RAB13_HUMAN
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RAB13_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 47.0588 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 47.0588 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 47.0588 | 4 | yes |
GO:0005525 | GTP binding | 35.2941 | 5 | yes |
GO:0016462 | pyrophosphatase activity | 35.2941 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 35.2941 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 35.2941 | 6 | yes |
GO:0019001 | guanyl nucleotide binding | 35.2941 | 5 | yes |
GO:0032561 | guanyl ribonucleotide binding | 35.2941 | 5 | yes |
GO:0003924 | GTPase activity | 33.3333 | 7 | yes |
GO:0003723 | RNA binding | 21.5686 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RAB13_HUMAN |
---|---|---|---|---|
GO:0008104 | protein localization | 60.7843 | 4 | yes |
GO:0071702 | organic substance transport | 54.9020 | 4 | yes |
GO:0071705 | nitrogen compound transport | 54.9020 | 4 | yes |
GO:0015031 | protein transport | 54.9020 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 52.9412 | 4 | yes |
GO:0006996 | organelle organization | 49.0196 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 39.2157 | 4 | no |
GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
GO:0046903 | secretion | 33.3333 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 31.3725 | 4 | no |
GO:0022607 | cellular component assembly | 31.3725 | 4 | yes |
GO:0051049 | regulation of transport | 31.3725 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 29.4118 | 4 | no |
GO:0033365 | protein localization to organelle | 29.4118 | 5 | no |
GO:0010646 | regulation of cell communication | 27.4510 | 4 | no |
GO:0072657 | protein localization to membrane | 25.4902 | 4 | yes |
GO:0098876 | vesicle-mediated transport to the plasma membrane | 25.4902 | 4 | yes |
GO:0006887 | exocytosis | 25.4902 | 4 | no |
GO:0006886 | intracellular protein transport | 23.5294 | 4 | no |
GO:0009966 | regulation of signal transduction | 23.5294 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 23.5294 | 4 | no |
GO:0007010 | cytoskeleton organization | 23.5294 | 5 | yes |
GO:1990778 | protein localization to cell periphery | 21.5686 | 5 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 21.5686 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 21.5686 | 4 | no |
GO:0033043 | regulation of organelle organization | 21.5686 | 5 | no |
GO:0010243 | response to organonitrogen compound | 21.5686 | 4 | yes |
GO:0030030 | cell projection organization | 21.5686 | 4 | yes |
GO:0071310 | cellular response to organic substance | 19.6078 | 4 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 19.6078 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 19.6078 | 4 | yes |
GO:0072659 | protein localization to plasma membrane | 17.6471 | 5 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 17.6471 | 4 | yes |
GO:1903530 | regulation of secretion by cell | 17.6471 | 4 | yes |
GO:0051046 | regulation of secretion | 17.6471 | 5 | yes |
GO:0071417 | cellular response to organonitrogen compound | 15.6863 | 4 | yes |
GO:1901652 | response to peptide | 15.6863 | 4 | yes |
GO:1901699 | cellular response to nitrogen compound | 15.6863 | 4 | yes |
GO:0016050 | vesicle organization | 15.6863 | 5 | yes |
GO:0017157 | regulation of exocytosis | 15.6863 | 5 | yes |
GO:1901653 | cellular response to peptide | 13.7255 | 5 | yes |
GO:0016197 | endosomal transport | 13.7255 | 4 | yes |
GO:0032868 | response to insulin | 13.7255 | 5 | yes |
GO:0032870 | cellular response to hormone stimulus | 13.7255 | 4 | yes |
GO:0043434 | response to peptide hormone | 13.7255 | 4 | yes |
GO:0048278 | vesicle docking | 13.7255 | 4 | yes |
GO:0061024 | membrane organization | 13.7255 | 4 | yes |
GO:0071375 | cellular response to peptide hormone stimulus | 11.7647 | 5 | yes |
GO:0071692 | protein localization to extracellular region | 11.7647 | 5 | yes |
GO:0090174 | organelle membrane fusion | 11.7647 | 6 | yes |
GO:0006906 | vesicle fusion | 11.7647 | 6 | yes |
GO:0009306 | protein secretion | 11.7647 | 4 | yes |
GO:0031175 | neuron projection development | 11.7647 | 6 | yes |
GO:0032456 | endocytic recycling | 11.7647 | 5 | yes |
GO:0032869 | cellular response to insulin stimulus | 11.7647 | 6 | yes |
GO:0035592 | establishment of protein localization to extracellular region | 11.7647 | 4 | yes |
GO:0048284 | organelle fusion | 11.7647 | 5 | yes |
GO:0061025 | membrane fusion | 11.7647 | 5 | yes |
GO:0010737 | protein kinase A signaling | 7.8431 | 4 | yes |
GO:0034330 | cell junction organization | 7.8431 | 4 | yes |
GO:0048210 | Golgi vesicle fusion to target membrane | 7.8431 | 7 | yes |
GO:0001667 | ameboidal-type cell migration | 5.8824 | 4 | yes |
GO:0010631 | epithelial cell migration | 5.8824 | 5 | yes |
GO:0030865 | cortical cytoskeleton organization | 5.8824 | 6 | yes |
GO:0034329 | cell junction assembly | 5.8824 | 5 | yes |
GO:0043542 | endothelial cell migration | 5.8824 | 6 | yes |
GO:0070830 | bicellular tight junction assembly | 3.9216 | 8 | yes |
GO:0097368 | establishment of Sertoli cell barrier | 3.9216 | 4 | yes |
GO:0120192 | tight junction assembly | 3.9216 | 7 | yes |
GO:0120193 | tight junction organization | 3.9216 | 6 | yes |
GO:0002064 | epithelial cell development | 3.9216 | 4 | yes |
GO:0007043 | cell-cell junction assembly | 3.9216 | 6 | yes |
GO:0030866 | cortical actin cytoskeleton organization | 3.9216 | 4 | yes |
GO:0035767 | endothelial cell chemotaxis | 3.9216 | 5 | yes |
GO:0044795 | trans-Golgi network to recycling endosome transport | 3.9216 | 5 | yes |
GO:0045216 | cell-cell junction organization | 3.9216 | 5 | yes |
GO:0060326 | cell chemotaxis | 3.9216 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PDE6D_HUMAN | [view interactions] | Low throughput | no | yes |
MILK2_HUMAN | [view interactions] | Low throughput | no | no |
LERL1_HUMAN | [view interactions] | Low throughput | no | no |
ACTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
OBRG_HUMAN | [view interactions] | Low throughput | no | no |
TBB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
OCRL_HUMAN | [view interactions] | Low throughput | no | yes |
EH1L1_HUMAN | [view interactions] | Low throughput | no | yes |
MILK1_HUMAN | [view interactions] | Low throughput | no | yes |
RAB13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SPT46_HUMAN | [view interactions] | High throughput | no | no |
WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FFAR1_HUMAN | [view interactions] | High throughput | no | no |
MSS4_HUMAN | [view interactions] | High throughput | no | yes |
TSN3_HUMAN | [view interactions] | High throughput | no | yes |
LRC25_HUMAN | [view interactions] | High throughput | no | yes |
PVR_HUMAN | [view interactions] | High throughput | no | yes |
OPALI_HUMAN | [view interactions] | High throughput | no | yes |
ARL4D_HUMAN | [view interactions] | High throughput | no | no |
COPT1_HUMAN | [view interactions] | High throughput | no | no |
F174A_HUMAN | [view interactions] | High throughput | no | yes |
ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
APJ_HUMAN | [view interactions] | High throughput | no | yes |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
MICA_HUMAN | [view interactions] | High throughput | no | no |
BT3A3_HUMAN | [view interactions] | High throughput | no | yes |
S1PR4_HUMAN | [view interactions] | High throughput | no | no |
CAH14_HUMAN | [view interactions] | High throughput | no | yes |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFFL_HUMAN | [view interactions] | High throughput | no | yes |
LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
NBR1_HUMAN | [view interactions] | High throughput | no | yes |
CACO2_HUMAN | [view interactions] | High throughput | no | yes |
SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
TGFR1_HUMAN | [view interactions] | High throughput | no | no |
SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SORT_HUMAN | [view interactions] | High throughput | no | yes |
RAB8B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
GBRD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BICL2_HUMAN | [view interactions] | High throughput | no | no |
E2F3_HUMAN | [view interactions] | High throughput | no | no |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANR44_HUMAN | [view interactions] | High throughput | no | no |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX55_HUMAN | [view interactions] | High throughput | no | yes |
CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
SHCBP_HUMAN | [view interactions] | High throughput | no | no |
RS3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PP6R1_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TF_HUMAN | [view interactions] | High throughput | no | no |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
DPPA4_HUMAN | [view interactions] | High throughput | no | no |
NANOG_HUMAN | [view interactions] | High throughput | no | no |
PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
DUS19_HUMAN | [view interactions] | High throughput | no | yes |
DUS6_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
COPE_HUMAN | [view interactions] | High throughput | no | yes |
HIF1A_HUMAN | [view interactions] | High throughput | no | no |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
WWOX_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
FLCN_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INS_HUMAN | [view interactions] | High throughput | no | no |
UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
BTNL9_HUMAN | [view interactions] | High throughput | no | no |
INSRR_HUMAN | [view interactions] | High throughput | no | no |
ATG4A_HUMAN | [view interactions] | High throughput | no | yes |
EXOC7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TBCD4_HUMAN | [view interactions] | Computational | no | yes |
EXOC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
EXOC5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EXOC6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LCAP_HUMAN | [view interactions] | Computational | no | yes |
RSP14_HUMAN | [view interactions] | Computational | no | no |
DEN1C_HUMAN | [view interactions] | Computational | no | no |
EXOC2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SNP23_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KAPCG_HUMAN | [view interactions] | Computational | no | no |
MYO5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EXOC8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KAPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TBCD1_HUMAN | [view interactions] | Computational | no | no |
EXOC4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DEN2B_HUMAN | [view interactions] | Computational | no | yes |
RALA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EXOC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STXB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |