0043412 macromolecule modification 34.7826 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 34.7826 5 no
GO:0031325 positive regulation of cellular metabolic process 34.7826 5 no
GO:0036211 protein modification process 32.6087 4 yes
GO:0060341 regulation of cellular localization 32.6087 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.6087 5 no
GO:0031399 regulation of protein modification process 32.6087 6 no
GO:0051247 positive regulation of protein metabolic process 32.6087 6 no
GO:0051130 positive regulation of cellular component organization 32.6087 5 no
GO:0043933 protein-containing complex organization 32.6087 4 no
GO:0032880 regulation of protein localization 30.4348 5 yes
GO:0010647 positive regulation of cell communication 28.2609 5 no
GO:0023056 positive regulation of signaling 28.2609 4 no
GO:0048584 positive regulation of response to stimulus 28.2609 4 no
GO:0033043 regulation of organelle organization 28.2609 5 no
GO:0031401 positive regulation of protein modification process 26.0870 7 no
GO:0019220 regulation of phosphate metabolic process 26.0870 6 no
GO:0030030 cell projection organization 26.0870 4 no
GO:0051174 regulation of phosphorus metabolic process 26.0870 5 no
GO:0065003 protein-containing complex assembly 26.0870 5 no
GO:0051049 regulation of transport 26.0870 4 no
GO:0022603 regulation of anatomical structure morphogenesis 23.9130 4 yes
GO:0010468 regulation of gene expression 23.9130 6 no
GO:0008104 protein localization 23.9130 4 no
GO:0009967 positive regulation of signal transduction 23.9130 5 no
GO:0042325 regulation of phosphorylation 23.9130 7 no
GO:0120036 plasma membrane bounded cell projection organization 23.9130 5 no
GO:0009891 positive regulation of biosynthetic process 23.9130 5 no
GO:0010638 positive regulation of organelle organization 23.9130 6 no
GO:0010648 negative regulation of cell communication 23.9130 5 no
GO:0023057 negative regulation of signaling 23.9130 4 no
GO:0050804 modulation of chemical synaptic transmission 23.9130 5 no
GO:0099177 regulation of trans-synaptic signaling 23.9130 4 no
GO:0009892 negative regulation of metabolic process 21.7391 4 no
GO:0007010 cytoskeleton organization 21.7391 5 no
GO:1902531 regulation of intracellular signal transduction 21.7391 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.7391 6 no
GO:1903829 positive regulation of protein localization 21.7391 5 no
GO:0042981 regulation of apoptotic process 21.7391 5 no
GO:0043067 regulation of programmed cell death 21.7391 4 no
GO:0048585 negative regulation of response to stimulus 21.7391 4 no
GO:0050890 cognition 21.7391 4 no
GO:2000026 regulation of multicellular organismal development 19.5652 4 yes
GO:1901565 organonitrogen compound catabolic process 17.3913 4 yes
GO:1900180 regulation of protein localization to nucleus 15.2174 6 yes
GO:0019752 carboxylic acid metabolic process 10.8696 5 yes
GO:0043436 oxoacid metabolic process 10.8696 4 yes
GO:0009743 response to carbohydrate 8.6957 4 yes
GO:0009063 amino acid catabolic process 6.5217 4 yes
GO:0009267 cellular response to starvation 6.5217 4 yes
GO:0016053 organic acid biosynthetic process 6.5217 4 yes
GO:0016054 organic acid catabolic process 6.5217 4 yes
GO:0030334 regulation of cell migration 6.5217 5 yes
GO:0043543 protein acylation 6.5217 5 yes
GO:0046394 carboxylic acid biosynthetic process 6.5217 5 yes
GO:0046395 carboxylic acid catabolic process 6.5217 5 yes
GO:1901566 organonitrogen compound biosynthetic process 6.5217 4 yes
GO:1901605 alpha-amino acid metabolic process 6.5217 4 yes
GO:1901606 alpha-amino acid catabolic process 6.5217 5 yes
GO:2000145 regulation of cell motility 6.5217 4 yes
GO:0006497 protein lipidation 4.3478 5 yes
GO:0006536 glutamate metabolic process 4.3478 6 yes
GO:0006538 glutamate catabolic process 4.3478 7 yes
GO:0006541 glutamine metabolic process 4.3478 6 yes
GO:0006542 glutamine biosynthetic process 4.3478 7 yes
GO:0008652 amino acid biosynthetic process 4.3478 4 yes
GO:0009064 glutamine family amino acid metabolic process 4.3478 5 yes
GO:0009065 glutamine family amino acid catabolic process 4.3478 6 yes
GO:0009084 glutamine family amino acid biosynthetic process 4.3478 6 yes
GO:0009746 response to hexose 4.3478 6 yes
GO:0009749 response to glucose 4.3478 7 yes
GO:0010594 regulation of endothelial cell migration 4.3478 5 yes
GO:0010632 regulation of epithelial cell migration 4.3478 4 yes
GO:0018345 protein palmitoylation 4.3478 6 yes
GO:0022613 ribonucleoprotein complex biogenesis 4.3478 4 yes
GO:0034284 response to monosaccharide 4.3478 5 yes
GO:0042254 ribosome biogenesis 4.3478 5 yes
GO:0043648 dicarboxylic acid metabolic process 4.3478 6 yes
GO:0043649 dicarboxylic acid catabolic process 4.3478 6 yes
GO:0045765 regulation of angiogenesis 4.3478 5 yes
GO:0170033 L-amino acid metabolic process 4.3478 5 yes
GO:0170034 L-amino acid biosynthetic process 4.3478 6 yes
GO:0170035 L-amino acid catabolic process 4.3478 6 yes
GO:0170038 proteinogenic amino acid biosynthetic process 4.3478 5 yes
GO:0170039 proteinogenic amino acid metabolic process 4.3478 4 yes
GO:0170040 proteinogenic amino acid catabolic process 4.3478 5 yes
GO:1901342 regulation of vasculature development 4.3478 5 yes
GO:1901607 alpha-amino acid biosynthetic process 4.3478 5 yes
GO:1903670 regulation of sprouting angiogenesis 4.3478 6 yes
GO:1904749 regulation of protein localization to nucleolus 4.3478 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GLNA_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOJ_HUMAN [view interactions] Low throughput no yes
ZNRF1_HUMAN [view interactions] Low throughput no yes
CRBN_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
NPL4_HUMAN [view interactions] Low throughput no yes
UFD1_HUMAN [view interactions] Low throughput no no
UBP15_HUMAN [view entry] [view interactions] Low throughput yes yes
SKIL_HUMAN [view interactions] High throughput no yes
BTK_HUMAN [view interactions] High throughput no no
RBBP6_HUMAN [view interactions] High throughput no yes
AP2A_HUMAN [view interactions] High throughput no no
5HT2A_HUMAN [view entry] [view interactions] High throughput yes yes
NAL12_HUMAN [view interactions] High throughput no yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MK06_HUMAN [view interactions] High throughput no yes
TB22B_HUMAN [view interactions] High throughput no no
CA094_HUMAN [view interactions] High throughput no no
DMXL2_HUMAN [view entry] [view interactions] High throughput yes yes
TCHP_HUMAN [view interactions] High throughput no yes
ANR16_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
HLAB_HUMAN [view interactions] High throughput no yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
RD3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
RABEK_HUMAN [view interactions] High throughput no yes
CP39A_HUMAN [view interactions] High throughput no no
ATTY_HUMAN [view interactions] High throughput no no
NUD18_HUMAN [view interactions] High throughput no no
PKHF2_HUMAN [view interactions] High throughput no yes
C8AP2_HUMAN [view interactions] High throughput no no
HIPK1_HUMAN [view interactions] High throughput no no
HIPK3_HUMAN [view interactions] High throughput no yes
NU5M_HUMAN [view interactions] High throughput no no
UBC9_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS2_HUMAN [view interactions] High throughput no yes
PIAS3_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CHP3_HUMAN [view interactions] High throughput no yes
BTG3_HUMAN [view interactions] High throughput no yes
LCOR_HUMAN [view interactions] High throughput no yes
DSCAM_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PCNA_HUMAN [view interactions] High throughput no no
PPARD_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
RSPH1_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ZFN2B_HUMAN [view interactions] High throughput no yes
NDK7_HUMAN [view interactions] High throughput no yes
UBAP2_HUMAN [view interactions] High throughput no yes
