GDIA_HUMAN
Evidence for PS localization
Functions
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GDIA_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 49.2754 | 4 | no |
| GO:0017076 | purine nucleotide binding | 49.2754 | 5 | no |
| GO:0043168 | anion binding | 49.2754 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 47.8261 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 46.3768 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 43.4783 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 43.4783 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 43.4783 | 6 | no |
| GO:0005525 | GTP binding | 39.1304 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 39.1304 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 39.1304 | 5 | no |
| GO:0003924 | GTPase activity | 37.6812 | 7 | no |
| GO:0019003 | GDP binding | 21.7391 | 5 | no |
| GO:0019900 | kinase binding | 20.2899 | 4 | no |
| GO:0051020 | GTPase binding | 8.6957 | 4 | yes |
| GO:0031267 | small GTPase binding | 7.2464 | 5 | yes |
| GO:0005096 | GTPase activator activity | 5.7971 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 5.7971 | 4 | yes |
| GO:0005092 | GDP-dissociation inhibitor activity | 4.3478 | 5 | yes |
| GO:0005093 | Rab GDP-dissociation inhibitor activity | 2.8986 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GDIA_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 52.1739 | 4 | yes |
| GO:0006996 | organelle organization | 44.9275 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.4783 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.4783 | 4 | yes |
| GO:0071702 | organic substance transport | 40.5797 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 40.5797 | 4 | yes |
| GO:0051049 | regulation of transport | 40.5797 | 4 | no |
| GO:0015031 | protein transport | 39.1304 | 4 | yes |
| GO:0010646 | regulation of cell communication | 36.2319 | 4 | no |
| GO:0022607 | cellular component assembly | 34.7826 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.8841 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 30.4348 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.4348 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.4348 | 4 | no |
| GO:0060341 | regulation of cellular localization | 28.9855 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 28.9855 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.5362 | 4 | no |
| GO:0030030 | cell projection organization | 26.0870 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 26.0870 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.0870 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 24.6377 | 5 | no |
| GO:0072657 | protein localization to membrane | 23.1884 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.1884 | 5 | no |
| GO:0006886 | intracellular protein transport | 23.1884 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.1884 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 23.1884 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 21.7391 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 21.7391 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 21.7391 | 4 | no |
| GO:0023056 | positive regulation of signaling | 21.7391 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.7391 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.2899 | 6 | yes |
| GO:0042981 | regulation of apoptotic process | 20.2899 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.2899 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.2899 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.2899 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.2899 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.2899 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 20.2899 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 18.8406 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 17.3913 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 17.3913 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 15.9420 | 4 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 15.9420 | 5 | yes |
| GO:0001558 | regulation of cell growth | 14.4928 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 14.4928 | 4 | yes |
| GO:0060284 | regulation of cell development | 14.4928 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 13.0435 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 13.0435 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 11.5942 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 11.5942 | 7 | yes |
| GO:0050767 | regulation of neurogenesis | 11.5942 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 11.5942 | 5 | yes |
| GO:0010038 | response to metal ion | 10.1449 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 10.1449 | 6 | yes |
| GO:0050769 | positive regulation of neurogenesis | 10.1449 | 6 | yes |
| GO:0051962 | positive regulation of nervous system development | 10.1449 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 8.6957 | 5 | yes |
| GO:1905475 | regulation of protein localization to membrane | 8.6957 | 6 | yes |
| GO:0030307 | positive regulation of cell growth | 8.6957 | 5 | yes |
| GO:0032482 | Rab protein signal transduction | 8.6957 | 6 | yes |
| GO:0045927 | positive regulation of growth | 8.6957 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 8.6957 | 4 | yes |
| GO:0050770 | regulation of axonogenesis | 8.6957 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 8.6957 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 8.6957 | 4 | yes |
| GO:0061387 | regulation of extent of cell growth | 7.2464 | 5 | yes |
| GO:0030516 | regulation of axon extension | 7.2464 | 5 | yes |
| GO:0048639 | positive regulation of developmental growth | 7.2464 | 5 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 5.7971 | 6 | yes |
| GO:0031345 | negative regulation of cell projection organization | 5.7971 | 6 | yes |
| GO:0045773 | positive regulation of axon extension | 5.7971 | 6 | yes |
| GO:0050772 | positive regulation of axonogenesis | 5.7971 | 6 | yes |
| GO:1903533 | regulation of protein targeting | 4.3478 | 7 | yes |
| GO:0045596 | negative regulation of cell differentiation | 4.3478 | 5 | yes |
| GO:0090313 | regulation of protein targeting to membrane | 2.8986 | 7 | yes |
| GO:0010721 | negative regulation of cell development | 2.8986 | 6 | yes |
| GO:0010977 | negative regulation of neuron projection development | 2.8986 | 7 | yes |
| GO:0050768 | negative regulation of neurogenesis | 2.8986 | 6 | yes |
| GO:0050771 | negative regulation of axonogenesis | 2.8986 | 6 | yes |
| GO:0051592 | response to calcium ion | 2.8986 | 5 | yes |
| GO:0051961 | negative regulation of nervous system development | 2.8986 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB3B_HUMAN | [view interactions] | Low throughput | no | no |
| RAB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAB1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | Low throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MIC10_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| RAB43_HUMAN | [view interactions] | High throughput | no | yes |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6C_HUMAN | [view interactions] | High throughput | no | no |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SR140_HUMAN | [view interactions] | High throughput | no | yes |
| HNRLL_HUMAN | [view interactions] | High throughput | no | yes |
| TAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TGRM1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB23_HUMAN | [view interactions] | High throughput | no | yes |
| BCD1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7E_HUMAN | [view interactions] | High throughput | no | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| ARLY_HUMAN | [view interactions] | High throughput | no | no |
| DCNL1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1O_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| PSF3_HUMAN | [view interactions] | High throughput | no | yes |
| HEXA_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCC2_HUMAN | [view interactions] | High throughput | no | no |
| SCRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMD3_HUMAN | [view interactions] | High throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIR2_HUMAN | [view interactions] | High throughput | no | no |
| IRS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC5_HUMAN | [view interactions] | High throughput | no | yes |
| DHX36_HUMAN | [view interactions] | High throughput | no | yes |
| OFUT2_HUMAN | [view interactions] | High throughput | no | no |
| TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| GNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB24_HUMAN | [view interactions] | High throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| RAB31_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS7_HUMAN | [view interactions] | High throughput | no | yes |
| SPT2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA98A_HUMAN | [view interactions] | High throughput | no | no |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT13_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC2_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| REPI1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB34_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2B_HUMAN | [view interactions] | High throughput | no | no |
| RAB8B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASEF_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP25_HUMAN | [view interactions] | High throughput | no | yes |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB22A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB32_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX11_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| ACAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |