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YES_HUMAN

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI000336 MOD_SPalmitoyl_4 MOD 1 7 -
ELMI000133 MOD_TYR_CSK MOD 533 541 -

Molecular function

Term Name % Distance from the top of the tree Annotated in YES_HUMAN
GO:0017076 purine nucleotide binding 34.8684 4 yes
GO:0032555 purine ribonucleotide binding 34.8684 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 34.8684 4 yes
GO:0019900 kinase binding 34.2105 4 no
GO:0019901 protein kinase binding 32.8947 5 no
GO:0046872 metal ion binding 25.0000 4 no
GO:0005524 ATP binding 23.0263 5 yes
GO:0030554 adenyl nucleotide binding 23.0263 5 yes
GO:0032559 adenyl ribonucleotide binding 23.0263 5 yes
GO:0016301 kinase activity 15.7895 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 15.7895 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 14.4737 4 yes
GO:0004713 protein tyrosine kinase activity 11.1842 4 yes
GO:0045309 protein phosphorylated amino acid binding 8.5526 4 yes
GO:0001784 phosphotyrosine residue binding 7.8947 5 yes
GO:0004715 non-membrane spanning protein tyrosine kinase activity 7.2368 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in YES_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 59.2105 4 yes
GO:0048523 negative regulation of cellular process 56.5789 4 no
GO:0031323 regulation of cellular metabolic process 56.5789 4 yes
GO:0080090 regulation of primary metabolic process 56.5789 4 yes
GO:0051128 regulation of cellular component organization 55.2632 4 no
GO:0051171 regulation of nitrogen compound metabolic process 54.6053 4 yes
GO:0010646 regulation of cell communication 52.6316 4 no
GO:0009893 positive regulation of metabolic process 51.9737 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 49.3421 5 yes
GO:0009966 regulation of signal transduction 46.7105 4 no
GO:0051246 regulation of protein metabolic process 46.0526 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 45.3947 5 yes
GO:0022607 cellular component assembly 44.7368 4 no
GO:0031325 positive regulation of cellular metabolic process 44.0789 5 yes
GO:0010468 regulation of gene expression 42.7632 5 yes
GO:0048584 positive regulation of response to stimulus 40.7895 4 yes
GO:0051049 regulation of transport 40.7895 4 yes
GO:1902531 regulation of intracellular signal transduction 39.4737 5 no
GO:0006996 organelle organization 38.8158 4 no
GO:0051247 positive regulation of protein metabolic process 37.5000 6 yes
GO:0019220 regulation of phosphate metabolic process 36.1842 6 yes
GO:0051174 regulation of phosphorus metabolic process 36.1842 5 yes
GO:0030030 cell projection organization 35.5263 4 no
GO:0009889 regulation of biosynthetic process 35.5263 4 yes
GO:0031326 regulation of cellular biosynthetic process 35.5263 5 yes
GO:0031399 regulation of protein modification process 35.5263 6 yes
GO:0008104 protein localization 34.8684 4 no
GO:0010647 positive regulation of cell communication 34.2105 5 no
GO:0023056 positive regulation of signaling 34.2105 4 no
GO:0042325 regulation of phosphorylation 34.2105 7 yes
GO:0010556 regulation of macromolecule biosynthetic process 33.5526 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.5526 5 yes
GO:0043085 positive regulation of catalytic activity 32.8947 4 no
GO:0010941 regulation of cell death 32.2368 4 no
GO:0120036 plasma membrane bounded cell projection organization 31.5789 5 no
GO:0001932 regulation of protein phosphorylation 31.5789 7 yes
GO:0009892 negative regulation of metabolic process 31.5789 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.9211 5 no
GO:0044087 regulation of cellular component biogenesis 30.9211 4 no
GO:0009967 positive regulation of signal transduction 30.9211 5 no
GO:0033043 regulation of organelle organization 30.2632 5 no
GO:0043067 regulation of programmed cell death 30.2632 5 no
GO:0010562 positive regulation of phosphorus metabolic process 30.2632 6 yes
GO:0045937 positive regulation of phosphate metabolic process 30.2632 7 yes
GO:0051130 positive regulation of cellular component organization 29.6053 5 no
GO:0042981 regulation of apoptotic process 29.6053 6 no
GO:0031401 positive regulation of protein modification process 29.6053 7 yes
GO:0045595 regulation of cell differentiation 28.9474 4 no
GO:0030155 regulation of cell adhesion 28.9474 4 yes
GO:0042327 positive regulation of phosphorylation 28.9474 8 yes
GO:0071310 cellular response to organic substance 28.9474 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 27.6316 5 no
GO:0060341 regulation of cellular localization 27.6316 4 no
GO:0030334 regulation of cell migration 27.6316 5 no
GO:2000145 regulation of cell motility 27.6316 4 no
GO:0022603 regulation of anatomical structure morphogenesis 27.6316 4 no
GO:0071702 organic substance transport 26.9737 4 no
GO:0001934 positive regulation of protein phosphorylation 26.9737 8 yes
GO:0051252 regulation of RNA metabolic process 26.9737 5 yes
GO:0042127 regulation of cell population proliferation 26.3158 4 no
GO:0016192 vesicle-mediated transport 26.3158 4 no
GO:0006796 phosphate-containing compound metabolic process 26.3158 4 no
GO:0032880 regulation of protein localization 25.6579 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.6579 6 no
GO:0031344 regulation of cell projection organization 25.6579 5 no
GO:0051094 positive regulation of developmental process 25.6579 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0036211 protein modification process 25.0000 4 yes
GO:0043412 macromolecule modification 25.0000 4 yes
GO:0051050 positive regulation of transport 24.3421 4 no
GO:0071705 nitrogen compound transport 24.3421 4 no
GO:0080134 regulation of response to stress 24.3421 4 yes
GO:0010628 positive regulation of gene expression 23.6842 6 no
GO:0006355 regulation of DNA-templated transcription 23.6842 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 23.6842 7 yes
GO:2001141 regulation of RNA biosynthetic process 23.6842 6 yes
GO:0007010 cytoskeleton organization 23.0263 5 no
GO:0051240 positive regulation of multicellular organismal process 23.0263 4 no
GO:0051493 regulation of cytoskeleton organization 23.0263 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 23.0263 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 23.0263 5 yes
GO:0043549 regulation of kinase activity 22.3684 5 no
GO:0043933 protein-containing complex organization 22.3684 4 no
GO:0009891 positive regulation of biosynthetic process 22.3684 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 22.3684 6 yes
GO:0010648 negative regulation of cell communication 21.7105 5 no
GO:0023057 negative regulation of signaling 21.7105 4 no
GO:0051248 negative regulation of protein metabolic process 21.7105 6 no
GO:0051347 positive regulation of transferase activity 21.7105 5 no
GO:0043408 regulation of MAPK cascade 21.7105 6 no
GO:0002684 positive regulation of immune system process 21.7105 4 yes
GO:0048585 negative regulation of response to stimulus 21.7105 4 yes
GO:0015031 protein transport 21.0526 4 no
GO:0008284 positive regulation of cell population proliferation 21.0526 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.0526 6 yes
GO:0050776 regulation of immune response 21.0526 4 yes
GO:0065003 protein-containing complex assembly 20.3947 5 no
GO:0030335 positive regulation of cell migration 20.3947 6 no
GO:0040017 positive regulation of locomotion 20.3947 4 no
GO:2000147 positive regulation of cell motility 20.3947 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.3947 6 yes
GO:0032101 regulation of response to external stimulus 20.3947 4 yes
GO:0045785 positive regulation of cell adhesion 19.0789 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 15.1316 8 yes
GO:1901701 cellular response to oxygen-containing compound 15.1316 4 yes
GO:0050778 positive regulation of immune response 14.4737 5 yes
GO:0022407 regulation of cell-cell adhesion 13.8158 5 yes
GO:0050865 regulation of cell activation 13.8158 4 yes
GO:0051254 positive regulation of RNA metabolic process 13.8158 6 yes
GO:0070848 response to growth factor 13.8158 4 yes
GO:0002694 regulation of leukocyte activation 13.1579 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 13.1579 7 yes
GO:0071363 cellular response to growth factor stimulus 13.1579 5 yes
GO:0031347 regulation of defense response 12.5000 5 yes
GO:0033993 response to lipid 12.5000 4 yes
GO:0034762 regulation of transmembrane transport 12.5000 4 yes
GO:0045893 positive regulation of DNA-templated transcription 12.5000 7 yes
GO:1902680 positive regulation of RNA biosynthetic process 12.5000 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 12.5000 8 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 11.1842 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 11.1842 4 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 11.1842 9 yes
GO:0051249 regulation of lymphocyte activation 10.5263 5 yes
GO:0002696 positive regulation of leukocyte activation 9.8684 5 yes
GO:0048013 ephrin receptor signaling pathway 9.8684 6 yes
GO:0050863 regulation of T cell activation 9.8684 6 yes
GO:0050867 positive regulation of cell activation 9.8684 5 yes
GO:0022409 positive regulation of cell-cell adhesion 9.2105 6 yes
GO:0071396 cellular response to lipid 9.2105 5 yes
GO:0032102 negative regulation of response to external stimulus 8.5526 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 8.5526 8 yes
GO:0051251 positive regulation of lymphocyte activation 7.8947 6 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 7.8947 6 yes
GO:0038093 Fc receptor signaling pathway 7.2368 5 yes
GO:0050727 regulation of inflammatory response 7.2368 5 yes
GO:0050870 positive regulation of T cell activation 7.2368 7 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 7.2368 7 yes
GO:0002431 Fc receptor mediated stimulatory signaling pathway 6.5789 5 yes
GO:0002683 negative regulation of immune system process 6.5789 4 yes
GO:0038094 Fc-gamma receptor signaling pathway 6.5789 6 yes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 6.5789 4 yes
GO:0031348 negative regulation of defense response 5.2632 5 yes
GO:0071560 cellular response to transforming growth factor beta stimulus 5.2632 4 yes
GO:0003018 vascular process in circulatory system 4.6053 4 yes
GO:0050728 negative regulation of inflammatory response 4.6053 6 yes
GO:0050777 negative regulation of immune response 4.6053 5 yes
GO:0002861 regulation of inflammatory response to antigenic stimulus 3.9474 5 yes
GO:0002862 negative regulation of inflammatory response to antigenic stimulus 3.9474 6 yes
GO:0032526 response to retinoic acid 3.9474 4 yes
GO:0071300 cellular response to retinoic acid 3.9474 5 yes
GO:0036120 cellular response to platelet-derived growth factor stimulus 2.6316 4 yes
GO:0010827 regulation of glucose transmembrane transport 1.9737 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in YES_HUMAN
DOID:0050686 organ system cancer 2.6316 3 no
DOID:0050700 cardiomyopathy 1.9737 4 no
DOID:0060036 intrinsic cardiomyopathy 1.9737 5 no
DOID:114 heart disease 1.9737 3 no
DOID:2843 long QT syndrome 1.9737 6 no
DOID:612 primary immunodeficiency disease 1.9737 3 no
DOID:331 central nervous system disease 1.9737 3 no
DOID:193 reproductive organ cancer 1.9737 4 no
DOID:10273 heart conduction disease 1.3158 4 no
DOID:0111962 combined immunodeficiency 1.3158 4 no
DOID:1289 neurodegenerative disease 1.3158 4 no
DOID:231 motor neuron disease 1.3158 5 no
DOID:120 female reproductive organ cancer 1.3158 5 no
DOID:10283 prostate cancer 1.3158 6 no
DOID:3856 male reproductive organ cancer 1.3158 5 no
DOID:1247 blood coagulation disease 1.3158 3 no
DOID:2218 blood platelet disease 1.3158 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CSF1R_HUMAN [view interactions] Low throughput no yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PDC6I_HUMAN [view entry] [view interactions] Low throughput yes yes
NHRF1_HUMAN [view interactions] Low throughput no no
OGT1_HUMAN [view entry] [view interactions] Low throughput yes yes
RL10_HUMAN [view entry] [view interactions] Low throughput yes yes
PGFRB_HUMAN [view interactions] Low throughput no yes
FGFR1_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
TNR6_HUMAN [view interactions] Low throughput no no
NCOA2_HUMAN [view interactions] Low throughput no no
CDCP1_HUMAN [view interactions] Low throughput no yes
YAP1_HUMAN [view interactions] Low throughput no yes
VGFR1_HUMAN [view interactions] Low throughput no no
CDN1B_HUMAN [view interactions] Low throughput no yes
LOX5_HUMAN [view interactions] Low throughput no no
SPR2A_HUMAN [view interactions] Low throughput no no
KHDR1_HUMAN [view interactions] Low throughput no yes
GPVI_HUMAN [view interactions] Low throughput no no
ACK1_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
NPHN_HUMAN [view interactions] Low throughput no no
CBL_HUMAN [view interactions] Low throughput no yes
CTND1_HUMAN [view entry] [view interactions] Low throughput yes no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
OCLN_HUMAN [view interactions] Low throughput no no
RASA1_HUMAN [view interactions] Low throughput no yes
CD36_HUMAN [view interactions] Low throughput no no
PECA1_HUMAN [view interactions] Low throughput no no
TRPV4_HUMAN [view interactions] Low throughput no yes
MCP_HUMAN [view interactions] Low throughput no no
DIAP1_HUMAN [view interactions] Low throughput no yes
EDNRA_HUMAN [view interactions] Low throughput no yes
DAB1_HUMAN [view interactions] Low throughput no yes
ACSL3_HUMAN [view entry] [view interactions] Low throughput yes yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
IL1R1_HUMAN [view interactions] Low throughput no no
SOCS1_HUMAN [view interactions] Low throughput no yes
MED28_HUMAN [view interactions] Low throughput no yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRE_HUMAN [view interactions] Low throughput no no
FLOT1_HUMAN [view entry] [view interactions] Low throughput yes yes
FGR_HUMAN [view interactions] High throughput no no
SNG1_HUMAN [view entry] [view interactions] High throughput yes yes
PAI2_HUMAN [view interactions] High throughput no no
KC1G2_HUMAN [view interactions] High throughput no yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
VA0D2_HUMAN [view interactions] High throughput no no
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
TBD_HUMAN [view interactions] High throughput no yes
CCNL2_HUMAN [view interactions] High throughput no yes
NPC2_HUMAN [view interactions] High throughput no yes
T185A_HUMAN [view interactions] High throughput no no
PIGM_HUMAN [view interactions] High throughput no no
C1QL4_HUMAN [view interactions] High throughput no no
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
PCDGK_HUMAN [view interactions] High throughput no yes
FLRT1_HUMAN [view interactions] High throughput no no
ACBD7_HUMAN [view interactions] High throughput no no
ERLEC_HUMAN [view interactions] High throughput no yes
PRUN2_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR2_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
SPIN1_HUMAN [view interactions] High throughput no no
OCRL_HUMAN [view interactions] High throughput no yes
KC1G3_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
RSMB_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
RSMN_HUMAN [view interactions] High throughput no yes
SIK2_HUMAN [view interactions] High throughput no yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
KPCD1_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
SR140_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
DHX15_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
SF3B1_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
CDK1_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
HNRPC_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
HNRC1_HUMAN [view interactions] High throughput no no
RHOC_HUMAN [view interactions] High throughput no no
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
RHOF_HUMAN [view interactions] High throughput no no
ERH_HUMAN [view interactions] High throughput no yes
RHOU_HUMAN [view interactions] High throughput no no
SF3B2_HUMAN [view interactions] High throughput no yes
RHOH_HUMAN [view interactions] High throughput no yes
SF3B3_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
SF3A1_HUMAN [view interactions] High throughput no yes
RND3_HUMAN [view interactions] High throughput no no
CHERP_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
SPF45_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
BCLF1_HUMAN [view interactions] High throughput no yes
RCBT2_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
DOK1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
SKAP2_HUMAN [view interactions] High throughput no no
HMGA2_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
DDR1_HUMAN [view interactions] High throughput no yes
SNP23_HUMAN [view entry] [view interactions] High throughput yes no
RB27A_HUMAN [view interactions] High throughput no yes
TSR1_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
ILF2_HUMAN [view interactions] High throughput no yes
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
VATE1_HUMAN [view entry] [view interactions] High throughput yes yes
PGM1_HUMAN [view interactions] High throughput no no
NSUN2_HUMAN [view interactions] High throughput no yes
PRP4B_HUMAN [view interactions] High throughput no yes
KS6A2_HUMAN [view interactions] High throughput no yes
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
DNJ5B_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
DNJC5_HUMAN [view interactions] High throughput no yes
ERBB3_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
M4K4_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
PHAG1_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
PGRC2_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
SHC2_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
SHF_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
SLAP1_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
STAP2_HUMAN [view interactions] High throughput no yes
LMAN1_HUMAN [view interactions] High throughput no yes
TENS3_HUMAN [view interactions] High throughput no no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
TXK_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
DSC3_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
POF1B_HUMAN [view interactions] High throughput no no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
ECM1_HUMAN [view interactions] High throughput no no
RAB9A_HUMAN [view interactions] High throughput no yes
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
STX6_HUMAN [view interactions] High throughput no yes
SPB4_HUMAN [view interactions] High throughput no no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
LEG7_HUMAN [view interactions] High throughput no no
ZFPL1_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
DPP4_HUMAN [view interactions] High throughput no no
PIM3_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
HASP_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
CACO2_HUMAN [view interactions] High throughput no yes
ADA15_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
PKHA7_HUMAN [view interactions] High throughput no yes
OLIG1_HUMAN [view interactions] High throughput no no
BECN1_HUMAN [view interactions] High throughput no yes
SOCS3_HUMAN [view interactions] High throughput no yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF2_HUMAN [view interactions] High throughput no yes
CA094_HUMAN [view interactions] High throughput no no
FUND1_HUMAN [view interactions] High throughput no yes
ZBT8A_HUMAN [view interactions] High throughput no yes
SSBP3_HUMAN [view interactions] High throughput no no
NIF3L_HUMAN [view interactions] High throughput no yes
THAP1_HUMAN [view interactions] High throughput no no
TRAF6_HUMAN [view interactions] High throughput no yes
CRTP1_HUMAN [view interactions] High throughput no yes
IKZF3_HUMAN [view interactions] High throughput no no
SF3A2_HUMAN [view interactions] High throughput no yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
AMOL2_HUMAN [view interactions] High throughput no no
CBLB_HUMAN [view interactions] High throughput no yes
SHLB2_HUMAN [view entry] [view interactions] High throughput yes no
DESM_HUMAN [view entry] [view interactions] High throughput yes no
CHM1A_HUMAN [view entry] [view interactions] High throughput yes no
SOCS7_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
T10IP_HUMAN [view interactions] High throughput no no
DRC4_HUMAN [view interactions] High throughput no yes
DDT4L_HUMAN [view interactions] High throughput no no
CE57L_HUMAN [view interactions] High throughput no yes
JKIP1_HUMAN [view interactions] High throughput no no
ZC21A_HUMAN [view interactions] High throughput no yes
DTX3_HUMAN [view interactions] High throughput no yes
ZN438_HUMAN [view interactions] High throughput no no
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
SOCS2_HUMAN [view interactions] High throughput no yes
DOK2_HUMAN [view interactions] High throughput no no
P55G_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
CBLC_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
ANDR_HUMAN [view interactions] High throughput no no
GAB1_HUMAN [view interactions] High throughput no yes
KIT_HUMAN [view interactions] High throughput no no
MET_HUMAN [view interactions] High throughput no yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
TMM17_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view interactions] High throughput no yes
TNFL6_HUMAN [view interactions] High throughput no yes
PSA1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SOBP_HUMAN [view interactions] High throughput no yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
NTM2B_HUMAN [view interactions] High throughput no no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
WIPF3_HUMAN [view interactions] High throughput no yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
SHOT1_HUMAN [view interactions] High throughput no no
PAXI_HUMAN [view interactions] High throughput no yes
ARHG5_HUMAN [view interactions] High throughput no yes
CPSF6_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
TRIM5_HUMAN [view interactions] High throughput no yes
MAP1A_HUMAN [view entry] [view interactions] High throughput yes yes
CCD33_HUMAN [view interactions] High throughput no no