ASPC1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
SOCS2_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
EYA4_HUMAN [view interactions] High throughput no yes
TENS2_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
ARI2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RIN3_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
LNP1_HUMAN [view interactions] High throughput no no
RBMS2_HUMAN [view interactions] High throughput no yes
OR2A4_HUMAN [view interactions] High throughput no no
PHF11_HUMAN [view interactions] High throughput no no
WDR59_HUMAN [view interactions] High throughput no yes
ERCC3_HUMAN [view interactions] High throughput no yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
MMTA2_HUMAN [view interactions] High throughput no yes
CR021_HUMAN [view interactions] High throughput no no
SSBP2_HUMAN [view interactions] High throughput no yes
RNH2C_HUMAN [view interactions] High throughput no yes
RN115_HUMAN [view interactions] High throughput no yes
TRIM7_HUMAN [view interactions] High throughput no yes
CREB3_HUMAN [view interactions] High throughput no no
BPHL_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
HXB6_HUMAN [view interactions] High throughput no no
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
AMPH_HUMAN [view entry] [view interactions] High throughput yes yes
NUDT3_HUMAN [view interactions] High throughput no yes
FUND2_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
PIGT_HUMAN [view interactions] High throughput no no
CCNC_HUMAN [view interactions] High throughput no yes
POGZ_HUMAN [view interactions] High throughput no yes
POTEF_HUMAN [view interactions] High throughput no no
ZN550_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
UBAC2_HUMAN [view interactions] High throughput no yes
PNMA2_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
SIK1_HUMAN [view interactions] High throughput no yes
MBNL1_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
PYRG1_HUMAN [view interactions] High throughput no no
UBP34_HUMAN [view interactions] High throughput no yes
F135A_HUMAN [view interactions] High throughput no yes
ARGL1_HUMAN [view interactions] High throughput no yes
SP16H_HUMAN [view interactions] High throughput no yes
RSRC1_HUMAN [view interactions] High throughput no yes
YTHD1_HUMAN [view interactions] High throughput no no
RBP56_HUMAN [view interactions] High throughput no yes
SRSF6_HUMAN [view interactions] High throughput no yes
TCP4_HUMAN [view interactions] High throughput no yes
STK26_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
ASXL2_HUMAN [view interactions] High throughput no no
ASXL3_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
SRBP2_HUMAN [view interactions] High throughput no yes
SPRNG_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
NIBA2_HUMAN [view interactions] High throughput no no
NUCB2_HUMAN [view interactions] High throughput no yes
PSD11_HUMAN [view entry] [view interactions] High throughput yes yes
AGM1_HUMAN [view interactions] High throughput no no
LA_HUMAN [view interactions] High throughput no yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
PPCE_HUMAN [view interactions] High throughput no yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
GUAA_HUMAN [view interactions] High throughput no no
HNRPU_HUMAN [view interactions] High throughput no yes
PSME1_HUMAN [view interactions] High throughput no yes
AIMP1_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
STXB2_HUMAN [view interactions] High throughput no no
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
TCPH_HUMAN [view entry] [view interactions] High throughput yes yes
ERAP1_HUMAN [view interactions] High throughput no yes
TLN1_HUMAN [view entry] [view interactions] High throughput yes no
FBW1A_HUMAN [view interactions] High throughput no yes
DHCR7_HUMAN [view interactions] High throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
CCNF_HUMAN [view interactions] High throughput no no