SCD_HUMAN
Evidence for PS localization
Functions
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed, PubMed). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed, PubMed). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation . Plays an important role in body energy homeostasis . Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SCD_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 26.6667 | 4 | yes |
| GO:0046872 | metal ion binding | 26.6667 | 5 | yes |
| GO:0000166 | nucleotide binding | 24.4444 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.4444 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.4444 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.4444 | 4 | no |
| GO:0043168 | anion binding | 24.4444 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 22.2222 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.2222 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.2222 | 6 | no |
| GO:0003723 | RNA binding | 22.2222 | 4 | no |
| GO:0046914 | transition metal ion binding | 6.6667 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SCD_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.1111 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.7778 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.7778 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.5556 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.5556 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 31.1111 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.1111 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.1111 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.1111 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.1111 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.1111 | 5 | no |
| GO:0010468 | regulation of gene expression | 28.8889 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.8889 | 5 | no |
| GO:0022607 | cellular component assembly | 28.8889 | 4 | no |
| GO:0023056 | positive regulation of signaling | 28.8889 | 4 | no |
| GO:0036211 | protein modification process | 28.8889 | 4 | no |
| GO:0043412 | macromolecule modification | 28.8889 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 24.4444 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.4444 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.4444 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.4444 | 5 | no |
| GO:0008104 | protein localization | 24.4444 | 4 | no |
| GO:0071702 | organic substance transport | 24.4444 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.4444 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.2222 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
| GO:0051049 | regulation of transport | 22.2222 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.0000 | 4 | yes |
| GO:0006631 | fatty acid metabolic process | 8.8889 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 8.8889 | 4 | yes |
| GO:0016053 | organic acid biosynthetic process | 8.8889 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 8.8889 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 8.8889 | 6 | yes |
| GO:0033993 | response to lipid | 8.8889 | 4 | yes |
| GO:0043436 | oxoacid metabolic process | 8.8889 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 8.8889 | 5 | yes |
| GO:0006633 | fatty acid biosynthetic process | 6.6667 | 5 | yes |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6.6667 | 6 | yes |
| GO:0033559 | unsaturated fatty acid metabolic process | 4.4444 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| PANK2_HUMAN | [view interactions] | High throughput | no | yes |
| PANK1_HUMAN | [view interactions] | High throughput | no | no |
| PANK3_HUMAN | [view interactions] | High throughput | no | yes |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RHG15_HUMAN | [view interactions] | High throughput | no | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST4_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC27_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STT3B_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DPTOR_HUMAN | [view interactions] | High throughput | no | no |
| PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| NED4L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSUN5_HUMAN | [view interactions] | High throughput | no | yes |
| RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRD_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESF1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASXL3_HUMAN | [view interactions] | High throughput | no | no |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF5_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG4_HUMAN | [view interactions] | High throughput | no | no |
| CLC4K_HUMAN | [view interactions] | High throughput | no | no |
| REEP2_HUMAN | [view interactions] | High throughput | no | yes |
| CERS4_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| CY561_HUMAN | [view interactions] | High throughput | no | yes |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| SC11C_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB13_HUMAN | [view interactions] | High throughput | no | yes |
| TLCD4_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| MCFD2_HUMAN | [view interactions] | High throughput | no | yes |
| S7A14_HUMAN | [view interactions] | High throughput | no | no |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| GPR42_HUMAN | [view interactions] | High throughput | no | no |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| CYBC1_HUMAN | [view interactions] | High throughput | no | yes |
| CD33_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXB1_HUMAN | [view interactions] | High throughput | no | yes |
| MF14B_HUMAN | [view interactions] | High throughput | no | no |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| IT70B_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |