Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TTYH1_HUMAN

GO
G2C
SynGO

Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TTYH1_HUMAN
GO:0008324 cation transmembrane transporter activity 36.1111 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 yes
GO:0046872 metal ion binding 30.5556 4 yes
GO:0015267 channel activity 27.7778 4 yes
GO:0005216 ion channel activity 25.0000 4 yes
GO:0046873 metal ion transmembrane transporter activity 25.0000 5 yes
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0008509 anion transmembrane transporter activity 22.2222 4 yes
GO:0005524 ATP binding 22.2222 5 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no
GO:0022836 gated channel activity 19.4444 5 yes
GO:0015103 inorganic anion transmembrane transporter activity 16.6667 4 yes
GO:0005253 anion channel activity 13.8889 5 yes
GO:0015108 chloride transmembrane transporter activity 13.8889 5 yes
GO:0005254 chloride channel activity 11.1111 6 yes
GO:0005225 volume-sensitive anion channel activity 8.3333 6 yes
GO:0005229 intracellular calcium activated chloride channel activity 8.3333 7 yes
GO:0005509 calcium ion binding 8.3333 5 yes
GO:0022839 ion gated channel activity 8.3333 6 yes
GO:0046915 transition metal ion transmembrane transporter activity 8.3333 6 yes
GO:0061778 intracellular chloride channel activity 8.3333 7 yes
GO:0005381 iron ion transmembrane transporter activity 5.5556 7 yes
GO:0072320 volume-sensitive chloride channel activity 5.5556 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TTYH1_HUMAN
GO:0048522 positive regulation of cellular process 47.2222 4 no
GO:0006811 ion transport 41.6667 4 yes
GO:0051049 regulation of transport 38.8889 4 no
GO:0071702 organic substance transport 36.1111 4 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0006812 cation transport 27.7778 5 yes
GO:0030001 metal ion transport 27.7778 6 yes
GO:0006820 anion transport 25.0000 5 yes
GO:0022607 cellular component assembly 25.0000 4 yes
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:0043269 regulation of ion transport 25.0000 5 no
GO:0048878 chemical homeostasis 25.0000 4 no
GO:0098660 inorganic ion transmembrane transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0048523 negative regulation of cellular process 22.2222 4 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0006821 chloride transport 16.6667 7 yes
GO:0015698 inorganic anion transport 16.6667 6 yes
GO:0030030 cell projection organization 13.8889 4 yes
GO:0120036 plasma membrane bounded cell projection organization 11.1111 5 yes
GO:0000041 transition metal ion transport 8.3333 7 yes
GO:0030031 cell projection assembly 8.3333 5 yes
GO:0120031 plasma membrane bounded cell projection assembly 8.3333 6 yes
GO:0006826 iron ion transport 5.5556 8 yes
GO:0046847 filopodium assembly 5.5556 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in TTYH1_HUMAN
DOID:331 central nervous system disease 5.5556 3 no
DOID:936 brain disease 5.5556 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GPR37_HUMAN [view interactions] Low throughput no no
TTYH1_HUMAN [view entry] [view interactions] Low throughput yes no
CERK1_HUMAN [view interactions] High throughput no no
TV23C_HUMAN [view interactions] High throughput no no
DNJC1_HUMAN [view interactions] High throughput no yes
TRPM4_HUMAN [view interactions] High throughput no no
SC11A_HUMAN [view interactions] High throughput no no
CERS4_HUMAN [view interactions] High throughput no yes
MTR1L_HUMAN [view interactions] High throughput no no
ADCY3_HUMAN [view interactions] High throughput no yes
DGKE_HUMAN [view interactions] High throughput no yes
ST7_HUMAN [view interactions] High throughput no yes
CSCL1_HUMAN [view interactions] High throughput no no
ALG3_HUMAN [view interactions] High throughput no yes
D19L4_HUMAN [view interactions] High throughput no no
ORML2_HUMAN [view interactions] High throughput no no
CERS5_HUMAN [view interactions] High throughput no yes
S12A4_HUMAN [view interactions] High throughput no yes
GOSR2_HUMAN [view interactions] High throughput no yes
KCNT2_HUMAN [view interactions] High throughput no no
PXMP2_HUMAN [view interactions] High throughput no no
ORML1_HUMAN [view interactions] High throughput no no
S1PR2_HUMAN [view interactions] High throughput no no
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
D19L3_HUMAN [view interactions] High throughput no yes
AT8B2_HUMAN [view interactions] High throughput no yes
CIA30_HUMAN [view interactions] High throughput no yes
RETST_HUMAN [view interactions] High throughput no yes
MICA2_HUMAN [view interactions] High throughput no yes
ABHD6_HUMAN [view entry] [view interactions] High throughput yes yes
STX5_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT1_HUMAN [view entry] [view interactions] High throughput yes no
BET1_HUMAN [view interactions] High throughput no no
SRBP2_HUMAN [view interactions] High throughput no yes
NSMA_HUMAN [view interactions] High throughput no yes
ST7L_HUMAN [view interactions] High throughput no no
ERMP1_HUMAN [view interactions] High throughput no no
ASTRA_HUMAN [view interactions] High throughput no no
HCN3_HUMAN [view interactions] High throughput no yes
STAR3_HUMAN [view interactions] High throughput no yes
ABD12_HUMAN [view interactions] High throughput no no
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
LRC8C_HUMAN [view interactions] High throughput no yes
AGRE5_HUMAN [view interactions] High throughput no no
POMT1_HUMAN [view interactions] High throughput no no
CLCN7_HUMAN [view interactions] High throughput no yes
DGLA_HUMAN [view entry] [view interactions] High throughput yes yes
AG10A_HUMAN [view interactions] High throughput no yes
S35F2_HUMAN [view interactions] High throughput no yes
MFSD9_HUMAN [view interactions] High throughput no yes
CAC1H_HUMAN [view entry] [view interactions] High throughput yes yes
PIGA_HUMAN [view interactions] High throughput no yes
STEA3_HUMAN [view interactions] High throughput no yes
S47A1_HUMAN [view interactions] High throughput no no
TMM94_HUMAN [view interactions] High throughput no yes
VANG2_HUMAN [view interactions] High throughput no no
SPCS2_HUMAN [view interactions] High throughput no yes
CHPT1_HUMAN [view interactions] High throughput no yes
AT132_HUMAN [view interactions] High throughput no yes
PDZD8_HUMAN [view interactions] High throughput no yes
THEM6_HUMAN [view interactions] High throughput no no
TM175_HUMAN [view interactions] High throughput no yes
S29A1_HUMAN [view entry] [view interactions] High throughput yes yes
ABCA7_HUMAN [view interactions] High throughput no yes
DHC24_HUMAN [view interactions] High throughput no yes
CLCC1_HUMAN [view interactions] High throughput no yes
ADCY9_HUMAN [view interactions] High throughput no yes
ADCY6_HUMAN [view interactions] High throughput no yes
HVCN1_HUMAN [view interactions] High throughput no yes
S4A7_HUMAN [view interactions] High throughput no no
S1PR5_HUMAN [view interactions] High throughput no no
PIGS_HUMAN [view interactions] High throughput no yes
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
SMO_HUMAN [view interactions] High throughput no yes
UN93B_HUMAN [view interactions] High throughput no yes
ENTP7_HUMAN [view interactions] High throughput no no
PCX3_HUMAN [view interactions] High throughput no no
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
FKRP_HUMAN [view interactions] High throughput no yes
PPM1L_HUMAN [view interactions] High throughput no yes
CGT_HUMAN [view interactions] High throughput no no
ZDHC9_HUMAN [view interactions] High throughput no yes