DEN2B_HUMAN [view interactions] High throughput no yes
FACC1_HUMAN [view interactions] High throughput no no
EPIPL_HUMAN [view entry] [view interactions] High throughput yes no
CEP83_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
DEN2C_HUMAN [view interactions] High throughput no no
AFAD_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
YLPM1_HUMAN [view interactions] High throughput no yes
CARD9_HUMAN [view interactions] High throughput no no
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
KCNA5_HUMAN [view interactions] High throughput no no
HCLS1_HUMAN [view interactions] High throughput no no
GLI1_HUMAN [view interactions] High throughput no no
GANP_HUMAN [view interactions] High throughput no yes
ZC3H1_HUMAN [view interactions] High throughput no yes
WIPF1_HUMAN [view interactions] High throughput no no
IF4G3_HUMAN [view interactions] High throughput no yes
EFS_HUMAN [view interactions] High throughput no no
TRI69_HUMAN [view interactions] High throughput no no
ASAP2_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
PER1_HUMAN [view interactions] High throughput no no
SHIP2_HUMAN [view interactions] High throughput no yes
IRS4_HUMAN [view interactions] High throughput no no
RN223_HUMAN [view interactions] High throughput no no
PRRT4_HUMAN [view interactions] High throughput no no
PAN2_HUMAN [view interactions] High throughput no no
NTM2E_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
4EBP1_HUMAN [view entry] [view interactions] High throughput yes yes
GPR35_HUMAN [view interactions] High throughput no no
MAMD1_HUMAN [view interactions] High throughput no no
GRPE2_HUMAN [view interactions] High throughput no yes
VPS54_HUMAN [view interactions] High throughput no no
LIMC1_HUMAN [view entry] [view interactions] High throughput yes no
FMN2_HUMAN [view entry] [view interactions] High throughput yes no
UIF_HUMAN [view interactions] High throughput no yes
CDK12_HUMAN [view interactions] High throughput no yes
IKBA_HUMAN [view interactions] High throughput no yes
F120C_HUMAN [view interactions] High throughput no yes
ANR12_HUMAN [view interactions] High throughput no yes
MBNL1_HUMAN [view interactions] High throughput no yes
ZNT4_HUMAN [view interactions] High throughput no no
ELL3_HUMAN [view interactions] High throughput no yes
JSPR1_HUMAN [view interactions] High throughput no no
ASXL3_HUMAN [view interactions] High throughput no no
MOT14_HUMAN [view interactions] High throughput no yes
SETD5_HUMAN [view interactions] High throughput no yes
CP51A_HUMAN [view interactions] High throughput no no
ZFHX2_HUMAN [view interactions] High throughput no no
PIFO_HUMAN [view interactions] High throughput no no
TX13A_HUMAN [view interactions] High throughput no no
PRAX_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
SALL3_HUMAN [view interactions] High throughput no no
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
RBM15_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
CIC_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
SAM11_HUMAN [view interactions] High throughput no no
BMR1A_HUMAN [view interactions] High throughput no no
DMRTB_HUMAN [view interactions] High throughput no no
CALL3_HUMAN [view interactions] High throughput no yes
LRC46_HUMAN [view interactions] High throughput no no
RBM33_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
NKD2_HUMAN [view interactions] High throughput no no
DUS22_HUMAN [view interactions] High throughput no yes
SHIP1_HUMAN [view interactions] High throughput no no
NICA_HUMAN [view interactions] High throughput no yes
MADD_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
ASAP3_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
VW5B2_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
NTM2A_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
PRSR1_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
IQGA3_HUMAN [view interactions] High throughput no no
MYPN_HUMAN [view interactions] High throughput no no
LRP10_HUMAN [view interactions] High throughput no no
TCF24_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
MED25_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
TSH1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
S39A5_HUMAN [view interactions] High throughput no no
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
FMN1_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
PEAR1_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
NTM2D_HUMAN [view interactions] High throughput no no
YES_HUMAN [view entry] [view interactions] High throughput yes yes
BCORL_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
IN80D_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
PKHN1_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
FHOD3_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
SMN_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
R3HD1_HUMAN [view interactions] High throughput no no
KLF5_HUMAN [view interactions] High throughput no yes
FA20C_HUMAN [view interactions] High throughput no no
ATF5_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
SET1B_HUMAN [view interactions] High throughput no yes
MALL_HUMAN [view interactions] High throughput no no
BSN_HUMAN [view entry] [view interactions] High throughput yes yes
CENPM_HUMAN [view interactions] High throughput no yes
KMT2B_HUMAN [view interactions] High throughput no no
RF1M_HUMAN [view interactions] High throughput no yes
ZBT21_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
KI26A_HUMAN [view interactions] High throughput no no
FA13A_HUMAN [view interactions] High throughput no yes
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZPBP2_HUMAN [view interactions] High throughput no no
TEN1_HUMAN [view interactions] High throughput no no
CC014_HUMAN [view interactions] High throughput no yes
CAMP3_HUMAN [view interactions] High throughput no no
CENPK_HUMAN [view interactions] High throughput no no
IRS2_HUMAN [view interactions] High throughput no yes
UT1_HUMAN [view interactions] High throughput no no
IFT52_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
R3HD2_HUMAN [view interactions] High throughput no yes
WDR36_HUMAN [view interactions] High throughput no yes
FFAR1_HUMAN [view interactions] High throughput no no
Z512B_HUMAN [view interactions] High throughput no yes
CEP43_HUMAN [view interactions] High throughput no no
DVL2_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
ZDH23_HUMAN [view interactions] High throughput no no
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
PCDB3_HUMAN [view interactions] High throughput no no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
FLNB_HUMAN [view interactions] High throughput no no
XRP2_HUMAN [view entry] [view interactions] High throughput yes no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
ZCHC9_HUMAN [view interactions] High throughput no yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
TMM59_HUMAN [view interactions] High throughput no yes
SIDT2_HUMAN [view interactions] High throughput no yes
CDK20_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
PAL4G_HUMAN [view interactions] High throughput no no
SODC_HUMAN [view interactions] High throughput no yes
PAL4C_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
SYT3_HUMAN [view entry] [view interactions] High throughput yes no
MED21_HUMAN [view interactions] High throughput no yes
HXB5_HUMAN [view interactions] High throughput no no
ZFY27_HUMAN [view interactions] High throughput no yes
CXB7_HUMAN [view interactions] High throughput no no
PAR2_HUMAN [view entry] [view interactions] High throughput yes yes
S2541_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
HS905_HUMAN [view interactions] High throughput no no
GPC5B_HUMAN [view entry] [view interactions] High throughput yes no
CC186_HUMAN [view interactions] High throughput no yes
RBBP6_HUMAN [view interactions] High throughput no yes
HS904_HUMAN [view interactions] High throughput no no
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
H90B3_HUMAN [view interactions] High throughput no no
TGFR2_HUMAN [view interactions] High throughput no no
H90B4_HUMAN [view interactions] High throughput no no
NAT10_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
BLMH_HUMAN [view interactions] High throughput no yes
BMX_HUMAN [view interactions] Computational no no
CD3Z_HUMAN [view interactions] Computational no no
KPCD_HUMAN [view entry] [view interactions] Computational yes yes
CD3G_HUMAN [view interactions] Computational no no
PP2AA_HUMAN [view entry] [view interactions] Computational yes yes
ARHG7_HUMAN [view entry] [view interactions] Computational yes yes
BLNK_HUMAN [view entry] [view interactions] Computational yes no
ACTN1_HUMAN [view entry] [view interactions] Computational yes yes
2A5E_HUMAN [view interactions] Computational no yes
EFNA1_HUMAN [view interactions] Computational no no
FAK2_HUMAN [view entry] [view interactions] Computational yes yes
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
GPC1_HUMAN [view entry] [view interactions] Computational yes no
VINC_HUMAN [view entry] [view interactions] Computational yes no
BTK_HUMAN [view interactions] Computational no no
MK01_HUMAN [view entry] [view interactions] Computational yes yes
2AAA_HUMAN [view entry] [view interactions] Computational yes no
2A5G_HUMAN [view interactions] Computational no yes
JIP3_HUMAN [view entry] [view interactions] Computational yes yes
NMDZ1_HUMAN [view entry] [view interactions] Computational yes yes
MK14_HUMAN [view interactions] Computational no yes
KSYK_HUMAN [view interactions] Computational no no
S1PR1_HUMAN [view interactions] Computational no no
NCK1_HUMAN [view interactions] Computational no yes
ITB5_HUMAN [view interactions] Computational no yes
EPHA3_HUMAN [view interactions] Computational no yes
BLK_HUMAN [view interactions] Computational no no
CD28_HUMAN [view interactions] Computational no no
RHG35_HUMAN [view interactions] Computational no yes
EFNB1_HUMAN [view interactions] Computational no yes
NRG2_HUMAN [view interactions] Computational no yes
ZAP70_HUMAN [view interactions] Computational no no
ABL1_HUMAN [view entry] [view interactions] Computational yes yes
RRAS_HUMAN [view interactions] Computational no yes
UNC5C_HUMAN [view interactions] Computational no no
2A5D_HUMAN [view entry] [view interactions] Computational yes yes
HBEGF_HUMAN [view interactions] Computational no no
WNT5A_HUMAN [view entry] [view interactions] Computational yes no
TDGF1_HUMAN [view interactions] Computational no no
PDGFB_HUMAN [view interactions] Computational no yes
FZD2_HUMAN [view interactions] Computational no no
2A5B_HUMAN [view interactions] Computational no yes
PP2AB_HUMAN [view interactions] Computational no yes
EGF_HUMAN [view interactions] Computational no no
2AAB_HUMAN [view interactions] Computational no yes
ELMO1_HUMAN [view interactions] Computational no no
EPHA4_HUMAN [view entry] [view interactions] Computational yes yes
NRG4_HUMAN [view interactions] Computational no no
EREG_HUMAN [view interactions] Computational no no
ITAV_HUMAN [view interactions] Computational no yes
EPHA7_HUMAN [view entry] [view interactions] Computational yes no
DAPP1_HUMAN [view interactions] Computational no yes
NRG3_HUMAN [view interactions] Computational no no
CLIC5_HUMAN [view interactions] Computational no no
PTN21_HUMAN [view interactions] Computational no yes
FER_HUMAN [view interactions] Computational no yes
GRB2_HUMAN [view entry] [view interactions] Computational yes yes
NCK2_HUMAN [view entry] [view interactions] Computational yes yes
NET1_HUMAN [view interactions] Computational no no
NRG1_HUMAN [view entry] [view interactions] Computational yes no
EPHB1_HUMAN [view interactions] Computational no no
FCGR1_HUMAN [view interactions] Computational no no
EPHA1_HUMAN [view interactions] Computational no yes
ITK_HUMAN [view interactions] Computational no no
LAT_HUMAN [view interactions] Computational no no
VAV_HUMAN [view interactions] Computational no no
FCG2A_HUMAN [view interactions] Computational no no
SH3G1_HUMAN [view entry] [view interactions] Computational yes no
PAK4_HUMAN [view interactions] Computational no yes
GIT2_HUMAN [view interactions] Computational no yes
MK11_HUMAN [view interactions] Computational no yes
DCC_HUMAN [view entry] [view interactions] Computational yes yes
PLCG2_HUMAN [view interactions] Computational no yes
DOCK1_HUMAN [view entry] [view interactions] Computational yes yes
EPHA2_HUMAN [view interactions] Computational no no
PTN13_HUMAN [view interactions] Computational no yes
TRPV6_HUMAN [view interactions] Computational no no
VAV2_HUMAN [view entry] [view interactions] Computational yes yes
NGEF_HUMAN [view entry] [view interactions] Computational yes yes
PAK1_HUMAN [view entry] [view interactions] Computational yes yes
STAT3_HUMAN [view entry] [view interactions] Computational yes yes
EFNA5_HUMAN [view interactions] Computational no yes
BTC_HUMAN [view interactions] Computational no no
CSK_HUMAN [view interactions] Computational no yes
GRB7_HUMAN [view interactions] Computational no no
RPGF1_HUMAN [view interactions] Computational no yes
IGLL5_HUMAN [view interactions] Computational no no
2A5A_HUMAN [view interactions] Computational no yes
PLCG1_HUMAN [view entry] [view interactions] Computational yes yes
SYUA_HUMAN [view entry] [view interactions] Computational yes no
CRK_HUMAN [view entry] [view interactions] Computational yes no
CAN2_HUMAN [view interactions] Computational no no