Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TNPO1_HUMAN

(Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TNPO1_HUMAN
GO:0003723 RNA binding 37.3134 4 yes
GO:0017076 purine nucleotide binding 29.8507 4 no
GO:0032555 purine ribonucleotide binding 29.8507 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.8507 4 no
GO:0046872 metal ion binding 25.3731 4 no
GO:0031267 small GTPase binding 11.9403 5 yes
GO:0051020 GTPase binding 11.9403 4 yes
GO:0005048 signal sequence binding 7.4627 4 yes
GO:0008139 nuclear localization sequence binding 7.4627 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TNPO1_HUMAN
GO:0031323 regulation of cellular metabolic process 49.2537 4 no
GO:0048522 positive regulation of cellular process 49.2537 4 no
GO:0060255 regulation of macromolecule metabolic process 46.2687 4 no
GO:0080090 regulation of primary metabolic process 46.2687 4 no
GO:0051171 regulation of nitrogen compound metabolic process 44.7761 4 no
GO:0048523 negative regulation of cellular process 37.3134 4 no
GO:0006996 organelle organization 34.3284 4 no
GO:0010468 regulation of gene expression 32.8358 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.8358 5 no
GO:0031325 positive regulation of cellular metabolic process 32.8358 5 no
GO:0051128 regulation of cellular component organization 32.8358 4 no
GO:0009893 positive regulation of metabolic process 32.8358 4 no
GO:0022607 cellular component assembly 31.3433 4 no
GO:0071702 organic substance transport 31.3433 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 29.8507 5 no
GO:0031326 regulation of cellular biosynthetic process 29.8507 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.8507 5 no
GO:0008104 protein localization 29.8507 4 yes
GO:0071705 nitrogen compound transport 29.8507 4 yes
GO:0009889 regulation of biosynthetic process 29.8507 4 no
GO:0010646 regulation of cell communication 26.8657 4 no
GO:0051049 regulation of transport 25.3731 4 no
GO:0015031 protein transport 25.3731 4 yes
GO:0009892 negative regulation of metabolic process 25.3731 4 no
GO:0010556 regulation of macromolecule biosynthetic process 23.8806 5 no
GO:0010605 negative regulation of macromolecule metabolic process 23.8806 5 no
GO:0051252 regulation of RNA metabolic process 23.8806 5 no
GO:0032880 regulation of protein localization 23.8806 5 no
GO:0060341 regulation of cellular localization 23.8806 4 no
GO:0009966 regulation of signal transduction 23.8806 4 no
GO:0051246 regulation of protein metabolic process 22.3881 5 no
GO:0031324 negative regulation of cellular metabolic process 20.8955 5 no
GO:0036211 protein modification process 20.8955 4 no
GO:0043412 macromolecule modification 20.8955 4 no
GO:0051130 positive regulation of cellular component organization 20.8955 5 no
GO:0030030 cell projection organization 20.8955 4 no
GO:0006886 intracellular protein transport 20.8955 4 yes
GO:0033365 protein localization to organelle 20.8955 5 yes
GO:0006913 nucleocytoplasmic transport 19.4030 5 yes
GO:0051169 nuclear transport 19.4030 4 yes
GO:0034504 protein localization to nucleus 16.4179 6 yes
GO:0051170 import into nucleus 16.4179 6 yes
GO:0072594 establishment of protein localization to organelle 16.4179 4 yes
GO:0006606 protein import into nucleus 14.9254 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in TNPO1_HUMAN
DOID:0050700 cardiomyopathy 2.9851 4 no
DOID:0060036 intrinsic cardiomyopathy 2.9851 5 no
DOID:114 heart disease 2.9851 3 no
DOID:1289 neurodegenerative disease 2.9851 4 no
DOID:231 motor neuron disease 2.9851 5 no
DOID:331 central nervous system disease 2.9851 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FUS_HUMAN [view entry] [view interactions] Low throughput yes yes
ROA1_HUMAN [view entry] [view interactions] Low throughput yes yes
NUP98_HUMAN [view interactions] Low throughput no no
PABP2_HUMAN [view interactions] Low throughput no yes
LRRK2_HUMAN [view interactions] Low throughput no yes
H31_HUMAN [view interactions] Low throughput no yes
TNPO1_HUMAN [view entry] [view interactions] Low throughput yes yes
RBM39_HUMAN [view interactions] Low throughput no yes
NU153_HUMAN [view interactions] Low throughput no yes
KIF17_HUMAN [view interactions] Low throughput no no
NXF1_HUMAN [view interactions] Low throughput no yes
HNRPM_HUMAN [view entry] [view interactions] Low throughput yes yes
RAN_HUMAN [view entry] [view interactions] Low throughput yes no
RGPD5_HUMAN [view interactions] Low throughput no no
SRP19_HUMAN [view interactions] Low throughput no yes
RL23A_HUMAN [view entry] [view interactions] Low throughput yes yes
NECD_HUMAN [view interactions] Low throughput no no
ULK2_HUMAN [view interactions] Low throughput no yes
TACD2_HUMAN [view interactions] High throughput no no
PACC1_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
GLPA_HUMAN [view interactions] High throughput no no
FOXE3_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
F234A_HUMAN [view interactions] High throughput no yes
OVOL2_HUMAN [view interactions] High throughput no no
EPHA1_HUMAN [view interactions] High throughput no yes
FXYD3_HUMAN [view interactions] High throughput no yes
XRP2_HUMAN [view entry] [view interactions] High throughput yes no
ARSF_HUMAN [view interactions] High throughput no no
F234B_HUMAN [view interactions] High throughput no yes
CMTD1_HUMAN [view entry] [view interactions] High throughput yes yes
BTNL9_HUMAN [view interactions] High throughput no no
ARMX6_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
F174A_HUMAN [view interactions] High throughput no yes
MAP7_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
VAMP5_HUMAN [view interactions] High throughput no no
CAH14_HUMAN [view interactions] High throughput no yes
TNR5_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
BAP1_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
ROA0_HUMAN [view interactions] High throughput no yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
IMA1_HUMAN [view entry] [view interactions] High throughput yes yes
IMA3_HUMAN [view interactions] High throughput no yes
IMB1_HUMAN [view entry] [view interactions] High throughput yes yes
NTF2_HUMAN [view interactions] High throughput no yes
RANG_HUMAN [view interactions] High throughput no no
SAR1B_HUMAN [view interactions] High throughput no yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
RBP2_HUMAN [view interactions] High throughput no yes
SLX9_HUMAN [view interactions] High throughput no yes
SIK3_HUMAN [view interactions] High throughput no yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC9_HUMAN [view interactions] High throughput no yes
THOC4_HUMAN [view interactions] High throughput no no
QKI_HUMAN [view interactions] High throughput no no
KIFC1_HUMAN [view interactions] High throughput no yes
MACIR_HUMAN [view interactions] High throughput no no
DCTN4_HUMAN [view entry] [view interactions] High throughput yes yes
NUP50_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
HEAT3_HUMAN [view interactions] High throughput no yes
PR14L_HUMAN [view interactions] High throughput no no
UGDH_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LDLR_HUMAN [view interactions] High throughput no yes
SRBP1_HUMAN [view interactions] High throughput no yes
SRBP2_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
IPO5_HUMAN [view entry] [view interactions] High throughput yes yes
VPS16_HUMAN [view entry] [view interactions] High throughput yes yes
TNPO3_HUMAN [view interactions] High throughput no yes
TCAB1_HUMAN [view interactions] High throughput no yes
SNRPA_HUMAN [view interactions] High throughput no yes
IPO4_HUMAN [view interactions] High throughput no no
IPO7_HUMAN [view entry] [view interactions] High throughput yes yes
IREB2_HUMAN [view interactions] High throughput no no
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
IPO9_HUMAN [view interactions] High throughput no no
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
RIR1_HUMAN [view entry] [view interactions] High throughput yes yes
PFD3_HUMAN [view interactions] High throughput no yes
TRXR1_HUMAN [view interactions] High throughput no yes
IPO8_HUMAN [view interactions] High throughput no no
RNBP6_HUMAN [view interactions] High throughput no yes
BYST_HUMAN [view interactions] High throughput no yes
GAR1_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
DRG1_HUMAN [view interactions] High throughput no yes
PRS10_HUMAN [view interactions] High throughput no yes
NFAC2_HUMAN [view interactions] High throughput no yes
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
YIPF5_HUMAN [view interactions] High throughput no yes
TNPO2_HUMAN [view interactions] High throughput no yes
ZN281_HUMAN [view interactions] High throughput no no
DAZP1_HUMAN [view interactions] High throughput no yes
ARBK1_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
YMEL1_HUMAN [view interactions] High throughput no yes
PSA_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
ZC3HF_HUMAN [view interactions] High throughput no yes
ATP5H_HUMAN [view interactions] High throughput no yes
PTMA_HUMAN [view interactions] High throughput no yes
S27A2_HUMAN [view interactions] High throughput no no
TNR6A_HUMAN [view interactions] High throughput no yes
DEFM_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
TFB2M_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
MIC25_HUMAN [view entry] [view interactions] High throughput yes yes
COIL_HUMAN [view interactions] High throughput no yes
ATP5L_HUMAN [view interactions] High throughput no yes
NU155_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
RT27_HUMAN [view interactions] High throughput no yes
PEX3_HUMAN [view interactions] High throughput no yes
TMM43_HUMAN [view interactions] High throughput no no
ZN330_HUMAN [view interactions] High throughput no yes
SGF29_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
FA83B_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
ATX10_HUMAN [view entry] [view interactions] High throughput yes yes
ATD3B_HUMAN [view interactions] High throughput no yes
AL3A2_HUMAN [view entry] [view interactions] High throughput yes yes
BI2L1_HUMAN [view interactions] High throughput no yes
PYGB_HUMAN [view entry] [view interactions] High throughput yes no
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
DDX54_HUMAN [view interactions] High throughput no yes
LYST_HUMAN [view interactions] High throughput no no
SPTC1_HUMAN [view interactions] High throughput no yes
SRPRB_HUMAN [view entry] [view interactions] High throughput yes no
SC61B_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
CCD47_HUMAN [view interactions] High throughput no yes
NDUBB_HUMAN [view interactions] High throughput no yes
KLF16_HUMAN [view interactions] High throughput no yes
S38A5_HUMAN [view interactions] High throughput no yes
NS1BP_HUMAN [view interactions] High throughput no yes
ATP7A_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RALB_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
TAGL_HUMAN [view interactions] High throughput no no
MOT11_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
AICDA_HUMAN [view interactions] High throughput no no
P2RY6_HUMAN [view interactions] High throughput no no
T255A_HUMAN [view interactions] High throughput no yes
TN13B_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
SHC2_HUMAN [view interactions] High throughput no yes
SHIP1_HUMAN [view interactions] High throughput no no
SLAP1_HUMAN [view interactions] High throughput no yes
SHIP2_HUMAN [view interactions] High throughput no yes
ZAP70_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
NEP_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
PHKG2_HUMAN [view interactions] High throughput no no
RAB38_HUMAN [view interactions] High throughput no no
RAB32_HUMAN [view interactions] High throughput no yes
RAB13_HUMAN [view entry] [view interactions] High throughput yes yes
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
NOTC1_HUMAN [view interactions] High throughput no yes
STIL_HUMAN [view interactions] High throughput no no
TCEA2_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
CD4_HUMAN [view interactions] High throughput no no
HDAC5_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
FOXP3_HUMAN [view interactions] High throughput no no
CAH9_HUMAN [view interactions] High throughput no no
ITA4_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
VSIG2_HUMAN [view interactions] High throughput no no
TARG1_HUMAN [view interactions] High throughput no no
5HT6R_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
XRCC3_HUMAN [view interactions] High throughput no no
AKAP5_HUMAN [view entry] [view interactions] High throughput yes yes
CSCL2_HUMAN [view interactions] High throughput no yes
AP4AT_HUMAN [view interactions] High throughput no no
MBOA1_HUMAN [view interactions] High throughput no no
SUCO_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
CBX4_HUMAN [view interactions] High throughput no yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
JUNB_HUMAN [view interactions] High throughput no yes
KCNK1_HUMAN [view interactions] High throughput no yes
KCTD5_HUMAN [view interactions] High throughput no no
RTKN_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
TGFI1_HUMAN [view interactions] High throughput no no
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
CCHCR_HUMAN [view interactions] High throughput no no
CNTLN_HUMAN [view interactions] High throughput no yes
PCID2_HUMAN [view interactions] High throughput no yes
ESYT2_HUMAN [view entry] [view interactions] High throughput yes yes
ZN768_HUMAN [view interactions] High throughput no yes
CLP1L_HUMAN [view interactions] High throughput no yes
TOP1M_HUMAN [view interactions] High throughput no yes
ABCG1_HUMAN [view interactions] High throughput no yes
PTPRA_HUMAN [view interactions] High throughput no yes
PTPRE_HUMAN [view interactions] High throughput no no
PTPRN_HUMAN [view interactions] High throughput no yes
SIGL1_HUMAN [view interactions] High throughput no no
TMA16_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
KC1A_HUMAN [view interactions] High throughput no yes
YAF2_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
SOCS6_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
WWOX_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
ZBT38_HUMAN [view interactions] High throughput no no
KDM6B_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
S15A3_HUMAN [view interactions] High throughput no yes
PPAP_HUMAN [view interactions] High throughput no no
DUS23_HUMAN [view interactions] High throughput no yes
PTPM1_HUMAN [view interactions] High throughput no yes
PTPRM_HUMAN [view interactions] High throughput no yes
PTPR2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
MN1_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
BRD4_HUMAN [view interactions] High throughput no yes
DJC15_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
DAXX_HUMAN [view interactions] High throughput no yes
H32_HUMAN [view interactions] Computational no yes
MAPK2_HUMAN [view interactions] Computational no yes
H37_HUMAN [view interactions] Computational no no
TTP_HUMAN [view interactions] Computational no yes
H33_HUMAN [view interactions] Computational no yes
XPO1_HUMAN [view entry] [view interactions] Computational yes yes
ATF1_HUMAN [view interactions] Computational no yes
ZC3HE_HUMAN [view interactions] Computational no yes
FOXO4_HUMAN [view interactions] Computational no no
H3C_HUMAN [view interactions] Computational no yes
NU107_HUMAN [view interactions] Computational no no