RAB21_HUMAN
Evidence for PS localization
Functions
Small GTPase involved in membrane trafficking control (PubMed, PubMed). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general . As a result, may regulate cell adhesion and migration . Involved in neurite growth . Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB21_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 32.6531 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 32.6531 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.6531 | 4 | yes |
| GO:0003723 | RNA binding | 26.5306 | 4 | no |
| GO:0042803 | protein homodimerization activity | 24.4898 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 22.4490 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.4490 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.4490 | 6 | yes |
| GO:0005525 | GTP binding | 20.4082 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 20.4082 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 20.4082 | 5 | yes |
| GO:0003924 | GTPase activity | 18.3673 | 7 | yes |
| GO:0019003 | GDP binding | 10.2041 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB21_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.9796 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 38.7755 | 4 | no |
| GO:0071702 | organic substance transport | 36.7347 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 36.7347 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 36.7347 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.7347 | 4 | no |
| GO:0008104 | protein localization | 34.6939 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 34.6939 | 4 | no |
| GO:0015031 | protein transport | 32.6531 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 32.6531 | 4 | no |
| GO:0006996 | organelle organization | 32.6531 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.6122 | 4 | yes |
| GO:0010468 | regulation of gene expression | 30.6122 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.5306 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 26.5306 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.4898 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 24.4898 | 4 | no |
| GO:0010646 | regulation of cell communication | 24.4898 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.4898 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.4898 | 5 | no |
| GO:0022607 | cellular component assembly | 24.4898 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.4490 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.4490 | 5 | no |
| GO:0010941 | regulation of cell death | 22.4490 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.4082 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 20.4082 | 4 | yes |
| GO:0051049 | regulation of transport | 20.4082 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 20.4082 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 20.4082 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.4082 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.4082 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 20.4082 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.4082 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 18.3673 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 18.3673 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 18.3673 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 16.3265 | 4 | yes |
| GO:0007264 | small GTPase mediated signal transduction | 14.2857 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 14.2857 | 4 | yes |
| GO:0051050 | positive regulation of transport | 14.2857 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 14.2857 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 12.2449 | 7 | yes |
| GO:0031346 | positive regulation of cell projection organization | 12.2449 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 12.2449 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 12.2449 | 5 | yes |
| GO:0060284 | regulation of cell development | 12.2449 | 5 | yes |
| GO:0001558 | regulation of cell growth | 10.2041 | 4 | yes |
| GO:0007265 | Ras protein signal transduction | 10.2041 | 5 | yes |
| GO:0030516 | regulation of axon extension | 10.2041 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 10.2041 | 4 | yes |
| GO:0051046 | regulation of secretion | 10.2041 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 10.2041 | 4 | yes |
| GO:0061387 | regulation of extent of cell growth | 10.2041 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 10.2041 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 8.1633 | 6 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 8.1633 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 8.1633 | 5 | yes |
| GO:0050769 | positive regulation of neurogenesis | 8.1633 | 6 | yes |
| GO:0051962 | positive regulation of nervous system development | 8.1633 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 6.1224 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 6.1224 | 5 | yes |
| GO:0032386 | regulation of intracellular transport | 6.1224 | 5 | yes |
| GO:0050821 | protein stabilization | 6.1224 | 4 | yes |
| GO:0010970 | transport along microtubule | 4.0816 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 4.0816 | 5 | yes |
| GO:0032388 | positive regulation of intracellular transport | 4.0816 | 5 | yes |
| GO:0032482 | Rab protein signal transduction | 4.0816 | 6 | yes |
| GO:0045807 | positive regulation of endocytosis | 4.0816 | 5 | yes |
| GO:0099111 | microtubule-based transport | 4.0816 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ITA2_HUMAN | [view interactions] | Low throughput | no | yes |
| ITA11_HUMAN | [view interactions] | Low throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DP13A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANR27_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VAMP7_HUMAN | [view interactions] | Low throughput | no | yes |
| RABX5_HUMAN | [view interactions] | Low throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2B_HUMAN | [view interactions] | High throughput | no | no |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S22AG_HUMAN | [view interactions] | High throughput | no | yes |
| FANCE_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG2_HUMAN | [view interactions] | High throughput | no | no |
| P2RX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUCO2_HUMAN | [view interactions] | High throughput | no | no |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| THIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MINT_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| DDR2_HUMAN | [view interactions] | High throughput | no | no |
| EPHB6_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLCM_HUMAN | [view interactions] | High throughput | no | yes |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| GPT_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| E41LB_HUMAN | [view interactions] | High throughput | no | yes |
| RAE2_HUMAN | [view interactions] | High throughput | no | yes |
| RAE1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| SERC2_HUMAN | [view interactions] | High throughput | no | yes |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MTMRD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |