FRIH_HUMAN
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in FRIH_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 30.6122 | 4 | no |
GO:0017076 | purine nucleotide binding | 26.5306 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 26.5306 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 24.4898 | 4 | no |
GO:0046872 | metal ion binding | 22.4490 | 4 | yes |
GO:0046914 | transition metal ion binding | 10.2041 | 5 | yes |
GO:0004322 | ferroxidase activity | 4.0816 | 5 | yes |
GO:0005506 | iron ion binding | 4.0816 | 6 | yes |
GO:0008198 | ferrous iron binding | 4.0816 | 7 | yes |
GO:0008199 | ferric iron binding | 4.0816 | 7 | yes |
GO:0016724 | oxidoreductase activity, acting on metal ions, oxygen as acceptor | 4.0816 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in FRIH_HUMAN |
---|---|---|---|---|
GO:0031323 | regulation of cellular metabolic process | 61.2245 | 4 | no |
GO:0048522 | positive regulation of cellular process | 59.1837 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 57.1429 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 57.1429 | 4 | no |
GO:0048523 | negative regulation of cellular process | 53.0612 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 46.9388 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 42.8571 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 42.8571 | 5 | no |
GO:0010646 | regulation of cell communication | 40.8163 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.8163 | 5 | no |
GO:0010468 | regulation of gene expression | 40.8163 | 5 | no |
GO:0009966 | regulation of signal transduction | 38.7755 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 38.7755 | 5 | no |
GO:0051128 | regulation of cellular component organization | 36.7347 | 4 | no |
GO:0008104 | protein localization | 36.7347 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 34.6939 | 6 | no |
GO:0031399 | regulation of protein modification process | 34.6939 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 34.6939 | 5 | no |
GO:0022607 | cellular component assembly | 32.6531 | 4 | no |
GO:0042325 | regulation of phosphorylation | 32.6531 | 7 | no |
GO:1902531 | regulation of intracellular signal transduction | 32.6531 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 32.6531 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.6531 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 32.6531 | 5 | no |
GO:0006996 | organelle organization | 30.6122 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 30.6122 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 28.5714 | 7 | no |
GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 28.5714 | 6 | no |
GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
GO:0080134 | regulation of response to stress | 28.5714 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 26.5306 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 26.5306 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 26.5306 | 7 | no |
GO:0031324 | negative regulation of cellular metabolic process | 26.5306 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.5306 | 5 | no |
GO:0051049 | regulation of transport | 26.5306 | 4 | no |
GO:0071702 | organic substance transport | 26.5306 | 4 | no |
GO:0071705 | nitrogen compound transport | 26.5306 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 24.4898 | 7 | no |
GO:0009894 | regulation of catabolic process | 24.4898 | 4 | no |
GO:0030030 | cell projection organization | 24.4898 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 24.4898 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 24.4898 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 22.4490 | 8 | no |
GO:0031329 | regulation of cellular catabolic process | 22.4490 | 5 | no |
GO:0051094 | positive regulation of developmental process | 22.4490 | 4 | no |
GO:0080135 | regulation of cellular response to stress | 22.4490 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 22.4490 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 22.4490 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 22.4490 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 20.4082 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 20.4082 | 5 | no |
GO:0010647 | positive regulation of cell communication | 20.4082 | 5 | no |
GO:0023056 | positive regulation of signaling | 20.4082 | 4 | no |
GO:0036211 | protein modification process | 20.4082 | 4 | no |
GO:0043412 | macromolecule modification | 20.4082 | 4 | no |
GO:0007010 | cytoskeleton organization | 20.4082 | 5 | no |
GO:0031344 | regulation of cell projection organization | 20.4082 | 5 | no |
GO:0033043 | regulation of organelle organization | 20.4082 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 20.4082 | 6 | no |
GO:0071310 | cellular response to organic substance | 20.4082 | 4 | no |
GO:0015031 | protein transport | 20.4082 | 4 | no |
GO:0006811 | ion transport | 12.2449 | 4 | yes |
GO:0006812 | cation transport | 12.2449 | 5 | yes |
GO:0008285 | negative regulation of cell population proliferation | 12.2449 | 5 | yes |
GO:0048878 | chemical homeostasis | 12.2449 | 4 | yes |
GO:0006873 | cellular ion homeostasis | 10.2041 | 4 | yes |
GO:0030003 | cellular cation homeostasis | 10.2041 | 5 | yes |
GO:0050801 | ion homeostasis | 10.2041 | 5 | yes |
GO:0055080 | cation homeostasis | 10.2041 | 6 | yes |
GO:0098771 | inorganic ion homeostasis | 10.2041 | 6 | yes |
GO:0006875 | cellular metal ion homeostasis | 8.1633 | 6 | yes |
GO:0030001 | metal ion transport | 8.1633 | 6 | yes |
GO:0055065 | metal ion homeostasis | 8.1633 | 7 | yes |
GO:0000041 | transition metal ion transport | 6.1224 | 7 | yes |
GO:0006826 | iron ion transport | 6.1224 | 8 | yes |
GO:0006879 | cellular iron ion homeostasis | 6.1224 | 8 | yes |
GO:0046916 | cellular transition metal ion homeostasis | 6.1224 | 7 | yes |
GO:0055072 | iron ion homeostasis | 6.1224 | 9 | yes |
GO:0055076 | transition metal ion homeostasis | 6.1224 | 8 | yes |
GO:0006880 | intracellular sequestering of iron ion | 4.0816 | 4 | yes |
GO:0048145 | regulation of fibroblast proliferation | 4.0816 | 5 | yes |
GO:0048147 | negative regulation of fibroblast proliferation | 4.0816 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TFR1_HUMAN | [view interactions] | Low throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FRIH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CD99_HUMAN | [view interactions] | Low throughput | no | no |
PHOCN_HUMAN | [view interactions] | Low throughput | no | yes |
PCBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PCBP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PCBP3_HUMAN | [view interactions] | Low throughput | no | yes |
DAXX_HUMAN | [view interactions] | Low throughput | no | yes |
NCOA4_HUMAN | [view interactions] | Low throughput | no | no |
PEPL_HUMAN | [view interactions] | High throughput | no | yes |
TGM5_HUMAN | [view interactions] | High throughput | no | no |
KLK10_HUMAN | [view interactions] | High throughput | no | no |
A2ML1_HUMAN | [view interactions] | High throughput | no | no |
CBPA4_HUMAN | [view interactions] | High throughput | no | no |
KLK11_HUMAN | [view interactions] | High throughput | no | no |
CRNN_HUMAN | [view interactions] | High throughput | no | no |
CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CPNS2_HUMAN | [view interactions] | High throughput | no | no |
POF1B_HUMAN | [view interactions] | High throughput | no | no |
RDHE2_HUMAN | [view interactions] | High throughput | no | yes |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
FMC1_HUMAN | [view interactions] | High throughput | no | no |
CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
LYRM1_HUMAN | [view interactions] | High throughput | no | no |
PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
GATA3_HUMAN | [view interactions] | High throughput | no | no |
VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
MPIP1_HUMAN | [view interactions] | High throughput | no | no |
MYL3_HUMAN | [view interactions] | High throughput | no | no |
SOX5_HUMAN | [view interactions] | High throughput | no | no |
BAG4_HUMAN | [view interactions] | High throughput | no | yes |
NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRD7_HUMAN | [view interactions] | High throughput | no | yes |
DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBR1_HUMAN | [view interactions] | High throughput | no | yes |
GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
ELL3_HUMAN | [view interactions] | High throughput | no | yes |
PACN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPR35_HUMAN | [view interactions] | High throughput | no | no |
MAX_HUMAN | [view interactions] | High throughput | no | yes |
MK09_HUMAN | [view interactions] | High throughput | no | yes |
ACSL1_HUMAN | [view interactions] | High throughput | no | no |
AMY1B_HUMAN | [view interactions] | High throughput | no | no |
AMY2B_HUMAN | [view interactions] | High throughput | no | no |
AMYP_HUMAN | [view interactions] | High throughput | no | no |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCHI1_HUMAN | [view interactions] | High throughput | no | yes |
NR1I3_HUMAN | [view interactions] | High throughput | no | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR5A2_HUMAN | [view interactions] | High throughput | no | yes |
TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
OSTP_HUMAN | [view interactions] | High throughput | no | yes |
UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
CEP55_HUMAN | [view interactions] | High throughput | no | yes |
VATB1_HUMAN | [view interactions] | High throughput | no | no |
IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ASB15_HUMAN | [view interactions] | High throughput | no | no |
ASB16_HUMAN | [view interactions] | High throughput | no | no |
AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
CEP57_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
TREX2_HUMAN | [view interactions] | High throughput | no | no |
KLK7_HUMAN | [view interactions] | High throughput | no | no |
IL1RA_HUMAN | [view interactions] | High throughput | no | no |
