Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SCD_HUMAN

Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed, PubMed). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed, PubMed). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation . Plays an important role in body energy homeostasis . Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SCD_HUMAN
GO:0003723 RNA binding 27.0270 4 no
GO:0017076 purine nucleotide binding 24.3243 4 no
GO:0032555 purine ribonucleotide binding 24.3243 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.3243 4 no
GO:0046872 metal ion binding 21.6216 4 yes
GO:0016462 pyrophosphatase activity 21.6216 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.6216 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.6216 6 no
GO:0046914 transition metal ion binding 8.1081 5 yes
GO:0004768 stearoyl-CoA 9-desaturase activity 5.4054 6 yes
GO:0005506 iron ion binding 5.4054 6 yes
GO:0016215 acyl-CoA desaturase activity 5.4054 5 yes
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 5.4054 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SCD_HUMAN
GO:0048522 positive regulation of cellular process 51.3514 4 no
GO:0022607 cellular component assembly 35.1351 4 no
GO:0031323 regulation of cellular metabolic process 35.1351 4 no
GO:0051171 regulation of nitrogen compound metabolic process 35.1351 4 no
GO:0060255 regulation of macromolecule metabolic process 35.1351 4 no
GO:0080090 regulation of primary metabolic process 35.1351 4 no
GO:0048523 negative regulation of cellular process 32.4324 4 no
GO:0051128 regulation of cellular component organization 32.4324 4 no
GO:0009893 positive regulation of metabolic process 32.4324 4 yes
GO:0006996 organelle organization 32.4324 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.7297 5 no
GO:0010646 regulation of cell communication 29.7297 4 no
GO:0048584 positive regulation of response to stimulus 29.7297 4 no
GO:0051246 regulation of protein metabolic process 29.7297 5 no
GO:0009966 regulation of signal transduction 29.7297 4 no
GO:0010468 regulation of gene expression 29.7297 5 no
GO:0010647 positive regulation of cell communication 27.0270 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.0270 5 no
GO:0023056 positive regulation of signaling 27.0270 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 27.0270 5 no
GO:0042127 regulation of cell population proliferation 27.0270 4 no
GO:0009967 positive regulation of signal transduction 27.0270 5 no
GO:0010941 regulation of cell death 24.3243 4 no
GO:0031325 positive regulation of cellular metabolic process 24.3243 5 no
GO:0031326 regulation of cellular biosynthetic process 24.3243 5 no
GO:0042981 regulation of apoptotic process 24.3243 6 no
GO:0043067 regulation of programmed cell death 24.3243 5 no
GO:0051247 positive regulation of protein metabolic process 24.3243 6 no
GO:0051252 regulation of RNA metabolic process 24.3243 5 no
GO:1902531 regulation of intracellular signal transduction 24.3243 5 no
GO:0030030 cell projection organization 24.3243 4 no
GO:0032880 regulation of protein localization 24.3243 5 no
GO:0060341 regulation of cellular localization 24.3243 4 no
GO:0009889 regulation of biosynthetic process 24.3243 4 no
GO:0010628 positive regulation of gene expression 21.6216 6 no
GO:0019220 regulation of phosphate metabolic process 21.6216 6 no
GO:0031399 regulation of protein modification process 21.6216 6 no
GO:0044087 regulation of cellular component biogenesis 21.6216 4 no
GO:0051174 regulation of phosphorus metabolic process 21.6216 5 no
GO:1902533 positive regulation of intracellular signal transduction 21.6216 6 no
GO:1903829 positive regulation of protein localization 21.6216 5 no
GO:0120036 plasma membrane bounded cell projection organization 21.6216 5 no
GO:0008104 protein localization 21.6216 4 no
GO:0008284 positive regulation of cell population proliferation 21.6216 5 no
GO:0071702 organic substance transport 21.6216 4 no
GO:0036211 protein modification process 21.6216 4 no
GO:0043412 macromolecule modification 21.6216 4 no
GO:0009892 negative regulation of metabolic process 21.6216 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.6216 5 no
GO:0051240 positive regulation of multicellular organismal process 18.9189 4 yes
GO:0008610 lipid biosynthetic process 16.2162 4 yes
GO:0016053 organic acid biosynthetic process 16.2162 4 yes
GO:0019752 carboxylic acid metabolic process 16.2162 5 yes
GO:0043436 oxoacid metabolic process 16.2162 4 yes
GO:0046394 carboxylic acid biosynthetic process 16.2162 5 yes
GO:0006631 fatty acid metabolic process 13.5135 4 yes
GO:0006633 fatty acid biosynthetic process 13.5135 5 yes
GO:0032787 monocarboxylic acid metabolic process 13.5135 6 yes
GO:0072330 monocarboxylic acid biosynthetic process 13.5135 6 yes
GO:0033993 response to lipid 8.1081 4 yes
GO:0006636 unsaturated fatty acid biosynthetic process 5.4054 6 yes
GO:0033559 unsaturated fatty acid metabolic process 5.4054 5 yes
GO:1903964 monounsaturated fatty acid metabolic process 5.4054 4 yes
GO:1903966 monounsaturated fatty acid biosynthetic process 5.4054 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
TMPS2_HUMAN [view interactions] High throughput no no
CL12B_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
TES_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
TNR6A_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
CLUA1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
AMFR_HUMAN [view interactions] High throughput no yes
CGRF1_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
PANK2_HUMAN [view interactions] High throughput no yes
PANK1_HUMAN [view interactions] High throughput no no
PANK3_HUMAN [view interactions] High throughput no yes
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
GP182_HUMAN [view interactions] High throughput no no
RBCC1_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RHG15_HUMAN [view interactions] High throughput no no
BAP31_HUMAN [view interactions] High throughput no yes
OST48_HUMAN [view entry] [view interactions] High throughput yes yes
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
OST4_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
TTC27_HUMAN [view interactions] High throughput no yes
UBE3B_HUMAN [view interactions] High throughput no yes
STT3B_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
CCD47_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
SPRNG_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
NED4L_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DHB12_HUMAN [view entry] [view interactions] High throughput yes yes
NSUN5_HUMAN [view interactions] High throughput no yes
RL14_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
MPCP_HUMAN [view entry] [view interactions] High throughput yes no
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
SSRD_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
SC61B_HUMAN [view interactions] High throughput no yes
DJC25_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
DHB11_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
KSR1_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
ASXL3_HUMAN [view interactions] High throughput no no
E2F3_HUMAN [view interactions] High throughput no no
SG196_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
RETR3_HUMAN [view interactions] High throughput no yes
RNF5_HUMAN [view interactions] High throughput no yes
SPAG4_HUMAN [view interactions] High throughput no no
CLC4K_HUMAN [view interactions] High throughput no no
REEP2_HUMAN [view interactions] High throughput no yes
CERS4_HUMAN [view interactions] High throughput no yes
SOAT_HUMAN [view interactions] High throughput no no
GPX8_HUMAN [view interactions] High throughput no no
CY561_HUMAN [view interactions] High throughput no yes
TIDC1_HUMAN [view interactions] High throughput no yes
SC11C_HUMAN [view interactions] High throughput no no
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
DHB13_HUMAN [view interactions] High throughput no yes
TLCD4_HUMAN [view interactions] High throughput no no
SCN3B_HUMAN [view interactions] High throughput no no
PVR_HUMAN [view interactions] High throughput no yes
TMX2_HUMAN [view interactions] High throughput no yes
MCFD2_HUMAN [view interactions] High throughput no yes
S7A14_HUMAN [view interactions] High throughput no no
IF3M_HUMAN [view interactions] High throughput no yes
GPR42_HUMAN [view interactions] High throughput no no
CC50B_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
GP152_HUMAN [view interactions] High throughput no no
CYBC1_HUMAN [view interactions] High throughput no yes
CD33_HUMAN [view interactions] High throughput no no
ERGI3_HUMAN [view interactions] High throughput no yes
JAGN1_HUMAN [view interactions] High throughput no no
MARH5_HUMAN [view interactions] High throughput no no
KCNJ6_HUMAN [view interactions] High throughput no no
CXB1_HUMAN [view interactions] High throughput no yes
MF14B_HUMAN [view interactions] High throughput no no
AQP6_HUMAN [view interactions] High throughput no no
VMA21_HUMAN [view interactions] High throughput no no
CR3L1_HUMAN [view interactions] High throughput no yes
TT30B_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
TECT3_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
SRBP1_HUMAN [view interactions] Computational no yes
FADS3_HUMAN [view interactions] Computational no no
NRIP1_HUMAN [view interactions] Computational no yes
HACD4_HUMAN [view interactions] Computational no no
TECR_HUMAN [view interactions] Computational no yes
PPARA_HUMAN [view interactions] Computational no yes
ELOV6_HUMAN [view interactions] Computational no yes
HACD1_HUMAN [view interactions] Computational no no
ELOV5_HUMAN [view interactions] Computational no yes
FA2H_HUMAN [view interactions] Computational no yes
DGAT1_HUMAN [view interactions] Computational no yes
HACD2_HUMAN [view interactions] Computational no yes
NR1H2_HUMAN [view interactions] Computational no yes
RXRB_HUMAN [view interactions] Computational no yes
SCD5_HUMAN [view entry] [view interactions] Computational yes yes
RXRA_HUMAN [view interactions] Computational no yes
ACOT1_HUMAN [view interactions] Computational no yes
DGAT2_HUMAN [view interactions] Computational no no
HACD3_HUMAN [view interactions] Computational no yes
FADS2_HUMAN [view interactions] Computational no yes
ACOT2_HUMAN [view interactions] Computational no yes
ACOT4_HUMAN [view interactions] Computational no yes
ACACA_HUMAN [view entry] [view interactions] Computational yes yes
CYB5_HUMAN [view interactions] Computational no no