GLNA_HUMAN
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed, PubMed). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia . Essential for proliferation of fetal skin fibroblasts (PubMed). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed). Plays a role in ribosomal 40S subunit biogenesis (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GLNA_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 30.4348 | 4 | yes |
GO:0005524 | ATP binding | 30.4348 | 5 | yes |
GO:0017076 | purine nucleotide binding | 30.4348 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 30.4348 | 6 | yes |
GO:0032555 | purine ribonucleotide binding | 30.4348 | 4 | yes |
GO:0032559 | adenyl ribonucleotide binding | 30.4348 | 5 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 30.4348 | 4 | yes |
GO:0043168 | anion binding | 30.4348 | 4 | yes |
GO:0043169 | cation binding | 26.0870 | 4 | yes |
GO:0046872 | metal ion binding | 23.9130 | 5 | yes |
GO:0003723 | RNA binding | 23.9130 | 4 | no |
GO:0004356 | glutamine synthetase activity | 4.3478 | 6 | yes |
GO:0016211 | ammonia ligase activity | 4.3478 | 5 | yes |
GO:0016409 | palmitoyltransferase activity | 4.3478 | 5 | yes |
GO:0016417 | S-acyltransferase activity | 4.3478 | 5 | yes |
GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4.3478 | 4 | yes |
GO:0016880 | acid-ammonia (or amide) ligase activity | 4.3478 | 4 | yes |
GO:0019706 | protein-cysteine S-palmitoyltransferase activity | 4.3478 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GLNA_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 56.5217 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 54.3478 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 52.1739 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 52.1739 | 4 | no |
GO:0010646 | regulation of cell communication | 47.8261 | 4 | no |
GO:0022607 | cellular component assembly | 47.8261 | 4 | no |
GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | no |
GO:0048523 | negative regulation of cellular process | 45.6522 | 4 | no |
GO:0006996 | organelle organization | 45.6522 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 43.4783 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 43.4783 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 41.3043 | 4 | no |
GO:0009966 | regulation of signal transduction | 41.3043 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 39.1304 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 36.9565 | 5 | no |
GO:0043412 | macromolecule modification | 34.7826 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 34.7826 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 34.7826 | 5 | no |
GO:0036211 | protein modification process | 32.6087 | 4 | yes |
GO:0060341 | regulation of cellular localization | 32.6087 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.6087 | 5 | no |
GO:0031399 | regulation of protein modification process | 32.6087 | 6 | no |
GO:0051247 | positive regulation of protein metabolic process | 32.6087 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 32.6087 | 5 | no |
GO:0043933 | protein-containing complex organization | 32.6087 | 4 | no |
GO:0032880 | regulation of protein localization | 30.4348 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 28.2609 | 5 | no |
GO:0023056 | positive regulation of signaling | 28.2609 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 28.2609 | 4 | no |
GO:0033043 | regulation of organelle organization | 28.2609 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 26.0870 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 26.0870 | 6 | no |
GO:0030030 | cell projection organization | 26.0870 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 26.0870 | 5 | no |
GO:0065003 | protein-containing complex assembly | 26.0870 | 5 | no |
GO:0051049 | regulation of transport | 26.0870 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 23.9130 | 4 | yes |
GO:0010468 | regulation of gene expression | 23.9130 | 6 | no |
GO:0008104 | protein localization | 23.9130 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 23.9130 | 5 | no |
GO:0042325 | regulation of phosphorylation | 23.9130 | 7 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 23.9130 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 23.9130 | 5 | no |
GO:0010638 | positive regulation of organelle organization | 23.9130 | 6 | no |
GO:0010648 | negative regulation of cell communication | 23.9130 | 5 | no |
GO:0023057 | negative regulation of signaling | 23.9130 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 23.9130 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 23.9130 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 21.7391 | 4 | no |
GO:0007010 | cytoskeleton organization | 21.7391 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 21.7391 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 21.7391 | 6 | no |
GO:1903829 | positive regulation of protein localization | 21.7391 | 5 | no |
GO:0042981 | regulation of apoptotic process | 21.7391 | 5 | no |
GO:0043067 | regulation of programmed cell death | 21.7391 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 21.7391 | 4 | no |
GO:0050890 | cognition | 21.7391 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 19.5652 | 4 | yes |
GO:1901565 | organonitrogen compound catabolic process | 17.3913 | 4 | yes |
GO:1900180 | regulation of protein localization to nucleus | 15.2174 | 6 | yes |
GO:0019752 | carboxylic acid metabolic process | 10.8696 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 10.8696 | 4 | yes |
GO:0009743 | response to carbohydrate | 8.6957 | 4 | yes |
GO:0009063 | amino acid catabolic process | 6.5217 | 4 | yes |
GO:0009267 | cellular response to starvation | 6.5217 | 4 | yes |
GO:0016053 | organic acid biosynthetic process | 6.5217 | 4 | yes |
GO:0016054 | organic acid catabolic process | 6.5217 | 4 | yes |
GO:0030334 | regulation of cell migration | 6.5217 | 5 | yes |
GO:0043543 | protein acylation | 6.5217 | 5 | yes |
GO:0046394 | carboxylic acid biosynthetic process | 6.5217 | 5 | yes |
GO:0046395 | carboxylic acid catabolic process | 6.5217 | 5 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 6.5217 | 4 | yes |
GO:1901605 | alpha-amino acid metabolic process | 6.5217 | 4 | yes |
GO:1901606 | alpha-amino acid catabolic process | 6.5217 | 5 | yes |
GO:2000145 | regulation of cell motility | 6.5217 | 4 | yes |
GO:0006497 | protein lipidation | 4.3478 | 5 | yes |
GO:0006536 | glutamate metabolic process | 4.3478 | 6 | yes |
GO:0006538 | glutamate catabolic process | 4.3478 | 7 | yes |
GO:0006541 | glutamine metabolic process | 4.3478 | 6 | yes |
GO:0006542 | glutamine biosynthetic process | 4.3478 | 7 | yes |
GO:0008652 | amino acid biosynthetic process | 4.3478 | 4 | yes |
GO:0009064 | glutamine family amino acid metabolic process | 4.3478 | 5 | yes |
GO:0009065 | glutamine family amino acid catabolic process | 4.3478 | 6 | yes |
GO:0009084 | glutamine family amino acid biosynthetic process | 4.3478 | 6 | yes |
GO:0009746 | response to hexose | 4.3478 | 6 | yes |
GO:0009749 | response to glucose | 4.3478 | 7 | yes |
GO:0010594 | regulation of endothelial cell migration | 4.3478 | 5 | yes |
GO:0010632 | regulation of epithelial cell migration | 4.3478 | 4 | yes |
GO:0018345 | protein palmitoylation | 4.3478 | 6 | yes |
GO:0022613 | ribonucleoprotein complex biogenesis | 4.3478 | 4 | yes |
GO:0034284 | response to monosaccharide | 4.3478 | 5 | yes |
GO:0042254 | ribosome biogenesis | 4.3478 | 5 | yes |
GO:0043648 | dicarboxylic acid metabolic process | 4.3478 | 6 | yes |
GO:0043649 | dicarboxylic acid catabolic process | 4.3478 | 6 | yes |
GO:0045765 | regulation of angiogenesis | 4.3478 | 5 | yes |
GO:0170033 | L-amino acid metabolic process | 4.3478 | 5 | yes |
GO:0170034 | L-amino acid biosynthetic process | 4.3478 | 6 | yes |
GO:0170035 | L-amino acid catabolic process | 4.3478 | 6 | yes |
GO:0170038 | proteinogenic amino acid biosynthetic process | 4.3478 | 5 | yes |
GO:0170039 | proteinogenic amino acid metabolic process | 4.3478 | 4 | yes |
GO:0170040 | proteinogenic amino acid catabolic process | 4.3478 | 5 | yes |
GO:1901342 | regulation of vasculature development | 4.3478 | 5 | yes |
GO:1901607 | alpha-amino acid biosynthetic process | 4.3478 | 5 | yes |
GO:1903670 | regulation of sprouting angiogenesis | 4.3478 | 6 | yes |
GO:1904749 | regulation of protein localization to nucleolus | 4.3478 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | Low throughput | no | yes |
ZNRF1_HUMAN | [view interactions] | Low throughput | no | yes |
CRBN_HUMAN | [view interactions] | Low throughput | no | yes |
EP300_HUMAN | [view interactions] | Low throughput | no | yes |
TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NPL4_HUMAN | [view interactions] | Low throughput | no | yes |
UFD1_HUMAN | [view interactions] | Low throughput | no | no |
UBP15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SKIL_HUMAN | [view interactions] | High throughput | no | yes |
BTK_HUMAN | [view interactions] | High throughput | no | no |
RBBP6_HUMAN | [view interactions] | High throughput | no | yes |
AP2A_HUMAN | [view interactions] | High throughput | no | no |
5HT2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAL12_HUMAN | [view interactions] | High throughput | no | yes |
DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
TB22B_HUMAN | [view interactions] | High throughput | no | no |
CA094_HUMAN | [view interactions] | High throughput | no | no |
DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCHP_HUMAN | [view interactions] | High throughput | no | yes |
ANR16_HUMAN | [view interactions] | High throughput | no | yes |
DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RD3_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
RABEK_HUMAN | [view interactions] | High throughput | no | yes |
CP39A_HUMAN | [view interactions] | High throughput | no | no |
ATTY_HUMAN | [view interactions] | High throughput | no | no |
NUD18_HUMAN | [view interactions] | High throughput | no | no |
PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
C8AP2_HUMAN | [view interactions] | High throughput | no | no |
HIPK1_HUMAN | [view interactions] | High throughput | no | no |
HIPK3_HUMAN | [view interactions] | High throughput | no | yes |
NU5M_HUMAN | [view interactions] | High throughput | no | no |
UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIAS2_HUMAN | [view interactions] | High throughput | no | yes |
PIAS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CHP3_HUMAN | [view interactions] | High throughput | no | yes |
BTG3_HUMAN | [view interactions] | High throughput | no | yes |
LCOR_HUMAN | [view interactions] | High throughput | no | yes |
DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCNA_HUMAN | [view interactions] | High throughput | no | no |
PPARD_HUMAN | [view interactions] | High throughput | no | yes |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RSPH1_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFN2B_HUMAN | [view interactions] | High throughput | no | yes |
NDK7_HUMAN | [view interactions] | High throughput | no | yes |
UBAP2_HUMAN | [view interactions] | High throughput | no | yes |
ASPC1_HUMAN | [view interactions] | High throughput | no | yes |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
TADBP_HUMAN | [view interactions] | High throughput | no | yes |
SOCS2_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
EYA4_HUMAN | [view interactions] | High throughput | no | yes |
TENS2_HUMAN | [view interactions] | High throughput | no | no |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
ARI2_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKT3_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
RIN3_HUMAN | [view interactions] | High throughput | no | yes |
ANDR_HUMAN | [view interactions] | High throughput | no | no |
LNP1_HUMAN | [view interactions] | High throughput | no | no |
RBMS2_HUMAN | [view interactions] | High throughput | no | yes |
OR2A4_HUMAN | [view interactions] | High throughput | no | no |
PHF11_HUMAN | [view interactions] | High throughput | no | no |
WDR59_HUMAN | [view interactions] | High throughput | no | yes |
ERCC3_HUMAN | [view interactions] | High throughput | no | yes |
ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
CR021_HUMAN | [view interactions] | High throughput | no | no |
SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
RNH2C_HUMAN | [view interactions] | High throughput | no | yes |
RN115_HUMAN | [view interactions] | High throughput | no | yes |
TRIM7_HUMAN | [view interactions] | High throughput | no | yes |
CREB3_HUMAN | [view interactions] | High throughput | no | no |
BPHL_HUMAN | [view interactions] | High throughput | no | no |
SARAF_HUMAN | [view interactions] | High throughput | no | no |
HXB6_HUMAN | [view interactions] | High throughput | no | no |
TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AMPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUDT3_HUMAN | [view interactions] | High throughput | no | yes |
FUND2_HUMAN | [view interactions] | High throughput | no | yes |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIGT_HUMAN | [view interactions] | High throughput | no | no |
CCNC_HUMAN | [view interactions] | High throughput | no | yes |
POGZ_HUMAN | [view interactions] | High throughput | no | yes |
POTEF_HUMAN | [view interactions] | High throughput | no | no |
ZN550_HUMAN | [view interactions] | High throughput | no | no |
PINK1_HUMAN | [view interactions] | High throughput | no | yes |
UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
LACTB_HUMAN | [view interactions] | High throughput | no | yes |
SIK1_HUMAN | [view interactions] | High throughput | no | yes |
MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
SSUH2_HUMAN | [view interactions] | High throughput | no | no |
RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PYRG1_HUMAN | [view interactions] | High throughput | no | no |
UBP34_HUMAN | [view interactions] | High throughput | no | yes |
F135A_HUMAN | [view interactions] | High throughput | no | yes |
ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
SP16H_HUMAN | [view interactions] | High throughput | no | yes |
RSRC1_HUMAN | [view interactions] | High throughput | no | yes |
YTHD1_HUMAN | [view interactions] | High throughput | no | no |
RBP56_HUMAN | [view interactions] | High throughput | no | yes |
SRSF6_HUMAN | [view interactions] | High throughput | no | yes |
TCP4_HUMAN | [view interactions] | High throughput | no | yes |
STK26_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
ASXL1_HUMAN | [view interactions] | High throughput | no | no |
ASXL2_HUMAN | [view interactions] | High throughput | no | no |
ASXL3_HUMAN | [view interactions] | High throughput | no | no |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NIBA2_HUMAN | [view interactions] | High throughput | no | no |
NUCB2_HUMAN | [view interactions] | High throughput | no | yes |
PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGM1_HUMAN | [view interactions] | High throughput | no | no |
LA_HUMAN | [view interactions] | High throughput | no | yes |
YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPCE_HUMAN | [view interactions] | High throughput | no | yes |
TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GUAA_HUMAN | [view interactions] | High throughput | no | no |
HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
PSME1_HUMAN | [view interactions] | High throughput | no | yes |
AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STXB2_HUMAN | [view interactions] | High throughput | no | no |
HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERAP1_HUMAN | [view interactions] | High throughput | no | yes |
TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CCNF_HUMAN | [view interactions] | High throughput | no | no |