RAB21_HUMAN
Evidence for PS localization
Functions
Small GTPase involved in membrane trafficking control (PubMed, PubMed). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general . As a result, may regulate cell adhesion and migration . Involved in neurite growth . Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed). [View more on UniProt]
Protein features
![](/static/images/legend1.gif)
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
RAB21_HUMAN has binary interactions with 50 proteins
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RAB21_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 37.9310 | 4 | yes |
GO:0043168 | anion binding | 37.9310 | 4 | yes |
GO:0017076 | purine nucleotide binding | 36.2069 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 34.4828 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 32.7586 | 4 | yes |
GO:0043169 | cation binding | 29.3103 | 4 | no |
GO:0046872 | metal ion binding | 27.5862 | 5 | no |
GO:0003723 | RNA binding | 25.8621 | 4 | no |
GO:0042803 | protein homodimerization activity | 22.4138 | 4 | no |
GO:0005525 | GTP binding | 20.6897 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 20.6897 | 6 | yes |
GO:0032561 | guanyl ribonucleotide binding | 20.6897 | 5 | yes |
GO:0016462 | pyrophosphatase activity | 18.9655 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 18.9655 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 18.9655 | 6 | yes |
GO:0003924 | GTPase activity | 15.5172 | 7 | yes |
GO:0019003 | GDP binding | 8.6207 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RAB21_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 48.2759 | 4 | yes |
GO:0008104 | protein localization | 43.1034 | 4 | yes |
GO:0071702 | organic substance transport | 39.6552 | 4 | yes |
GO:0071705 | nitrogen compound transport | 37.9310 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 36.2069 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 36.2069 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 36.2069 | 4 | no |
GO:0051128 | regulation of cellular component organization | 34.4828 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 34.4828 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 34.4828 | 4 | no |
GO:0015031 | protein transport | 32.7586 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 32.7586 | 4 | no |
GO:0010468 | regulation of gene expression | 32.7586 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 32.7586 | 5 | no |
GO:0006996 | organelle organization | 31.0345 | 4 | no |
GO:0022607 | cellular component assembly | 29.3103 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 27.5862 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 27.5862 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 27.5862 | 5 | no |
GO:0010646 | regulation of cell communication | 27.5862 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.5862 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 27.5862 | 6 | no |
GO:0051049 | regulation of transport | 25.8621 | 4 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.8621 | 6 | no |
GO:0060341 | regulation of cellular localization | 24.1379 | 4 | yes |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ANR27_HUMAN | [view interactions] | Low throughput | no | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASNS_HUMAN | [view interactions] | High throughput | no | yes |
ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
ATX3_HUMAN | [view interactions] | High throughput | no | yes |
BACH1_HUMAN | [view interactions] | High throughput | no | no |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
BROMI_HUMAN | [view interactions] | High throughput | no | no |
C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCHL_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CL16A_HUMAN | [view interactions] | High throughput | no | yes |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
CLPP_HUMAN | [view interactions] | High throughput | no | yes |