PPAP_HUMAN | [view interactions] | High throughput | no | no |
IL37_HUMAN | [view interactions] | High throughput | no | no |
ASAH1_HUMAN | [view interactions] | High throughput | no | yes |
LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
ECM1_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
PPT1_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
SHPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX21_HUMAN | [view interactions] | High throughput | no | yes |
GSDMA_HUMAN | [view interactions] | High throughput | no | no |
GUAD_HUMAN | [view interactions] | High throughput | no | yes |
SPB13_HUMAN | [view interactions] | High throughput | no | no |
SBSN_HUMAN | [view interactions] | High throughput | no | no |
SPB5_HUMAN | [view interactions] | High throughput | no | no |
ACADV_HUMAN | [view interactions] | High throughput | no | yes |
MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
ZA2G_HUMAN | [view interactions] | High throughput | no | no |
PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FILA2_HUMAN | [view interactions] | High throughput | no | no |
VPP2_HUMAN | [view interactions] | High throughput | no | yes |
KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHX16_HUMAN | [view interactions] | High throughput | no | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRPS3_HUMAN | [view interactions] | High throughput | no | no |
RAP2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
XRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
RAP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
TM192_HUMAN | [view interactions] | High throughput | no | yes |
RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MATR3_HUMAN | [view interactions] | High throughput | no | yes |
RS12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SET_HUMAN | [view interactions] | High throughput | no | yes |
SP16H_HUMAN | [view interactions] | High throughput | no | yes |
RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASPH_HUMAN | [view interactions] | High throughput | no | yes |
AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1S1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1S2_HUMAN | [view interactions] | High throughput | no | no |
CP51A_HUMAN | [view interactions] | High throughput | no | no |
ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGC2_HUMAN | [view interactions] | High throughput | no | no |
HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTS_HUMAN | [view interactions] | High throughput | no | no |
B2MG_HUMAN | [view interactions] | High throughput | no | yes |
MK10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FRIL_HUMAN | [view interactions] | High throughput | no | yes |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LBP_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC16_HUMAN | [view interactions] | High throughput | no | yes |
PIAS4_HUMAN | [view interactions] | High throughput | no | yes |
TCAM2_HUMAN | [view interactions] | High throughput | no | no |
ANKR1_HUMAN | [view interactions] | High throughput | no | no |
NAL12_HUMAN | [view interactions] | High throughput | no | yes |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
CYTM_HUMAN | [view interactions] | High throughput | no | no |
KLK5_HUMAN | [view interactions] | High throughput | no | no |
SPA12_HUMAN | [view interactions] | High throughput | no | no |
FBX50_HUMAN | [view interactions] | High throughput | no | no |
PLBL1_HUMAN | [view interactions] | High throughput | no | no |
TGM3_HUMAN | [view interactions] | High throughput | no | no |
SEMG2_HUMAN | [view interactions] | High throughput | no | no |
SPB4_HUMAN | [view interactions] | High throughput | no | no |
MAOX_HUMAN | [view interactions] | High throughput | no | yes |
HUTH_HUMAN | [view interactions] | High throughput | no | yes |
CASPE_HUMAN | [view interactions] | High throughput | no | no |
SPB3_HUMAN | [view interactions] | High throughput | no | no |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
TGM1_HUMAN | [view interactions] | High throughput | no | no |
FILA_HUMAN | [view interactions] | High throughput | no | no |
SAP3_HUMAN | [view interactions] | High throughput | no | yes |
CBPM_HUMAN | [view interactions] | High throughput | no | no |
INVO_HUMAN | [view interactions] | High throughput | no | no |
SEMG1_HUMAN | [view interactions] | High throughput | no | no |
RET4_HUMAN | [view interactions] | High throughput | no | no |
IGKC_HUMAN | [view interactions] | High throughput | no | no |
CYTN_HUMAN | [view interactions] | High throughput | no | no |
CYTS_HUMAN | [view interactions] | High throughput | no | no |
SPB7_HUMAN | [view interactions] | High throughput | no | no |
LX12B_HUMAN | [view interactions] | High throughput | no | no |
CATL2_HUMAN | [view interactions] | High throughput | no | yes |
ACOHC_HUMAN | [view interactions] | Computational | no | yes |
SCAR5_HUMAN | [view interactions] | Computational | no | yes |
CD44_HUMAN | [view interactions] | Computational | no | yes |
COX8A_HUMAN | [view interactions] | Computational | no | yes |