ABCD1_HUMAN
Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (PubMed, PubMed, PubMed, PubMed). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial function like, mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ABCD1_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 33.3333 | 4 | yes |
GO:0000166 | nucleotide binding | 33.3333 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 33.3333 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 33.3333 | 4 | yes |
GO:0017076 | purine nucleotide binding | 33.3333 | 5 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 33.3333 | 6 | yes |
GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | yes |
GO:0015399 | primary active transmembrane transporter activity | 29.6296 | 4 | yes |
GO:0042803 | protein homodimerization activity | 22.2222 | 4 | yes |
GO:0003723 | RNA binding | 22.2222 | 4 | no |
GO:0008324 | monoatomic cation transmembrane transporter activity | 22.2222 | 4 | no |
GO:0022890 | inorganic cation transmembrane transporter activity | 22.2222 | 4 | no |
GO:0005524 | ATP binding | 18.5185 | 5 | yes |
GO:0016887 | ATP hydrolysis activity | 18.5185 | 7 | yes |
GO:0030554 | adenyl nucleotide binding | 18.5185 | 6 | yes |
GO:0032559 | adenyl ribonucleotide binding | 18.5185 | 5 | yes |
GO:0046943 | carboxylic acid transmembrane transporter activity | 11.1111 | 4 | yes |
GO:0046982 | protein heterodimerization activity | 11.1111 | 4 | yes |
GO:0047617 | fatty acyl-CoA hydrolase activity | 11.1111 | 6 | yes |
GO:0005324 | long-chain fatty acid transmembrane transporter activity | 11.1111 | 5 | yes |
GO:0008028 | monocarboxylic acid transmembrane transporter activity | 11.1111 | 5 | yes |
GO:0015245 | fatty acid transmembrane transporter activity | 11.1111 | 4 | yes |
GO:0016289 | acyl-CoA hydrolase activity | 11.1111 | 5 | yes |
GO:0016790 | thiolester hydrolase activity | 11.1111 | 4 | yes |
GO:0043531 | ADP binding | 7.4074 | 5 | yes |
GO:0071077 | adenosine 3,5-bisphosphate transmembrane transporter activity | 7.4074 | 5 | yes |
GO:0000295 | adenine nucleotide transmembrane transporter activity | 7.4074 | 6 | yes |
GO:0005346 | purine ribonucleotide transmembrane transporter activity | 7.4074 | 4 | yes |
GO:0015215 | nucleotide transmembrane transporter activity | 7.4074 | 4 | yes |
GO:0015216 | purine nucleotide transmembrane transporter activity | 7.4074 | 5 | yes |
GO:0015607 | ABC-type fatty-acyl-CoA transporter activity | 7.4074 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ABCD1_HUMAN |
---|---|---|---|---|
GO:0006996 | organelle organization | 51.8519 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 44.4444 | 4 | yes |
GO:0022607 | cellular component assembly | 40.7407 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | yes |
GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 29.6296 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 29.6296 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 29.6296 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 29.6296 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 25.9259 | 4 | yes |
GO:0010468 | regulation of gene expression | 25.9259 | 6 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.9259 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 25.9259 | 5 | yes |
GO:0061024 | membrane organization | 25.9259 | 4 | yes |
GO:0008104 | protein localization | 25.9259 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 22.2222 | 4 | yes |
GO:0009894 | regulation of catabolic process | 22.2222 | 4 | yes |
GO:0030030 | cell projection organization | 22.2222 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 22.2222 | 5 | yes |
GO:0010646 | regulation of cell communication | 22.2222 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 22.2222 | 5 | no |
GO:0043933 | protein-containing complex organization | 22.2222 | 4 | no |
GO:0065003 | protein-containing complex assembly | 22.2222 | 5 | no |
GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 22.2222 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 18.5185 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 18.5185 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 18.5185 | 5 | yes |
GO:0019693 | ribose phosphate metabolic process | 18.5185 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 18.5185 | 5 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 18.5185 | 6 | yes |
GO:0072521 | purine-containing compound metabolic process | 18.5185 | 4 | yes |
GO:0006163 | purine nucleotide metabolic process | 18.5185 | 5 | yes |
GO:0006753 | nucleoside phosphate metabolic process | 18.5185 | 4 | yes |
GO:0009117 | nucleotide metabolic process | 18.5185 | 5 | yes |
GO:0009150 | purine ribonucleotide metabolic process | 18.5185 | 6 | yes |
GO:0009259 | ribonucleotide metabolic process | 18.5185 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 14.8148 | 6 | yes |
GO:0016042 | lipid catabolic process | 14.8148 | 4 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 14.8148 | 6 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 14.8148 | 4 | yes |
GO:0006869 | lipid transport | 14.8148 | 5 | yes |
GO:0008610 | lipid biosynthetic process | 14.8148 | 4 | yes |
GO:0009896 | positive regulation of catabolic process | 11.1111 | 5 | yes |
GO:0010629 | negative regulation of gene expression | 11.1111 | 7 | yes |
GO:0015711 | organic anion transport | 11.1111 | 5 | yes |
GO:0015718 | monocarboxylic acid transport | 11.1111 | 7 | yes |
GO:0015849 | organic acid transport | 11.1111 | 5 | yes |
GO:0015908 | fatty acid transport | 11.1111 | 6 | yes |
GO:0015909 | long-chain fatty acid transport | 11.1111 | 7 | yes |
GO:0015910 | long-chain fatty acid import into peroxisome | 11.1111 | 5 | yes |
GO:0015919 | peroxisomal membrane transport | 11.1111 | 5 | yes |
GO:0016053 | organic acid biosynthetic process | 11.1111 | 4 | yes |
GO:0016054 | organic acid catabolic process | 11.1111 | 4 | yes |
GO:0019395 | fatty acid oxidation | 11.1111 | 5 | yes |
GO:0019752 | carboxylic acid metabolic process | 11.1111 | 5 | yes |
GO:0030258 | lipid modification | 11.1111 | 4 | yes |
GO:0031329 | regulation of cellular catabolic process | 11.1111 | 5 | yes |
GO:0032365 | intracellular lipid transport | 11.1111 | 4 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 11.1111 | 6 | yes |
GO:0034440 | lipid oxidation | 11.1111 | 5 | yes |
GO:0042760 | very long-chain fatty acid catabolic process | 11.1111 | 6 | yes |
GO:0043436 | oxoacid metabolic process | 11.1111 | 4 | yes |
GO:0043457 | regulation of cellular respiration | 11.1111 | 6 | yes |
GO:0043467 | regulation of generation of precursor metabolites and energy | 11.1111 | 5 | yes |
GO:0043574 | peroxisomal transport | 11.1111 | 4 | yes |
GO:0044242 | cellular lipid catabolic process | 11.1111 | 4 | yes |
GO:0046394 | carboxylic acid biosynthetic process | 11.1111 | 5 | yes |
GO:0046395 | carboxylic acid catabolic process | 11.1111 | 5 | yes |
GO:0046942 | carboxylic acid transport | 11.1111 | 6 | yes |
GO:0051881 | regulation of mitochondrial membrane potential | 11.1111 | 4 | yes |
GO:0072329 | monocarboxylic acid catabolic process | 11.1111 | 6 | yes |
GO:0072330 | monocarboxylic acid biosynthetic process | 11.1111 | 6 | yes |
GO:1901565 | organonitrogen compound catabolic process | 11.1111 | 4 | yes |
GO:1902001 | fatty acid transmembrane transport | 11.1111 | 5 | yes |
GO:1903426 | regulation of reactive oxygen species biosynthetic process | 11.1111 | 5 | yes |
GO:1903427 | negative regulation of reactive oxygen species biosynthetic process | 11.1111 | 6 | yes |
GO:1903715 | regulation of aerobic respiration | 11.1111 | 7 | yes |
GO:1905039 | carboxylic acid transmembrane transport | 11.1111 | 4 | yes |
GO:2000377 | regulation of reactive oxygen species metabolic process | 11.1111 | 5 | yes |
GO:2000378 | negative regulation of reactive oxygen species metabolic process | 11.1111 | 6 | yes |
GO:0000038 | very long-chain fatty acid metabolic process | 11.1111 | 5 | yes |
GO:0001676 | long-chain fatty acid metabolic process | 11.1111 | 5 | yes |
GO:0001817 | regulation of cytokine production | 11.1111 | 4 | yes |
GO:0002082 | regulation of oxidative phosphorylation | 11.1111 | 8 | yes |
GO:0006631 | fatty acid metabolic process | 11.1111 | 4 | yes |
GO:0006633 | fatty acid biosynthetic process | 11.1111 | 5 | yes |
GO:0006635 | fatty acid beta-oxidation | 11.1111 | 6 | yes |
GO:0007031 | peroxisome organization | 11.1111 | 5 | yes |
GO:0009062 | fatty acid catabolic process | 11.1111 | 5 | yes |
GO:0010565 | regulation of cellular ketone metabolic process | 7.4074 | 5 | yes |
GO:0019216 | regulation of lipid metabolic process | 7.4074 | 5 | yes |
GO:0019217 | regulation of fatty acid metabolic process | 7.4074 | 6 | yes |
GO:0030497 | fatty acid elongation | 7.4074 | 6 | yes |
GO:0031331 | positive regulation of cellular catabolic process | 7.4074 | 6 | yes |
GO:0031998 | regulation of fatty acid beta-oxidation | 7.4074 | 6 | yes |
GO:0032000 | positive regulation of fatty acid beta-oxidation | 7.4074 | 7 | yes |
GO:0033559 | unsaturated fatty acid metabolic process | 7.4074 | 5 | yes |
GO:0033865 | nucleoside bisphosphate metabolic process | 7.4074 | 5 | yes |
GO:0033869 | nucleoside bisphosphate catabolic process | 7.4074 | 6 | yes |
GO:0033875 | ribonucleoside bisphosphate metabolic process | 7.4074 | 6 | yes |
GO:0034031 | ribonucleoside bisphosphate catabolic process | 7.4074 | 7 | yes |
GO:0034032 | purine nucleoside bisphosphate metabolic process | 7.4074 | 5 | yes |
GO:0034034 | purine nucleoside bisphosphate catabolic process | 7.4074 | 6 | yes |
GO:0034655 | nucleobase-containing compound catabolic process | 7.4074 | 4 | yes |
GO:0035337 | fatty-acyl-CoA metabolic process | 7.4074 | 4 | yes |
GO:0036109 | alpha-linolenic acid metabolic process | 7.4074 | 4 | yes |
GO:0036111 | very long-chain fatty-acyl-CoA metabolic process | 7.4074 | 5 | yes |
GO:0036113 | very long-chain fatty-acyl-CoA catabolic process | 7.4074 | 6 | yes |
GO:0036115 | fatty-acyl-CoA catabolic process | 7.4074 | 5 | yes |
GO:0042304 | regulation of fatty acid biosynthetic process | 7.4074 | 6 | yes |
GO:0042758 | long-chain fatty acid catabolic process | 7.4074 | 6 | yes |
GO:0043217 | myelin maintenance | 7.4074 | 6 | yes |
GO:0043651 | linoleic acid metabolic process | 7.4074 | 4 | yes |
GO:0044273 | sulfur compound catabolic process | 7.4074 | 4 | yes |
GO:0045723 | positive regulation of fatty acid biosynthetic process | 7.4074 | 7 | yes |
GO:0045834 | positive regulation of lipid metabolic process | 7.4074 | 5 | yes |
GO:0045923 | positive regulation of fatty acid metabolic process | 7.4074 | 6 | yes |
GO:0046320 | regulation of fatty acid oxidation | 7.4074 | 7 | yes |
GO:0046321 | positive regulation of fatty acid oxidation | 7.4074 | 7 | yes |
GO:0046434 | organophosphate catabolic process | 7.4074 | 4 | yes |
GO:0046889 | positive regulation of lipid biosynthetic process | 7.4074 | 6 | yes |
GO:0046890 | regulation of lipid biosynthetic process | 7.4074 | 5 | yes |
GO:0050994 | regulation of lipid catabolic process | 7.4074 | 5 | yes |
GO:0050996 | positive regulation of lipid catabolic process | 7.4074 | 6 | yes |
GO:0051900 | regulation of mitochondrial depolarization | 7.4074 | 5 | yes |
GO:0055089 | fatty acid homeostasis | 7.4074 | 4 | yes |
GO:0055092 | sterol homeostasis | 7.4074 | 4 | yes |
GO:0062012 | regulation of small molecule metabolic process | 7.4074 | 4 | yes |
GO:0062013 | positive regulation of small molecule metabolic process | 7.4074 | 5 | yes |
GO:0072523 | purine-containing compound catabolic process | 7.4074 | 5 | yes |
GO:0080134 | regulation of response to stress | 7.4074 | 4 | yes |
GO:0080135 | regulation of cellular response to stress | 7.4074 | 4 | yes |
GO:0106027 | neuron projection organization | 7.4074 | 6 | yes |
GO:1900015 | regulation of cytokine production involved in inflammatory response | 7.4074 | 5 | yes |
GO:1900016 | negative regulation of cytokine production involved in inflammatory response | 7.4074 | 6 | yes |
GO:1900407 | regulation of cellular response to oxidative stress | 7.4074 | 5 | yes |
GO:1901136 | carbohydrate derivative catabolic process | 7.4074 | 4 | yes |
GO:1901292 | nucleoside phosphate catabolic process | 7.4074 | 5 | yes |
GO:1901361 | organic cyclic compound catabolic process | 7.4074 | 4 | yes |
GO:1901568 | fatty acid derivative metabolic process | 7.4074 | 4 | yes |
GO:1901569 | fatty acid derivative catabolic process | 7.4074 | 5 | yes |
GO:1902882 | regulation of response to oxidative stress | 7.4074 | 5 | yes |
GO:1990535 | neuron projection maintenance | 7.4074 | 7 | yes |
GO:2001279 | regulation of unsaturated fatty acid biosynthetic process | 7.4074 | 7 | yes |
GO:2001280 | positive regulation of unsaturated fatty acid biosynthetic process | 7.4074 | 8 | yes |
GO:0001818 | negative regulation of cytokine production | 7.4074 | 5 | yes |
GO:0003254 | regulation of membrane depolarization | 7.4074 | 4 | yes |
GO:0006195 | purine nucleotide catabolic process | 7.4074 | 6 | yes |
GO:0007009 | plasma membrane organization | 7.4074 | 5 | yes |
GO:0009154 | purine ribonucleotide catabolic process | 7.4074 | 6 | yes |
GO:0009166 | nucleotide catabolic process | 7.4074 | 6 | yes |
GO:0009261 | ribonucleotide catabolic process | 7.4074 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PEX19_HUMAN | [view interactions] | Low throughput | no | yes |
ABCD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ABCD2_HUMAN | [view interactions] | Low throughput | no | no |
ABCD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
S27A2_HUMAN | [view interactions] | Low throughput | no | no |
RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VP26B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAS_HUMAN | [view interactions] | High throughput | no | no |
APJ_HUMAN | [view interactions] | High throughput | no | yes |
S15A1_HUMAN | [view interactions] | High throughput | no | no |
VASN_HUMAN | [view interactions] | High throughput | no | yes |
SCN3B_HUMAN | [view interactions] | High throughput | no | no |
ROAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERF2_HUMAN | [view interactions] | High throughput | no | yes |
POTE1_HUMAN | [view interactions] | High throughput | no | no |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S39A4_HUMAN | [view interactions] | High throughput | no | no |
IQCF1_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S39AC_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
EMC4_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
FBX6_HUMAN | [view interactions] | High throughput | no | yes |
GPR12_HUMAN | [view interactions] | High throughput | no | no |
HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CREL1_HUMAN | [view interactions] | High throughput | no | yes |
AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTLA4_HUMAN | [view interactions] | High throughput | no | no |
CKLF8_HUMAN | [view interactions] | High throughput | no | yes |
TMEM9_HUMAN | [view interactions] | High throughput | no | no |
AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
BACE2_HUMAN | [view interactions] | High throughput | no | yes |
S10A2_HUMAN | [view interactions] | High throughput | no | no |
GP182_HUMAN | [view interactions] | High throughput | no | no |
EFMT3_HUMAN | [view interactions] | High throughput | no | no |
BCL2_HUMAN | [view interactions] | High throughput | no | no |
CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RND2_HUMAN | [view interactions] | High throughput | no | no |
MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
TP4A3_HUMAN | [view interactions] | High throughput | no | no |
PEX3_HUMAN | [view interactions] | High throughput | no | yes |
NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADAS_HUMAN | [view interactions] | High throughput | no | yes |
ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |