GEPH_HUMAN
Evidence for PS localization
Functions
Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GEPH_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.7692 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.8462 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.9231 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.0769 | 5 | yes |
| GO:0005524 | ATP binding | 21.1538 | 5 | yes |
| GO:0046872 | metal ion binding | 19.2308 | 4 | yes |
| GO:0008940 | nitrate reductase activity | 3.8462 | 4 | yes |
| GO:0016779 | nucleotidyltransferase activity | 3.8462 | 4 | yes |
| GO:0061598 | molybdopterin adenylyltransferase activity | 3.8462 | 6 | yes |
| GO:0070566 | adenylyltransferase activity | 3.8462 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GEPH_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.3846 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 38.4615 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.4615 | 4 | no |
| GO:0006996 | organelle organization | 36.5385 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.6154 | 4 | no |
| GO:0022607 | cellular component assembly | 34.6154 | 4 | no |
| GO:0008104 | protein localization | 34.6154 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.6923 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.6923 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.6923 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.6923 | 4 | no |
| GO:0051049 | regulation of transport | 28.8462 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 28.8462 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.9231 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.9231 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.9231 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.9231 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.9231 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0034330 | cell junction organization | 25.0000 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.0769 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 23.0769 | 6 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 23.0769 | 5 | no |
| GO:0036211 | protein modification process | 23.0769 | 4 | yes |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | yes |
| GO:0010468 | regulation of gene expression | 23.0769 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.1538 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.1538 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.1538 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.1538 | 6 | no |
| GO:0030030 | cell projection organization | 21.1538 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.1538 | 5 | no |
| GO:0006811 | ion transport | 21.1538 | 4 | no |
| GO:0050808 | synapse organization | 21.1538 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 21.1538 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.1538 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.1538 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.1538 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.1538 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 17.3077 | 4 | yes |
| GO:0072657 | protein localization to membrane | 13.4615 | 4 | yes |
| GO:0010038 | response to metal ion | 11.5385 | 4 | yes |
| GO:0043113 | receptor clustering | 9.6154 | 5 | yes |
| GO:0072578 | neurotransmitter-gated ion channel clustering | 7.6923 | 6 | yes |
| GO:0018130 | heterocycle biosynthetic process | 5.7692 | 4 | yes |
| GO:0097112 | gamma-aminobutyric acid receptor clustering | 5.7692 | 7 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 5.7692 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 5.7692 | 4 | yes |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | 3.8462 | 5 | yes |
| GO:0007529 | establishment of synaptic specificity at neuromuscular junction | 3.8462 | 6 | yes |
| GO:0018315 | molybdenum incorporation into molybdenum-molybdopterin complex | 3.8462 | 6 | yes |
| GO:0019720 | Mo-molybdopterin cofactor metabolic process | 3.8462 | 4 | yes |
| GO:0032324 | molybdopterin cofactor biosynthetic process | 3.8462 | 4 | yes |
| GO:0042040 | metal incorporation into metallo-molybdopterin complex | 3.8462 | 5 | yes |
| GO:0072579 | glycine receptor clustering | 3.8462 | 7 | yes |
| GO:0090407 | organophosphate biosynthetic process | 3.8462 | 4 | yes |
| GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 3.8462 | 4 | yes |
| GO:0099628 | neurotransmitter receptor diffusion trapping | 3.8462 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GEPH_HUMAN |
|---|---|---|---|---|
| DOID:0060695 | hyperekplexia | 3.8462 | 3 | no |
| DOID:331 | central nervous system disease | 3.8462 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAD10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEUM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRAP_HUMAN | [view interactions] | Low throughput | no | no |
| MTOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VASP_HUMAN | [view interactions] | Low throughput | no | yes |
| ENAH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRCC3_HUMAN | [view interactions] | High throughput | no | no |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| PAAF1_HUMAN | [view interactions] | High throughput | no | yes |
| PP4R1_HUMAN | [view interactions] | High throughput | no | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIP30_HUMAN | [view interactions] | High throughput | no | yes |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| NRDC_HUMAN | [view interactions] | High throughput | no | no |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICU1_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA5_HUMAN | [view interactions] | High throughput | no | yes |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAS1_HUMAN | [view interactions] | High throughput | no | no |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| MITD1_HUMAN | [view interactions] | High throughput | no | no |
| PCKGC_HUMAN | [view interactions] | High throughput | no | no |
| TSSK1_HUMAN | [view interactions] | High throughput | no | no |
| OD3L2_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| KLKB1_HUMAN | [view interactions] | High throughput | no | no |
| KMO_HUMAN | [view interactions] | High throughput | no | no |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| STS_HUMAN | [view interactions] | High throughput | no | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APC4_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| ZC21C_HUMAN | [view interactions] | High throughput | no | yes |
| ARSH_HUMAN | [view interactions] | High throughput | no | no |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| ZAR1L_HUMAN | [view interactions] | High throughput | no | no |
| NAA15_HUMAN | [view interactions] | High throughput | no | yes |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GARS_HUMAN | [view interactions] | Computational | no | yes |
| VGLU1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SUOX_HUMAN | [view interactions] | Computational | no | no |
| GBRG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| IQEC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GBRA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MOC2B_HUMAN | [view interactions] | Computational | no | yes |
| VIAAT_HUMAN | [view interactions] | Computational | no | yes |