RAB21_HUMAN
Evidence for PS localization
Functions
Small GTPase involved in membrane trafficking control (PubMed, PubMed). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general . As a result, may regulate cell adhesion and migration . Involved in neurite growth . Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB21_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 37.9310 | 4 | yes |
| GO:0043168 | anion binding | 37.9310 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 36.2069 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 34.4828 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.7586 | 4 | yes |
| GO:0043169 | cation binding | 29.3103 | 4 | no |
| GO:0046872 | metal ion binding | 27.5862 | 5 | no |
| GO:0003723 | RNA binding | 25.8621 | 4 | no |
| GO:0042803 | protein homodimerization activity | 22.4138 | 4 | no |
| GO:0005525 | GTP binding | 20.6897 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 20.6897 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 20.6897 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 18.9655 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 18.9655 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 18.9655 | 6 | yes |
| GO:0003924 | GTPase activity | 15.5172 | 7 | yes |
| GO:0019003 | GDP binding | 8.6207 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB21_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.2759 | 4 | yes |
| GO:0008104 | protein localization | 43.1034 | 4 | yes |
| GO:0071702 | organic substance transport | 39.6552 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.9310 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.2069 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.2069 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.2069 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.4828 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 34.4828 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 34.4828 | 4 | no |
| GO:0015031 | protein transport | 32.7586 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 32.7586 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.7586 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.7586 | 5 | no |
| GO:0006996 | organelle organization | 31.0345 | 4 | no |
| GO:0022607 | cellular component assembly | 29.3103 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.5862 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 27.5862 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.5862 | 5 | no |
| GO:0010646 | regulation of cell communication | 27.5862 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.5862 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.5862 | 6 | no |
| GO:0051049 | regulation of transport | 25.8621 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.8621 | 6 | no |
| GO:0060341 | regulation of cellular localization | 24.1379 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.1379 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.4138 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.4138 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.4138 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.6897 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 20.6897 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 20.6897 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 20.6897 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 20.6897 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.6897 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 20.6897 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.6897 | 5 | no |
| GO:0032880 | regulation of protein localization | 20.6897 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 17.2414 | 5 | yes |
| GO:0060284 | regulation of cell development | 17.2414 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 17.2414 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 17.2414 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 15.5172 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 15.5172 | 6 | yes |
| GO:0051050 | positive regulation of transport | 15.5172 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 15.5172 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 15.5172 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 15.5172 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 15.5172 | 4 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 12.0690 | 5 | yes |
| GO:0051046 | regulation of secretion | 12.0690 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 12.0690 | 4 | yes |
| GO:0001558 | regulation of cell growth | 10.3448 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 10.3448 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 10.3448 | 7 | yes |
| GO:0031346 | positive regulation of cell projection organization | 10.3448 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 10.3448 | 5 | yes |
| GO:0050769 | positive regulation of neurogenesis | 10.3448 | 6 | yes |
| GO:0050821 | protein stabilization | 10.3448 | 4 | yes |
| GO:0051962 | positive regulation of nervous system development | 10.3448 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 8.6207 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 8.6207 | 5 | yes |
| GO:0032386 | regulation of intracellular transport | 8.6207 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 8.6207 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 6.8966 | 5 | yes |
| GO:0030516 | regulation of axon extension | 6.8966 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 6.8966 | 4 | yes |
| GO:0061387 | regulation of extent of cell growth | 6.8966 | 5 | yes |
| GO:0010970 | transport along microtubule | 5.1724 | 4 | yes |
| GO:0032388 | positive regulation of intracellular transport | 5.1724 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 5.1724 | 6 | yes |
| GO:0099111 | microtubule-based transport | 5.1724 | 4 | yes |
| GO:0032482 | Rab protein signal transduction | 3.4483 | 6 | yes |
| GO:0045807 | positive regulation of endocytosis | 3.4483 | 5 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 3.4483 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 3.4483 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DP13A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANR27_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VAMP7_HUMAN | [view interactions] | Low throughput | no | yes |
| RABX5_HUMAN | [view interactions] | Low throughput | no | no |
| ITA2_HUMAN | [view interactions] | Low throughput | no | yes |
| ITA11_HUMAN | [view interactions] | Low throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| MINT_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| THIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| DDR2_HUMAN | [view interactions] | High throughput | no | no |
| EPHB6_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBA1_HUMAN | [view interactions] | High throughput | no | yes |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| GPT_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| E41LB_HUMAN | [view interactions] | High throughput | no | yes |
| RAE2_HUMAN | [view interactions] | High throughput | no | yes |
| RAE1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| SERC2_HUMAN | [view interactions] | High throughput | no | yes |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| ABHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2B_HUMAN | [view interactions] | High throughput | no | no |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S22AG_HUMAN | [view interactions] | High throughput | no | yes |
| FANCE_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG2_HUMAN | [view interactions] | High throughput | no | no |
| P2RX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUCO2_HUMAN | [view interactions] | High throughput | no | no |