GDIA_HUMAN
Evidence for PS localization
Functions
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GDIA_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 47.1429 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 47.1429 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 45.7143 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 42.8571 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 42.8571 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 42.8571 | 6 | no |
| GO:0003924 | GTPase activity | 37.1429 | 7 | no |
| GO:0005525 | GTP binding | 37.1429 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 37.1429 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 37.1429 | 5 | no |
| GO:0019003 | GDP binding | 21.4286 | 4 | no |
| GO:0030695 | GTPase regulator activity | 15.7143 | 4 | yes |
| GO:0051020 | GTPase binding | 12.8571 | 4 | yes |
| GO:0031267 | small GTPase binding | 11.4286 | 5 | yes |
| GO:0005096 | GTPase activator activity | 8.5714 | 4 | yes |
| GO:0005092 | GDP-dissociation inhibitor activity | 4.2857 | 5 | yes |
| GO:0005093 | Rab GDP-dissociation inhibitor activity | 2.8571 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GDIA_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 54.2857 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 47.1429 | 4 | yes |
| GO:0071702 | organic substance transport | 42.8571 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 42.8571 | 4 | yes |
| GO:0015031 | protein transport | 42.8571 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 42.8571 | 4 | yes |
| GO:0051049 | regulation of transport | 41.4286 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | yes |
| GO:0006996 | organelle organization | 38.5714 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.2857 | 4 | no |
| GO:0022607 | cellular component assembly | 31.4286 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.4286 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.4286 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.4286 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 30.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.1429 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.1429 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 27.1429 | 5 | no |
| GO:0006886 | intracellular protein transport | 27.1429 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.7143 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.7143 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 25.7143 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 24.2857 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.8571 | 4 | yes |
| GO:0030030 | cell projection organization | 22.8571 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.8571 | 6 | no |
| GO:0023056 | positive regulation of signaling | 22.8571 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.4286 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.4286 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.4286 | 5 | no |
| GO:0072657 | protein localization to membrane | 21.4286 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.4286 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 21.4286 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 20.0000 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 17.1429 | 5 | yes |
| GO:0007264 | small GTPase mediated signal transduction | 15.7143 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 15.7143 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 15.7143 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 14.2857 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 14.2857 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 14.2857 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 14.2857 | 5 | yes |
| GO:0001558 | regulation of cell growth | 12.8571 | 4 | yes |
| GO:0007265 | Ras protein signal transduction | 12.8571 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 12.8571 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 11.4286 | 6 | yes |
| GO:0060284 | regulation of cell development | 10.0000 | 5 | yes |
| GO:0010720 | positive regulation of cell development | 10.0000 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 10.0000 | 7 | yes |
| GO:0051960 | regulation of nervous system development | 8.5714 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 8.5714 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 8.5714 | 6 | yes |
| GO:0032386 | regulation of intracellular transport | 8.5714 | 5 | yes |
| GO:0032482 | Rab protein signal transduction | 8.5714 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 8.5714 | 6 | yes |
| GO:0050769 | positive regulation of neurogenesis | 8.5714 | 6 | yes |
| GO:0051223 | regulation of protein transport | 7.1429 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 7.1429 | 5 | yes |
| GO:0010038 | response to metal ion | 7.1429 | 4 | yes |
| GO:0030307 | positive regulation of cell growth | 7.1429 | 5 | yes |
| GO:0030516 | regulation of axon extension | 7.1429 | 5 | yes |
| GO:0045927 | positive regulation of growth | 7.1429 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 7.1429 | 4 | yes |
| GO:0050770 | regulation of axonogenesis | 7.1429 | 5 | yes |
| GO:0051051 | negative regulation of transport | 7.1429 | 4 | yes |
| GO:1905475 | regulation of protein localization to membrane | 5.7143 | 6 | yes |
| GO:0045773 | positive regulation of axon extension | 5.7143 | 6 | yes |
| GO:0048639 | positive regulation of developmental growth | 5.7143 | 5 | yes |
| GO:0050772 | positive regulation of axonogenesis | 5.7143 | 6 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 4.2857 | 4 | yes |
| GO:1903828 | negative regulation of protein localization | 4.2857 | 5 | yes |
| GO:0033157 | regulation of intracellular protein transport | 4.2857 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 4.2857 | 4 | yes |
| GO:0051592 | response to calcium ion | 2.8571 | 5 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 2.8571 | 6 | yes |
| GO:0031345 | negative regulation of cell projection organization | 2.8571 | 6 | yes |
| GO:0045596 | negative regulation of cell differentiation | 2.8571 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | Low throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | Low throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| GNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB24_HUMAN | [view interactions] | High throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| RAB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB34_HUMAN | [view interactions] | High throughput | no | yes |
| REPI1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUBP3_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT13_HUMAN | [view interactions] | High throughput | no | no |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA98A_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPT2_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS7_HUMAN | [view interactions] | High throughput | no | yes |
| RAB31_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2B_HUMAN | [view interactions] | High throughput | no | no |
| RAB8B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB22A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP25_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASEF_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB32_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX11_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| MIC10_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| RAB43_HUMAN | [view interactions] | High throughput | no | yes |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6C_HUMAN | [view interactions] | High throughput | no | no |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SR140_HUMAN | [view interactions] | High throughput | no | yes |
| HNRLL_HUMAN | [view interactions] | High throughput | no | yes |
| TAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TGRM1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB23_HUMAN | [view interactions] | High throughput | no | yes |
| BCD1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7E_HUMAN | [view interactions] | High throughput | no | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| ARLY_HUMAN | [view interactions] | High throughput | no | no |
| DCNL1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1O_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| PSF3_HUMAN | [view interactions] | High throughput | no | yes |
| HEXA_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| RCC2_HUMAN | [view interactions] | High throughput | no | no |
| SCRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMD3_HUMAN | [view interactions] | High throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL2CL_HUMAN | [view interactions] | Computational | no | yes |
| RB3GP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TPC13_HUMAN | [view interactions] | Computational | no | yes |
| TPPC1_HUMAN | [view interactions] | Computational | no | yes |
| RAB7B_HUMAN | [view interactions] | Computational | no | no |
| MTMRD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCZ1_HUMAN | [view interactions] | Computational | no | yes |
| CCZ1B_HUMAN | [view interactions] | Computational | no | yes |
| RAE2_HUMAN | [view interactions] | Computational | no | yes |
| TPC12_HUMAN | [view interactions] | Computational | no | yes |
| RB39B_HUMAN | [view interactions] | Computational | no | no |
| RIN2_HUMAN | [view interactions] | Computational | no | yes |
| GAPD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK14_HUMAN | [view interactions] | Computational | no | yes |
| DEN2A_HUMAN | [view interactions] | Computational | no | no |
| TPC6A_HUMAN | [view interactions] | Computational | no | yes |
| TPPC8_HUMAN | [view interactions] | Computational | no | yes |
| DEN1A_HUMAN | [view interactions] | Computational | no | no |
| DEND3_HUMAN | [view interactions] | Computational | no | no |
| MON1B_HUMAN | [view interactions] | Computational | no | yes |
| TPPC4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MTMR5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RIC1_HUMAN | [view interactions] | Computational | no | no |
| RGP1_HUMAN | [view interactions] | Computational | no | yes |
| TPC10_HUMAN | [view interactions] | Computational | no | no |
| DEN6B_HUMAN | [view interactions] | Computational | no | no |
| ANR27_HUMAN | [view interactions] | Computational | no | yes |
| TPC2L_HUMAN | [view interactions] | Computational | no | yes |
| DEN1B_HUMAN | [view interactions] | Computational | no | yes |
| RAB3I_HUMAN | [view interactions] | Computational | no | no |
| TPC6B_HUMAN | [view interactions] | Computational | no | yes |
| DEN2C_HUMAN | [view interactions] | Computational | no | no |
| DEN5A_HUMAN | [view interactions] | Computational | no | yes |
| ALS2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK11_HUMAN | [view interactions] | Computational | no | yes |
| HPS4_HUMAN | [view interactions] | Computational | no | yes |
| TPC2A_HUMAN | [view interactions] | Computational | no | yes |
| TPC2B_HUMAN | [view interactions] | Computational | no | no |
| MON1A_HUMAN | [view interactions] | Computational | no | no |
| RIN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DEN2B_HUMAN | [view interactions] | Computational | no | yes |
| DEN5B_HUMAN | [view interactions] | Computational | no | yes |
| HPS1_HUMAN | [view interactions] | Computational | no | yes |
| VAS1_HUMAN | [view interactions] | Computational | no | yes |
| RIN3_HUMAN | [view interactions] | Computational | no | yes |
| TPPC5_HUMAN | [view interactions] | Computational | no | yes |
| DEN1C_HUMAN | [view interactions] | Computational | no | no |
| RINL_HUMAN | [view interactions] | Computational | no | no |
| R3GEF_HUMAN | [view interactions] | Computational | no | yes |
| DEN4C_HUMAN | [view interactions] | Computational | no | yes |
| RAE1_HUMAN | [view interactions] | Computational | no | yes |
| DEN2D_HUMAN | [view interactions] | Computational | no | yes |
| DEN6A_HUMAN | [view interactions] | Computational | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DEN4B_HUMAN | [view interactions] | Computational | no | yes |
| MADD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB9B_HUMAN | [view interactions] | Computational | no | yes |
| TPC11_HUMAN | [view interactions] | Computational | no | no |