GEPH_HUMAN
Evidence for PS localization
Functions
Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GEPH_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.4762 | 4 | yes |
| GO:0000166 | nucleotide binding | 34.5238 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 34.5238 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 32.1429 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.7619 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 28.5714 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 26.1905 | 5 | yes |
| GO:0043169 | cation binding | 25.0000 | 4 | yes |
| GO:0005524 | ATP binding | 23.8095 | 5 | yes |
| GO:0046872 | metal ion binding | 23.8095 | 5 | yes |
| GO:0008940 | nitrate reductase activity | 2.3810 | 4 | yes |
| GO:0016779 | nucleotidyltransferase activity | 2.3810 | 4 | yes |
| GO:0061598 | molybdopterin adenylyltransferase activity | 2.3810 | 6 | yes |
| GO:0070566 | adenylyltransferase activity | 2.3810 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GEPH_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 46.4286 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 46.4286 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.2381 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | no |
| GO:0006996 | organelle organization | 39.2857 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.0952 | 4 | no |
| GO:0008104 | protein localization | 35.7143 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 35.7143 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.5238 | 4 | no |
| GO:0022607 | cellular component assembly | 32.1429 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.1429 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.5714 | 4 | no |
| GO:0007010 | cytoskeleton organization | 28.5714 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.3810 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 27.3810 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.1905 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.8095 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | no |
| GO:0051049 | regulation of transport | 23.8095 | 4 | no |
| GO:0023056 | positive regulation of signaling | 23.8095 | 4 | no |
| GO:0036211 | protein modification process | 23.8095 | 4 | no |
| GO:0043412 | macromolecule modification | 23.8095 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
| GO:0034330 | cell junction organization | 22.6190 | 4 | yes |
| GO:0010468 | regulation of gene expression | 22.6190 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.6190 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.6190 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.4286 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.2381 | 4 | yes |
| GO:0030030 | cell projection organization | 20.2381 | 4 | no |
| GO:0031399 | regulation of protein modification process | 20.2381 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.2381 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 20.2381 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.2381 | 6 | no |
| GO:0032880 | regulation of protein localization | 20.2381 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.2381 | 5 | no |
| GO:0050808 | synapse organization | 15.4762 | 5 | yes |
| GO:0072657 | protein localization to membrane | 11.9048 | 4 | yes |
| GO:0010038 | response to metal ion | 9.5238 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 8.3333 | 4 | yes |
| GO:0043113 | receptor clustering | 7.1429 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 7.1429 | 4 | yes |
| GO:0072578 | neurotransmitter-gated ion channel clustering | 4.7619 | 6 | yes |
| GO:0090407 | organophosphate biosynthetic process | 3.5714 | 4 | yes |
| GO:0097112 | gamma-aminobutyric acid receptor clustering | 3.5714 | 7 | yes |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | 2.3810 | 5 | yes |
| GO:0007529 | establishment of synaptic specificity at neuromuscular junction | 2.3810 | 6 | yes |
| GO:0019720 | Mo-molybdopterin cofactor metabolic process | 2.3810 | 4 | yes |
| GO:0032324 | molybdopterin cofactor biosynthetic process | 2.3810 | 4 | yes |
| GO:0072579 | glycine receptor clustering | 2.3810 | 7 | yes |
| GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 2.3810 | 4 | yes |
| GO:0099628 | neurotransmitter receptor diffusion trapping | 2.3810 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VASP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ENAH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAD10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEUM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLRA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDKL5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRAP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KLKB1_HUMAN | [view interactions] | High throughput | no | no |
| KMO_HUMAN | [view interactions] | High throughput | no | no |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| STS_HUMAN | [view interactions] | High throughput | no | no |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APC4_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| ZC21C_HUMAN | [view interactions] | High throughput | no | yes |
| ARSH_HUMAN | [view interactions] | High throughput | no | no |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| ZAR1L_HUMAN | [view interactions] | High throughput | no | no |
| NAA15_HUMAN | [view interactions] | High throughput | no | yes |
| DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCC3_HUMAN | [view interactions] | High throughput | no | no |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| PAAF1_HUMAN | [view interactions] | High throughput | no | yes |
| PP4R1_HUMAN | [view interactions] | High throughput | no | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIP30_HUMAN | [view interactions] | High throughput | no | yes |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| NRDC_HUMAN | [view interactions] | High throughput | no | no |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MICU1_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADPPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASGL1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COMD2_HUMAN | [view interactions] | High throughput | no | yes |
| DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGKG_HUMAN | [view interactions] | High throughput | no | no |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| EVL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FADS2_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| P66B_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQEC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDRG4_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| LAT1_HUMAN | [view interactions] | High throughput | no | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA5_HUMAN | [view interactions] | High throughput | no | yes |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAS1_HUMAN | [view interactions] | High throughput | no | no |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| MITD1_HUMAN | [view interactions] | High throughput | no | no |
| PCKGC_HUMAN | [view interactions] | High throughput | no | no |
| TSSK1_HUMAN | [view interactions] | High throughput | no | no |
| CMA1D_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |