Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAB21_HUMAN

Small GTPase involved in membrane trafficking control (PubMed, PubMed). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general . As a result, may regulate cell adhesion and migration . Involved in neurite growth . Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed). [View more on UniProt]

020406080100120140160180200220
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%

Interacting region for partners were not defined.

RAB21_HUMAN has binary interactions with 50 proteins

RAB21_HUMAN1433F_HUMANVAC14_HUMANRABE1_HUMANIGF1R_HUMANKCC2A_HUMANRB11A_HUMANRTN4_HUMANTF65_HUMANITB1_HUMANRASN_HUMANHOOK3_HUMANGDIA_HUMANTBA1A_HUMANRASH_HUMANHNRH2_HUMANGCR_HUMANELAV1_HUMANCHM4B_HUMANCALX_HUMANALDH2_HUMANRAB1A_HUMANVIGLN_HUMANMACF1_HUMANRASK_HUMANGRP75_HUMANHCN1_HUMANSYT6_HUMANHNRH1_HUMANABHEB_HUMANNPM_HUMANRAF1_HUMANARF1_HUMANDP13A_HUMANP2RX1_HUMANDHE3_HUMANPSDE_HUMANCAC1C_HUMANHS90A_HUMANOST48_HUMANVDAC3_HUMANANS1B_HUMANTKT_HUMANGDIB_HUMANLDHA_HUMANEF2_HUMANTGON2_HUMANPRKN_HUMANLAMP1_HUMANRSSA_HUMANDLRB1_HUMANRAB21_HUMAN1433F_HUMANVAC14_HUMANRABE1_HUMANIGF1R_HUMANKCC2A_HUMANRB11A_HUMANRTN4_HUMANTF65_HUMANITB1_HUMANRASN_HUMANHOOK3_HUMANGDIA_HUMANTBA1A_HUMANRASH_HUMANHNRH2_HUMANGCR_HUMANELAV1_HUMANCHM4B_HUMANCALX_HUMANALDH2_HUMANRAB1A_HUMANVIGLN_HUMANMACF1_HUMANRASK_HUMANGRP75_HUMANHCN1_HUMANSYT6_HUMANHNRH1_HUMANABHEB_HUMANNPM_HUMANRAF1_HUMANARF1_HUMANDP13A_HUMANP2RX1_HUMANDHE3_HUMANPSDE_HUMANCAC1C_HUMANHS90A_HUMANOST48_HUMANVDAC3_HUMANANS1B_HUMANTKT_HUMANGDIB_HUMANLDHA_HUMANEF2_HUMANTGON2_HUMANPRKN_HUMANLAMP1_HUMANRSSA_HUMANDLRB1_HUMAN
Download full PS network for entry.

No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

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