UXS1_HUMAN [view interactions] High throughput no yes
F210B_HUMAN [view interactions] High throughput no yes
EFNB1_HUMAN [view interactions] High throughput no yes
UBE4A_HUMAN [view entry] [view interactions] High throughput yes yes
LEMD2_HUMAN [view interactions] High throughput no yes
B4GT7_HUMAN [view interactions] High throughput no yes
CA043_HUMAN [view interactions] High throughput no yes
LPCT4_HUMAN [view interactions] High throughput no yes
T120B_HUMAN [view interactions] High throughput no yes
PIGO_HUMAN [view interactions] High throughput no no
RETR3_HUMAN [view interactions] High throughput no yes
MBOA5_HUMAN [view interactions] High throughput no no
LRC8E_HUMAN [view interactions] High throughput no no
AT2B2_HUMAN [view entry] [view interactions] High throughput yes yes
T179B_HUMAN [view interactions] High throughput no no
DGAT1_HUMAN [view interactions] High throughput no yes
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
TRI13_HUMAN [view interactions] High throughput no no
S27A2_HUMAN [view interactions] High throughput no no
MANEA_HUMAN [view interactions] High throughput no yes
GLT12_HUMAN [view interactions] High throughput no yes
TPC2_HUMAN [view interactions] High throughput no no
TM186_HUMAN [view interactions] High throughput no no
XYLT2_HUMAN [view interactions] High throughput no no
NDC1_HUMAN [view interactions] High throughput no yes
ABCD1_HUMAN [view entry] [view interactions] High throughput yes no
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
CP51A_HUMAN [view interactions] High throughput no no
SNX14_HUMAN [view entry] [view interactions] High throughput yes yes
ADCK2_HUMAN [view interactions] High throughput no yes
S27A6_HUMAN [view interactions] High throughput no yes
DJC30_HUMAN [view interactions] High throughput no no
ALG12_HUMAN [view interactions] High throughput no yes
S12A6_HUMAN [view interactions] High throughput no yes
MIA2_HUMAN [view interactions] High throughput no yes
ACSL4_HUMAN [view entry] [view interactions] High throughput yes yes
CNNM1_HUMAN [view interactions] High throughput no yes
ABCB6_HUMAN [view interactions] High throughput no yes
NAT14_HUMAN [view interactions] High throughput no no
KDIS_HUMAN [view interactions] High throughput no yes
TLCD4_HUMAN [view interactions] High throughput no no
DJC18_HUMAN [view interactions] High throughput no yes
AGRL1_HUMAN [view entry] [view interactions] High throughput yes no
AT11C_HUMAN [view interactions] High throughput no no
PIGM_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
POMT2_HUMAN [view interactions] High throughput no yes
POPD1_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
TMTC3_HUMAN [view interactions] High throughput no yes
PGAP1_HUMAN [view interactions] High throughput no no
CSCL2_HUMAN [view interactions] High throughput no yes
ANO10_HUMAN [view interactions] High throughput no yes
SMAD5_HUMAN [view interactions] High throughput no no
ABCBA_HUMAN [view interactions] High throughput no yes
CTL1_HUMAN [view interactions] High throughput no no
CTL5_HUMAN [view interactions] High throughput no no
PMGT1_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
EXT1_HUMAN [view interactions] High throughput no yes
DCAKD_HUMAN [view entry] [view interactions] High throughput yes no
PDE3B_HUMAN [view interactions] High throughput no no
S12A7_HUMAN [view interactions] High throughput no yes
SPP2B_HUMAN [view interactions] High throughput no yes
LMAN2_HUMAN [view interactions] High throughput no yes
TM223_HUMAN [view interactions] High throughput no yes
ALG11_HUMAN [view interactions] High throughput no yes
PEX16_HUMAN [view interactions] High throughput no yes
ABHD3_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view interactions] High throughput no yes
GOLI4_HUMAN [view interactions] High throughput no yes
EBP_HUMAN [view interactions] High throughput no no
ASTRB_HUMAN [view interactions] High throughput no yes
CDS1_HUMAN [view interactions] High throughput no yes
TGO1_HUMAN [view interactions] High throughput no yes
LRC8A_HUMAN [view entry] [view interactions] High throughput yes no
GPC5C_HUMAN [view interactions] High throughput no no
P121A_HUMAN [view interactions] High throughput no yes
S27A3_HUMAN [view interactions] High throughput no no
LPAR1_HUMAN [view entry] [view interactions] High throughput yes no
TM143_HUMAN [view interactions] High throughput no yes
XPR1_HUMAN [view interactions] High throughput no yes
MBLC2_HUMAN [view interactions] High throughput no yes
HCN2_HUMAN [view entry] [view interactions] High throughput yes no
PEX10_HUMAN [view interactions] High throughput no yes
SOAT1_HUMAN [view interactions] High throughput no no
ERGI2_HUMAN [view interactions] High throughput no yes
TMC6_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
SPCS1_HUMAN [view interactions] High throughput no yes
TM87A_HUMAN [view interactions] High throughput no yes
ASTRC_HUMAN [view interactions] High throughput no no
EPHX4_HUMAN [view interactions] High throughput no yes
GOGA5_HUMAN [view interactions] High throughput no yes
SC11C_HUMAN [view interactions] High throughput no no
SEC20_HUMAN [view interactions] High throughput no yes
IQGA3_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
CGRF1_HUMAN [view interactions] High throughput no yes
NDUB5_HUMAN [view interactions] High throughput no yes
ABCB9_HUMAN [view interactions] High throughput no yes
CTR3_HUMAN [view interactions] High throughput no no
S35F1_HUMAN [view interactions] High throughput no yes
MRP7_HUMAN [view interactions] High throughput no yes
FACR2_HUMAN [view interactions] High throughput no yes
TACAN_HUMAN [view interactions] High throughput no no
TMM68_HUMAN [view interactions] High throughput no yes
TM192_HUMAN [view interactions] High throughput no yes
F189B_HUMAN [view interactions] High throughput no no
LRC8D_HUMAN [view interactions] High throughput no no
ATP7B_HUMAN [view interactions] High throughput no no
SCFD2_HUMAN [view interactions] High throughput no yes
S35F5_HUMAN [view interactions] High throughput no no
BAP29_HUMAN [view interactions] High throughput no yes
FITM2_HUMAN [view interactions] High throughput no no
B3A2_HUMAN [view interactions] High throughput no yes
GPHRA_HUMAN [view interactions] High throughput no no
LCLT1_HUMAN [view interactions] High throughput no no
TM164_HUMAN [view interactions] High throughput no yes
PLCD_HUMAN [view interactions] High throughput no yes
PLCB_HUMAN [view interactions] High throughput no yes
LMBD2_HUMAN [view interactions] High throughput no yes
COA1_HUMAN [view interactions] High throughput no yes
GPAT4_HUMAN [view interactions] High throughput no yes
PIEZ1_HUMAN [view interactions] High throughput no no
TM115_HUMAN [view interactions] High throughput no yes
MACOI_HUMAN [view interactions] High throughput no no
TMM62_HUMAN [view interactions] High throughput no yes
TRPM7_HUMAN [view interactions] High throughput no no
ANO6_HUMAN [view entry] [view interactions] High throughput yes no
GOLM1_HUMAN [view interactions] High throughput no yes
SCD_HUMAN [view entry] [view interactions] High throughput yes yes
PIGW_HUMAN [view interactions] High throughput no no
LRC8B_HUMAN [view interactions] High throughput no yes
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
GPAA1_HUMAN [view interactions] High throughput no yes
CCR9_HUMAN [view interactions] High throughput no no
SCAP_HUMAN [view interactions] High throughput no yes
DRD2_HUMAN [view entry] [view interactions] High throughput yes no
AT8A1_HUMAN [view entry] [view interactions] High throughput yes yes
5HT6R_HUMAN [view interactions] High throughput no yes
T161B_HUMAN [view interactions] High throughput no no
ABCA2_HUMAN [view interactions] High throughput no yes
TMM60_HUMAN [view interactions] High throughput no no
ABCA3_HUMAN [view interactions] High throughput no yes
CPSF4_HUMAN [view interactions] High throughput no yes
D19L1_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
CXG1_HUMAN [view interactions] High throughput no no
ENTP4_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
ALG9_HUMAN [view interactions] High throughput no yes
MOT13_HUMAN [view interactions] High throughput no no
GHDC_HUMAN [view interactions] High throughput no yes
PIGQ_HUMAN [view interactions] High throughput no yes
TM219_HUMAN [view interactions] High throughput no yes
MFS12_HUMAN [view interactions] High throughput no yes
SL9A1_HUMAN [view interactions] High throughput no no
USE1_HUMAN [view interactions] High throughput no yes
BSCL2_HUMAN [view interactions] High throughput no yes
AT2A3_HUMAN [view interactions] High throughput no yes
HACD2_HUMAN [view interactions] High throughput no yes
DGLB_HUMAN [view entry] [view interactions] High throughput yes no
MANEL_HUMAN [view interactions] High throughput no no
PIGN_HUMAN [view interactions] High throughput no yes
ABCD4_HUMAN [view interactions] High throughput no yes
CC033_HUMAN [view interactions] High throughput no yes
MRP4_HUMAN [view interactions] High throughput no no
UBP30_HUMAN [view interactions] High throughput no yes
PLCC_HUMAN [view interactions] High throughput no no
CERS6_HUMAN [view interactions] High throughput no yes
LTMD1_HUMAN [view interactions] High throughput no no
SGPL1_HUMAN [view interactions] High throughput no yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
RDH12_HUMAN [view interactions] High throughput no no
LPAR3_HUMAN [view interactions] High throughput no no
HACD3_HUMAN [view interactions] High throughput no yes
TM214_HUMAN [view interactions] High throughput no no
TPC1_HUMAN [view interactions] High throughput no yes
FADS1_HUMAN [view interactions] High throughput no yes
PGAP4_HUMAN [view interactions] High throughput no no
MDR1_HUMAN [view entry] [view interactions] High throughput yes no
SNX25_HUMAN [view interactions] High throughput no no
CC167_HUMAN [view interactions] High throughput no yes
S35F6_HUMAN [view interactions] High throughput no yes
PM34_HUMAN [view interactions] High throughput no yes
PHTF2_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
TUSC3_HUMAN [view interactions] High throughput no yes
ALG8_HUMAN [view interactions] High throughput no yes
MAN1_HUMAN [view interactions] High throughput no yes
PLD6_HUMAN [view interactions] High throughput no yes
FUT8_HUMAN [view interactions] High throughput no yes
TM39B_HUMAN [view interactions] High throughput no yes
FZD2_HUMAN [view interactions] High throughput no no
FZD7_HUMAN [view interactions] High throughput no yes
GET1_HUMAN [view interactions] High throughput no yes
DHRS7_HUMAN [view interactions] High throughput no yes
STX18_HUMAN [view interactions] High throughput no yes
MYO9A_HUMAN [view entry] [view interactions] High throughput yes yes
TAM41_HUMAN [view interactions] High throughput no no
KCNJ8_HUMAN [view interactions] High throughput no yes
MA1A2_HUMAN [view interactions] High throughput no yes
KCJ11_HUMAN [view interactions] High throughput no no
PLPL6_HUMAN [view entry] [view interactions] High throughput yes yes
LMBR1_HUMAN [view interactions] High throughput no yes
CHST7_HUMAN [view interactions] High throughput no yes
S12A9_HUMAN [view interactions] High throughput no yes
GOSR1_HUMAN [view entry] [view interactions] High throughput yes yes
IPIL2_HUMAN [view interactions] High throughput no no
TM39A_HUMAN [view interactions] High throughput no yes