FRIH_HUMAN
Evidence for PS localization
Functions
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FRIH_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.3571 | 4 | no |
| GO:0043168 | anion binding | 26.7857 | 4 | no |
| GO:0043169 | cation binding | 25.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 25.0000 | 5 | yes |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.2143 | 4 | no |
| GO:0019900 | kinase binding | 23.2143 | 4 | no |
| GO:0046914 | transition metal ion binding | 10.7143 | 6 | yes |
| GO:0004322 | ferroxidase activity | 3.5714 | 5 | yes |
| GO:0005506 | iron ion binding | 3.5714 | 7 | yes |
| GO:0008198 | ferrous iron binding | 3.5714 | 8 | yes |
| GO:0008199 | ferric iron binding | 3.5714 | 8 | yes |
| GO:0016724 | oxidoreductase activity, acting on metal ions, oxygen as acceptor | 3.5714 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FRIH_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.5714 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.5714 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.5714 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 53.5714 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 41.0714 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.0714 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.0714 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.0714 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 39.2857 | 4 | no |
| GO:0008104 | protein localization | 39.2857 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.2857 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.2857 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.5000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.7143 | 5 | no |
| GO:0022607 | cellular component assembly | 35.7143 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.9286 | 5 | no |
| GO:0006996 | organelle organization | 32.1429 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.1429 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.3571 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.3571 | 6 | no |
| GO:0031399 | regulation of protein modification process | 30.3571 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0051049 | regulation of transport | 26.7857 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.7857 | 6 | no |
| GO:0071702 | organic substance transport | 26.7857 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.7857 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.2143 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.2143 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.2143 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.2143 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 21.4286 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.4286 | 4 | no |
| GO:0015031 | protein transport | 21.4286 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.4286 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 21.4286 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 21.4286 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.4286 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.4286 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.4286 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.4286 | 4 | no |
| GO:0030030 | cell projection organization | 21.4286 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 21.4286 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.4286 | 8 | no |
| GO:0006811 | monoatomic ion transport | 12.5000 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 12.5000 | 5 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 12.5000 | 5 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 10.7143 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 10.7143 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 10.7143 | 4 | yes |
| GO:0030001 | metal ion transport | 8.9286 | 6 | yes |
| GO:0000041 | transition metal ion transport | 7.1429 | 7 | yes |
| GO:0006826 | iron ion transport | 7.1429 | 8 | yes |
| GO:0006879 | intracellular iron ion homeostasis | 7.1429 | 4 | yes |
| GO:0006880 | intracellular sequestering of iron ion | 3.5714 | 4 | yes |
| GO:0048145 | regulation of fibroblast proliferation | 3.5714 | 5 | yes |
| GO:0048147 | negative regulation of fibroblast proliferation | 3.5714 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NCOA4_HUMAN | [view interactions] | Low throughput | no | no |
| TFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FRIH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD99_HUMAN | [view interactions] | Low throughput | no | no |
| PHOCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCBP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCBP3_HUMAN | [view interactions] | Low throughput | no | yes |
| DAXX_HUMAN | [view interactions] | Low throughput | no | yes |
| RET4_HUMAN | [view interactions] | High throughput | no | no |
| SEMG1_HUMAN | [view interactions] | High throughput | no | no |
| INVO_HUMAN | [view interactions] | High throughput | no | no |
| CBPM_HUMAN | [view interactions] | High throughput | no | no |
| SAP3_HUMAN | [view interactions] | High throughput | no | yes |
| FILA_HUMAN | [view interactions] | High throughput | no | no |
| TGM1_HUMAN | [view interactions] | High throughput | no | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| SPB3_HUMAN | [view interactions] | High throughput | no | no |
| CASPE_HUMAN | [view interactions] | High throughput | no | no |
| HUTH_HUMAN | [view interactions] | High throughput | no | yes |
| MAOX_HUMAN | [view interactions] | High throughput | no | yes |
| SPB4_HUMAN | [view interactions] | High throughput | no | no |
| SEMG2_HUMAN | [view interactions] | High throughput | no | no |
| TGM3_HUMAN | [view interactions] | High throughput | no | no |
| CYTM_HUMAN | [view interactions] | High throughput | no | no |
| PLBL1_HUMAN | [view interactions] | High throughput | no | no |
| FBX50_HUMAN | [view interactions] | High throughput | no | no |
| SPA12_HUMAN | [view interactions] | High throughput | no | no |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| FMC1_HUMAN | [view interactions] | High throughput | no | no |
| LYRM1_HUMAN | [view interactions] | High throughput | no | no |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MD13L_HUMAN | [view interactions] | High throughput | no | no |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP1_HUMAN | [view interactions] | High throughput | no | no |
| SOX5_HUMAN | [view interactions] | High throughput | no | no |
| MYL3_HUMAN | [view interactions] | High throughput | no | no |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR1_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| ELL3_HUMAN | [view interactions] | High throughput | no | yes |
| PACN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| MK09_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| AMY1B_HUMAN | [view interactions] | High throughput | no | no |
| AMY2B_HUMAN | [view interactions] | High throughput | no | no |
| AMYP_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCHI1_HUMAN | [view interactions] | High throughput | no | yes |
| NR1I3_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR5A2_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| OSTP_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASB15_HUMAN | [view interactions] | High throughput | no | no |
| ASB16_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CEP57_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| TREX2_HUMAN | [view interactions] | High throughput | no | no |
| KLK7_HUMAN | [view interactions] | High throughput | no | no |
| IL1RA_HUMAN | [view interactions] | High throughput | no | no |
| PPAP_HUMAN | [view interactions] | High throughput | no | no |
| IL37_HUMAN | [view interactions] | High throughput | no | no |
| ASAH1_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| ECM1_HUMAN | [view interactions] | High throughput | no | no |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SHPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX21_HUMAN | [view interactions] | High throughput | no | yes |
| GSDMA_HUMAN | [view interactions] | High throughput | no | no |
| GUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB13_HUMAN | [view interactions] | High throughput | no | no |
| SBSN_HUMAN | [view interactions] | High throughput | no | no |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
| ZA2G_HUMAN | [view interactions] | High throughput | no | no |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FILA2_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX16_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRPS3_HUMAN | [view interactions] | High throughput | no | no |
| RAP2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
| RAP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| RS12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1S2_HUMAN | [view interactions] | High throughput | no | no |
| CP51A_HUMAN | [view interactions] | High throughput | no | no |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGC2_HUMAN | [view interactions] | High throughput | no | no |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| B2MG_HUMAN | [view interactions] | High throughput | no | yes |
| MK10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| TAF6_HUMAN | [view interactions] | High throughput | no | no |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NLE1_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LBP_HUMAN | [view interactions] | High throughput | no | no |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIAS4_HUMAN | [view interactions] | High throughput | no | yes |
| TCAM2_HUMAN | [view interactions] | High throughput | no | no |
| ANKR1_HUMAN | [view interactions] | High throughput | no | no |
| NAL12_HUMAN | [view interactions] | High throughput | no | yes |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| RDHE2_HUMAN | [view interactions] | High throughput | no | yes |
| POF1B_HUMAN | [view interactions] | High throughput | no | no |
| CPNS2_HUMAN | [view interactions] | High throughput | no | no |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRNN_HUMAN | [view interactions] | High throughput | no | no |
| KLK11_HUMAN | [view interactions] | High throughput | no | no |
| CBPA4_HUMAN | [view interactions] | High throughput | no | no |
| KLK5_HUMAN | [view interactions] | High throughput | no | no |
| A2ML1_HUMAN | [view interactions] | High throughput | no | no |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| TGM5_HUMAN | [view interactions] | High throughput | no | no |
| PEPL_HUMAN | [view interactions] | High throughput | no | yes |
| CATL2_HUMAN | [view interactions] | High throughput | no | yes |
| LX12B_HUMAN | [view interactions] | High throughput | no | no |
| SPB7_HUMAN | [view interactions] | High throughput | no | no |
| CYTS_HUMAN | [view interactions] | High throughput | no | no |
| CYTN_HUMAN | [view interactions] | High throughput | no | no |
| IGKC_HUMAN | [view interactions] | High throughput | no | no |