SCD_HUMAN
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed, PubMed). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed, PubMed). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation . Plays an important role in body energy homeostasis . Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SCD_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 27.0270 | 4 | no |
GO:0017076 | purine nucleotide binding | 24.3243 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 24.3243 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 24.3243 | 4 | no |
GO:0046872 | metal ion binding | 21.6216 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 21.6216 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.6216 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.6216 | 6 | no |
GO:0046914 | transition metal ion binding | 8.1081 | 5 | yes |
GO:0004768 | stearoyl-CoA 9-desaturase activity | 5.4054 | 6 | yes |
GO:0005506 | iron ion binding | 5.4054 | 6 | yes |
GO:0016215 | acyl-CoA desaturase activity | 5.4054 | 5 | yes |
GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | 5.4054 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SCD_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 51.3514 | 4 | no |
GO:0022607 | cellular component assembly | 35.1351 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 35.1351 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 35.1351 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 35.1351 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 35.1351 | 4 | no |
GO:0048523 | negative regulation of cellular process | 32.4324 | 4 | no |
GO:0051128 | regulation of cellular component organization | 32.4324 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 32.4324 | 4 | yes |
GO:0006996 | organelle organization | 32.4324 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 29.7297 | 5 | no |
GO:0010646 | regulation of cell communication | 29.7297 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 29.7297 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 29.7297 | 5 | no |
GO:0009966 | regulation of signal transduction | 29.7297 | 4 | no |
GO:0010468 | regulation of gene expression | 29.7297 | 5 | no |
GO:0010647 | positive regulation of cell communication | 27.0270 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.0270 | 5 | no |
GO:0023056 | positive regulation of signaling | 27.0270 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.0270 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 27.0270 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 27.0270 | 5 | no |
GO:0010941 | regulation of cell death | 24.3243 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 24.3243 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 24.3243 | 5 | no |
GO:0042981 | regulation of apoptotic process | 24.3243 | 6 | no |
GO:0043067 | regulation of programmed cell death | 24.3243 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 24.3243 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 24.3243 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 24.3243 | 5 | no |
GO:0030030 | cell projection organization | 24.3243 | 4 | no |
GO:0032880 | regulation of protein localization | 24.3243 | 5 | no |
GO:0060341 | regulation of cellular localization | 24.3243 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 24.3243 | 4 | no |
GO:0010628 | positive regulation of gene expression | 21.6216 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 21.6216 | 6 | no |
GO:0031399 | regulation of protein modification process | 21.6216 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 21.6216 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 21.6216 | 5 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 21.6216 | 6 | no |
GO:1903829 | positive regulation of protein localization | 21.6216 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 21.6216 | 5 | no |
GO:0008104 | protein localization | 21.6216 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 21.6216 | 5 | no |
GO:0071702 | organic substance transport | 21.6216 | 4 | no |
GO:0036211 | protein modification process | 21.6216 | 4 | no |
GO:0043412 | macromolecule modification | 21.6216 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 21.6216 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 21.6216 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 18.9189 | 4 | yes |
GO:0008610 | lipid biosynthetic process | 16.2162 | 4 | yes |
GO:0016053 | organic acid biosynthetic process | 16.2162 | 4 | yes |
GO:0019752 | carboxylic acid metabolic process | 16.2162 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 16.2162 | 4 | yes |
GO:0046394 | carboxylic acid biosynthetic process | 16.2162 | 5 | yes |
GO:0006631 | fatty acid metabolic process | 13.5135 | 4 | yes |
GO:0006633 | fatty acid biosynthetic process | 13.5135 | 5 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 13.5135 | 6 | yes |
GO:0072330 | monocarboxylic acid biosynthetic process | 13.5135 | 6 | yes |
GO:0033993 | response to lipid | 8.1081 | 4 | yes |
GO:0006636 | unsaturated fatty acid biosynthetic process | 5.4054 | 6 | yes |
GO:0033559 | unsaturated fatty acid metabolic process | 5.4054 | 5 | yes |
GO:1903964 | monounsaturated fatty acid metabolic process | 5.4054 | 4 | yes |
GO:1903966 | monounsaturated fatty acid biosynthetic process | 5.4054 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMPS2_HUMAN | [view interactions] | High throughput | no | no |
CL12B_HUMAN | [view interactions] | High throughput | no | no |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
TES_HUMAN | [view interactions] | High throughput | no | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
H4_HUMAN | [view interactions] | High throughput | no | yes |
RU17_HUMAN | [view interactions] | High throughput | no | yes |
CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
AMFR_HUMAN | [view interactions] | High throughput | no | yes |
CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
PANK2_HUMAN | [view interactions] | High throughput | no | yes |
PANK1_HUMAN | [view interactions] | High throughput | no | no |
PANK3_HUMAN | [view interactions] | High throughput | no | yes |
TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GP182_HUMAN | [view interactions] | High throughput | no | no |
RBCC1_HUMAN | [view interactions] | High throughput | no | no |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RHG15_HUMAN | [view interactions] | High throughput | no | no |
BAP31_HUMAN | [view interactions] | High throughput | no | yes |
OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OST4_HUMAN | [view interactions] | High throughput | no | no |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TTC27_HUMAN | [view interactions] | High throughput | no | yes |
UBE3B_HUMAN | [view interactions] | High throughput | no | yes |
STT3B_HUMAN | [view interactions] | High throughput | no | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCD47_HUMAN | [view interactions] | High throughput | no | yes |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
ATG7_HUMAN | [view interactions] | High throughput | no | yes |
NED4L_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NSUN5_HUMAN | [view interactions] | High throughput | no | yes |
RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SSRD_HUMAN | [view interactions] | High throughput | no | yes |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
SC61B_HUMAN | [view interactions] | High throughput | no | yes |
DJC25_HUMAN | [view interactions] | High throughput | no | yes |
CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
DHB11_HUMAN | [view interactions] | High throughput | no | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASXL3_HUMAN | [view interactions] | High throughput | no | no |
E2F3_HUMAN | [view interactions] | High throughput | no | no |
SG196_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
RETR3_HUMAN | [view interactions] | High throughput | no | yes |
RNF5_HUMAN | [view interactions] | High throughput | no | yes |
SPAG4_HUMAN | [view interactions] | High throughput | no | no |
CLC4K_HUMAN | [view interactions] | High throughput | no | no |
REEP2_HUMAN | [view interactions] | High throughput | no | yes |
CERS4_HUMAN | [view interactions] | High throughput | no | yes |
SOAT_HUMAN | [view interactions] | High throughput | no | no |
GPX8_HUMAN | [view interactions] | High throughput | no | no |
CY561_HUMAN | [view interactions] | High throughput | no | yes |
TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
SC11C_HUMAN | [view interactions] | High throughput | no | no |
STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHB13_HUMAN | [view interactions] | High throughput | no | yes |
TLCD4_HUMAN | [view interactions] | High throughput | no | no |
SCN3B_HUMAN | [view interactions] | High throughput | no | no |
PVR_HUMAN | [view interactions] | High throughput | no | yes |
TMX2_HUMAN | [view interactions] | High throughput | no | yes |
MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
S7A14_HUMAN | [view interactions] | High throughput | no | no |
IF3M_HUMAN | [view interactions] | High throughput | no | yes |
GPR42_HUMAN | [view interactions] | High throughput | no | no |
CC50B_HUMAN | [view interactions] | High throughput | no | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GP152_HUMAN | [view interactions] | High throughput | no | no |
CYBC1_HUMAN | [view interactions] | High throughput | no | yes |
CD33_HUMAN | [view interactions] | High throughput | no | no |
ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
JAGN1_HUMAN | [view interactions] | High throughput | no | no |
MARH5_HUMAN | [view interactions] | High throughput | no | no |
KCNJ6_HUMAN | [view interactions] | High throughput | no | no |
CXB1_HUMAN | [view interactions] | High throughput | no | yes |
MF14B_HUMAN | [view interactions] | High throughput | no | no |
AQP6_HUMAN | [view interactions] | High throughput | no | no |
VMA21_HUMAN | [view interactions] | High throughput | no | no |
CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
TT30B_HUMAN | [view interactions] | High throughput | no | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
TECT3_HUMAN | [view interactions] | High throughput | no | yes |
TECT2_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRBP1_HUMAN | [view interactions] | Computational | no | yes |
FADS3_HUMAN | [view interactions] | Computational | no | no |
NRIP1_HUMAN | [view interactions] | Computational | no | yes |
HACD4_HUMAN | [view interactions] | Computational | no | no |
TECR_HUMAN | [view interactions] | Computational | no | yes |
PPARA_HUMAN | [view interactions] | Computational | no | yes |
ELOV6_HUMAN | [view interactions] | Computational | no | yes |
HACD1_HUMAN | [view interactions] | Computational | no | no |
ELOV5_HUMAN | [view interactions] | Computational | no | yes |
FA2H_HUMAN | [view interactions] | Computational | no | yes |
DGAT1_HUMAN | [view interactions] | Computational | no | yes |
HACD2_HUMAN | [view interactions] | Computational | no | yes |
NR1H2_HUMAN | [view interactions] | Computational | no | yes |
RXRB_HUMAN | [view interactions] | Computational | no | yes |
SCD5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RXRA_HUMAN | [view interactions] | Computational | no | yes |
ACOT1_HUMAN | [view interactions] | Computational | no | yes |
DGAT2_HUMAN | [view interactions] | Computational | no | no |
HACD3_HUMAN | [view interactions] | Computational | no | yes |
FADS2_HUMAN | [view interactions] | Computational | no | yes |
ACOT2_HUMAN | [view interactions] | Computational | no | yes |
ACOT4_HUMAN | [view interactions] | Computational | no | yes |
ACACA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CYB5_HUMAN | [view interactions] | Computational | no | no |